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Gene: Cop1 (COP1, E3 ubiquitin ligase) Rattus norvegicus

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Symbol:

Cop1

Name:

COP1, E3 ubiquitin ligase

RGD ID:

1304773

Description:

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and response to ionizing radiation. Located in Golgi membrane. Orthologous to human COP1 (COP1 E3 ubiquitin ligase); PARTICIPATES IN p53 signaling pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

E3 ubiquitin-protein ligase COP1; E3 ubiquitin-protein ligase RFWD2; LOC100360800; LOC360860; MGC109175; Rfwd2; RGD1304773; ring finger and WD repeat domain 2; ring finger and WD repeat domain 2, E3 ubiquitin protein ligase; similar to constitutive photomorphogenic protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	COP1 (COP1 E3 ubiquitin ligase)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB
Mus musculus (house mouse):	Cop1 (COP1, E3 ubiquitin ligase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cop1 (COP1 E3 ubiquitin ligase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	COP1 (COP1 E3 ubiquitin ligase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	COP1 (COP1 E3 ubiquitin ligase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cop1 (COP1 E3 ubiquitin ligase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	COP1 (COP1 E3 ubiquitin ligase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	COP1 (COP1 E3 ubiquitin ligase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cop1 (COP1 E3 ubiquitin ligase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Cop1 (COP1 E3 ubiquitin ligase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ARL8A (ARF like GTPase 8A)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	COP1 (COP1 E3 ubiquitin ligase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Cop1 (COP1, E3 ubiquitin ligase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cop1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cop1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cop1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Allele / Splice:

Rfwd2^em1Mcwi

Genetic Models:

SS-Rfwd2^em1Mcwi

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	73,954,058 - 74,095,283 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	73,963,145 - 74,095,269 (+)	Ensembl				GRCr8
mRatBN7.2	13	71,467,164 - 71,561,826 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	71,429,961 - 71,538,890 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	74,044,221 - 74,138,940 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	75,344,334 - 75,439,013 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	72,603,700 - 72,698,383 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	76,942,883 - 77,076,015 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	76,942,928 - 77,075,723 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	81,853,391 - 81,986,197 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	74,552,876 - 74,590,608 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	71,277,941 - 71,371,841 (+)	NCBI		Celera
RGSC_v3.1	13	74,979,314 - 74,981,857 (-)	NCBI
Cytogenetic Map	13	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

all-trans-retinoic acid (ISO)

amphetamine (EXP)

aristolochic acid A (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Butylbenzyl phthalate (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

crocidolite asbestos (ISO)

ethanol (ISO)

fenvalerate (EXP)

ketoconazole (ISO)

paracetamol (ISO)

potassium chromate (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

titanium dioxide (ISO)

trichloroethene (ISO)

triphenyl phosphate (ISO)

tunicamycin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of fatty acid biosynthetic process (IEA,ISO)

positive regulation of proteasomal ubiquitin-dependent protein catabolic process (IEA,ISO)

proteasome-mediated ubiquitin-dependent protein catabolic process (IBA,IEA,ISO)

response to ionizing radiation (IEA,ISO)

ubiquitin-dependent protein catabolic process (IEA,ISO)

Cellular Component

Cul4A-RING E3 ubiquitin ligase complex (IEA,ISO)

Golgi membrane (IDA)

nucleus (IEA)

Molecular Function

metal ion binding (IEA)

protein binding (ISO)

transferase activity (IEA)

ubiquitin protein ligase activity (IBA,IEA,ISO)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

p53 signaling pathway (IEA)

ubiquitin/proteasome degradation pathway (IEA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal circadian regulation of systemic arterial blood pressure (IMP)

salt-sensitive hypertension (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Cytosol-derived proteins are sufficient for Arp2/3 recruitment and ARF/coatomer-dependent actin polymerization on Golgi membranes.	Chen JL, etal., FEBS Lett. 2004 May 21;566(1-3):281-6.
2.	Characterization of biological pathways associated with a 1.37 Mbp genomic region protective of hypertension in Dahl S rats.	Cowley AW, etal., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:14739464	PMID:18815134	PMID:19805145	PMID:27658392	PMID:38909848

Genomics

Comparative Map Data

Cop1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	73,954,058 - 74,095,283 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	73,963,145 - 74,095,269 (+)	Ensembl				GRCr8
mRatBN7.2	13	71,467,164 - 71,561,826 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	71,429,961 - 71,538,890 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	74,044,221 - 74,138,940 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	75,344,334 - 75,439,013 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	72,603,700 - 72,698,383 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	76,942,883 - 77,076,015 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	76,942,928 - 77,075,723 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	81,853,391 - 81,986,197 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	74,552,876 - 74,590,608 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	71,277,941 - 71,371,841 (+)	NCBI		Celera
RGSC_v3.1	13	74,979,314 - 74,981,857 (-)	NCBI
Cytogenetic Map	13	q22	NCBI

COP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	175,944,831 - 176,207,286 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	175,944,828 - 176,207,510 (-)	Ensembl			hg38	GRCh38
GRCh37	1	175,913,967 - 176,176,422 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	174,180,590 - 174,442,993 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	172,645,624 - 172,908,027	NCBI
Celera	1	149,024,694 - 149,287,018 (-)	NCBI		Celera
Cytogenetic Map	1	q25.1-q25.2	NCBI
HuRef	1	147,140,664 - 147,403,100 (-)	NCBI		HuRef
CHM1_1	1	177,337,538 - 177,600,480 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	175,300,159 - 175,562,553 (-)	NCBI		T2T-CHM13v2.0

Cop1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	159,059,734 - 159,182,442 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	159,059,890 - 159,175,210 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	159,232,156 - 159,354,872 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	159,232,320 - 159,347,640 (+)	Ensembl			mm10	GRCm38
MGSCv37	1	161,162,457 - 161,277,711 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	161,069,003 - 161,184,257 (+)	NCBI		MGSCv36	mm8
Celera	1	161,631,243 - 161,748,921 (+)	NCBI		Celera
Cytogenetic Map	1	H1	NCBI
cM Map	1	69.03	NCBI

Cop1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	15,662,546 - 15,859,306 (-)	Ensembl
ChiLan1.0	NW_004955406	15,662,546 - 15,859,306 (-)	NCBI	ChiLan1.0	ChiLan1.0

COP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	73,506,205 - 73,784,010 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	73,186,486 - 73,457,341 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	151,459,354 - 151,727,131 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	155,155,860 - 155,425,664 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	155,156,185 - 155,425,156 (-)	Ensembl			panPan2	panpan1.1

COP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	23,320,483 - 23,565,093 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	23,277,209 - 23,563,397 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	22,845,782 - 23,088,376 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	23,068,997 - 23,312,240 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	23,069,323 - 23,326,866 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	22,980,843 - 23,224,152 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	23,074,250 - 23,317,391 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	23,217,346 - 23,460,833 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Cop1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	94,415,666 - 94,590,738 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936481	12,262,409 - 12,437,571 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936481	12,262,415 - 12,437,627 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

COP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	117,915,443 - 118,114,259 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	9	117,913,504 - 118,114,268 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	129,664,173 - 129,764,054 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

COP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	53,057,479 - 53,316,662 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	53,057,784 - 53,314,398 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666055	54,611,740 - 54,870,873 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cop1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624771	5,922,067 - 6,133,597 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624771	5,922,086 - 6,132,537 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Cop1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	10	38,538,118 - 38,664,476 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Cop1
1141 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	317
Count of miRNA genes:	203
Interacting mature miRNAs:	228
Transcripts:	ENSRNOT00000040505
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298066	Bp159	Blood pressure QTL 159		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	48639634	93639634	Rat
10755495	Bp387	Blood pressure QTL 387	3.78		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37216241	90057603	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	38975045	103588154	Rat
8655951	Rf63	Renal function QTL 63	12.2		blood urea nitrogen amount (VT:0005265)	plasma urea nitrogen level (CMO:0000586)	13	71610804	109350286	Rat
70220	Bp55	Blood pressure QTL 55	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	39924693	84924693	Rat
8655945	Rf61	Renal function QTL 61	3.6		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	13	71610804	89333251	Rat
71119	Thym2	Thymus enlargement QTL 2	3.8		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	13	48749814	87285480	Rat
4889861	Pur29	Proteinuria QTL 29	13.8	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	39968211	83286298	Rat
1331783	Bp221	Blood pressure QTL 221	3.72886		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	71610804	89333251	Rat
8655959	Pur32	Proteinuria QTL 32	8.4		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	72984506	99745408	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	67635937	109350286	Rat
1300166	Kidm6	Kidney mass QTL 6	3.93		kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	13	71610804	89333251	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	7421791	87286911	Rat
61340	Bp25	Blood pressure QTL 25	4.2	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37087983	82087983	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
1549897	Stresp12	Stress response QTL 12	3.35		stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	13	40983585	85983585	Rat
724564	Uae11	Urinary albumin excretion QTL 11	5.7		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	13	47354258	94285672	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	21120177	109350286	Rat
738027	Lnnr6	Liver neoplastic nodule remodeling QTL 6	3.3		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	65613454	109350286	Rat
7387280	Uae43	Urinary albumin excretion QTL 43	5.69	0.4174	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	68983334	109350286	Rat
738026	Lnnr5	Liver neoplastic nodule remodeling QTL 5	3.29		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	62424592	88113509	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	33794096	78794096	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	67635937	109350286	Rat
61349	Bp31	Blood pressure QTL 31	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	39924693	84924693	Rat
1576318	Schws5	Schwannoma susceptibility QTL 5		0.0351	nervous system integrity trait (VT:0010566)	post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)	13	64497900	109350286	Rat
2303563	Bw89	Body weight QTL 89	6		body mass (VT:0001259)	body weight (CMO:0000012)	13	34834947	79834947	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	11081740	103588154	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
12879477	Bp401	Blood pressure QTL 401			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	39814726	84814726	Rat
1331750	Bp220	Blood pressure QTL 220	2.98		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	39968211	84968211	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	64375743	109350286	Rat
11530006	Niddm72	Non-insulin dependent diabetes mellitus QTL 72		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	38286298	83286298	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	103588154	Rat
2293341	Glom15	Glomerulus QTL 15	9.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	13	67635937	109350286	Rat

Markers in Region

D13Rat42

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	71,437,071 - 71,437,240 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	76,950,525 - 76,950,693	NCBI	Rnor6.0
Rnor_5.0	13	81,860,983 - 81,861,151	UniSTS	Rnor5.0
RGSC_v3.4	13	74,560,206 - 74,560,623	RGD	RGSC3.4
RGSC_v3.4	13	74,560,243 - 74,560,411	UniSTS	RGSC3.4
Celera	13	71,247,857 - 71,248,025	UniSTS
RGSC_v3.1	13	74,574,431 - 74,574,599	RGD
RH 3.4 Map	13	448.0	RGD
RH 3.4 Map	13	448.0	UniSTS
RH 2.0 Map	13	539.4	RGD
FHH x ACI Map	13	30.36	RGD
Cytogenetic Map	13	q22	UniSTS

RH142379

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	71,561,260 - 71,561,427 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	77,075,152 - 77,075,318	NCBI	Rnor6.0
Rnor_5.0	13	81,985,632 - 81,985,798	UniSTS	Rnor5.0
RGSC_v3.4	13	74,965,519 - 74,965,685	UniSTS	RGSC3.4
Celera	13	71,371,276 - 71,371,442	UniSTS
Cytogenetic Map	13	q22	UniSTS

RH134650

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	71,561,521 - 71,561,733 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	77,075,413 - 77,075,624	NCBI	Rnor6.0
Rnor_5.0	13	81,985,893 - 81,986,104	UniSTS	Rnor5.0
RGSC_v3.4	13	74,965,213 - 74,965,424	UniSTS	RGSC3.4
Celera	13	71,371,537 - 71,371,748	UniSTS
Cytogenetic Map	13	q22	UniSTS

Genetic Models

This gene Cop1 is modified in the following models/strains:

SS-Rfwd2^em1Mcwi

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001025126	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001428839	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001428840	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001428841	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006250113	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006250114	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272480	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272481	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272482	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272483	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272484	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC091284	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000040505 ⟹ ENSRNOP00000048511

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	73,963,145 - 74,095,269 (+)	Ensembl
mRatBN7.2 Ensembl	13	71,429,961 - 71,538,890 (+)	Ensembl
Rnor_6.0 Ensembl	13	76,942,928 - 77,075,723 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000076581 ⟹ ENSRNOP00000068073

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	13	76,962,504 - 77,075,685 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000076851

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	13	76,980,611 - 77,075,723 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000076892

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	13	76,994,533 - 77,004,167 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000076908 ⟹ ENSRNOP00000068019

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	13	76,943,633 - 76,979,449 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000167156 ⟹ ENSRNOP00000103221

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	73,985,608 - 74,095,269 (+)	Ensembl

RefSeq Acc Id:

NM_001025126 ⟹ NP_001020297

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	74,000,599 - 74,095,277 (+)	NCBI
mRatBN7.2	13	71,467,164 - 71,561,826 (+)	NCBI
Rnor_6.0	13	76,980,611 - 77,075,717 (+)	NCBI
Rnor_5.0	13	81,853,391 - 81,986,197 (+)	NCBI
Celera	13	71,277,941 - 71,371,841 (+)	RGD

Sequence:

show sequence

TTTTTGATTTCAGATTAACTTTACTTTTGTACTCTATGAAAGGTATTTTTGAGAAGTTTGAAGA
CAAAAGGGGACTAATAAAAAGCTGAGGCTAGAACAGACTATAATGCTGTACGCTTGCTTGATTT
ATACATCCTCTGTTTGGACTGTGTAGAGTAACTCATATACTTACAATTTCAGGAGATGAGTGGC
TTGTACTCCCCCGTCAGTGAAGATAGCACGGTGCCTCAATTTGAAGCTCCTTCTCCATCGCACA
GTAGCATTATTGACTCTACAGAATACAGCCAACCTCCAGGCTTCAGTGGGCCGTCTCAGACAAA
GAAACAGCCTTGGTATAACAGCACATTAGCATCAAGACGAAAGCGACTCACTGCTCATTTTGAA
GACTTAGAGCAGTGTTATTTTTCTACAAGGATGTCTCGTATCTCAGATGACAGTAGAACTGCAA
GCCAGTTAGATGAATTTCAAGAATGCTTGTCCAAATTTACTCGATATAACTCTGTAAGACCGTT
GGCCACATTGTCTTATGCTAGTGATCTGTATAATGGTTCCAGCATAGTTTCTAGTATTGAATTT
GACCGGGATTGTGACTACTTTGCAATTGCTGGAGTTACAAAGAAGATTAAAGTCTATGAATATG
GCACAGTCATCCAGGATGCAGTGGATATTCATTACCCTGAGAATGAAATGACCTGCAATTCCAA
AATCAGCTGTATCAGTTGGAGTAGTTACCATAAGAACCTGCTAGCCAGCAGTGATTATGAAGGC
ACCGTTATACTATGGGATGGATTCACAGGACAGAGGTCAAAGGTCTATCAGGAGCATGAAAAGA
GGTGTTGGAGTGTCGACTTTAATTTGATGGATCCCAAACTTCTGGCTTCAGGTTCTGATGATGC
AAAAGTGAAGCTTTGGTCCACCAATTTAGACAATTCTGTGGCAAGCATCGAGGCAAAAGCTAAT
GTGTGTTGTGTGAAGTTCAGCCCCTCCTCCAGGTACCATCTGGCTTTTGGCTGTGCAGATCACT
GTGTCCACTACTACGATCTTCGTAACACTAAACAGCCAATAATGGTGTTCAAGGGGCACCGAAA
AGCAGTGTCTTATGCCAAGTTTGTGAGTGGTGAAGAAATTGTCTCTGCCTCAACAGACAGCCAA
CTAAAACTGTGGAATGTGGGGAAACCATACTGTCTACGTTCCTTCAAGGGTCATATTAATGAAA
AAAACTTTGTAGGCCTTGCTTCCAATGGAGATTATATAGCTTGTGGAAGTGAGAACAACTCCCT
CTACCTGTACTATAAAGGACTTTCTAAGACTTTGCTAACTTTTAAGTTTGATACAGTTAAGAGT
GTATTAGATAAAGACCGGAAAGAAGATGACACCAATGAATTTGTCAGTGCTGTGTGTTGGCGGG
CACTATCAGATGGGGAGTCCAATGTGCTGATTGCTGCTAACAGCCAGGGTACAATTAAGGTGCT
AGAATTGGTATAAAGAATTTCCTGAAGTCAAATTGTGTTTGATCCCCCCAAAAGCCGTCTGCAG
CTGATGATGAGAAGAGAAAGAAATGGCATGTGATGTCTCTCCCAACGTCGTTTGGATGTGTTCT
GAGTACCTTTTCCCTCCTTTTTGCCTTTGGGACATTGGGAATATCCAGAGAATTCTCCGCCGTC
AGTGTAACTATGAACTTTGCTGTTGGCAGTGTGGCTATCTAATTTTTGTGATAGGGAAACAAAT
TCTTTTAAATAAAAATAAATAACAAAAAAAAAAAGTTTATCGAGCCACAGCTGAGCTGGAAACA
CCTTTGTCAGGTGGAGTGAGAGTCTTTCGAAGAAGTAGCACTTGTGGGCTGTACAGAATGTTCT
GGCTGGGGCTGGAAAGAGGCTCGGTGAATAAGAGCACTGGCTGCTCCTACAGAGGATCTGGGTT
CAGTCCCCAGAGTCCCCAGCACCTACGTAGCAGCTCACTGCCACTTATGATTCCAGTAGATCTG
ACCTCCTCTTCTGGCCTCCTTGAGCACCAGGTATGCATGTGGTGCACATACAAACATCCGGACA
AAACGCTCACACATAAAAATGAAAATAAATCTTATTTTAAAACAAAAAAAAAAAAAAAAAAAAA
AAAAAA

hide sequence

RefSeq Acc Id:

XM_063272480 ⟹ XP_063128550

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	73,954,058 - 74,095,283 (+)	NCBI

RefSeq Acc Id:

XM_063272481 ⟹ XP_063128551

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	73,954,058 - 74,095,283 (+)	NCBI

RefSeq Acc Id:

XM_063272482 ⟹ XP_063128552

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	73,954,058 - 74,095,283 (+)	NCBI

RefSeq Acc Id:

XM_063272483 ⟹ XP_063128553

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	73,954,058 - 74,095,283 (+)	NCBI

RefSeq Acc Id:

XM_063272484 ⟹ XP_063128554

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	73,991,323 - 74,095,283 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001020297	(Get FASTA)	NCBI Sequence Viewer
	NP_001415768	(Get FASTA)	NCBI Sequence Viewer
	NP_001415769	(Get FASTA)	NCBI Sequence Viewer
	NP_001415770	(Get FASTA)	NCBI Sequence Viewer
	XP_063128550	(Get FASTA)	NCBI Sequence Viewer
	XP_063128551	(Get FASTA)	NCBI Sequence Viewer
	XP_063128552	(Get FASTA)	NCBI Sequence Viewer
	XP_063128553	(Get FASTA)	NCBI Sequence Viewer
	XP_063128554	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH91284	(Get FASTA)	NCBI Sequence Viewer
	EDM09450	(Get FASTA)	NCBI Sequence Viewer
	EDM09451	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000048511
	ENSRNOP00000048511.7
	ENSRNOP00000103221
	ENSRNOP00000103221.1

RefSeq Acc Id:

NP_001020297 ⟸ NM_001025126

- Sequence:

show sequence

MSGLYSPVSEDSTVPQFEAPSPSHSSIIDSTEYSQPPGFSGPSQTKKQPWYNSTLASRRKRLTA
HFEDLEQCYFSTRMSRISDDSRTASQLDEFQECLSKFTRYNSVRPLATLSYASDLYNGSSIVSS
IEFDRDCDYFAIAGVTKKIKVYEYGTVIQDAVDIHYPENEMTCNSKISCISWSSYHKNLLASSD
YEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNLDNSVASIEA
KANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSAST
DSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDT
VKSVLDKDRKEDDTNEFVSAVCWRALSDGESNVLIAANSQGTIKVLELV

hide sequence

Ensembl Acc Id:

ENSRNOP00000068019 ⟸ ENSRNOT00000076908

Ensembl Acc Id:

ENSRNOP00000068073 ⟸ ENSRNOT00000076581

Ensembl Acc Id:

ENSRNOP00000048511 ⟸ ENSRNOT00000040505

RefSeq Acc Id:	XP_063128550 ⟸ XM_063272480
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063128552 ⟸ XM_063272482
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063128551 ⟸ XM_063272481
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063128553 ⟸ XM_063272483
- Peptide Label:	isoform X4
- UniProtKB:	A0A096UWG1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063128554 ⟸ XM_063272484
- Peptide Label:	isoform X5
- UniProtKB:	F1LUP6 (UniProtKB/TrEMBL), Q5BJY0 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000103221 ⟸ ENSRNOT00000167156

Protein Domains

RING-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A096UWG1-F1-model_v2	AlphaFold	A0A096UWG1	1-733	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698923

Promoter ID:

EPDNEW_R9448

Type:

initiation region

Name:

Rfwd2_1

Description:

ring finger and WD repeat domain 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	76,943,284 - 76,943,344	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1304773	AgrOrtholog
BioCyc Gene	G2FUF-17773	BioCyc
Ensembl Genes	ENSRNOG00000042492	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000040505	ENTREZGENE
	ENSRNOT00000040505.8	UniProtKB/TrEMBL
	ENSRNOT00000167156	ENTREZGENE
	ENSRNOT00000167156.1	UniProtKB/TrEMBL
Gene3D-CATH	2.130.10.10	UniProtKB/TrEMBL
	3.30.40.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7304516	IMAGE-MGC_LOAD
InterPro	COP1	UniProtKB/TrEMBL
	G-protein_beta_WD-40_rep	UniProtKB/TrEMBL
	WD40/YVTN_repeat-like_dom	UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/TrEMBL
	WD40_repeat_CS	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
	Znf_RING	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
	Znf_RING_CS	UniProtKB/TrEMBL
KEGG Report	rno:360860	UniProtKB/TrEMBL
MGC_CLONE	MGC:109175	IMAGE-MGC_LOAD
NCBI Gene	360860	ENTREZGENE
PANTHER	E3 UBIQUITIN-PROTEIN LIGASE COP1	UniProtKB/TrEMBL
	PTHR44080	UniProtKB/TrEMBL
Pfam	WD40	UniProtKB/TrEMBL
	zf-C3HC4_2	UniProtKB/TrEMBL
PhenoGen	Cop1	PhenoGen
PRINTS	GPROTEINBRPT	UniProtKB/TrEMBL
PROSITE	WD_REPEATS_1	UniProtKB/TrEMBL
	WD_REPEATS_2	UniProtKB/TrEMBL
	ZF_RING_1	UniProtKB/TrEMBL
	ZF_RING_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000042492	RatGTEx
SMART	RING	UniProtKB/TrEMBL
	WD40	UniProtKB/TrEMBL
Superfamily-SCOP	RING/U-box	UniProtKB/TrEMBL
	WD40_like	UniProtKB/TrEMBL
UniProt	A0A096UWG1	ENTREZGENE, UniProtKB/TrEMBL
	A6ID47	ENTREZGENE, UniProtKB/TrEMBL
	F1LUP6	ENTREZGENE
	Q5BJY0	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	F1LUP6	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-05-12	Rfwd2	ring finger and WD repeat domain 2	Rfwd2	ring finger and WD repeat domain 2, E3 ubiquitin protein ligase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-08-14	Rfwd2	ring finger and WD repeat domain 2, E3 ubiquitin protein ligase	Rfwd2	ring finger and WD repeat domain 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-08-09	Rfwd2	ring finger and WD repeat domain 2	LOC100360800	ring finger and WD repeat domain 2	Data merged from RGD:2321358	737654	APPROVED
2010-05-05	LOC100360800	ring finger and WD repeat domain 2			Symbol and Name status set to provisional	70820	PROVISIONAL
2009-01-22	Rfwd2	ring finger and WD repeat domain 2	RGD1304773	similar to constitutive photomorphogenic protein 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	RGD1304773	similar to constitutive photomorphogenic protein 1	RGD1304773_predicted	similar to constitutive photomorphogenic protein 1 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1304773_predicted	similar to constitutive photomorphogenic protein 1 (predicted)	LOC360860_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC360860_predicted	similar to constitutive photomorphogenic protein 1 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

Mammalian Phenotype

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Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

Mammalian Phenotype