COP1 (COP1 E3 ubiquitin ligase) - Rat Genome Database

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Gene: COP1 (COP1 E3 ubiquitin ligase) Pan paniscus
Analyze
Symbol: COP1
Name: COP1 E3 ubiquitin ligase
RGD ID: 11710963
Description: ENCODES a protein that exhibits metal ion binding (inferred); ubiquitin protein ligase activity (inferred); INVOLVED IN positive regulation of proteasomal ubiquitin-dependent protein catabolic process (inferred); proteasome-mediated ubiquitin-dependent protein catabolic process (inferred); response to ionizing radiation (inferred); PARTICIPATES IN p53 signaling pathway; ASSOCIATED WITH 1q24 Deletion Syndrome (ortholog); antithrombin III deficiency (ortholog); autistic disorder (ortholog); FOUND IN Golgi membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: COP1, E3 ubiquitin ligase; E3 ubiquitin-protein ligase COP1; RFWD2; ring finger and WD repeat domain 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2173,506,205 - 73,784,010 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1173,186,486 - 73,457,341 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01151,459,354 - 151,727,131 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11155,155,860 - 155,425,664 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1155,156,185 - 155,425,156 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
COP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2173,506,205 - 73,784,010 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1173,186,486 - 73,457,341 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01151,459,354 - 151,727,131 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11155,155,860 - 155,425,664 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1155,156,185 - 155,425,156 (-)Ensemblpanpan1.1panPan2
COP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381175,944,831 - 176,207,286 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1175,944,831 - 176,207,286 (-)EnsemblGRCh38hg38GRCh38
GRCh371175,913,967 - 176,176,422 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361174,180,590 - 174,442,993 (-)NCBINCBI36Build 36hg18NCBI36
Build 341172,645,624 - 172,908,027NCBI
Celera1149,024,694 - 149,287,018 (-)NCBICelera
Cytogenetic Map1q25.1-q25.2NCBI
HuRef1147,140,664 - 147,403,100 (-)NCBIHuRef
CHM1_11177,337,538 - 177,600,480 (-)NCBICHM1_1
T2T-CHM13v2.01175,300,159 - 175,562,553 (-)NCBIT2T-CHM13v2.0
Cop1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391159,059,734 - 159,182,442 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1159,059,890 - 159,175,210 (+)EnsemblGRCm39 Ensembl
GRCm381159,232,156 - 159,354,872 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1159,232,320 - 159,347,640 (+)EnsemblGRCm38mm10GRCm38
MGSCv371161,162,457 - 161,277,711 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361161,069,003 - 161,184,257 (+)NCBIMGSCv36mm8
Celera1161,631,243 - 161,748,921 (+)NCBICelera
Cytogenetic Map1H1NCBI
cM Map169.03NCBI
Cop1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81373,954,058 - 74,095,283 (+)NCBIGRCr8
mRatBN7.21371,467,164 - 71,561,826 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1371,429,961 - 71,538,890 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1374,044,221 - 74,138,940 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01375,344,334 - 75,439,013 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01372,603,700 - 72,698,383 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01376,942,883 - 77,076,015 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1376,942,928 - 77,075,723 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01381,853,391 - 81,986,197 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41374,552,876 - 74,590,608 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11374,979,314 - 74,981,857 (-)NCBI
Celera1371,277,941 - 71,371,841 (+)NCBICelera
Cytogenetic Map13q22NCBI
Cop1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540615,662,546 - 15,859,306 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540615,662,546 - 15,859,306 (-)NCBIChiLan1.0ChiLan1.0
COP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1723,320,483 - 23,565,093 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl723,277,209 - 23,563,397 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha722,845,782 - 23,088,376 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0723,068,997 - 23,312,240 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl723,069,323 - 23,326,866 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1722,980,843 - 23,224,152 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0723,074,250 - 23,317,391 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0723,217,346 - 23,460,833 (+)NCBIUU_Cfam_GSD_1.0
Cop1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934494,415,666 - 94,590,738 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648112,262,409 - 12,437,571 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648112,262,415 - 12,437,627 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9117,915,443 - 118,114,259 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19117,913,504 - 118,114,268 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29129,664,173 - 129,764,054 (-)NCBISscrofa10.2Sscrofa10.2susScr3
COP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12553,057,479 - 53,316,662 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2553,057,784 - 53,314,398 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605554,611,740 - 54,870,873 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cop1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247715,922,067 - 6,133,597 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247715,922,086 - 6,132,537 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000037408   ⟹   ENSPPAP00000014721
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1155,156,185 - 155,425,156 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000037418   ⟹   ENSPPAP00000014731
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1155,207,408 - 155,425,156 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000037421   ⟹   ENSPPAP00000014734
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1155,365,647 - 155,425,156 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000037424   ⟹   ENSPPAP00000014737
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1155,367,343 - 155,425,156 (-)Ensembl
RefSeq Acc Id: XM_008978351   ⟹   XP_008976599
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2173,506,208 - 73,784,010 (+)NCBI
NHGRI_mPanPan1173,186,486 - 73,457,341 (+)NCBI
Mhudiblu_PPA_v01151,459,354 - 151,727,131 (-)NCBI
PanPan1.11155,155,860 - 155,425,664 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034941231   ⟹   XP_034797122
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2173,506,206 - 73,784,010 (+)NCBI
NHGRI_mPanPan1173,186,523 - 73,457,341 (+)NCBI
Mhudiblu_PPA_v01151,459,354 - 151,727,086 (-)NCBI
RefSeq Acc Id: XM_034941236   ⟹   XP_034797127
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2173,506,206 - 73,784,010 (+)NCBI
NHGRI_mPanPan1173,186,717 - 73,457,341 (+)NCBI
Mhudiblu_PPA_v01151,459,354 - 151,727,086 (-)NCBI
RefSeq Acc Id: XM_034941240   ⟹   XP_034797131
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2173,506,205 - 73,784,010 (+)NCBI
NHGRI_mPanPan1173,186,714 - 73,457,341 (+)NCBI
Mhudiblu_PPA_v01151,459,354 - 151,727,089 (-)NCBI
RefSeq Acc Id: XM_034941252   ⟹   XP_034797143
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2173,516,874 - 73,784,010 (+)NCBI
NHGRI_mPanPan1173,187,289 - 73,457,341 (+)NCBI
Mhudiblu_PPA_v01151,459,354 - 151,726,554 (-)NCBI
RefSeq Acc Id: XM_063598396   ⟹   XP_063454466
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2173,506,206 - 73,784,010 (+)NCBI
RefSeq Acc Id: XM_063598401   ⟹   XP_063454471
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2173,506,210 - 73,784,010 (+)NCBI
RefSeq Acc Id: XM_063598407   ⟹   XP_063454477
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2173,538,841 - 73,784,010 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_008976599   ⟸   XM_008978351
- Peptide Label: isoform X1
- UniProtKB: A0A2R9ACT7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034797131   ⟸   XM_034941240
- Peptide Label: isoform X5
- UniProtKB: A0A2R9ACT7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034797122   ⟸   XM_034941231
- Peptide Label: isoform X2
- UniProtKB: A0A2R9ACT7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034797127   ⟸   XM_034941236
- Peptide Label: isoform X3
- UniProtKB: A0A2R9ACT7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034797143   ⟸   XM_034941252
- Peptide Label: isoform X8
RefSeq Acc Id: ENSPPAP00000014737   ⟸   ENSPPAT00000037424
RefSeq Acc Id: ENSPPAP00000014734   ⟸   ENSPPAT00000037421
RefSeq Acc Id: ENSPPAP00000014731   ⟸   ENSPPAT00000037418
RefSeq Acc Id: ENSPPAP00000014721   ⟸   ENSPPAT00000037408
RefSeq Acc Id: XP_063454466   ⟸   XM_063598396
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063454471   ⟸   XM_063598401
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063454477   ⟸   XM_063598407
- Peptide Label: isoform X7
Protein Domains
RING-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000030430 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000037408.1 UniProtKB/TrEMBL
  ENSPPAT00000037418.1 UniProtKB/TrEMBL
  ENSPPAT00000037421.1 UniProtKB/TrEMBL
  ENSPPAT00000037424.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro COP1 UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/TrEMBL
NCBI Gene RFWD2 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE COP1 UniProtKB/TrEMBL
  PTHR44080 UniProtKB/TrEMBL
Pfam WD40 UniProtKB/TrEMBL
  zf-C3HC4_2 UniProtKB/TrEMBL
PROSITE WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
SMART RING UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
  SSF50978 UniProtKB/TrEMBL
UniProt A0A2R9ABU5_PANPA UniProtKB/TrEMBL
  A0A2R9ACT7 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9ACU6_PANPA UniProtKB/TrEMBL
  A0A2R9AHL8_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-29 COP1  COP1 E3 ubiquitin ligase    COP1, E3 ubiquitin ligase  Symbol and/or name change 5135510 APPROVED
2017-12-19 COP1  COP1, E3 ubiquitin ligase  RFWD2  ring finger and WD repeat domain 2  Symbol and/or name change 5135510 APPROVED