Actg1 (actin, gamma 1) - Rat Genome Database

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Gene: Actg1 (actin, gamma 1) Rattus norvegicus
Analyze
Symbol: Actg1
Name: actin, gamma 1
RGD ID: 1304556
Description: A structural constituent of postsynaptic actin cytoskeleton. Involved in response to calcium ion and response to mechanical stimulus. Is active in postsynaptic actin cytoskeleton and presynaptic actin cytoskeleton. Human ortholog(s) of this gene implicated in Baraitser-Winter syndrome 2 and autosomal dominant nonsyndromic deafness 20. Orthologous to human ACTG1 (actin gamma 1); PARTICIPATES IN auditory mechanotransduction pathway; arrhythmogenic right ventricular cardiomyopathy pathway; dilated cardiomyopathy pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Actg; actin, cytoplasmic 2; actin, gamma, cytoplasmic; actin, gamma, cytoplasmic 1; gamma-actin; LOC287876
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,118,106 - 106,120,951 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10106,118,108 - 106,120,951 (-)EnsemblGRCr8
mRatBN7.210105,619,738 - 105,622,587 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl372,977,767 - 72,979,694 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl10105,619,737 - 105,624,232 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10110,724,157 - 110,726,999 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010110,187,175 - 110,190,017 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,540,227 - 105,543,072 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,518,429 - 109,521,288 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl375,643,054 - 75,644,954 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl10109,519,134 - 109,520,846 (-)Ensemblrn6Rnor6.0
Rnor_5.010109,113,705 - 109,116,103 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410109,773,489 - 109,776,334 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera10104,164,981 - 104,167,826 (-)NCBICelera
RGSC_v3.110109,787,992 - 109,790,826 (-)NCBI
Cytogenetic Map10q32.3NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3'-diindolylmethane  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
amphetamine  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-lapachone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bufalin  (ISO)
buspirone  (EXP)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cytochalasin D  (ISO)
D-glucose  (EXP)
DDE  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
dihydroartemisinin  (ISO)
dioxygen  (EXP)
diuron  (ISO)
dopamine  (EXP)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
eugenol  (EXP)
Evodiamine  (ISO)
fenoldopam  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fumonisin B1  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (EXP)
GW 4064  (ISO)
ivermectin  (ISO)
jaspamide  (ISO)
leflunomide  (ISO)
levofloxacin  (EXP)
mancozeb  (ISO)
metacetamol  (ISO)
methamphetamine  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
microcystin-LR  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nitrates  (ISO)
ozone  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorododecanoic acid  (EXP)
phenformin  (EXP)
phenobarbital  (EXP)
PhIP  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
rac-lactic acid  (ISO)
rotenone  (EXP)
Salinomycin  (ISO)
selenium atom  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
yohimbine  (EXP)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. beta-Actin is confined to structures having high capacity of remodelling in developing and adult rat cerebellum. Micheva KD, etal., Eur J Neurosci. 1998 Dec;10(12):3785-98.
5. Possible role of non-muscle alpha-actinins in muscle cell mechanosensitivity. Ogneva IV, etal., PLoS One. 2014 Apr 29;9(4):e96395. doi: 10.1371/journal.pone.0096395. eCollection 2014.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Role of cytosolic calcium in regulation of cytoskeletal gene expression by insulin. Weinstock RS, etal., Am J Physiol. 1993 Apr;264(4 Pt 1):E519-25.
Additional References at PubMed
PMID:2372296   PMID:2402472   PMID:9334353   PMID:12063253   PMID:12947022   PMID:14760703   PMID:15194427   PMID:16189514   PMID:16502470   PMID:16510873   PMID:17634366   PMID:18796539  
PMID:19013151   PMID:19144319   PMID:19946888   PMID:20458337   PMID:21516116   PMID:21557262   PMID:21630459   PMID:21753002   PMID:22516433   PMID:22855531   PMID:23376485   PMID:23382103  
PMID:23533145   PMID:23580065   PMID:23979707   PMID:25416956   PMID:25705373   PMID:25910212   PMID:27840001   PMID:28259758   PMID:28493397   PMID:29891944  


Genomics

Comparative Map Data
Actg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,118,106 - 106,120,951 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10106,118,108 - 106,120,951 (-)EnsemblGRCr8
mRatBN7.210105,619,738 - 105,622,587 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl372,977,767 - 72,979,694 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl10105,619,737 - 105,624,232 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10110,724,157 - 110,726,999 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010110,187,175 - 110,190,017 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,540,227 - 105,543,072 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,518,429 - 109,521,288 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl375,643,054 - 75,644,954 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl10109,519,134 - 109,520,846 (-)Ensemblrn6Rnor6.0
Rnor_5.010109,113,705 - 109,116,103 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410109,773,489 - 109,776,334 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera10104,164,981 - 104,167,826 (-)NCBICelera
RGSC_v3.110109,787,992 - 109,790,826 (-)NCBI
Cytogenetic Map10q32.3NCBI
ACTG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381781,509,971 - 81,512,799 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1781,509,413 - 81,523,847 (-)Ensemblhg38GRCh38
GRCh371779,476,997 - 79,479,825 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361777,091,594 - 77,094,422 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341777,091,593 - 77,094,422NCBI
Cytogenetic Map17q25.3NCBI
HuRef1774,925,813 - 74,928,708 (-)NCBIHuRef
CHM1_11779,563,278 - 79,566,173 (-)NCBICHM1_1
T2T-CHM13v2.01782,427,089 - 82,429,917 (-)NCBIT2T-CHM13v2.0
Actg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911120,236,513 - 120,239,321 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11120,236,516 - 120,239,368 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3811120,345,687 - 120,348,495 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11120,345,690 - 120,348,542 (-)Ensemblmm10GRCm38
MGSCv3711120,207,004 - 120,209,798 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611120,161,780 - 120,171,339 (-)NCBIMGSCv36mm8
Celera11132,080,255 - 132,083,049 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1184.07NCBI
Actg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555061,546,678 - 1,552,105 (+)Ensembl
ChiLan1.0NW_0049555061,546,678 - 1,549,611 (+)NCBIChiLan1.0ChiLan1.0
ACTG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21998,096,764 - 98,099,674 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117102,996,909 - 102,999,820 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01775,965,911 - 75,968,822 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11781,668,221 - 81,671,087 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1781,668,221 - 81,671,087 (-)EnsemblpanPan2panpan1.1
ACTG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.19635,978 - 638,328 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl9635,978 - 638,328 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha91,238,649 - 1,241,000 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.091,229,608 - 1,232,436 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl91,229,663 - 1,232,434 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.191,254,519 - 1,256,870 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.091,380,335 - 1,382,686 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.091,460,286 - 1,462,637 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Actg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056021,238,788 - 1,241,248 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365945,170,711 - 5,173,247 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365945,170,711 - 5,173,251 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACTG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl121,313,641 - 1,323,217 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1121,320,355 - 1,323,219 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2121,163,186 - 1,166,032 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACTG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11673,456,907 - 73,459,777 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607744,839,199 - 44,842,119 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Actg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480110,496,718 - 10,499,637 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462480110,496,876 - 10,499,737 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Actg1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1963,672,093 - 63,674,984 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Actg1
17 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:104
Count of miRNA genes:79
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000054976
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093723381107556066Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1097202388107556066Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1091127270107556066Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091727883107713808Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1097202388107556066Rat

Markers in Region
PMC138261P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12p11UniSTS
Cytogenetic Map10q32.3UniSTS
Cytogenetic Map18p12UniSTS
PMC156330P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1951,258,498 - 51,259,502UniSTS
Celera1213,454,501 - 13,455,354UniSTS
Cytogenetic Map12p11UniSTS
Cytogenetic Map18p12UniSTS
Cytogenetic Map19q12UniSTS
Cytogenetic Map10q32.3UniSTS
PMC201106P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12p11UniSTS
Cytogenetic Map10q32.3UniSTS
Cytogenetic Map19q12UniSTS
Cytogenetic Map18p12UniSTS
PMC22644P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12p11UniSTS
Cytogenetic Map10q32.3UniSTS
Cytogenetic Map18p12UniSTS
PMC302066P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12p11UniSTS
Cytogenetic Map10q32.3UniSTS
Cytogenetic Map18p12UniSTS
PMC97568P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12p11UniSTS
Cytogenetic Map10q32.3UniSTS
Cytogenetic Map18p12UniSTS
RH128697  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10q32.3UniSTS
Cytogenetic Map18p12UniSTS
PMC156124P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12p11UniSTS
Cytogenetic Map10q32.3UniSTS
Cytogenetic Map19q12UniSTS
Cytogenetic Map18p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
25 23 116 277 174 172 110 117 110 12 559 289 11 236 119 152 62 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001127449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CF110974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK364554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK595239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000054976   ⟹   ENSRNOP00000051859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10105,619,737 - 105,622,665 (-)Ensembl
Rnor_6.0 Ensembl10109,519,134 - 109,520,846 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl393,434,045 - 93,474,629 (+)Ensembl
mRatBN7.2 Ensembl372,977,767 - 72,979,694 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099821   ⟹   ENSRNOP00000096406
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10106,118,108 - 106,120,951 (-)Ensembl
mRatBN7.2 Ensembl10105,619,745 - 105,624,232 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102734   ⟹   ENSRNOP00000109636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl393,434,045 - 93,474,629 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108340   ⟹   ENSRNOP00000084530
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10105,619,737 - 105,624,232 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108494   ⟹   ENSRNOP00000096150
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10106,118,108 - 106,120,951 (-)Ensembl
mRatBN7.2 Ensembl10105,619,745 - 105,624,232 (-)Ensembl
RefSeq Acc Id: NM_001127449   ⟹   NP_001120921
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,118,106 - 106,120,951 (-)NCBI
mRatBN7.210105,619,742 - 105,622,587 (-)NCBI
Rnor_6.010109,518,433 - 109,521,288 (-)NCBI
Rnor_5.010109,113,705 - 109,116,103 (-)NCBI
RGSC_v3.410109,773,489 - 109,776,334 (-)RGD
Celera10104,164,981 - 104,167,826 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001120921 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM06825 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000096150
  ENSRNOP00000096150.1
GenBank Protein P63259 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001120921   ⟸   NM_001127449
- UniProtKB: P63259 (UniProtKB/Swiss-Prot),   A6HLC1 (UniProtKB/TrEMBL),   A0A8L2QLX4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000051859   ⟸   ENSRNOT00000054976
Ensembl Acc Id: ENSRNOP00000084530   ⟸   ENSRNOT00000108340
Ensembl Acc Id: ENSRNOP00000096406   ⟸   ENSRNOT00000099821
Ensembl Acc Id: ENSRNOP00000096150   ⟸   ENSRNOT00000108494
Ensembl Acc Id: ENSRNOP00000109636   ⟸   ENSRNOT00000102734

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63259-F1-model_v2 AlphaFold P63259 1-375 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304556 AgrOrtholog
BioCyc Gene G2FUF-22440 BioCyc
Ensembl Genes ENSRNOG00000036701 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000053452 Ensembl
Ensembl Transcript ENSRNOT00000108494 ENTREZGENE
  ENSRNOT00000108494.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.420.40 UniProtKB/Swiss-Prot
  Actin, Chain A, domain 4 UniProtKB/Swiss-Prot
InterPro Actin UniProtKB/Swiss-Prot
  Actin/actin-like_CS UniProtKB/Swiss-Prot
  Actin_CS UniProtKB/Swiss-Prot
  ATPase_NBD UniProtKB/Swiss-Prot
KEGG Report rno:287876 UniProtKB/Swiss-Prot
NCBI Gene 287876 ENTREZGENE
PANTHER PTHR11937 UniProtKB/Swiss-Prot
Pfam Actin UniProtKB/Swiss-Prot
PhenoGen Actg1 PhenoGen
PRINTS ACTIN UniProtKB/Swiss-Prot
PROSITE ACTINS_1 UniProtKB/Swiss-Prot
  ACTINS_2 UniProtKB/Swiss-Prot
  ACTINS_ACT_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000036701 RatGTEx
  ENSRNOG00000053452 RatGTEx
SMART ACTIN UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53067 UniProtKB/Swiss-Prot
UniProt A0A8I6AQR0_RAT UniProtKB/TrEMBL
  A0A8L2QLX4 ENTREZGENE
  A6HLC1 ENTREZGENE, UniProtKB/TrEMBL
  ACTG_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P02571 UniProtKB/Swiss-Prot
  P14104 UniProtKB/Swiss-Prot
  P99022 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Actg1  actin, gamma 1  LOC295810  similar to Actin, cytoplasmic 2 (Gamma-actin)  Data merged from RGD:1589770 1643240 APPROVED
2008-08-29 Actg1  actin, gamma 1  Actg1  actin, gamma, cytoplasmic 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC295810  similar to Actin, cytoplasmic 2 (Gamma-actin)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-30 Actg1  actin, gamma, cytoplasmic 1  Actg  actin, gamma, cytoplasmic  Symbol and Name updated 1299863 APPROVED
2005-12-06 Actg  actin, gamma, cytoplasmic  Actg_predicted  actin, gamma, cytoplasmic (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Actg_predicted  actin, gamma, cytoplasmic (predicted)      Symbol and Name status set to approved 70820 APPROVED