Nqo2 (N-ribosyldihydronicotinamide:quinone dehydrogenase 2) - Rat Genome Database

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Gene: Nqo2 (N-ribosyldihydronicotinamide:quinone dehydrogenase 2) Rattus norvegicus
Analyze
Symbol: Nqo2
Name: N-ribosyldihydronicotinamide:quinone dehydrogenase 2
RGD ID: 1303320
Description: Predicted to enable several functions, including anion binding activity; dihydronicotinamide riboside quinone reductase activity; and melatonin binding activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; positive regulation of neuron apoptotic process; and positive regulation of vascular associated smooth muscle cell proliferation. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Parkinson's disease; agranulocytosis; breast cancer; and breast carcinoma. Orthologous to human NQO2 (N-ribosyldihydronicotinamide:quinone dehydrogenase 2); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC94180; N-ribosyldihydronicotinamide:quinone reductase 2; NAD(P)H dehydrogenase, quinone 2; NAD(P)H quinone dehydrogenase 2; NRH dehydrogenase [quinone] 2; NRH:quinone oxidoreductase 2; QR2; quinone reductase 2; ribosyldihydronicotinamide dehydrogenase; ribosyldihydronicotinamide dehydrogenase [quinone]
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81731,114,825 - 31,144,062 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1731,114,529 - 31,143,662 (-)EnsemblGRCr8
mRatBN7.21730,909,482 - 30,938,725 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1730,909,187 - 30,938,320 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1730,723,881 - 30,752,881 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01732,327,627 - 32,356,626 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01730,719,617 - 30,748,617 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01732,131,847 - 32,158,559 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1732,132,347 - 32,158,538 (-)Ensemblrn6Rnor6.0
Rnor_5.01734,023,011 - 34,051,834 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41737,255,630 - 37,283,753 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1730,474,024 - 30,502,465 (-)NCBICelera
RGSC_v3.11737,258,472 - 37,286,594 (-)NCBI
Cytogenetic Map17p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dichloroindophenol  (ISO)
2-hydroxypropanoic acid  (ISO)
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
4',5,7-trihydroxy-3'-methoxyflavone  (ISO)
4'-hydroxydiclofenac  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (EXP)
amodiaquine  (ISO)
aristolochic acids  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium dichloride  (ISO)
capsaicin  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chloroquine  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
deoxycholic acid  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fenthion  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
flutriafol  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
hesperetin  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP)
mefenamic acid  (ISO)
melatonin  (ISO)
menadione  (ISO)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodimethylamine  (EXP)
N-ribosylnicotinamide  (ISO)
nefazodone  (EXP)
nickel sulfate  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
oxidopamine  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
primaquine  (ISO)
pterostilbene  (ISO)
quercetin  (ISO)
quinacrine  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
sarin  (ISO)
SB 431542  (ISO)
scopolamine  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulforaphane  (ISO)
T-2 toxin  (ISO)
tacrine  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
ubiquinone-1  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Loss of quinone reductase 2 function selectively facilitates learning behaviors. Benoit CE, etal., J Neurosci. 2010 Sep 22;30(38):12690-700. doi: 10.1523/JNEUROSCI.2808-10.2010.
2. Transthyretin: A key gene involved in the maintenance of memory capacities during aging. Brouillette J and Quirion R, Neurobiol Aging. 2007 May 16.
3. BALT development and augmentation of hyperoxic lung injury in mice deficient in NQO1 and NQO2. Das A, etal., Free Radic Biol Med. 2006 May 15;40(10):1843-56. Epub 2006 Feb 17.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Association of superoxide dismutases and NAD(P)H quinone oxidoreductases with prognosis of patients with breast carcinomas. Hubackova M, etal., Int J Cancer. 2012 Jan 15;130(2):338-48. doi: 10.1002/ijc.26006. Epub 2011 Apr 20.
6. Disruption of dihydronicotinamide riboside:quinone oxidoreductase 2 (NQO2) leads to myeloid hyperplasia of bone marrow and decreased sensitivity to menadione toxicity. Long DJ 2nd, etal., J Biol Chem 2002 Nov 29;277(48):46131-9. Epub 2002 Sep 25.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. NQO2 gene is associated with clozapine-induced agranulocytosis. Ostrousky O, etal., Tissue Antigens. 2003 Dec;62(6):483-91.
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. Association of NRH:quinone oxidoreductase 2 gene promoter polymorphism with higher gene expression and increased susceptibility to Parkinson's disease. Wang W, etal., J Gerontol A Biol Sci Med Sci. 2008 Feb;63(2):127-34.
14. Resveratrol inhibits angiotensin II-induced ERK1/2 activation by downregulating quinone reductase 2 in rat vascular smooth muscle cells. Zhang X, etal., J Biomed Res. 2012 Mar;26(2):103-9. doi: 10.1016/S1674-8301(12)60019-0.
15. Downregulation of quinone reductase 2 attenuates vascular smooth muscle cells proliferation and neointimal formation in balloon injured rat carotid artery. Zhang XW, etal., Cell Physiol Biochem. 2012;29(3-4):453-62. doi: 10.1159/000338499. Epub 2012 Apr 3.
Additional References at PubMed
PMID:10945627   PMID:15489334   PMID:18254726   PMID:19056867   PMID:23376485   PMID:23533145   PMID:36650666  


Genomics

Comparative Map Data
Nqo2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81731,114,825 - 31,144,062 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1731,114,529 - 31,143,662 (-)EnsemblGRCr8
mRatBN7.21730,909,482 - 30,938,725 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1730,909,187 - 30,938,320 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1730,723,881 - 30,752,881 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01732,327,627 - 32,356,626 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01730,719,617 - 30,748,617 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01732,131,847 - 32,158,559 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1732,132,347 - 32,158,538 (-)Ensemblrn6Rnor6.0
Rnor_5.01734,023,011 - 34,051,834 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41737,255,630 - 37,283,753 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1730,474,024 - 30,502,465 (-)NCBICelera
RGSC_v3.11737,258,472 - 37,286,594 (-)NCBI
Cytogenetic Map17p12NCBI
NQO2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3862,999,894 - 3,019,755 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl62,987,987 - 3,022,109 (+)Ensemblhg38GRCh38
GRCh3763,000,128 - 3,019,989 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3662,945,066 - 2,964,993 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3462,945,229 - 2,964,993NCBI
Celera64,229,080 - 4,249,008 (+)NCBICelera
Cytogenetic Map6p25.2NCBI
HuRef62,873,204 - 2,893,131 (+)NCBIHuRef
CHM1_163,002,428 - 3,022,361 (+)NCBICHM1_1
T2T-CHM13v2.062,868,796 - 2,888,657 (+)NCBIT2T-CHM13v2.0
Nqo2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391334,148,642 - 34,172,448 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1334,148,670 - 34,172,426 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381333,964,655 - 33,988,465 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1333,964,687 - 33,988,443 (+)Ensemblmm10GRCm38
MGSCv371334,056,528 - 34,080,334 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361333,972,216 - 33,993,112 (+)NCBIMGSCv36mm8
Celera1335,093,939 - 35,117,741 (+)NCBICelera
Cytogenetic Map13A3.3NCBI
cM Map1314.01NCBI
Nqo2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546510,186,928 - 10,200,237 (-)Ensembl
ChiLan1.0NW_00495546510,186,928 - 10,200,098 (-)NCBIChiLan1.0ChiLan1.0
NQO2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2517,613,398 - 17,647,746 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1613,606,253 - 13,645,470 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v062,819,422 - 2,844,765 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.162,928,021 - 2,947,304 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl62,928,021 - 2,947,304 (+)EnsemblpanPan2panpan1.1
NQO2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1353,294,776 - 3,315,438 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl353,294,850 - 3,312,836 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha353,301,901 - 3,322,549 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0353,350,127 - 3,370,739 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl353,350,161 - 3,370,710 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1353,225,857 - 3,246,468 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0353,248,146 - 3,268,605 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0354,580,552 - 4,601,200 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
NQO2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl71,792,876 - 1,806,301 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.171,792,745 - 1,805,916 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.271,825,528 - 1,829,240 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NQO2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11769,149,197 - 69,168,476 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1769,147,937 - 69,161,045 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660442,937,996 - 2,957,287 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nqo2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475621,857,721 - 21,867,727 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475621,857,048 - 21,869,657 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Nqo2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11452,453,273 - 52,538,208 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nqo2
349 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:197
Count of miRNA genes:135
Interacting mature miRNAs:147
Transcripts:ENSRNOT00000024141
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172266079955604694Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172149899450592236Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17857434232199534Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172723344565155015Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 79 59 6 343 179 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000024141   ⟹   ENSRNOP00000024141
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1731,114,529 - 31,143,662 (-)Ensembl
mRatBN7.2 Ensembl1730,909,187 - 30,938,320 (-)Ensembl
Rnor_6.0 Ensembl1732,132,347 - 32,158,538 (-)Ensembl
RefSeq Acc Id: NM_001004214   ⟹   NP_001004214
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,115,124 - 31,143,662 (-)NCBI
mRatBN7.21730,909,781 - 30,938,320 (-)NCBI
Rnor_6.01732,132,140 - 32,158,164 (-)NCBI
Rnor_5.01734,023,011 - 34,051,834 (-)NCBI
RGSC_v3.41737,255,630 - 37,283,753 (-)RGD
Celera1730,474,024 - 30,502,465 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253867   ⟹   XP_006253929
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,114,825 - 31,144,062 (-)NCBI
mRatBN7.21730,909,482 - 30,938,723 (-)NCBI
Rnor_6.01732,131,847 - 32,158,559 (-)NCBI
Rnor_5.01734,023,011 - 34,051,834 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253868   ⟹   XP_006253930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,114,825 - 31,143,777 (-)NCBI
mRatBN7.21730,909,482 - 30,938,435 (-)NCBI
Rnor_6.01732,131,847 - 32,158,263 (-)NCBI
Rnor_5.01734,023,011 - 34,051,834 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039095490   ⟹   XP_038951418
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,114,825 - 31,143,570 (-)NCBI
mRatBN7.21730,909,482 - 30,935,815 (-)NCBI
RefSeq Acc Id: XM_039095491   ⟹   XP_038951419
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,114,825 - 31,144,057 (-)NCBI
mRatBN7.21730,909,482 - 30,938,725 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001004214 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253929 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253930 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951418 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951419 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH79157 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024141
GenBank Protein Q6AY80 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001004214   ⟸   NM_001004214
- UniProtKB: Q6AY80 (UniProtKB/Swiss-Prot),   A6J7H5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253929   ⟸   XM_006253867
- Peptide Label: isoform X1
- UniProtKB: Q6AY80 (UniProtKB/Swiss-Prot),   A6J7H5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253930   ⟸   XM_006253868
- Peptide Label: isoform X2
- UniProtKB: A6J7H5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024141   ⟸   ENSRNOT00000024141
RefSeq Acc Id: XP_038951419   ⟸   XM_039095491
- Peptide Label: isoform X2
- UniProtKB: A6J7H5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951418   ⟸   XM_039095490
- Peptide Label: isoform X1
- UniProtKB: Q6AY80 (UniProtKB/Swiss-Prot),   A6J7H5 (UniProtKB/TrEMBL)
Protein Domains
Flavodoxin-like fold

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AY80-F1-model_v2 AlphaFold Q6AY80 1-231 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700415
Promoter ID:EPDNEW_R10939
Type:initiation region
Name:Nqo2_1
Description:N-ribosyldihydronicotinamide:quinone reductase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10940  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01732,158,204 - 32,158,264EPDNEW
RGD ID:13700416
Promoter ID:EPDNEW_R10940
Type:single initiation site
Name:Nqo2_2
Description:N-ribosyldihydronicotinamide:quinone reductase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10939  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01732,158,558 - 32,158,618EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303320 AgrOrtholog
BioCyc Gene G2FUF-9596 BioCyc
Ensembl Genes ENSRNOG00000017820 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000024141 ENTREZGENE
Gene3D-CATH 3.40.50.360 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7128990 IMAGE-MGC_LOAD
InterPro Flavodoxin_fold UniProtKB/Swiss-Prot
  Flavoprotein-like_sf UniProtKB/Swiss-Prot
  NAD(P)H_dehydrogenase_qn UniProtKB/Swiss-Prot
KEGG Report rno:291084 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94180 IMAGE-MGC_LOAD
NCBI Gene 291084 ENTREZGENE
PANTHER NAD P H OXIDOREDUCTASE-RELATED UniProtKB/Swiss-Prot
  RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE] UniProtKB/Swiss-Prot
Pfam Flavodoxin_2 UniProtKB/Swiss-Prot
PhenoGen Nqo2 PhenoGen
RatGTEx ENSRNOG00000017820 RatGTEx
Superfamily-SCOP SSF52218 UniProtKB/Swiss-Prot
UniProt A0A8L2QE49_RAT UniProtKB/TrEMBL
  A6J7H5 ENTREZGENE, UniProtKB/TrEMBL
  NQO2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-08-03 Nqo2  N-ribosyldihydronicotinamide:quinone dehydrogenase 2  Nqo2  N-ribosyldihydronicotinamide:quinone reductase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-02-01 Nqo2  N-ribosyldihydronicotinamide:quinone reductase 2  Nqo2  NAD(P)H quinone dehydrogenase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-29 Nqo2  NAD(P)H quinone dehydrogenase 2  Nqo2  NAD(P)H dehydrogenase, quinone 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Nqo2  NAD(P)H dehydrogenase, quinone 2      Symbol and Name status set to approved 1299863 APPROVED
2005-02-14 Nqo2  NAD(P)H dehydrogenase, quinone 2      Symbol and Name status set to provisional 70820 PROVISIONAL