Xbp1 (X-box binding protein 1) - Rat Genome Database

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Gene: Xbp1 (X-box binding protein 1) Rattus norvegicus
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Symbol: Xbp1
Name: X-box binding protein 1
RGD ID: 1303073
Description: Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in several processes, including endoplasmic reticulum unfolded protein response; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; and serotonin secretion, neurotransmission. Located in nucleus. Biomarker of borna disease and metabolic dysfunction-associated steatotic liver disease. Orthologous to human XBP1 (X-box binding protein 1); PARTICIPATES IN endoplasmic reticulum stress - the unfolded protein response pathway; forkhead class A signaling pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (R)-noradrenaline; (S)-nicotine; 1,4-dithiothreitol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hepatocarcinogenesis-related transcription factor; HTF; X-box-binding protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81484,604,623 - 84,609,707 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1484,604,107 - 84,609,706 (+)EnsemblGRCr8
mRatBN7.21480,390,629 - 80,395,713 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1480,390,643 - 80,395,693 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1484,792,890 - 84,797,957 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01486,033,004 - 86,038,075 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01482,482,326 - 82,487,393 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01485,753,736 - 85,758,820 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1485,753,760 - 85,758,145 (+)Ensemblrn6Rnor6.0
Rnor_5.01486,423,839 - 86,428,923 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41486,151,910 - 86,156,975 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1479,276,264 - 79,281,348 (+)NCBICelera
RGSC_v3.11486,171,054 - 86,176,119 (+)NCBI
Cytogenetic Map14q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-anisomycin  (ISO)
(R)-noradrenaline  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-nicotine  (EXP)
1,4-dithiothreitol  (EXP,ISO)
1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dichlorophenol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-deoxy-D-glucose  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-acetyldeoxynivalenol  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-aminophenol  (EXP)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-m-cresol  (ISO)
4-nitrophenol  (ISO)
4-phenylbutyric acid  (EXP,ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
Aloe emodin  (ISO)
alpha-pinene  (ISO)
aluminium atom  (ISO)
aluminium sulfate (anhydrous)  (ISO)
aluminium(0)  (ISO)
AM-251  (ISO)
amiloride  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amosite asbestos  (ISO)
antimony trichloride  (ISO)
antimony(0)  (ISO)
antimycin A  (EXP,ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
atrazine  (EXP,ISO)
baicalein  (EXP)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzoates  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (ISO)
bilirubin IXalpha  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
boric acid  (ISO)
bortezomib  (ISO)
brefeldin A  (ISO)
brequinar  (ISO)
bromobenzene  (EXP)
bupropion  (ISO)
busulfan  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
Butylparaben  (ISO)
C.I. Natural Red 20  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
Calcimycin  (ISO)
canagliflozin  (ISO)
cannabidiol  (ISO)
Cannabidivarin  (ISO)
cannabigerol  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbaryl  (ISO)
carbon nanotube  (ISO)
carfilzomib  (ISO)
casticin  (ISO)
cerium  (ISO)
cerulenin  (ISO)
ceruletide  (EXP)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chloroacetic acid  (ISO)
chlorogenic acid  (EXP)
chloropicrin  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chrysene  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (EXP,ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
curcumin  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP,ISO)
D-penicillamine  (ISO)
dantrolene  (ISO)
DDE  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
Dibromoacetonitrile  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
Didecyldimethylammonium  (ISO)
diethyl phthalate  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ebselen  (EXP)
elaidic acid  (EXP)
endosulfan  (EXP)
entinostat  (ISO)
erlotinib hydrochloride  (EXP)
esketamine  (ISO)
ethanol  (ISO)
ethylbenzene  (ISO)
ethylene glycol  (EXP)
fenofibrate  (EXP,ISO)
fenpyroximate  (ISO)
fentin chloride  (EXP)
ferric ammonium citrate  (ISO)
flutamide  (EXP,ISO)
folic acid  (ISO)
folpet  (ISO)
fructose  (ISO)
furan  (EXP,ISO)
gadolinium trichloride  (EXP)
gallic acid  (EXP)
gemcitabine  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glycine  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
graphene oxide  (ISO)
hemin  (ISO)
hexadecanoic acid  (EXP,ISO)
homocysteine  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxychloroquine  (ISO)
ibuprofen  (ISO)
Ibutilide  (EXP)
ifosfamide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
indoxyl sulfate  (ISO)
isoliquiritigenin  (EXP)
ketamine  (ISO)
L-1,4-dithiothreitol  (EXP,ISO)
L-glutamic acid  (EXP)
L-methionine  (ISO)
lactacystin  (ISO)
lanthanum atom  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP)
leflunomide  (ISO)
letrozole  (EXP)
linuron  (ISO)
lipopolysaccharide  (ISO)
luteolin  (ISO)
lycopene  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
melatonin  (EXP,ISO)
menadione  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methidathion  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mevastatin  (ISO)
microcystin-LR  (ISO)
minocycline  (EXP)
MK-2206  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
montelukast  (ISO)
morin  (EXP)
Mycotrienin II  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (ISO)
nicotine  (EXP)
nilotinib  (ISO)
Nodularin  (ISO)
o-xylene  (ISO)
ochratoxin A  (ISO)
okadaic acid  (EXP)
oleic acid  (ISO)
orlistat  (ISO)
oxybenzone  (ISO)
ozone  (EXP,ISO)
Pachymic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
patulin  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
Perhexiline maleate  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
picene  (ISO)
picoxystrobin  (ISO)
pinostrobin  (ISO)
pirinixic acid  (ISO)
potassium iodide  (ISO)
prallethrin  (ISO)
procymidone  (ISO)
progesterone  (ISO)
propylparaben  (ISO)
pyrazinecarboxamide  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rhosin  (ISO)
ricolinostat  (ISO)
Riluzole  (ISO)
rimonabant  (ISO)
rotenone  (ISO)
rutin  (EXP)
Salidroside  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
serpentine asbestos  (ISO)
sertraline  (ISO)
Shikonin  (EXP,ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sincalide  (EXP)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP,ISO)
Sodium iodate  (ISO)
sorafenib  (ISO)
SR 144528  (ISO)
streptozocin  (EXP,ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
Sunset Yellow FCF  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP,ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thapsigargin  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
toxoflavin  (ISO)
toyocamycin  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
Trienomycin A  (ISO)
trierixin  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
trovafloxacin  (EXP)
tunicamycin  (EXP,ISO)
urethane  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vanillic acid  (ISO)
withaferin A  (ISO)
zearalenone  (ISO)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adipose tissue development  (IEA,ISO,ISS)
angiogenesis  (IEA,ISO,ISS)
apoptotic process  (IEA)
cell differentiation  (IEA)
cellular response to amino acid stimulus  (IEA,ISO,ISS)
cellular response to antibiotic  (IEP)
cellular response to fluid shear stress  (ISO,ISS)
cellular response to fructose stimulus  (ISO)
cellular response to glucose starvation  (IEA,ISO,ISS)
cellular response to glucose stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to interleukin-4  (IEA,ISO,ISS)
cellular response to laminar fluid shear stress  (ISO,ISS)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to lipopolysaccharide  (IEA,ISO,ISS)
cellular response to nutrient  (ISO)
cellular response to oxidative stress  (ISO)
cellular response to peptide hormone stimulus  (IEA,ISO,ISS)
cellular response to vascular endothelial growth factor stimulus  (ISO)
cholesterol homeostasis  (IEA,ISO,ISS)
DNA-templated transcription  (IEA)
endoplasmic reticulum unfolded protein response  (IDA,IEA,ISO,ISS)
endothelial cell proliferation  (IEA,ISO,ISS)
epithelial cell maturation  (ISO)
epithelial cell maturation involved in salivary gland development  (ISO)
exocrine pancreas development  (ISO)
fatty acid homeostasis  (IEA,ISO,ISS)
glucose homeostasis  (ISO)
intracellular triglyceride homeostasis  (IEA,ISO,ISS)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IEA,ISO)
IRE1-mediated unfolded protein response  (ISO,ISS)
liver development  (IEA,ISO,ISS)
muscle organ development  (IEA)
negative regulation of apoptotic process  (IEA,ISO,ISS)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (IEA,IMP,ISO)
negative regulation of endoplasmic reticulum unfolded protein response  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of myotube differentiation  (ISO)
negative regulation of SMAD protein signal transduction  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
neuron development  (ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of angiogenesis  (IEA,ISO)
positive regulation of autophagy  (ISO)
positive regulation of B cell differentiation  (IEA,ISO,ISS)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of cytokine production involved in inflammatory response  (ISO)
positive regulation of endothelial cell apoptotic process  (ISO)
positive regulation of fat cell differentiation  (IEA,ISO,ISS)
positive regulation of hepatocyte proliferation  (IEA,ISO,ISS)
positive regulation of immunoglobulin production  (IEA,ISO,ISS)
positive regulation of interleukin-6 production  (ISO)
positive regulation of lactation  (IEA,ISO,ISS)
positive regulation of MHC class II biosynthetic process  (IEA,ISO,ISS)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of plasma cell differentiation  (IEA,ISO,ISS)
positive regulation of proteasomal protein catabolic process  (ISO)
positive regulation of protein acetylation  (ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of T cell differentiation  (IEA,ISO,ISS)
positive regulation of TOR signaling  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
positive regulation of vascular wound healing  (IEA,ISO)
protein destabilization  (IEA,ISO,ISS)
regulation of autophagy  (IEA,ISO,ISS)
regulation of cell growth  (ISO)
regulation of DNA-templated transcription  (IEA,TAS)
regulation of protein stability  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to electrical stimulus  (IDA)
response to endoplasmic reticulum stress  (ISO)
response to insulin-like growth factor stimulus  (IEA,ISO,ISS)
response to nutrient  (IEA,IEP)
response to unfolded protein  (IEA)
response to xenobiotic stimulus  (IDA)
serotonin secretion, neurotransmission  (IDA)
sterol homeostasis  (IEA,ISO,ISS)
transcription by RNA polymerase II  (IDA,ISO)
ubiquitin-dependent protein catabolic process  (IEA,ISO,ISS)
vascular endothelial growth factor receptor signaling pathway  (ISO)

Cellular Component
cytoplasm  (IEA,ISO,ISS)
cytosol  (ISO)
endoplasmic reticulum  (IEA,ISO,ISS)
endoplasmic reticulum membrane  (IEA,ISO)
membrane  (IEA)
nucleus  (IBA,IDA,IEA,ISO)
presynapse  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Sigmar1 regulates endoplasmic reticulum stress-induced C/EBP-homologous protein expression in cardiomyocytes. Alam S, etal., Biosci Rep. 2017 Jul 16;37(4):BSR20170898. doi: 10.1042/BSR20170898. Print 2017 Aug 31.
2. Unfolded protein response is involved in the pathology of human congenital hypothyroid goiter and rat non-goitrous congenital hypothyroidism. Baryshev M, etal., J Mol Endocrinol 2004 Jun;32(3):903-20.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction. Gupta S, etal., PLoS Biol. 2010 Jul 6;8(7):e1000410. doi: 10.1371/journal.pbio.1000410.
6. Expression of XBP1s in peritoneal mesothelial cells is critical for inflammation-induced peritoneal fibrosis. Liu A, etal., Sci Rep. 2019 Dec 13;9(1):19043. doi: 10.1038/s41598-019-55557-1.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria. Nakamura S, etal., J Biol Chem. 2009 May 29;284(22):14809-18. doi: 10.1074/jbc.M901488200. Epub 2009 Mar 30.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Ozcan U, etal., Science. 2004 Oct 15;306(5695):457-61.
11. Rapamycin inhibits postprandial-mediated X-box-binding protein-1 splicing in rat liver. Pfaffenbach KT, etal., J Nutr. 2010 May;140(5):879-84. Epub 2010 Mar 17.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. The dysregulation of endoplasmic reticulum stress response in acute-on-chronic liver failure patients caused by acute exacerbation of chronic hepatitis B. Ren F, etal., J Viral Hepat. 2016 Jan;23(1):23-31. doi: 10.1111/jvh.12438. Epub 2015 Jul 31.
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
18. ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells. Tan Z, etal., J Neuroinflammation. 2018 Sep 21;15(1):275. doi: 10.1186/s12974-018-1311-5.
19. Behavioral stress and activated serotonergic neurotransmission induce XBP-1 splicing in the rat brain. Toda H, etal., Brain Res. 2006 Sep 27;1112(1):26-32. Epub 2006 Aug 2.
20. The impact of the unfolded protein response on human disease. Wang S and Kaufman RJ, J Cell Biol. 2012 Jun 25;197(7):857-67. doi: 10.1083/jcb.201110131.
21. Endoplasmic reticulum stress and neurodegeneration in rats neonatally infected with borna disease virus. Williams BL and Lipkin WI, J Virol. 2006 Sep;80(17):8613-26. doi: 10.1128/JVI.00836-06.
22. Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis. Zhang H, etal., PLoS One. 2015 Sep 22;10(9):e0138203. doi: 10.1371/journal.pone.0138203. eCollection 2015.
Additional References at PubMed
PMID:1903538   PMID:2196176   PMID:8657566   PMID:10652269   PMID:10675042   PMID:11460154   PMID:11779464   PMID:12612580   PMID:12805554   PMID:14559994   PMID:15489334   PMID:16332684  
PMID:16362047   PMID:16461360   PMID:17612490   PMID:17715997   PMID:18556558   PMID:18946015   PMID:19135031   PMID:19328063   PMID:20102225   PMID:20170659   PMID:20348923   PMID:20348926  
PMID:20349222   PMID:20408817   PMID:20439489   PMID:20955178   PMID:21317886   PMID:21337367   PMID:21436843   PMID:21784843   PMID:22529213   PMID:22580202   PMID:22715395   PMID:22970712  
PMID:23152784   PMID:23184933   PMID:23457509   PMID:23508570   PMID:23529610   PMID:23623498   PMID:24333444   PMID:24753614   PMID:25007519   PMID:25190803   PMID:25239945   PMID:25280941  
PMID:25656649   PMID:26315405   PMID:26319553   PMID:26883836   PMID:27133203   PMID:27929749   PMID:27957794   PMID:29414031   PMID:29956773   PMID:30317635   PMID:32199617   PMID:33055426  
PMID:33393852   PMID:33395585   PMID:33789142   PMID:34676402   PMID:34964131   PMID:35008595   PMID:35497095   PMID:36705422  


Genomics

Comparative Map Data
Xbp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81484,604,623 - 84,609,707 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1484,604,107 - 84,609,706 (+)EnsemblGRCr8
mRatBN7.21480,390,629 - 80,395,713 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1480,390,643 - 80,395,693 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1484,792,890 - 84,797,957 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01486,033,004 - 86,038,075 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01482,482,326 - 82,487,393 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01485,753,736 - 85,758,820 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1485,753,760 - 85,758,145 (+)Ensemblrn6Rnor6.0
Rnor_5.01486,423,839 - 86,428,923 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41486,151,910 - 86,156,975 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1479,276,264 - 79,281,348 (+)NCBICelera
RGSC_v3.11486,171,054 - 86,176,119 (+)NCBI
Cytogenetic Map14q21NCBI
XBP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382228,794,560 - 28,800,569 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2228,794,555 - 28,800,597 (-)Ensemblhg38GRCh38
GRCh372229,190,548 - 29,196,557 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362227,520,548 - 27,526,560 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342227,515,102 - 27,521,114NCBI
Celera2212,990,518 - 12,996,530 (-)NCBICelera
Cytogenetic Map22q12.1NCBI
HuRef2212,155,463 - 12,161,487 (-)NCBIHuRef
CHM1_12229,149,582 - 29,155,594 (-)NCBICHM1_1
T2T-CHM13v2.02229,255,848 - 29,261,869 (-)NCBIT2T-CHM13v2.0
Xbp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39115,470,641 - 5,475,993 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl115,470,659 - 5,475,893 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38115,520,641 - 5,525,993 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl115,520,659 - 5,525,893 (+)Ensemblmm10GRCm38
MGSCv37115,420,970 - 5,425,875 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36115,420,970 - 5,425,875 (+)NCBIMGSCv36mm8
Celera116,013,954 - 6,018,865 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.61NCBI
Xbp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554553,037,885 - 3,041,827 (-)NCBIChiLan1.0ChiLan1.0
XBP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22338,792,985 - 38,799,011 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12241,491,735 - 41,497,760 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0229,863,479 - 9,869,491 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12227,566,423 - 27,572,627 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2227,567,041 - 27,571,943 (-)EnsemblpanPan2panpan1.1
XBP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12622,162,675 - 22,168,149 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2622,163,222 - 22,168,105 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2622,034,265 - 22,039,738 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02622,536,044 - 22,541,803 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2622,536,033 - 22,541,796 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12622,246,365 - 22,251,835 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02622,509,837 - 22,515,563 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02622,572,658 - 22,578,379 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Xbp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118112,975,309 - 112,979,534 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366572,891,907 - 2,896,174 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366572,891,171 - 2,895,409 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
XBP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1446,008,377 - 46,016,526 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11446,011,239 - 46,016,526 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21449,015,849 - 49,016,650 (-)NCBISscrofa10.2Sscrofa10.2susScr3
XBP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11911,670,605 - 11,677,168 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045114,476,586 - 114,483,163 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Xbp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247475,123,085 - 5,128,465 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Xbp1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11174,465,840 - 74,471,293 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Xbp1
52 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:166
Count of miRNA genes:127
Interacting mature miRNAs:136
Transcripts:ENSRNOT00000014044
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1459848686104848686Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)1484164970100078267Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1477914838104348525Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)147297021087582095Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143067446985041098Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1474255551109089856Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147764007196755654Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1462398852107398852Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1477640071100078267Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1460854936105854936Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1474255551109089856Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147764007196755654Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1459848686104848686Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144261625899224555Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)146592028399224555Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143941117087582095Rat

Markers in Region
D14Wox29  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21480,391,337 - 80,391,552 (+)MAPPERmRatBN7.2
Rnor_6.01485,754,445 - 85,754,659NCBIRnor6.0
Rnor_5.01486,424,548 - 86,424,762UniSTSRnor5.0
RGSC_v3.41486,152,600 - 86,152,814UniSTSRGSC3.4
Celera1479,276,973 - 79,277,187UniSTS
Cytogenetic Map14q21UniSTS
RH130248  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21480,395,444 - 80,395,624 (+)MAPPERmRatBN7.2
Rnor_6.01485,758,552 - 85,758,731NCBIRnor6.0
Rnor_5.01486,428,655 - 86,428,834UniSTSRnor5.0
RGSC_v3.41486,156,707 - 86,156,886UniSTSRGSC3.4
Celera1479,281,080 - 79,281,259UniSTS
RH 3.4 Map14571.5UniSTS
Cytogenetic Map14q21UniSTS
Xbp1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21480,394,057 - 80,394,147 (+)MAPPERmRatBN7.2
Rnor_6.01485,757,165 - 85,757,254NCBIRnor6.0
Rnor_5.01486,427,268 - 86,427,357UniSTSRnor5.0
Celera1479,279,693 - 79,279,782UniSTS
Cytogenetic Map14q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000014044   ⟹   ENSRNOP00000014044
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1484,604,107 - 84,609,687 (+)Ensembl
mRatBN7.2 Ensembl1480,390,643 - 80,395,693 (+)Ensembl
Rnor_6.0 Ensembl1485,753,760 - 85,758,145 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102562   ⟹   ENSRNOP00000094622
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1484,605,548 - 84,609,706 (+)Ensembl
mRatBN7.2 Ensembl1480,391,554 - 80,395,693 (+)Ensembl
RefSeq Acc Id: NM_001004210   ⟹   NP_001004210
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81484,604,623 - 84,609,707 (+)NCBI
mRatBN7.21480,390,629 - 80,395,713 (+)NCBI
Rnor_6.01485,753,736 - 85,758,820 (+)NCBI
Rnor_5.01486,423,839 - 86,428,923 (+)NCBI
RGSC_v3.41486,151,910 - 86,156,975 (+)RGD
Celera1479,276,264 - 79,281,348 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001271731   ⟹   NP_001258660
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81484,604,623 - 84,609,707 (+)NCBI
mRatBN7.21480,390,629 - 80,395,713 (+)NCBI
Rnor_6.01485,753,736 - 85,758,820 (+)NCBI
Rnor_5.01486,423,839 - 86,428,923 (+)NCBI
Celera1479,276,264 - 79,281,348 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001004210   ⟸   NM_001004210
- Peptide Label: isoform XBP1(U)
- UniProtKB: Q9R1S4 (UniProtKB/Swiss-Prot),   A6IKL9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258660   ⟸   NM_001271731
- Peptide Label: isoform XBP1(S)
- UniProtKB: A0A140TAA7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014044   ⟸   ENSRNOT00000014044
Ensembl Acc Id: ENSRNOP00000094622   ⟸   ENSRNOT00000102562
Protein Domains
bZIP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R1S4-F1-model_v2 AlphaFold Q9R1S4 1-267 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699456
Promoter ID:EPDNEW_R9980
Type:multiple initiation site
Name:Xbp1_1
Description:X-box binding protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01485,753,745 - 85,753,805EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303073 AgrOrtholog
BioCyc Gene G2FUF-15140 BioCyc
Ensembl Genes ENSRNOG00000010298 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000014044 ENTREZGENE
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7115933 IMAGE-MGC_LOAD
InterPro bZIP UniProtKB/Swiss-Prot
  bZIP_sf UniProtKB/Swiss-Prot
  ER_Stress-Reg_TF UniProtKB/Swiss-Prot
KEGG Report rno:289754 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94999 IMAGE-MGC_LOAD
NCBI Gene 289754 ENTREZGENE
PANTHER X-BOX BINDING PROTEIN 1 UniProtKB/Swiss-Prot
  X-BOX-BINDING PROTEIN 1 UniProtKB/Swiss-Prot
Pfam bZIP_2 UniProtKB/Swiss-Prot
PhenoGen Xbp1 PhenoGen
PROSITE BZIP UniProtKB/Swiss-Prot
  BZIP_BASIC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010298 RatGTEx
SMART BRLZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57959 UniProtKB/Swiss-Prot
UniProt A0A140TAA7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ANK3_RAT UniProtKB/TrEMBL
  A6IKL9 ENTREZGENE, UniProtKB/TrEMBL
  A6IKM0_RAT UniProtKB/TrEMBL
  A6IKM1_RAT UniProtKB/TrEMBL
  A6IKM2_RAT UniProtKB/TrEMBL
  A6IKM3_RAT UniProtKB/TrEMBL
  A6IKM4_RAT UniProtKB/TrEMBL
  A6IKM5_RAT UniProtKB/TrEMBL
  Q9R1S4 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Xbp1  X-box binding protein 1      Symbol and Name status set to approved 1299863 APPROVED
2005-02-14 Xbp1  X-box binding protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL