Tlr6 (toll-like receptor 6) - Rat Genome Database

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Gene: Tlr6 (toll-like receptor 6) Rattus norvegicus
Analyze
Symbol: Tlr6
Name: toll-like receptor 6
RGD ID: 1303030
Description: Enables lipopeptide binding activity. Involved in several processes, including microglial cell activation; nitric oxide metabolic process; and toll-like receptor signaling pathway. Predicted to be located in Golgi apparatus and membrane raft. Predicted to be part of Toll-like receptor 2-Toll-like receptor 6 protein complex. Predicted to be active in plasma membrane. Used to study bacterial pneumonia. Biomarker of perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in aspergillosis; asthma; infective endocarditis; rhinitis; and tuberculosis. Orthologous to human TLR6 (toll like receptor 6); PARTICIPATES IN Toll-like receptor signaling pathway; Chagas disease pathway; phagocytosis pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81443,715,809 - 43,727,019 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1443,698,751 - 43,740,462 (+)EnsemblGRCr8
mRatBN7.21443,362,164 - 43,374,500 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1443,362,164 - 43,375,685 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1443,721,986 - 43,733,208 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01445,021,938 - 45,033,160 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01443,502,105 - 43,513,327 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01445,024,351 - 45,041,188 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1445,024,351 - 45,046,446 (+)Ensemblrn6Rnor6.0
Rnor_5.01444,835,326 - 44,850,999 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41446,089,365 - 46,100,687 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1442,506,234 - 42,517,444 (+)NCBICelera
RGSC_v3.11446,091,755 - 46,103,077 (+)NCBI
Cytogenetic Map14p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (ISO)
buta-1,3-diene  (ISO)
butyric acid  (ISO)
cadmium selenide  (ISO)
carbon nanotube  (ISO)
ceric oxide  (ISO)
choline  (ISO)
cisplatin  (ISO)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dioxygen  (ISO)
doxorubicin  (EXP)
endosulfan  (EXP)
ethanol  (ISO)
ethylparaben  (ISO)
flutamide  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP)
levamisole  (ISO)
manganese(II) chloride  (EXP)
mangiferin  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
nickel atom  (ISO)
o-anisidine  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP)
parthenolide  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
sulforaphane  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antibacterial innate immune response  (IEA,ISO)
cellular response to amyloid-beta  (IEA,ISO)
cellular response to diacyl bacterial lipopeptide  (IBA,ISO)
cellular response to oxidised low-density lipoprotein particle stimulus  (IEA,ISO)
detection of diacyl bacterial lipopeptide  (ISO)
immune response  (IEA,TAS)
immune system process  (IEA)
inflammatory response  (IBA,IEA)
innate immune response  (IEA)
microglial cell activation  (IDA)
MyD88-dependent toll-like receptor signaling pathway  (IEA,ISO)
negative regulation of interleukin-8 production  (IEA,ISO)
negative regulation of toll-like receptor 2 signaling pathway  (IEA,ISO)
negative regulation of tumor necrosis factor production  (IEA,ISO)
nitric oxide metabolic process  (IDA)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of cytokine production  (IEA)
positive regulation of cytokine production involved in inflammatory response  (IEA,ISO)
positive regulation of extrinsic apoptotic signaling pathway  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of inflammatory response  (IEA,ISO)
positive regulation of interleukin-1 beta production  (IEA,ISO)
positive regulation of JUN kinase activity  (ISO)
positive regulation of macrophage activation  (IEA,ISO)
positive regulation of nitric oxide biosynthetic process  (IEA,ISO)
positive regulation of NLRP3 inflammasome complex assembly  (IEA,ISO)
positive regulation of reactive oxygen species biosynthetic process  (IEA,ISO)
regulation of tumor necrosis factor production  (IEA)
response to bacterial lipoprotein  (IDA)
signal transduction  (IEA)
toll-like receptor signaling pathway  (IBA,IDA,IEA,IMP)
toll-like receptor TLR6:TLR2 signaling pathway  (IEA,ISO)
TRIF-dependent toll-like receptor signaling pathway  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. TLR4 links podocytes with the innate immune system to mediate glomerular injury. Banas MC, etal., J Am Soc Nephrol. 2008 Apr;19(4):704-13. doi: 10.1681/ASN.2007040395. Epub 2008 Feb 6.
2. Toll-like receptor 6 drives interleukin-17A expression during experimental hypersensitivity pneumonitis. Fong DJ, etal., Immunology. 2010 May;130(1):125-36. Epub 2010 Jan 11.
3. P2X7 Receptor Antagonist A804598 Inhibits Inflammation in Brain and Liver in C57BL/6J Mice Exposed to Chronic Ethanol and High Fat Diet. Freire D, etal., J Neuroimmune Pharmacol. 2019 Jun;14(2):263-277. doi: 10.1007/s11481-018-9816-3. Epub 2018 Oct 23.
4. A Toll-like receptor 2/6 agonist reduces allergic airway inflammation in chronic respiratory sensitisation to Timothy grass pollen antigens. Fuchs B, etal., Int Arch Allergy Immunol. 2010;152(2):131-9. Epub 2009 Dec 16.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. An association between single nucleotide polymorphisms within TLR and TREM-1 genes and infective endocarditis. Golovkin AS, etal., Cytokine. 2015 Jan;71(1):16-21. doi: 10.1016/j.cyto.2014.08.001. Epub 2014 Sep 16.
7. Combinations of TLR and NOD2 ligands stimulate rat microglial P2X4R expression. Guo LH, etal., Biochem Biophys Res Commun. 2006 Oct 27;349(3):1156-62. Epub 2006 Sep 1.
8. Pyrexia, anorexia, adipsia, and depressed motor activity in rats during systemic inflammation induced by the Toll-like receptors-2 and -6 agonists MALP-2 and FSL-1. Hubschle T, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Jan;290(1):R180-7. Epub 2005 Sep 8.
9. Beneficial effects of TLR-2/6 ligation in pulmonary bacterial infection and immunization with Pseudomonas aeruginosa. Kerber-Momot T, etal., Inflammation. 2010 Feb;33(1):58-64.
10. TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation. Kesh S, etal., Ann N Y Acad Sci. 2005 Dec;1062:95-103.
11. Macrophage-activating lipopeptide-2 (MALP-2) induces a localized inflammatory response in rats resulting in activation of brain sites implicated in fever. Knorr C, etal., Brain Res. 2008 Apr 18;1205:36-46. Epub 2008 Feb 21.
12. Toll-like receptor heterodimer variants protect from childhood asthma. Kormann MS, etal., J Allergy Clin Immunol. 2008 Jul;122(1):86-92, 92.e1-8. Epub 2008 Jun 10.
13. Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols (GPIs) of Plasmodium falciparum: Cell signaling receptors, GPI structural requirement, and regulation of GPI activity. Krishnegowda G, etal., J Biol Chem 2004 Dec 28;.
14. Pathogen recognition by the innate immune system. Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
15. Changes in intestinal Toll-like receptors and cytokines precede histological injury in a rat model of necrotizing enterocolitis. Liu Y, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Sep;297(3):G442-50. Epub 2009 Jul 16.
16. Full-exon resequencing reveals toll-like receptor variants contribute to human susceptibility to tuberculosis disease. Ma X, etal., PLoS One. 2007 Dec 19;2(12):e1318.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Respiratory syncytial virus activates innate immunity through Toll-like receptor 2. Murawski MR, etal., J Virol. 2009 Feb;83(3):1492-500. Epub 2008 Nov 19.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. Polymorphisms in the toll-like receptor 2 subfamily and risk of asthma: a case-control analysis in a Chinese population. Qian FH, etal., J Investig Allergol Clin Immunol. 2010;20(4):340-6.
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
25. Toll-like receptor 6 gene (TLR6): single-nucleotide polymorphism frequencies and preliminary association with the diagnosis of asthma. Tantisira K, etal., Genes Immun. 2004 Aug;5(5):343-6.
26. Increased Toll-like Receptor-MyD88-NFκB-Proinflammatory neuroimmune signaling in the orbitofrontal cortex of humans with alcohol use disorder. Vetreno RP, etal., Alcohol Clin Exp Res. 2021 Sep;45(9):1747-1761. doi: 10.1111/acer.14669. Epub 2021 Aug 20.
27. MicroRNA-494-3p alleviates inflammatory response in sepsis by targeting TLR6. Wang HF, etal., Eur Rev Med Pharmacol Sci. 2019 Apr;23(7):2971-2977. doi: 10.26355/eurrev_201904_17578.
Additional References at PubMed
PMID:10231569   PMID:11431423   PMID:15294986   PMID:16880211   PMID:19931471   PMID:20037584   PMID:22198949   PMID:23155421   PMID:23812099   PMID:24091496   PMID:25088687  


Genomics

Comparative Map Data
Tlr6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81443,715,809 - 43,727,019 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1443,698,751 - 43,740,462 (+)EnsemblGRCr8
mRatBN7.21443,362,164 - 43,374,500 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1443,362,164 - 43,375,685 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1443,721,986 - 43,733,208 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01445,021,938 - 45,033,160 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01443,502,105 - 43,513,327 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01445,024,351 - 45,041,188 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1445,024,351 - 45,046,446 (+)Ensemblrn6Rnor6.0
Rnor_5.01444,835,326 - 44,850,999 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41446,089,365 - 46,100,687 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1442,506,234 - 42,517,444 (+)NCBICelera
RGSC_v3.11446,091,755 - 46,103,077 (+)NCBI
Cytogenetic Map14p11NCBI
TLR6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38438,822,897 - 38,868,390 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl438,822,897 - 38,856,901 (-)Ensemblhg38GRCh38
GRCh37438,824,518 - 38,859,376 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36438,504,803 - 38,507,555 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34438,650,973 - 38,653,726NCBI
Celera439,263,872 - 39,296,634 (-)NCBICelera
Cytogenetic Map4p14NCBI
HuRef438,149,688 - 38,182,937 (-)NCBIHuRef
CHM1_1438,824,910 - 38,858,032 (-)NCBICHM1_1
T2T-CHM13v2.0438,793,030 - 38,827,904 (-)NCBIT2T-CHM13v2.0
Tlr6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39565,109,373 - 65,128,387 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl565,109,374 - 65,117,440 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38564,953,092 - 64,970,942 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl564,952,031 - 64,960,097 (-)Ensemblmm10GRCm38
MGSCv37565,344,334 - 65,351,273 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36565,232,241 - 65,239,169 (-)NCBIMGSCv36mm8
Celera562,225,900 - 62,232,840 (-)NCBICelera
Cytogenetic Map5C3.1NCBI
cM Map533.54NCBI
Tlr6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554438,422,534 - 8,424,942 (+)Ensembl
ChiLan1.0NW_0049554438,401,461 - 8,427,175 (+)NCBIChiLan1.0ChiLan1.0
TLR6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2339,012,720 - 39,034,220 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1439,201,456 - 39,226,747 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0433,153,151 - 33,174,053 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1439,007,970 - 39,038,717 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl439,009,103 - 39,011,490 (-)EnsemblpanPan2panpan1.1
TLR6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1373,504,357 - 73,523,964 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl373,520,706 - 73,523,099 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha376,051,457 - 76,071,053 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
Tlr6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528539,677,687 - 39,695,258 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364826,607,753 - 6,610,143 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364826,607,723 - 6,610,161 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLR6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl830,159,754 - 30,180,650 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1830,159,744 - 30,180,650 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2831,642,296 - 31,644,684 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TLR6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12711,439,288 - 11,461,580 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2711,459,181 - 11,461,571 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604757,852,558 - 57,878,018 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tlr6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248407,323,022 - 7,349,334 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tlr6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11121,952,804 - 21,960,343 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tlr6
42 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:144
Count of miRNA genes:116
Interacting mature miRNAs:126
Transcripts:ENSRNOT00000002933
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143802371083023710Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143900944484009444Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143123808072970315Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143067446985041098Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143802371083023710Rat
7387267Uae42Urinary albumin excretion QTL 420.61urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)142252151767521517Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141889519263895192Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141790672654251504Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143802371083023710Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144261625899224555Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143941117087582095Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143802371083023710Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 157 91 90 59 92 59 6 355 192 11 135 80 90 31 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000002933   ⟹   ENSRNOP00000002933
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1443,720,468 - 43,729,660 (+)Ensembl
mRatBN7.2 Ensembl1443,366,787 - 43,375,685 (+)Ensembl
Rnor_6.0 Ensembl1445,033,309 - 45,046,446 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076753   ⟹   ENSRNOP00000068444
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1443,720,457 - 43,740,462 (+)Ensembl
mRatBN7.2 Ensembl1443,362,164 - 43,373,373 (+)Ensembl
Rnor_6.0 Ensembl1445,024,351 - 45,040,175 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108237   ⟹   ENSRNOP00000081116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1443,699,907 - 43,728,852 (+)Ensembl
mRatBN7.2 Ensembl1443,366,822 - 43,375,197 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000126180   ⟹   ENSRNOP00000107154
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1443,720,483 - 43,727,868 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000128820   ⟹   ENSRNOP00000111954
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1443,698,751 - 43,728,852 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000138938   ⟹   ENSRNOP00000107323
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1443,720,477 - 43,739,438 (+)Ensembl
RefSeq Acc Id: NM_207604   ⟹   NP_997487
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81443,715,809 - 43,727,019 (+)NCBI
mRatBN7.21443,362,164 - 43,373,373 (+)NCBI
Rnor_6.01445,024,351 - 45,040,175 (+)NCBI
Rnor_5.01444,835,326 - 44,850,999 (+)NCBI
RGSC_v3.41446,089,365 - 46,100,687 (+)RGD
Celera1442,506,234 - 42,517,444 (+)RGD
Sequence:
RefSeq Acc Id: XM_006250960   ⟹   XP_006251022
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81443,720,382 - 43,727,019 (+)NCBI
mRatBN7.21443,366,736 - 43,374,500 (+)NCBI
Rnor_6.01445,033,622 - 45,041,188 (+)NCBI
Rnor_5.01444,835,326 - 44,850,999 (+)NCBI
Sequence:
RefSeq Acc Id: NP_997487   ⟸   NM_207604
- UniProtKB: A6JDF8 (UniProtKB/TrEMBL),   Q6P690 (UniProtKB/TrEMBL),   A0A096MKA9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251022   ⟸   XM_006250960
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000002933   ⟸   ENSRNOT00000002933
Ensembl Acc Id: ENSRNOP00000068444   ⟸   ENSRNOT00000076753
Ensembl Acc Id: ENSRNOP00000081116   ⟸   ENSRNOT00000108237
Ensembl Acc Id: ENSRNOP00000107154   ⟸   ENSRNOT00000126180
Ensembl Acc Id: ENSRNOP00000107323   ⟸   ENSRNOT00000138938
Ensembl Acc Id: ENSRNOP00000111954   ⟸   ENSRNOT00000128820
Protein Domains
TIR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V695-F1-model_v2 AlphaFold G3V695 1-811 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303030 AgrOrtholog
BioCyc Gene G2FUF-15727 BioCyc
Ensembl Genes ENSRNOG00000002161 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002933.7 UniProtKB/TrEMBL
  ENSRNOT00000076753.4 UniProtKB/TrEMBL
  ENSRNOT00000108237 ENTREZGENE
  ENSRNOT00000108237.2 UniProtKB/TrEMBL
  ENSRNOT00000126180.1 UniProtKB/TrEMBL
  ENSRNOT00000128820.1 UniProtKB/TrEMBL
  ENSRNOT00000138938.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10140 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5621142 IMAGE-MGC_LOAD
InterPro Cys-rich_flank_reg_C UniProtKB/TrEMBL
  L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  Toll-Interleukin_rcpt UniProtKB/TrEMBL
  Toll-like_receptor UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/TrEMBL
KEGG Report rno:305353 UniProtKB/TrEMBL
MGC_CLONE MGC:72634 IMAGE-MGC_LOAD
NCBI Gene 305353 ENTREZGENE
PANTHER PTHR24365 UniProtKB/TrEMBL
  PTHR24365:SF422 UniProtKB/TrEMBL
Pfam LRR_8 UniProtKB/TrEMBL
  LRRCT UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
PhenoGen Tlr6 PhenoGen
PIRSF Toll-like_receptor UniProtKB/TrEMBL
PRINTS INTRLKN1R1F UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002161 RatGTEx
SMART LRR_TYP UniProtKB/TrEMBL
  LRRCT UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
UniProt A0A096MKA9 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LR39_RAT UniProtKB/TrEMBL
  A0ABK0LXR4_RAT UniProtKB/TrEMBL
  A0ABK0M5L4_RAT UniProtKB/TrEMBL
  A6JDF8 ENTREZGENE, UniProtKB/TrEMBL
  G3V695_RAT UniProtKB/TrEMBL
  Q6P690 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Tlr6  toll-like receptor 6      Symbol and Name status set to approved 1299863 APPROVED
2005-02-14 Tlr6  toll-like receptor 6      Symbol and Name status set to provisional 70820 PROVISIONAL