TLR6 (toll-like receptor 6) - Rat Genome Database

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Keyword

Gene: TLR6 (toll-like receptor 6) Homo sapiens

Symbol:

TLR6

Name:

toll-like receptor 6

Description:

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq, Jan 2011]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

CD286; OTTHUMP00000158730; OTTHUMP00000218187; OTTHUMP00000218188; toll-like receptor 6

Orthologs:

Mus musculus : Tlr6 (toll-like receptor 6) MGI
Rattus norvegicus : Tlr6 (toll-like receptor 6)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	4	38,716,797 - 38,749,911	-	NCBI
Human Genome Assembly HuRef	4	38,149,688 - 38,182,937	-	NCBI
Human Genome Assembly GRCh37	4	38,825,325 - 38,858,438	-	NCBI
Human Genome Assembly Build 36	4	38,504,803 - 38,507,555	-	NCBI
Human Cytogenetic Map	4	p14		NCBI
Human Genome Assembly	4	38,650,973 - 38,653,726		NCBI