Sptbn1 (spectrin, beta, non-erythrocytic 1) - Rat Genome Database

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Gene: Sptbn1 (spectrin, beta, non-erythrocytic 1) Rattus norvegicus
Analyze
Symbol: Sptbn1
Name: spectrin, beta, non-erythrocytic 1
RGD ID: 727922
Description: Predicted to enable GTPase binding activity; actin filament binding activity; and ankyrin binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in several processes, including Golgi to plasma membrane protein transport; central nervous system formation; and positive regulation of interleukin-2 production. Predicted to act upstream of or within regulation of SMAD protein signal transduction. Part of protein-containing complex. Is active in glutamatergic synapse and postsynapse. Orthologous to human SPTBN1 (spectrin beta, non-erythrocytic 1); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beta II spectrin-like (short form); bSPII-; cytoskeleton protein; non-erythroid spectrin beta; short form of beta II spectrin; spectrin beta 2; spectrin beta chain, brain 1; spectrin beta chain, non-erythrocytic 1; spectrin beta non-erythrocytic 1; Spnb1; Spnb2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814108,042,629 - 108,217,884 (-)NCBIGRCr8
mRatBN7.214103,841,713 - 104,016,900 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl14103,842,684 - 104,008,507 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx14108,170,773 - 108,336,283 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.014109,405,426 - 109,571,087 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.014105,877,837 - 106,043,513 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014114,517,839 - 114,700,199 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14114,518,816 - 114,692,764 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014114,188,053 - 114,356,233 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.414111,076,741 - 111,246,286 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.114111,255,392 - 111,259,578 (+)NCBI
Celera14102,708,226 - 102,873,561 (-)NCBICelera
Cytogenetic Map14q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-methoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetohydrazide  (ISO)
acrolein  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
AM-251  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
apigenin  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
Brodifacoum  (EXP)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP)
choline  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
disulfiram  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fumonisin B1  (ISO)
geldanamycin  (ISO)
genistein  (EXP)
gentamycin  (EXP)
hydrogen cyanide  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
levonorgestrel  (ISO)
lipopolysaccharide  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
Methylazoxymethanol acetate  (EXP)
nickel atom  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
parathion  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium cyanide  (ISO)
progesterone  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sulfadimethoxine  (EXP)
sulindac sulfide  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone undecanoate  (ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triptonide  (ISO)
tungsten  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc protoporphyrin  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. TGF-beta signaling pathway inactivation and cell cycle deregulation in the development of gastric cancer: role of the beta-spectrin, ELF. Kim SS, etal., Biochem Biophys Res Commun. 2006 Jun 16;344(4):1216-23. Epub 2006 Apr 19.
3. Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin. Lehtonen S, etal., Am J Pathol. 2004 Sep;165(3):923-36.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Multicolour Multilevel STED nanoscopy of Actin/Spectrin Organization at Synapses. Sidenstein SC, etal., Sci Rep. 2016 May 25;6:26725. doi: 10.1038/srep26725.
10. Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice. Tang Y, etal., Science. 2003 Jan 24;299(5606):574-7.
Additional References at PubMed
PMID:9537418   PMID:10477754   PMID:10806113   PMID:11274145   PMID:12477932   PMID:14593108   PMID:15262991   PMID:16025302   PMID:17114649   PMID:17620337   PMID:18723693   PMID:18796539  
PMID:19056867   PMID:20458337   PMID:21966409   PMID:22681889   PMID:22871113   PMID:23239625   PMID:24337748   PMID:24625528   PMID:25468996   PMID:35352799  


Genomics

Comparative Map Data
Sptbn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814108,042,629 - 108,217,884 (-)NCBIGRCr8
mRatBN7.214103,841,713 - 104,016,900 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl14103,842,684 - 104,008,507 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx14108,170,773 - 108,336,283 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.014109,405,426 - 109,571,087 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.014105,877,837 - 106,043,513 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014114,517,839 - 114,700,199 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14114,518,816 - 114,692,764 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014114,188,053 - 114,356,233 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.414111,076,741 - 111,246,286 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.114111,255,392 - 111,259,578 (+)NCBI
Celera14102,708,226 - 102,873,561 (-)NCBICelera
Cytogenetic Map14q22NCBI
SPTBN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38254,456,327 - 54,671,446 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl254,456,327 - 54,671,446 (+)EnsemblGRCh38hg38GRCh38
GRCh37254,683,464 - 54,898,583 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36254,536,958 - 54,752,087 (+)NCBINCBI36Build 36hg18NCBI36
Build 34254,697,181 - 54,799,245NCBI
Celera254,523,740 - 54,739,107 (+)NCBICelera
Cytogenetic Map2p16.2NCBI
HuRef254,485,674 - 54,631,223 (+)NCBIHuRef
CHM1_1254,613,602 - 54,828,713 (+)NCBICHM1_1
T2T-CHM13v2.0254,450,519 - 54,665,452 (+)NCBIT2T-CHM13v2.0
Sptbn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391130,049,395 - 30,218,384 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1130,049,395 - 30,218,175 (-)EnsemblGRCm39 Ensembl
GRCm381130,099,395 - 30,268,384 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1130,099,395 - 30,268,175 (-)EnsemblGRCm38mm10GRCm38
MGSCv371129,999,395 - 30,119,772 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361130,000,434 - 30,119,772 (-)NCBIMGSCv36mm8
Celera1132,468,358 - 32,593,393 (-)NCBICelera
Cytogenetic Map11A3.3NCBI
cM Map1117.44NCBI
Sptbn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544120,248,578 - 20,378,038 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544120,248,578 - 20,378,038 (+)NCBIChiLan1.0ChiLan1.0
SPTBN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21271,664,972 - 71,804,527 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A71,668,924 - 71,876,651 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A54,608,711 - 54,816,083 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A55,822,415 - 55,961,925 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A55,822,415 - 55,961,925 (+)Ensemblpanpan1.1panPan2
SPTBN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11055,429,989 - 55,571,917 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1055,429,940 - 55,571,916 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1055,325,541 - 55,524,492 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01056,373,040 - 56,571,581 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1056,374,468 - 56,571,581 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11056,064,719 - 56,261,769 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01056,353,568 - 56,552,022 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01056,700,647 - 56,842,710 (+)NCBIUU_Cfam_GSD_1.0
Sptbn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629227,462,919 - 27,650,484 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936491956,986 - 1,108,640 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936491920,830 - 1,108,374 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPTBN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl386,585,054 - 86,784,149 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1386,585,225 - 86,784,316 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SPTBN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11452,266,197 - 52,487,111 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1452,262,416 - 52,487,112 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604559,248,465 - 59,459,178 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sptbn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248336,947,273 - 7,089,924 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248336,947,611 - 7,144,688 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sptbn1
970 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:95
Count of miRNA genes:84
Interacting mature miRNAs:86
Transcripts:ENSRNOT00000008210
Prediction methods:Microtar, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat

Markers in Region
RH138476  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.214103,915,473 - 103,915,715 (+)MAPPERmRatBN7.2
Rnor_6.014114,592,356 - 114,592,597NCBIRnor6.0
Rnor_5.014114,260,592 - 114,260,833UniSTSRnor5.0
RGSC_v3.414111,173,182 - 111,173,423UniSTSRGSC3.4
Celera14102,780,741 - 102,780,982UniSTS
Cytogenetic Map14q22UniSTS
RH141179  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.214103,849,330 - 103,849,522 (+)MAPPERmRatBN7.2
Rnor_6.014114,525,457 - 114,525,648NCBIRnor6.0
Rnor_5.014114,194,700 - 114,194,891UniSTSRnor5.0
RGSC_v3.414111,239,448 - 111,239,639UniSTSRGSC3.4
Celera14102,714,873 - 102,715,064UniSTS
Cytogenetic Map14q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 2
Medium 3 43 57 41 19 41 8 11 74 35 41 9 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001410274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF218849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF337905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY238344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC090340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000008210   ⟹   ENSRNOP00000008210
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl14103,842,684 - 104,008,507 (-)Ensembl
Rnor_6.0 Ensembl14114,518,816 - 114,692,764 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000083528   ⟹   ENSRNOP00000074766
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl14114,518,943 - 114,649,173 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000084595   ⟹   ENSRNOP00000071233
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl14103,851,083 - 103,941,784 (-)Ensembl
Rnor_6.0 Ensembl14114,518,940 - 114,583,122 (-)Ensembl
RefSeq Acc Id: NM_001410274   ⟹   NP_001397203
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814108,042,629 - 108,217,836 (-)NCBI
mRatBN7.214103,841,713 - 104,016,900 (-)NCBI
RefSeq Acc Id: XM_063273289   ⟹   XP_063129359
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814108,042,629 - 108,217,535 (-)NCBI
RefSeq Acc Id: XM_063273290   ⟹   XP_063129360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814108,042,629 - 108,217,315 (-)NCBI
RefSeq Acc Id: XM_063273291   ⟹   XP_063129361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814108,042,629 - 108,209,472 (-)NCBI
RefSeq Acc Id: XM_063273292   ⟹   XP_063129362
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814108,042,629 - 108,216,832 (-)NCBI
RefSeq Acc Id: XM_063273294   ⟹   XP_063129364
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814108,042,629 - 108,148,963 (-)NCBI
RefSeq Acc Id: XM_063273295   ⟹   XP_063129365
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814108,049,980 - 108,217,884 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000008210   ⟸   ENSRNOT00000008210
RefSeq Acc Id: ENSRNOP00000071233   ⟸   ENSRNOT00000084595
RefSeq Acc Id: ENSRNOP00000074766   ⟸   ENSRNOT00000083528
RefSeq Acc Id: NP_001397203   ⟸   NM_001410274
- UniProtKB: A6JQC5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129359   ⟸   XM_063273289
- Peptide Label: isoform X1
- UniProtKB: A6JQC5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129360   ⟸   XM_063273290
- Peptide Label: isoform X1
- UniProtKB: A6JQC5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129362   ⟸   XM_063273292
- Peptide Label: isoform X1
- UniProtKB: A6JQC5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129361   ⟸   XM_063273291
- Peptide Label: isoform X1
- UniProtKB: A6JQC5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129364   ⟸   XM_063273294
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063129365   ⟸   XM_063273295
- Peptide Label: isoform X3
Protein Domains
Calponin-homology (CH)   PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K8W9-F1-model_v2 AlphaFold A0A0G2K8W9 1-2358 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699548
Promoter ID:EPDNEW_R10063
Type:single initiation site
Name:Sptbn1_1
Description:spectrin, beta, non-erythrocytic 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.014114,583,071 - 114,583,131EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727922 AgrOrtholog
BioCyc Gene G2FUF-14644 BioCyc
Ensembl Genes ENSRNOG00000005434 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008210 ENTREZGENE
  ENSRNOT00000008210.7 UniProtKB/TrEMBL
  ENSRNOT00000084595.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
  1.20.58.60 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7303580 IMAGE-MGC_LOAD
InterPro Actinin_actin-bd_CS UniProtKB/TrEMBL
  Calponin-like_dom_sf UniProtKB/TrEMBL
  CH-domain UniProtKB/TrEMBL
  PH_9 UniProtKB/TrEMBL
  PH_dom-spectrin-type UniProtKB/TrEMBL
  PH_like_dom UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  Spectrin/alpha-actinin UniProtKB/TrEMBL
  Spectrin_bsu UniProtKB/TrEMBL
  Spectrin_repeat UniProtKB/TrEMBL
KEGG Report rno:305614 UniProtKB/TrEMBL
MGC_CLONE MGC:105994 IMAGE-MGC_LOAD
NCBI Gene 305614 ENTREZGENE
PANTHER SPECTRIN BETA CHAIN, NON-ERYTHROCYTIC 1 UniProtKB/TrEMBL
  SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN UniProtKB/TrEMBL
Pfam PF00307 UniProtKB/TrEMBL
  PH_9 UniProtKB/TrEMBL
  Spectrin UniProtKB/TrEMBL
PhenoGen Sptbn1 PhenoGen
PIRSF Spectrin_beta_subunit UniProtKB/TrEMBL
PRINTS SPECTRINPH UniProtKB/TrEMBL
PROSITE ACTININ_1 UniProtKB/TrEMBL
  ACTININ_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  PS50021 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005434 RatGTEx
SMART SM00033 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
  SPEC UniProtKB/TrEMBL
Superfamily-SCOP Calponin-homology UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
  Spectrin repeat UniProtKB/TrEMBL
UniProt A0A0G2JZY6_RAT UniProtKB/TrEMBL
  A6JQC5 ENTREZGENE, UniProtKB/TrEMBL
  G3V6S0_RAT UniProtKB/TrEMBL
  Q5D002_RAT UniProtKB/TrEMBL
  Q6XD99_RAT UniProtKB/TrEMBL
  Q9WUX0_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 Sptbn1  spectrin, beta, non-erythrocytic 1  Spnb2  spectrin beta 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-04 Spnb2  spectrin beta 2  Spnb1l  beta II spectrin-like (short form)  Data merged from RGD:621726 737654 APPROVED
2008-03-13 Spnb1l  beta II spectrin-like (short form)  Spnb1  short form of beta II spectrin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Spnb2  spectrin beta 2      Symbol and Name status set to approved 1299863 APPROVED
2005-01-20 Spnb1  short form of beta II spectrin      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Spnb1  short form of beta II spectrin      Symbol and Name status set to provisional 70820 PROVISIONAL