Ap3m2 (adaptor related protein complex 3 subunit mu 2)

Gene: Ap3m2 (adaptor related protein complex 3 subunit mu 2) Rattus norvegicus

Analyze

Symbol:

Ap3m2

Name:

adaptor related protein complex 3 subunit mu 2

RGD ID:

70969

Description:

Predicted to be involved in anterograde synaptic vesicle transport and synaptic vesicle endocytosis. Is active in synaptic vesicle. Orthologous to human AP3M2 (adaptor related protein complex 3 subunit mu 2); INTERACTS WITH 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

adapter-related protein complex 3 mu-2 subunit; adapter-related protein complex 3 subunit mu-2; adaptor-related protein complex 3 subunit mu-2; adaptor-related protein complex 3, mu 2 subunit; AP-3 complex subunit mu-2; clathrin assembly protein assembly protein complex 1 medium chain homolog 2; clathrin assembly protein assembly protein complex 3 mu-2 medium chain; clathrin coat assembly protein AP47 homolog 2; clathrin coat-associated protein AP47 homolog 2; golgi adaptor AP-1 47 kDa protein homolog 2; HA1 47 kDa subunit homolog 2; MGC93230; mu3B-adaptin; P47B

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	75,908,459 - 75,937,915 (+)	NCBI		GRCr8
mRatBN7.2	16	69,217,526 - 69,237,372 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	69,217,633 - 69,235,431 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	74,491,898 - 74,507,281 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	77,924,257 - 77,939,760 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	73,173,400 - 73,188,903 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	74,075,842 - 74,091,230 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	74,076,812 - 74,091,139 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	73,708,174 - 73,723,223 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	73,687,443 - 73,704,278 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	73,688,647 - 73,706,426 (+)	NCBI
Celera	16	67,111,665 - 67,127,395 (+)	NCBI		Celera
Cytogenetic Map	16	q12.5	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

IMMUNODEFICIENCY 15 (ISO)

immunodeficiency 15B (ISO)

torsion dystonia 6 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-alpha-phellandrene (ISO)

1,2,4-trimethylbenzene (EXP)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methoxyethanol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

acetamide (EXP)

acrylamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-phellandrene (ISO)

ammonium chloride (EXP)

benzene (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

carbon nanotube (ISO)

choline (ISO)

cisplatin (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

diethyl maleate (EXP)

dorsomorphin (ISO)

ethyl methanesulfonate (ISO)

folic acid (ISO)

fulvestrant (ISO)

gentamycin (EXP)

indometacin (ISO)

L-methionine (ISO)

methyl methanesulfonate (ISO)

nickel atom (ISO)

ozone (EXP)

paracetamol (EXP,ISO)

progesterone (ISO)

quercetin (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tunicamycin (ISO)

undecane (EXP)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anterograde axonal transport (ISO,ISS)

anterograde synaptic vesicle transport (IEA,ISO,ISS)

endocytosis (IBA)

intracellular protein transport (IEA)

intracellular transport (NAS)

neurotransmitter secretion (NAS)

synaptic vesicle endocytosis (ISO)

vesicle-mediated transport (IEA)

Cellular Component

axon cytoplasm (IEA)

clathrin adaptor complex (IEA)

cytoplasmic vesicle (IBA)

cytoplasmic vesicle membrane (IEA)

GABA-ergic synapse (ISO)

glutamatergic synapse (ISO)

Golgi apparatus (IEA)

synaptic vesicle (EXP,IDA)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Gene Data Set	MGD Curation, June 12, 2002
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Cloning of rodent megsin revealed its up-regulation in mesangioproliferative nephritis.	Nangaku M, etal., Kidney Int 2001 Aug;60(2):641-52.
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	Two rat homologs of clathrin-associated adaptor proteins.	Pevsner J, etal., Gene 1994 Sep 2;146(2):279-83.
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Hidden proteome of synaptic vesicles in the mammalian brain.	Taoufiq Z, etal., Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33586-33596. doi: 10.1073/pnas.2011870117. Epub 2020 Dec 21.

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:21998198	PMID:25931508

Genomics

Comparative Map Data

Ap3m2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	75,908,459 - 75,937,915 (+)	NCBI		GRCr8
mRatBN7.2	16	69,217,526 - 69,237,372 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	69,217,633 - 69,235,431 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	74,491,898 - 74,507,281 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	77,924,257 - 77,939,760 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	73,173,400 - 73,188,903 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	74,075,842 - 74,091,230 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	74,076,812 - 74,091,139 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	73,708,174 - 73,723,223 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	73,687,443 - 73,704,278 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	73,688,647 - 73,706,426 (+)	NCBI
Celera	16	67,111,665 - 67,127,395 (+)	NCBI		Celera
Cytogenetic Map	16	q12.5	NCBI

AP3M2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	42,153,063 - 42,171,183 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	42,152,946 - 42,171,673 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	42,010,581 - 42,028,701 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	42,129,761 - 42,147,858 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	42,129,760 - 42,147,858	NCBI
Celera	8	40,959,278 - 40,977,658 (+)	NCBI		Celera
Cytogenetic Map	8	p11.21	NCBI
HuRef	8	40,537,926 - 40,556,180 (+)	NCBI		HuRef
CHM1_1	8	42,058,770 - 42,077,010 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	42,427,379 - 42,445,504 (+)	NCBI		T2T-CHM13v2.0

Ap3m2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	23,277,370 - 23,297,308 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	23,277,370 - 23,295,638 (-)	Ensembl		GRCm39 Ensembl
GRCm38	8	22,787,354 - 22,807,292 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	22,787,354 - 22,805,622 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	23,897,826 - 23,916,126 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	24,252,900 - 24,271,176 (-)	NCBI		MGSCv36	mm8
Celera	8	24,277,100 - 24,295,419 (-)	NCBI		Celera
Cytogenetic Map	8	A2	NCBI
cM Map	8	11.42	NCBI

Ap3m2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955536	767,306 - 812,204 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955536	767,470 - 900,268 (-)	NCBI	ChiLan1.0	ChiLan1.0

AP3M2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	60,605,245 - 60,623,563 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	36,322,564 - 36,340,883 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	41,397,123 - 41,415,379 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	38,842,803 - 38,861,030 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	38,842,811 - 38,861,030 (+)	Ensembl	panpan1.1		panPan2

AP3M2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	23,500,988 - 23,518,193 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	23,454,325 - 23,518,193 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	24,005,479 - 24,022,678 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	25,246,167 - 25,266,357 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	25,202,710 - 25,266,368 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	23,620,257 - 23,637,441 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	24,183,842 - 24,201,040 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	24,234,760 - 24,251,957 (-)	NCBI		UU_Cfam_GSD_1.0

Ap3m2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	46,547,219 - 46,569,288 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936785	508,848 - 525,391 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936785	503,615 - 525,361 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AP3M2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	11,167,161 - 11,190,854 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	11,167,118 - 11,190,857 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	13,140,152 - 13,161,984 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AP3M2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	40,142,577 - 40,161,013 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	40,142,666 - 40,161,008 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666052	1,625,641 - 1,644,086 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ap3m2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624780	1,068,498 - 1,086,551 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624780	1,054,796 - 1,091,688 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ap3m2
231 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	499
Count of miRNA genes:	269
Interacting mature miRNAs:	327
Transcripts:	ENSRNOT00000025675
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1600378	Arunc4	Aerobic running capacity QTL 4		0.03	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	16	380245	80345693	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor depth of invasion (CMO:0001888)	16	17696791	82635055	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor depth of invasion (CMO:0001888)	16	17696791	82635055	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor diameter (CMO:0001889)	16	17696791	82635055	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor diameter (CMO:0001889)	16	17696791	82635055	Rat
70215	Niddm29	Non-insulin dependent diabetes mellitus QTL 29	3.54		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	16	19004435	75226532	Rat
8694453	Bw172	Body weight QTL 172	8.33	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	16	24325513	69325513	Rat
6903294	Stl30	Serum triglyceride level QTL 30	2.6	0.0013	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	16	25152793	70152793	Rat
1578768	Stresp22	Stress response QTL 22	2.8		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	16	35288870	80288870	Rat
2293690	Bss45	Bone structure and strength QTL 45	5.13	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	16	37752156	82752156	Rat
2300163	Bmd64	Bone mineral density QTL 64	5.3	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	16	37752156	82752156	Rat
7205510	Activ5	Activity QTL 5	3.78	0.00028	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	42396345	84729064	Rat
8694429	Bw164	Body weight QTL 164	5	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	16	52726464	84729064	Rat
8694364	Abfw7	Abdominal fat weight QTL 7	12.22	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	16	52726464	84729064	Rat
7411648	Foco22	Food consumption QTL 22	15	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	52726464	84729064	Rat
631525	Pia14	Pristane induced arthritis QTL 14	4.4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	16	55711087	83402471	Rat
1298527	Arunc2	Aerobic running capacity QTL 2	2.9		exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	16	68532716	75029966	Rat

Markers in Region

RH133057

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	69,235,201 - 69,235,398 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	74,092,885 - 74,093,081	NCBI	Rnor6.0
Rnor_5.0	16	73,724,878 - 73,725,074	UniSTS	Rnor5.0
RGSC_v3.4	16	73,705,933 - 73,706,129	UniSTS	RGSC3.4
Celera	16	67,129,050 - 67,129,246	UniSTS
RH 3.4 Map	16	635.9	UniSTS
Cytogenetic Map	16	q12.5	UniSTS

RH141696

Rat Assembly	Chr	Position (strand)	Source
Celera	16	67,117,641 - 67,117,821	UniSTS
RH 3.4 Map	16	635.6	UniSTS
Cytogenetic Map	16	q12.5	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			3		11				74	4	21	11
Low	3	43	54	41	8	41	8	11		31	20		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_133305	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039094175	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039094177	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063275047	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC086993	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473970	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FB336139	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HH767478	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L07074	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000025675 ⟹ ENSRNOP00000025675

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	69,217,633 - 69,235,431 (+)	Ensembl
Rnor_6.0 Ensembl	16	74,076,812 - 74,091,139 (+)	Ensembl

RefSeq Acc Id:

NM_133305 ⟹ NP_579839

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	75,920,644 - 75,936,027 (+)	NCBI
mRatBN7.2	16	69,218,164 - 69,233,547 (+)	NCBI
Rnor_6.0	16	74,075,842 - 74,091,230 (+)	NCBI
Rnor_5.0	16	73,708,174 - 73,723,223 (+)	NCBI
RGSC_v3.4	16	73,687,443 - 73,704,278 (+)	RGD
Celera	16	67,111,665 - 67,127,395 (+)	RGD

Sequence:

show sequence

TCCAGGGGCCGACTCTGCTCAGGAGAATTAGAAAGCGCATCGTGTATGTTATTTCGAATAGGAA
CCATGGTAGAGTAACGATAAGTTAAAATTTTAATATATTTCATTTGACCCAAACATATCAGCAG
TATTAGATTAATGGGTCTAGCCAAATCCAGAGGCTCACAGACTGAAACAGCACACTTCTCCCAC
TGGCCTCTTCTTCACCATGATTCACAGTCTTTTCTTGATCAACTCTGCTGGGGATATTTTCCTG
GAGAAGCACTGGAAAAGCGTGGTCAGCCGCTCTGTTTGCGATTACTTTTTCGAGGCCCAAGAGA
GAGCTACGGAGGCTGAAAATGTGCCTCCCGTCATCCCCACACCTCACCACTACCTTCTGAGCGT
TTACCGGCACAAGATCTTCTTTGTGGCTGTGATCCAGACGGAGGTCCCGCCTCTGTTTGTCATT
GAATTCCTTCACCGAGTAGTGGACACATTTCAGGACTATTTCGGGGTCTGCTCTGAGCCAGTGA
TCAAAGACAACGTGGTGGTGGTCTACGAGGTGTTGGAAGAGATGCTGGACAATGGGTTCCCCTT
GGCTACGGAGTCGAACATCCTCAAGGAGCTGATAAAGCCTCCCACCATTCTCCGGACAGTAGTC
AACACCATCACAGGAAGCACCAATGTGGGCGACCAGCTTCCAACTGGGCAGCTGTCGGTGGTGC
CTTGGCGACGGACTGGGGTGAAATATACCAACAACGAGGCCTATTTCGACGTGGTTGAAGAGAT
AGACGCCATCATTGACAAATCAGGTTCCACAGTCACCGCTGAGATCCAAGGGGTGATTGATGCC
TGTGTTAAACTGACCGGGATGCCAGATCTCACGCTGTCCTTCATGAACCCCAGGTTGCTGGATG
ATGTTAGCTTCCACCCCTGTGTCCGTTTCAAGCGCTGGGAATCTGAGCGCATCCTCTCCTTCAT
CCCTCCTGACGGCAACTTCCGCCTGCTCTCCTACCACGTCAGTGCACAGAACCTAGTTGCCATT
CCAGTCTATGTCAAACACAGCATCAGCTTCCGGGACAGTGGCTCACTTGGACGCTTTGAAATCA
CAGTGGGGCCGAAGCAGACCATGGGGAAGACCATAGAGGGTGTGACTGTAACCAGCCAGATGCC
CAAAGGAGTCTTGAACATGAGCCTCACTCCATCCCAGGGGACACACACGTTTGACCCGGTGACA
AAGATGCTGTCTTGGGATGTAGGAAAAATAAACCCGCAAAAGCTGCCAAGTTTGAAGGGGACAA
TGGGTCTCCAGGTCGGAGCTTCTAAACCCGATGAGAACCCTACAATTAACCTTCAGTTCAAGAT
CCAGCAGCTGGCCATTTCTGGACTCAAAGTGAACCGTCTGGATATGTACGGAGAGAAGTACAAG
CCCTTTAAGGGCATAAAATACATGACCAAAGCCGGCAAGTTCCAAGTCCGAACCTGAAGGGAAA
GTCTTGGTGAAGGAACACTCACGAACACTTTTTCGTTTCTTACTTGTCTAAAAGTAAAATGTCA
GCCTGTTTCTTAGGTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039094175 ⟹ XP_038950103

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	75,908,459 - 75,937,915 (+)	NCBI
mRatBN7.2	16	69,217,526 - 69,237,372 (+)	NCBI

RefSeq Acc Id:

XM_039094177 ⟹ XP_038950105

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	75,920,442 - 75,937,915 (+)	NCBI
mRatBN7.2	16	69,218,054 - 69,237,372 (+)	NCBI

RefSeq Acc Id:

XM_063275047 ⟹ XP_063131117

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	75,920,534 - 75,937,915 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_579839	(Get FASTA)	NCBI Sequence Viewer
	XP_038950103	(Get FASTA)	NCBI Sequence Viewer
	XP_038950105	(Get FASTA)	NCBI Sequence Viewer
	XP_063131117	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA57232	(Get FASTA)	NCBI Sequence Viewer
	AAH86993	(Get FASTA)	NCBI Sequence Viewer
	CAR81023	(Get FASTA)	NCBI Sequence Viewer
	CBX84501	(Get FASTA)	NCBI Sequence Viewer
	EDM09016	(Get FASTA)	NCBI Sequence Viewer
	EDM09017	(Get FASTA)	NCBI Sequence Viewer
	EDM09018	(Get FASTA)	NCBI Sequence Viewer
	EDM09019	(Get FASTA)	NCBI Sequence Viewer
	EDM09020	(Get FASTA)	NCBI Sequence Viewer
	EDM09021	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000025675
	ENSRNOP00000025675.5
	ENSRNOP00055010181
	ENSRNOP00060040127
	ENSRNOP00065010315
GenBank Protein	P53678	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_579839 ⟸ NM_133305

- UniProtKB:

P53678 (UniProtKB/Swiss-Prot), A6IW52 (UniProtKB/TrEMBL), V9GZ82 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MIHSLFLINSAGDIFLEKHWKSVVSRSVCDYFFEAQERATEAENVPPVIPTPHHYLLSVYRHKI
FFVAVIQTEVPPLFVIEFLHRVVDTFQDYFGVCSEPVIKDNVVVVYEVLEEMLDNGFPLATESN
ILKELIKPPTILRTVVNTITGSTNVGDQLPTGQLSVVPWRRTGVKYTNNEAYFDVVEEIDAIID
KSGSTVTAEIQGVIDACVKLTGMPDLTLSFMNPRLLDDVSFHPCVRFKRWESERILSFIPPDGN
FRLLSYHVSAQNLVAIPVYVKHSISFRDSGSLGRFEITVGPKQTMGKTIEGVTVTSQMPKGVLN
MSLTPSQGTHTFDPVTKMLSWDVGKINPQKLPSLKGTMGLQVGASKPDENPTINLQFKIQQLAI
SGLKVNRLDMYGEKYKPFKGIKYMTKAGKFQVRT

hide sequence

RefSeq Acc Id:

ENSRNOP00000025675 ⟸ ENSRNOT00000025675

RefSeq Acc Id:	XP_038950103 ⟸ XM_039094175
- Peptide Label:	isoform X1
- UniProtKB:	P53678 (UniProtKB/Swiss-Prot), A6IW52 (UniProtKB/TrEMBL), V9GZ82 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038950105 ⟸ XM_039094177
- Peptide Label:	isoform X1
- UniProtKB:	P53678 (UniProtKB/Swiss-Prot), A6IW52 (UniProtKB/TrEMBL), V9GZ82 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063131117 ⟸ XM_063275047
- Peptide Label:	isoform X1
- UniProtKB:	P53678 (UniProtKB/Swiss-Prot), A6IW52 (UniProtKB/TrEMBL)

Protein Domains

AP complex mu/sigma subunit MHD

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P53678-F1-model_v2	AlphaFold	P53678	1-418	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:70969	AgrOrtholog
BioCyc Gene	G2FUF-10884	BioCyc
Ensembl Genes	ENSRNOG00000018650	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055007623	UniProtKB/Swiss-Prot
	ENSRNOG00060027777	UniProtKB/Swiss-Prot
	ENSRNOG00065008713	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000025675	UniProtKB/TrEMBL
	ENSRNOT00000025675.6	UniProtKB/Swiss-Prot
	ENSRNOT00055012764	UniProtKB/Swiss-Prot
	ENSRNOT00060048211	UniProtKB/Swiss-Prot
	ENSRNOT00065013867	UniProtKB/Swiss-Prot
Gene3D-CATH	3.30.450.60	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Mu homology domain, subdomain B	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7131933	IMAGE-MGC_LOAD
InterPro	AP2_Mu_C_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	AP_mu_sigma_su	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Clathrin_mu	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Clathrin_mu_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Longin-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MHD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:140667	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:93230	IMAGE-MGC_LOAD
NCBI Gene	140667	ENTREZGENE
PANTHER	AP COMPLEX SUBUNIT MU	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	AP-3 COMPLEX SUBUNIT MU-2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Adap_comp_sub	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Clat_adaptor_s	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Ap3m2	PhenoGen
PIRSF	Clathrin_mu	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	CLATHRINADPT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	CLAT_ADAPTOR_M_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CLAT_ADAPTOR_M_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MHD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000018650	RatGTEx
	ENSRNOG00055007623	RatGTEx
	ENSRNOG00060027777	RatGTEx
	ENSRNOG00065008713	RatGTEx
Superfamily-SCOP	SSF49447	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF64356	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A6IW52	ENTREZGENE, UniProtKB/TrEMBL
	A6IW53_RAT	UniProtKB/TrEMBL
	A6IW54_RAT	UniProtKB/TrEMBL
	A6IW55_RAT	UniProtKB/TrEMBL
	A6IW56_RAT	UniProtKB/TrEMBL
	AP3M2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	V9GZ82	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-05-03	Ap3m2	adaptor related protein complex 3 subunit mu 2	Ap3m2	adaptor-related protein complex 3, mu 2 subunit	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-07-09	Ap3m2	adaptor-related protein complex 3, mu 2 subunit			Symbol and Name updated to reflect Human and Mouse nomenclature	70877	APPROVED

RGD Curation Notes

Note Type	Note	Reference

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar