Scrg1 (stimulator of chondrogenesis 1) - Rat Genome Database

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Gene: Scrg1 (stimulator of chondrogenesis 1) Rattus norvegicus
Analyze
Symbol: Scrg1
Name: stimulator of chondrogenesis 1
RGD ID: 68377
Description: Predicted to be involved in mesenchymal stem cell proliferation. Predicted to be located in cytoplasm. Predicted to be active in Golgi apparatus and neuron projection terminus. Orthologous to human SCRG1 (stimulator of chondrogenesis 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: scrapie responsive gene 1; scrapie-responsive gene 1 protein; scrapie-responsive protein 1; scRG-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81637,770,739 - 37,799,010 (-)NCBIGRCr8
mRatBN7.21632,760,028 - 32,788,299 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1632,760,028 - 32,788,299 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1636,352,690 - 36,380,930 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01639,764,030 - 39,792,270 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01635,983,847 - 36,011,977 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01636,127,536 - 36,161,041 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1636,125,904 - 36,161,089 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01635,936,797 - 35,940,130 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41636,182,355 - 36,210,980 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11636,182,429 - 36,211,055 (-)NCBI
Celera1632,699,050 - 32,726,910 (-)NCBICelera
Cytogenetic Map16p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Gene expression in scrapie. Cloning of a new scrapie-responsive gene and the identification of increased levels of seven other mRNA transcripts. Dandoy-Dron F, etal., J Biol Chem 1998 Mar 27;273(13):7691-7.
2. Mouse scrapie responsive gene 1 (Scrg1): genomic organization, physical linkage to sap30, genetic mapping on chromosome 8, and expression in neuronal primary cell cultures. Dron M, etal., Genomics 2000 Nov 15;70(1):140-9.
3. Characterization of the human analogue of a Scrapie-responsive gene. Dron M, etal., J Biol Chem 1998 Jul 17;273(29):18015-8.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:14622145  


Genomics

Comparative Map Data
Scrg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81637,770,739 - 37,799,010 (-)NCBIGRCr8
mRatBN7.21632,760,028 - 32,788,299 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1632,760,028 - 32,788,299 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1636,352,690 - 36,380,930 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01639,764,030 - 39,792,270 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01635,983,847 - 36,011,977 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01636,127,536 - 36,161,041 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1636,125,904 - 36,161,089 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01635,936,797 - 35,940,130 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41636,182,355 - 36,210,980 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11636,182,429 - 36,211,055 (-)NCBI
Celera1632,699,050 - 32,726,910 (-)NCBICelera
Cytogenetic Map16p11NCBI
SCRG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384173,384,701 - 173,519,144 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4173,384,701 - 173,406,380 (-)EnsemblGRCh38hg38GRCh38
GRCh374174,305,852 - 174,440,295 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364174,545,874 - 174,557,192 (-)NCBINCBI36Build 36hg18NCBI36
Build 344174,684,029 - 174,695,347NCBI
Celera4171,634,399 - 171,645,725 (-)NCBICelera
Cytogenetic Map4q34.1NCBI
HuRef4170,057,217 - 170,068,546 (-)NCBIHuRef
CHM1_14174,285,753 - 174,297,067 (-)NCBICHM1_1
T2T-CHM13v2.04176,724,109 - 176,858,933 (-)NCBIT2T-CHM13v2.0
Scrg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39857,909,093 - 57,932,441 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl857,908,957 - 57,930,619 (+)EnsemblGRCm39 Ensembl
GRCm38857,455,882 - 57,479,360 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl857,455,923 - 57,477,585 (+)EnsemblGRCm38mm10GRCm38
MGSCv37859,934,720 - 59,956,382 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36860,348,177 - 60,369,728 (+)NCBIMGSCv36mm8
Celera860,094,930 - 60,116,631 (+)NCBICelera
Cytogenetic Map8B2NCBI
cM Map829.8NCBI
Scrg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540333,599,019 - 33,626,484 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540333,599,197 - 33,626,095 (+)NCBIChiLan1.0ChiLan1.0
SCRG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23171,148,532 - 171,159,743 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14171,529,476 - 171,540,674 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04165,616,284 - 165,627,563 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14177,853,633 - 177,983,092 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4177,853,633 - 177,864,917 (-)Ensemblpanpan1.1panPan2
SCRG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12523,986,911 - 24,010,522 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2523,986,994 - 24,010,357 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2524,637,793 - 24,661,452 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02524,150,260 - 24,173,937 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2524,150,344 - 24,173,722 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12524,096,512 - 24,120,175 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02523,986,872 - 24,011,628 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02524,136,764 - 24,160,429 (-)NCBIUU_Cfam_GSD_1.0
Scrg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494324,150,992 - 24,170,017 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365164,565,446 - 4,584,259 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365164,565,282 - 4,584,431 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCRG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1416,634,776 - 16,664,558 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11416,620,592 - 16,664,082 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SCRG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17119,498,835 - 119,502,082 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7119,496,047 - 119,502,082 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603799,520,759 - 99,536,793 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Scrg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247694,867,114 - 4,889,482 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Scrg1
168 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:82
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000017888
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)163195152060148445Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 43 3
Low 22 21 20 1
Below cutoff 1 15 17 7 17 7 5 6 6 6 14 7 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000017888   ⟹   ENSRNOP00000017888
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1636,125,904 - 36,161,089 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110541   ⟹   ENSRNOP00000084059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1632,760,028 - 32,788,299 (-)Ensembl
RefSeq Acc Id: NM_033499   ⟹   NP_277034
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81637,770,739 - 37,799,010 (-)NCBI
mRatBN7.21632,760,028 - 32,788,299 (-)NCBI
Rnor_6.01636,127,536 - 36,161,041 (-)NCBI
Rnor_5.01635,936,797 - 35,940,130 (-)NCBI
RGSC_v3.41636,182,355 - 36,210,980 (-)RGD
Celera1632,699,050 - 32,726,910 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_277034 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA10668 (Get FASTA)   NCBI Sequence Viewer  
  EDL87167 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000084059
  ENSRNOP00000084059.1
  ENSRNOP00055016881
  ENSRNOP00060008445
  ENSRNOP00065004476
GenBank Protein Q9Z0K6 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_277034   ⟸   NM_033499
- Peptide Label: precursor
- UniProtKB: Q9Z0K6 (UniProtKB/Swiss-Prot),   A6KIV2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000017888   ⟸   ENSRNOT00000017888
RefSeq Acc Id: ENSRNOP00000084059   ⟸   ENSRNOT00000110541

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z0K6-F1-model_v2 AlphaFold Q9Z0K6 1-98 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68377 AgrOrtholog
BioCyc Gene G2FUF-11533 BioCyc
Ensembl Genes ENSRNOG00000013228 Ensembl
  ENSRNOG00000069516 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055012291 UniProtKB/Swiss-Prot
  ENSRNOG00060006918 UniProtKB/Swiss-Prot
  ENSRNOG00065004342 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000110541 ENTREZGENE
  ENSRNOT00000110541.1 UniProtKB/Swiss-Prot
  ENSRNOT00055020908 UniProtKB/Swiss-Prot
  ENSRNOT00060011315 UniProtKB/Swiss-Prot
  ENSRNOT00065006327 UniProtKB/Swiss-Prot
InterPro SCRG1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64458 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 64458 ENTREZGENE
PANTHER PTHR17463 UniProtKB/Swiss-Prot
  SCRAPIE-RESPONSIVE PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SCRAPIE-RESPONSIVE PROTEIN 1 SCRG1 UniProtKB/TrEMBL
Pfam SCRG1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Scrg1 PhenoGen
RatGTEx ENSRNOG00000013228 RatGTEx
  ENSRNOG00000069516 RatGTEx
  ENSRNOG00055012291 RatGTEx
  ENSRNOG00060006918 RatGTEx
  ENSRNOG00065004342 RatGTEx
TIGR TC233874
UniProt A6KIV2 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z0K6 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-12-15 Scrg1  stimulator of chondrogenesis 1  Scrg1  scrapie responsive gene 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Scrg1  scrapie responsive gene 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference