Enables fatty acid binding activity. Involved in G protein-coupled receptor signaling pathway; positive regulation of calcium ion transport into cytosol; and positive regulation of insulin secretion. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human FFAR1 (free fatty acid receptor 1); INTERACTS WITH aldehydo-D-glucose; ammonium chloride; bisphenol A.
[FFAR1 protein affects the susceptibility to Dietary Fats] affects the reaction [Glucose results in increased secretion of INS1 protein] and FFAR1 protein affects the reaction [Palmitic Acid promotes the reaction [Glucose results in increased secretion of INS1 protein]]
[FFAR1 protein affects the susceptibility to Dietary Fats] affects the reaction [Glucose results in increased secretion of INS1 protein] and FFAR1 protein affects the reaction [Palmitic Acid promotes the reaction [Glucose results in increased secretion of INS1 protein]]
[sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of FFAR1 mRNA
[FFAR1 protein affects the susceptibility to Dietary Fats] affects the reaction [Glucose results in increased secretion of INS1 protein] and FFAR1 protein affects the reaction [Palmitic Acid promotes the reaction [Glucose results in increased secretion of INS1 protein]]
[sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of FFAR1 mRNA
[sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of FFAR1 mRNA
[sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of FFAR1 mRNA
Oleic acid interacts with GPR40 to induce Ca2+ signaling in rat islet beta-cells: mediation by PLC and L-type Ca2+ channel and link to insulin release.
Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice.