Cst11 (cystatin 11) - Rat Genome Database

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Gene: Cst11 (cystatin 11) Rattus norvegicus
Analyze
Symbol: Cst11
Name: cystatin 11
RGD ID: 620589
Description: Predicted to enable cysteine-type endopeptidase inhibitor activity. Predicted to be involved in androgen receptor signaling pathway; defense response to Gram-negative bacterium; and killing of cells of another organism. Predicted to be located in extracellular region. Predicted to be active in several cellular components, including nucleus; sperm flagellum; and sperm head. Orthologous to human CST11 (cystatin 11); INTERACTS WITH ammonium chloride; bisphenol A; copper atom.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cystatin-11
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83156,664,551 - 156,667,275 (-)NCBIGRCr8
mRatBN7.23136,211,414 - 136,214,138 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3136,211,414 - 136,214,138 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3140,163,405 - 140,165,998 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03148,747,551 - 148,750,144 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03146,437,032 - 146,439,756 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03143,096,056 - 143,098,780 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3143,096,056 - 143,098,780 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03149,504,896 - 149,507,620 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43137,524,412 - 137,527,136 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13137,429,984 - 137,432,709 (-)NCBI
Celera3135,052,841 - 135,055,541 (-)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,ISO,ISS)
extracellular region  (IEA)
nucleus  (IBA,ISO,ISS)
sperm flagellum  (IBA,ISO,ISS)
sperm head  (IBA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Cystatin E1 and E2, new members of male reproductive tract subgroup within cystatin type 2 family. Li Y, etal., Biol Reprod 2003 Aug;69(2):489-500.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12072414  


Genomics

Comparative Map Data
Cst11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83156,664,551 - 156,667,275 (-)NCBIGRCr8
mRatBN7.23136,211,414 - 136,214,138 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3136,211,414 - 136,214,138 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3140,163,405 - 140,165,998 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03148,747,551 - 148,750,144 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03146,437,032 - 146,439,756 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03143,096,056 - 143,098,780 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3143,096,056 - 143,098,780 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03149,504,896 - 149,507,620 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43137,524,412 - 137,527,136 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13137,429,984 - 137,432,709 (-)NCBI
Celera3135,052,841 - 135,055,541 (-)NCBICelera
Cytogenetic Map3q41NCBI
CST11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382023,450,412 - 23,452,876 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2023,450,403 - 23,452,876 (-)EnsemblGRCh38hg38GRCh38
GRCh372023,431,049 - 23,433,513 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362023,379,041 - 23,381,482 (-)NCBINCBI36Build 36hg18NCBI36
Build 342023,379,040 - 23,381,482NCBI
Celera2023,504,421 - 23,506,862 (-)NCBICelera
Cytogenetic Map20p11.21NCBI
HuRef2023,392,703 - 23,395,144 (-)NCBIHuRef
CHM1_12023,431,037 - 23,433,478 (-)NCBICHM1_1
T2T-CHM13v2.02023,509,944 - 23,512,411 (-)NCBIT2T-CHM13v2.0
Cst11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392148,610,538 - 148,613,417 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2148,610,529 - 148,613,417 (-)EnsemblGRCm39 Ensembl
GRCm382148,768,618 - 148,771,497 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2148,768,609 - 148,771,497 (-)EnsemblGRCm38mm10GRCm38
MGSCv372148,594,354 - 148,597,233 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362148,460,059 - 148,462,938 (-)NCBIMGSCv36mm8
Celera2150,030,906 - 150,034,699 (-)NCBICelera
Cytogenetic Map2G3NCBI
cM Map273.54NCBI
Cst11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541530,445,556 - 30,453,439 (-)NCBIChiLan1.0ChiLan1.0
CST11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22124,317,163 - 24,319,887 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12024,313,996 - 24,316,720 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02023,385,639 - 23,388,363 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12023,736,631 - 23,739,084 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2023,736,631 - 23,739,084 (-)Ensemblpanpan1.1panPan2
CST11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.124181,410 - 184,213 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl24180,692 - 184,323 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha24203,332 - 205,991 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.024573,867 - 576,594 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl24573,905 - 576,594 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.124176,259 - 178,909 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.024275,596 - 278,262 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.024559,406 - 562,092 (+)NCBIUU_Cfam_GSD_1.0
Cst11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640148,695,442 - 148,699,181 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366202,115,924 - 2,119,639 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366202,115,927 - 2,119,683 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CST11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1730,414,051 - 30,417,127 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11730,415,161 - 30,416,984 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21734,503,160 - 34,505,987 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CST11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_0236660787,271,760 - 7,274,744 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cst11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474123,104,474 - 23,106,333 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cst11
21 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:25
Count of miRNA genes:23
Interacting mature miRNAs:25
Transcripts:ENSRNOT00000006427
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system reproductive system
High
Medium
Low 5
Below cutoff 2 2 1 9

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000006427   ⟹   ENSRNOP00000006427
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3136,211,414 - 136,214,138 (-)Ensembl
Rnor_6.0 Ensembl3143,096,056 - 143,098,780 (-)Ensembl
RefSeq Acc Id: NM_139085   ⟹   NP_620785
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83156,664,551 - 156,667,275 (-)NCBI
mRatBN7.23136,211,414 - 136,214,138 (-)NCBI
Rnor_6.03143,096,056 - 143,098,780 (-)NCBI
Rnor_5.03149,504,896 - 149,507,620 (-)NCBI
RGSC_v3.43137,524,412 - 137,527,136 (-)RGD
Celera3135,052,841 - 135,055,541 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_620785 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAM21709 (Get FASTA)   NCBI Sequence Viewer  
  EDL95091 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006427
  ENSRNOP00000006427.1
  ENSRNOP00055032155
  ENSRNOP00060002081
  ENSRNOP00065029704
GenBank Protein Q8K5A3 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_620785   ⟸   NM_139085
- Peptide Label: precursor
- UniProtKB: Q8K5A3 (UniProtKB/Swiss-Prot),   A6K7C8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006427   ⟸   ENSRNOT00000006427
Protein Domains
Cystatin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K5A3-F1-model_v2 AlphaFold Q8K5A3 1-139 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620589 AgrOrtholog
BioCyc Gene G2FUF-47494 BioCyc
Ensembl Genes ENSRNOG00000004808 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055023049 UniProtKB/Swiss-Prot
  ENSRNOG00060001986 UniProtKB/Swiss-Prot
  ENSRNOG00065021693 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006427 ENTREZGENE
  ENSRNOT00000006427.3 UniProtKB/Swiss-Prot
  ENSRNOT00055039602 UniProtKB/Swiss-Prot
  ENSRNOT00060003097 UniProtKB/Swiss-Prot
  ENSRNOT00065036881 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.450.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CST11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cystatin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cystatin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:245916 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 245916 ENTREZGENE
PANTHER CYSTATIN-11 UniProtKB/Swiss-Prot
  CYSTATIN-11 UniProtKB/TrEMBL
  CYSTATIN-11 UniProtKB/TrEMBL
  PTHR47886 UniProtKB/Swiss-Prot
Pfam Cystatin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cst11 PhenoGen
RatGTEx ENSRNOG00000004808 RatGTEx
  ENSRNOG00055023049 RatGTEx
  ENSRNOG00060001986 RatGTEx
  ENSRNOG00065021693 RatGTEx
SMART SM00043 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Cystatin/monellin UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6K7C8 ENTREZGENE, UniProtKB/TrEMBL
  CST11_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Cst11  cystatin 11      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Cst11  cystatin 11      Symbol and Name status set to provisional 70820 PROVISIONAL