Arpc1b (actin related protein 2/3 complex, subunit 1B) - Rat Genome Database

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Gene: Arpc1b (actin related protein 2/3 complex, subunit 1B) Rattus norvegicus
Analyze
Symbol: Arpc1b
Name: actin related protein 2/3 complex, subunit 1B
RGD ID: 2155
Description: Predicted to enable actin filament binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in response to estradiol and response to estrogen. Part of tubulobulbar complex. Human ortholog(s) of this gene implicated in gastritis; immunodeficiency 71; and myelodysplastic syndrome. Orthologous to human ARPC1B (actin related protein 2/3 complex subunit 1B); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; Rab family mediated signaling pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: actin-related protein 2/3 complex subunit 1B; Actin-related protein complex 1b; arp2/3 complex 41 kDa subunit; p41-ARC; p41Arc
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81214,595,939 - 14,609,501 (-)NCBIGRCr8
mRatBN7.2129,482,176 - 9,495,772 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,480,831 - 9,495,747 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1210,286,931 - 10,300,462 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01210,910,133 - 10,923,665 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0129,933,561 - 9,947,093 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01211,252,300 - 11,265,849 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1211,252,296 - 11,265,865 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01213,321,403 - 13,334,951 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4129,796,269 - 9,803,639 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1129,826,196 - 9,833,567 (-)NCBI
Celera1211,287,122 - 11,300,659 (-)NCBICelera
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-nitrofluorene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (EXP)
aconitine  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aripiprazole  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
chlorpyrifos  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
FR900359  (ISO)
genistein  (ISO)
glafenine  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
naphthalenes  (EXP)
nickel atom  (ISO)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP)
pyrethrins  (EXP)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sulindac sulfide  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Caveolin 1 (Cav-1) and actin-related protein 2/3 complex, subunit 1B (ARPC1B) expressions as prognostic indicators for oral squamous cell carcinoma (OSCC). Auzair LB, etal., Eur Arch Otorhinolaryngol. 2015 Jul 3.
2. Changes associated with lenalidomide treatment in the gene expression profiles of patients with del(5q). Belickova M, etal., Clin Lymphoma Myeloma Leuk. 2012 Oct;12(5):375-83. doi: 10.1016/j.clml.2012.04.003. Epub 2012 May 18.
3. Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia. Cai L, etal., Cell. 2008 Sep 5;134(5):828-42. doi: 10.1016/j.cell.2008.06.054.
4. Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cells. Chiu TT, etal., Mol Biol Cell. 2010 Oct 15;21(20):3529-39. doi: 10.1091/mbc.E10-04-0316. Epub 2010 Aug 25.
5. Disruption of tubulobulbar complex by high intratesticular estrogens leading to failed spermiation. D'Souza R, etal., Endocrinology. 2009 Apr;150(4):1861-9. doi: 10.1210/en.2008-1232. Epub 2008 Dec 18.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Decreased expression of the seven ARP2/3 complex genes in human gastric cancers. Kaneda A, etal., Cancer Lett. 2004 Aug 30;212(2):203-10.
9. Estrogen and androgen regulate actin-remodeling and endocytosis-related genes during rat spermiation. Kumar A, etal., Mol Cell Endocrinol. 2015 Mar 15;404:91-101. doi: 10.1016/j.mce.2014.12.029. Epub 2015 Jan 28.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress. Prabakaran S, etal., Mol Psychiatry. 2004 Jul;9(7):684-97, 643.
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
19. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. Welch MD, etal., J Cell Biol 1997 Jul 28;138(2):375-84.
20. Altered mucosal DNA methylation in parallel with highly active Helicobacter pylori-related gastritis. Yoshida T, etal., Gastric Cancer. 2013 Oct;16(4):488-97. doi: 10.1007/s10120-012-0230-x. Epub 2013 Jan 6.
Additional References at PubMed
PMID:11741539   PMID:15489334   PMID:20458337   PMID:21423176   PMID:23376485   PMID:27113856   PMID:28242260   PMID:28972183   PMID:35352799  


Genomics

Comparative Map Data
Arpc1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81214,595,939 - 14,609,501 (-)NCBIGRCr8
mRatBN7.2129,482,176 - 9,495,772 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,480,831 - 9,495,747 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1210,286,931 - 10,300,462 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01210,910,133 - 10,923,665 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0129,933,561 - 9,947,093 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01211,252,300 - 11,265,849 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1211,252,296 - 11,265,865 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01213,321,403 - 13,334,951 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4129,796,269 - 9,803,639 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1129,826,196 - 9,833,567 (-)NCBI
Celera1211,287,122 - 11,300,659 (-)NCBICelera
Cytogenetic Map12p11NCBI
ARPC1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38799,374,259 - 99,394,816 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl799,374,249 - 99,394,816 (+)EnsemblGRCh38hg38GRCh38
GRCh37798,972,353 - 98,992,439 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36798,810,265 - 98,830,360 (+)NCBINCBI36Build 36hg18NCBI36
Build 34798,616,979 - 98,637,053NCBI
Celera793,706,528 - 93,726,623 (+)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef793,608,035 - 93,628,135 (+)NCBIHuRef
CHM1_1798,902,377 - 98,922,501 (+)NCBICHM1_1
T2T-CHM13v2.07100,610,955 - 100,633,717 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2798,332,071 - 98,352,197 (+)NCBI
Arpc1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395145,051,066 - 145,064,996 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5145,051,025 - 145,067,515 (+)EnsemblGRCm39 Ensembl
GRCm385145,114,256 - 145,128,186 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5145,114,215 - 145,130,705 (+)EnsemblGRCm38mm10GRCm38
MGSCv375145,875,125 - 145,889,055 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365145,367,857 - 145,381,713 (+)NCBIMGSCv36mm8
Celera5142,106,218 - 142,120,149 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map585.03NCBI
Arpc1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546015,055,480 - 15,069,093 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546015,055,753 - 15,069,093 (+)NCBIChiLan1.0ChiLan1.0
ARPC1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26117,231,895 - 117,252,410 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17165,496,564 - 165,517,159 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0791,348,120 - 91,368,299 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17104,861,582 - 104,870,382 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7104,861,582 - 104,870,369 (+)Ensemblpanpan1.1panPan2
ARPC1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1610,192,299 - 10,198,383 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl610,178,462 - 10,198,309 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha611,819,059 - 11,832,117 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0610,192,483 - 10,205,575 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl610,134,810 - 10,205,481 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1610,062,441 - 10,075,520 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0610,040,965 - 10,054,042 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0610,274,762 - 10,287,831 (-)NCBIUU_Cfam_GSD_1.0
Arpc1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344138,283,052 - 138,294,275 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367501,650,979 - 1,662,206 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367501,651,026 - 1,662,208 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARPC1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl36,220,939 - 6,342,637 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.136,329,737 - 6,342,641 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.236,520,442 - 6,527,677 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARPC1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12813,764,637 - 13,780,317 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660702,517,817 - 2,538,868 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arpc1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474032,805,610 - 32,821,918 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474032,805,647 - 32,821,986 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Arpc1b
133 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:49
Count of miRNA genes:35
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000001315
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12390696910373166Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12683319017870186Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12931821612829686Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat

Markers in Region
AW208418  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,482,384 - 9,482,495 (+)MAPPERmRatBN7.2
Rnor_6.01211,252,507 - 11,252,617NCBIRnor6.0
Rnor_5.01213,321,610 - 13,321,720UniSTSRnor5.0
RGSC_v3.4129,796,476 - 9,796,586UniSTSRGSC3.4
Celera1211,287,329 - 11,287,439UniSTS
Cytogenetic Map12p11UniSTS
RH127787  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,482,333 - 9,482,659 (+)MAPPERmRatBN7.2
mRatBN7.21531,903,244 - 31,903,431 (+)MAPPERmRatBN7.2
Rnor_6.01538,029,775 - 38,029,961NCBIRnor6.0
Rnor_6.01211,252,456 - 11,252,781NCBIRnor6.0
Rnor_5.01541,870,760 - 41,870,946UniSTSRnor5.0
Rnor_5.01213,321,559 - 13,321,884UniSTSRnor5.0
RGSC_v3.4129,796,425 - 9,796,750UniSTSRGSC3.4
RGSC_v3.41536,799,280 - 36,799,466UniSTSRGSC3.4
Celera1531,613,626 - 31,613,812UniSTS
Celera1211,287,278 - 11,287,603UniSTS
RH 3.4 Map15259.29UniSTS
Cytogenetic Map12p11UniSTS
Cytogenetic Map15p12UniSTS
RH129626  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21531,903,371 - 31,903,560 (+)MAPPERmRatBN7.2
mRatBN7.2129,482,210 - 9,482,393 (+)MAPPERmRatBN7.2
Rnor_6.01211,252,333 - 11,252,515NCBIRnor6.0
Rnor_6.01538,029,902 - 38,030,090NCBIRnor6.0
Rnor_5.01541,870,887 - 41,871,075UniSTSRnor5.0
Rnor_5.01213,321,436 - 13,321,618UniSTSRnor5.0
RGSC_v3.4129,796,302 - 9,796,484UniSTSRGSC3.4
RGSC_v3.41536,799,407 - 36,799,595UniSTSRGSC3.4
Celera1531,613,753 - 31,613,941UniSTS
Celera1211,287,155 - 11,287,337UniSTS
Cytogenetic Map15p12UniSTS
Cytogenetic Map12p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 40 11 8
Low 1
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000001315   ⟹   ENSRNOP00000001315
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,482,291 - 9,495,747 (-)Ensembl
Rnor_6.0 Ensembl1211,252,296 - 11,265,865 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114214   ⟹   ENSRNOP00000091680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,480,831 - 9,495,712 (-)Ensembl
RefSeq Acc Id: NM_019289   ⟹   NP_062162
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81214,595,939 - 14,609,488 (-)NCBI
mRatBN7.2129,482,178 - 9,495,739 (-)NCBI
Rnor_6.01211,252,300 - 11,265,849 (-)NCBI
Rnor_5.01213,321,403 - 13,334,951 (-)NCBI
RGSC_v3.4129,796,269 - 9,803,639 (-)RGD
Celera1211,287,122 - 11,300,659 (-)RGD
Sequence:
RefSeq Acc Id: XM_039089713   ⟹   XP_038945641
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81214,595,939 - 14,609,501 (-)NCBI
mRatBN7.2129,482,176 - 9,495,772 (-)NCBI
RefSeq Acc Id: NP_062162   ⟸   NM_019289
- UniProtKB: O88656 (UniProtKB/Swiss-Prot),   A6K1G1 (UniProtKB/TrEMBL),   A0A8L2Q086 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000001315   ⟸   ENSRNOT00000001315
RefSeq Acc Id: XP_038945641   ⟸   XM_039089713
- Peptide Label: isoform X1
- UniProtKB: O88656 (UniProtKB/Swiss-Prot),   A6K1G1 (UniProtKB/TrEMBL),   A0A8L2Q086 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000091680   ⟸   ENSRNOT00000114214

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88656-F1-model_v2 AlphaFold O88656 1-372 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698419
Promoter ID:EPDNEW_R8943
Type:initiation region
Name:Arpc1b_1
Description:actin related protein 2/3 complex, subunit 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01211,265,834 - 11,265,894EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2155 AgrOrtholog
BioCyc Gene G2FUF-20055 BioCyc
Ensembl Genes ENSRNOG00000000991 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001315.7 UniProtKB/TrEMBL
  ENSRNOT00000114214 ENTREZGENE
  ENSRNOT00000114214.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5622004 IMAGE-MGC_LOAD
InterPro ARPC1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54227 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72489 IMAGE-MGC_LOAD
NCBI Gene 54227 ENTREZGENE
PANTHER PTHR10709 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10709:SF10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Arpc1b PhenoGen
PIRSF ARP2/3_su1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE WD_REPEATS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000991 RatGTEx
SMART WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC217626
UniProt A0A8L2Q086 ENTREZGENE, UniProtKB/TrEMBL
  A6K1G1 ENTREZGENE, UniProtKB/TrEMBL
  ARC1B_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Arpc1b  actin related protein 2/3 complex, subunit 1B    Actin-related protein complex 1b  Name updated 629478 APPROVED
2002-06-10 Arpc1b  Actin-related protein complex 1b      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function human homolog is a subunit of the Arp2/3 protein complex 631743
gene_process human homolog is involved in control of actin polymerization 631743