Uhrf1 (ubiquitin-like with PHD and ring finger domains 1) - Rat Genome Database

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Gene: Uhrf1 (ubiquitin-like with PHD and ring finger domains 1) Rattus norvegicus
Analyze
Symbol: Uhrf1
Name: ubiquitin-like with PHD and ring finger domains 1
RGD ID: 1595855
Description: Predicted to enable several functions, including DNA binding activity; histone H3 ubiquitin ligase activity; and zinc ion binding activity. Involved in response to peptide hormone. Predicted to be located in nuclear matrix; nucleoplasm; and replication fork. Predicted to be part of euchromatin and heterochromatin. Orthologous to human UHRF1 (ubiquitin like with PHD and ring finger domains 1); PARTICIPATES IN DNA modification pathway; histone modification pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ac2-121; E3 ubiquitin-protein ligase UHRF1; liver regeneration-related protein LRRG126; Np95; nuclear protein 95; RING-type E3 ubiquitin transferase UHRF1; ubiquitin-like PHD and RING finger domain-containing protein 1; ubiquitin-like, containing PHD and RING finger domains, 1; ubiquitin-like, containing PHD and RING finger domains, 1 (mapped); ubiquitin-like-containing PHD and RING finger domains protein 1; Uhrf1_mapped
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,220,162 - 1,241,792 (+)NCBIGRCr8
mRatBN7.291,133,117 - 1,154,639 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,134,909 - 1,154,631 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx91,580,592 - 1,600,307 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.096,928,574 - 6,948,303 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.095,885,636 - 5,905,351 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,738,211 - 10,758,403 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,738,222 - 10,757,954 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.099,729,983 - 9,750,175 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera97,356,596 - 7,375,693 (-)NCBICelera
Cytogenetic Map9q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
4-hydroxynon-2-enal  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
AM-251  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
auraptene  (ISO)
azoxystrobin  (ISO)
bazedoxifene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
boron nitride  (ISO)
C60 fullerene  (EXP)
caffeine  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
D-glucose  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diethyl maleate  (EXP)
dorsomorphin  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
folic acid  (ISO)
fonofos  (ISO)
FR900359  (ISO)
fructose  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycerol 2-phosphate  (ISO)
glyphosate  (ISO)
hydroquinone  (ISO)
imiquimod  (ISO)
indole-3-methanol  (EXP)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
Lasiocarpine  (ISO)
lead(0)  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
MeIQx  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
niclosamide  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
palbociclib  (ISO)
paracetamol  (EXP)
parathion  (ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phytoestrogen  (ISO)
pirinixic acid  (ISO)
plumbagin  (ISO)
progesterone  (ISO)
propofol  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
sunitinib  (ISO)
terbufos  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (ISO,ISS)
euchromatin  (IEA,ISO,ISS)
heterochromatin  (IEA,ISO,ISS)
nuclear matrix  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)
replication fork  (IEA,ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. On how mammalian transcription factors recognize methylated DNA. Buck-Koehntop BA and Defossez PA, Epigenetics. 2013 Feb;8(2):131-7. doi: 10.4161/epi.23632. Epub 2013 Jan 16.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. E3 ubiquitin-protein ligases in rat kidney collecting duct: response to vasopressin stimulation and withdrawal. Lee YJ, etal., Am J Physiol Renal Physiol. 2011 Oct;301(4):F883-96. doi: 10.1152/ajprenal.00117.2011. Epub 2011 Jul 6.
4. Tudor: a versatile family of histone methylation 'readers'. Lu R and Wang GG, Trends Biochem Sci. 2013 Nov;38(11):546-55. doi: 10.1016/j.tibs.2013.08.002. Epub 2013 Sep 10.
5. Readout of epigenetic modifications. Patel DJ and Wang Z, Annu Rev Biochem. 2013;82:81-118. doi: 10.1146/annurev-biochem-072711-165700.
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Intake of grape-derived polyphenols reduces C26 tumor growth by inhibiting angiogenesis and inducing apoptosis. Walter A, etal., FASEB J. 2010 Sep;24(9):3360-9. doi: 10.1096/fj.09-149419. Epub 2010 May 4.
Additional References at PubMed
PMID:10646863   PMID:12477932   PMID:14993289   PMID:15361834   PMID:17065439   PMID:17673620   PMID:17967883   PMID:17994007   PMID:18692478   PMID:21029866   PMID:21489993   PMID:21745816  
PMID:21777816   PMID:22945642  


Genomics

Comparative Map Data
Uhrf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,220,162 - 1,241,792 (+)NCBIGRCr8
mRatBN7.291,133,117 - 1,154,639 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,134,909 - 1,154,631 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx91,580,592 - 1,600,307 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.096,928,574 - 6,948,303 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.095,885,636 - 5,905,351 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,738,211 - 10,758,403 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,738,222 - 10,757,954 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.099,729,983 - 9,750,175 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera97,356,596 - 7,375,693 (-)NCBICelera
Cytogenetic Map9q11NCBI
UHRF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38194,903,080 - 4,962,154 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl194,903,080 - 4,962,154 (+)EnsemblGRCh38hg38GRCh38
GRCh37194,903,092 - 4,962,165 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,860,510 - 4,913,165 (+)NCBINCBI36Build 36hg18NCBI36
Build 34194,861,813 - 4,913,162NCBI
Celera194,846,530 - 4,899,186 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef194,671,491 - 4,723,801 (+)NCBIHuRef
CHM1_1194,909,372 - 4,962,038 (+)NCBICHM1_1
T2T-CHM13v2.0194,888,314 - 4,947,375 (+)NCBIT2T-CHM13v2.0
Uhrf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391756,610,405 - 56,630,486 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1756,610,321 - 56,630,486 (+)EnsemblGRCm39 Ensembl
GRCm381756,303,337 - 56,323,486 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1756,303,321 - 56,323,486 (+)EnsemblGRCm38mm10GRCm38
MGSCv371756,442,760 - 56,462,909 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361755,937,126 - 55,957,195 (+)NCBIMGSCv36mm8
Celera1760,657,174 - 60,672,221 (+)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.26NCBI
Uhrf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554954,153,898 - 4,154,611 (-)NCBIChiLan1.0ChiLan1.0
UHRF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2209,302,493 - 9,355,349 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1198,531,805 - 8,584,592 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0193,926,583 - 3,979,163 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1194,872,753 - 4,925,330 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl194,872,753 - 4,925,330 (+)Ensemblpanpan1.1panPan2
UHRF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12054,858,673 - 54,889,769 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2054,859,947 - 54,889,907 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2054,583,125 - 54,615,199 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02055,513,260 - 55,545,335 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2055,513,262 - 55,545,339 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12054,574,546 - 54,606,612 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02055,055,222 - 55,087,332 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02055,253,102 - 55,285,205 (-)NCBIUU_Cfam_GSD_1.0
Uhrf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118214,944,645 - 214,972,502 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365882,862,367 - 2,888,946 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365882,863,651 - 2,890,116 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UHRF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl273,898,071 - 73,931,769 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1273,898,061 - 73,937,727 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2274,678,503 - 74,712,233 (-)NCBISscrofa10.2Sscrofa10.2susScr3
UHRF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.164,592,362 - 4,642,179 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl64,592,919 - 4,642,445 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660813,489,316 - 3,544,391 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Uhrf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248284,898,677 - 4,929,872 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248284,898,786 - 4,929,136 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Uhrf1
45 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:142
Count of miRNA genes:125
Interacting mature miRNAs:129
Transcripts:ENSRNOT00000075265
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9114209783Rat
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat

Markers in Region
RH138759  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.291,136,126 - 1,136,356 (-)MAPPERmRatBN7.2
Rnor_6.0910,756,493 - 10,756,722NCBIRnor6.0
Rnor_5.099,748,265 - 9,748,494UniSTSRnor5.0
Celera97,373,783 - 7,374,012UniSTS
Cytogenetic Map9q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 26 31 22 19 22 43 20 37
Low 17 20 13 13 8 11 31 11 4 11 8
Below cutoff 6 6 6 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000075265   ⟹   ENSRNOP00000066794
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl91,134,909 - 1,154,631 (+)Ensembl
Rnor_6.0 Ensembl910,739,309 - 10,757,954 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000083848   ⟹   ENSRNOP00000070294
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl91,135,146 - 1,154,631 (+)Ensembl
Rnor_6.0 Ensembl910,738,222 - 10,757,720 (-)Ensembl
RefSeq Acc Id: NM_001393844   ⟹   NP_001380773
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,222,300 - 1,241,792 (+)NCBI
mRatBN7.291,135,146 - 1,154,639 (+)NCBI
RefSeq Acc Id: NM_001393845   ⟹   NP_001380774
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,223,186 - 1,241,792 (+)NCBI
mRatBN7.291,136,032 - 1,154,639 (+)NCBI
RefSeq Acc Id: NM_001393846   ⟹   NP_001380775
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,222,063 - 1,241,792 (+)NCBI
mRatBN7.291,134,909 - 1,154,639 (+)NCBI
RefSeq Acc Id: XM_039083462   ⟹   XP_038939390
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,220,162 - 1,241,792 (+)NCBI
mRatBN7.291,133,117 - 1,154,639 (+)NCBI
RefSeq Acc Id: XM_063267061   ⟹   XP_063123131
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,222,289 - 1,241,792 (+)NCBI
RefSeq Acc Id: XM_063267062   ⟹   XP_063123132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,223,195 - 1,241,792 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000066794   ⟸   ENSRNOT00000075265
RefSeq Acc Id: ENSRNOP00000070294   ⟸   ENSRNOT00000083848
RefSeq Acc Id: XP_038939390   ⟸   XM_039083462
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JXJ2 (UniProtKB/TrEMBL),   A0A0G2JT07 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001380775   ⟸   NM_001393846
- Peptide Label: isoform 2
- UniProtKB: Q7TPK1 (UniProtKB/Swiss-Prot),   Q4FZR4 (UniProtKB/Swiss-Prot),   A0A0G2JT07 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001380773   ⟸   NM_001393844
- Peptide Label: isoform 1
- UniProtKB: A0A0G2JXJ2 (UniProtKB/TrEMBL),   A0A0G2JT07 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001380774   ⟸   NM_001393845
- Peptide Label: isoform 1
- UniProtKB: A0A0G2JXJ2 (UniProtKB/TrEMBL),   A0A0G2JT07 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123131   ⟸   XM_063267061
- Peptide Label: isoform X2
- UniProtKB: Q7TPK1 (UniProtKB/Swiss-Prot),   Q4FZR4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063123132   ⟸   XM_063267062
- Peptide Label: isoform X2
- UniProtKB: Q7TPK1 (UniProtKB/Swiss-Prot),   Q4FZR4 (UniProtKB/Swiss-Prot)
Protein Domains
PHD-type   RING-type   Ubiquitin-like   YDG

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TPK1-F1-model_v2 AlphaFold Q7TPK1 1-774 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696466
Promoter ID:EPDNEW_R6986
Type:initiation region
Name:Uhrf1_1
Description:ubiquitin-like with PHD and ring finger domains 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0910,757,671 - 10,757,731EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1595855 AgrOrtholog
BioCyc Gene G2FUF-28535 BioCyc
Ensembl Genes ENSRNOG00000048411 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075265 ENTREZGENE
  ENSRNOT00000075265.3 UniProtKB/TrEMBL
  ENSRNOT00000083848 ENTREZGENE
  ENSRNOT00000083848.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.30.1150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.30.140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7388089 IMAGE-MGC_LOAD
InterPro PUA-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRA-YDG_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRA_YDG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TTD_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-like_dom UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin_dom UniProtKB/Swiss-Prot
  Ubl_UHRF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UHRF1/2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_PHD-finger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:316129 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:116402 IMAGE-MGC_LOAD
NCBI Gene 316129 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE UHRF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR14140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAD_SRA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TTD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ubiquitin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Uhrf1 PhenoGen
PROSITE UBIQUITIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  YDG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_PHD_1 UniProtKB/Swiss-Prot
  ZF_PHD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000048411 RatGTEx
SMART PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBQ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57903 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF88697 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JT07 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JXJ2 ENTREZGENE, UniProtKB/TrEMBL
  A6KQY6_RAT UniProtKB/TrEMBL
  A6KQY7_RAT UniProtKB/TrEMBL
  Q4FZR4 ENTREZGENE
  Q7TPK1 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q4FZR4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-08-29 Uhrf1  ubiquitin-like with PHD and ring finger domains 1  Uhrf1  ubiquitin-like, containing PHD and RING finger domains, 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-13   ubiquitin-like, containing PHD and RING finger domains, 1  Uhrf1  ubiquitin-like, containing PHD and RING finger domains, 1 (mapped)  Name updated 737654 APPROVED
2007-04-11 Uhrf1  ubiquitin-like, containing PHD and RING finger domains, 1 (mapped)  Uhrf1_mapped  ubiquitin-like, containing PHD and RING finger domains, 1 (mapped)  Data merged from RGD:3190 737654 APPROVED
2006-11-20 Uhrf1  ubiquitin-like, containing PHD and RING finger domains, 1 (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Uhrf1_mapped  ubiquitin-like, containing PHD and RING finger domains, 1 (mapped)  Uhrf1  ubiquitin-like, containing PHD and RING finger domains, 1  Symbol and Name updated 1556543 APPROVED
2004-09-10 Uhrf1  ubiquitin-like, containing PHD and RING finger domains, 1  Np95  nuclear protein 95  Symbol and Name updated 1299863 APPROVED
2002-06-10 Np95  Nuclear protein 95      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains RING finger associated domain 634611
gene_domains contains zinc finger domain 634611
gene_function possesses zinc chelating function 634611
gene_function involved in cell cycle progression and/or DNA replication 1302256