UHRF1 (ubiquitin like with PHD and ring finger domains 1) - Rat Genome Database

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Gene: UHRF1 (ubiquitin like with PHD and ring finger domains 1) Sus scrofa
Analyze
Symbol: UHRF1
Name: ubiquitin like with PHD and ring finger domains 1
RGD ID: 14225268
Description: ENCODES a protein that exhibits nucleic acid binding (ortholog); INVOLVED IN response to peptide hormone (ortholog); PARTICIPATES IN DNA modification pathway; histone modification pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); Colonic Neoplasms (ortholog); genetic disease (ortholog); FOUND IN chromatin (inferred); euchromatin (inferred); heterochromatin (inferred); INTERACTS WITH resveratrol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: E3 ubiquitin-protein ligase UHRF1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl273,898,071 - 73,931,769 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1273,898,061 - 73,937,727 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2274,678,503 - 74,712,233 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
resveratrol  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:25966093   PMID:30032202  


Genomics

Comparative Map Data
UHRF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl273,898,071 - 73,931,769 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1273,898,061 - 73,937,727 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2274,678,503 - 74,712,233 (-)NCBISscrofa10.2Sscrofa10.2susScr3
UHRF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38194,903,080 - 4,962,154 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl194,903,080 - 4,962,154 (+)EnsemblGRCh38hg38GRCh38
GRCh37194,903,092 - 4,962,165 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,860,510 - 4,913,165 (+)NCBINCBI36Build 36hg18NCBI36
Build 34194,861,813 - 4,913,162NCBI
Celera194,846,530 - 4,899,186 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef194,671,491 - 4,723,801 (+)NCBIHuRef
CHM1_1194,909,372 - 4,962,038 (+)NCBICHM1_1
T2T-CHM13v2.0194,888,314 - 4,947,375 (+)NCBIT2T-CHM13v2.0
Uhrf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391756,610,405 - 56,630,486 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1756,610,321 - 56,630,486 (+)EnsemblGRCm39 Ensembl
GRCm381756,303,337 - 56,323,486 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1756,303,321 - 56,323,486 (+)EnsemblGRCm38mm10GRCm38
MGSCv371756,442,760 - 56,462,909 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361755,937,126 - 55,957,195 (+)NCBIMGSCv36mm8
Celera1760,657,174 - 60,672,221 (+)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.26NCBI
Uhrf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,220,162 - 1,241,792 (+)NCBIGRCr8
mRatBN7.291,133,117 - 1,154,639 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,134,909 - 1,154,631 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx91,580,592 - 1,600,307 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.096,928,574 - 6,948,303 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.095,885,636 - 5,905,351 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,738,211 - 10,758,403 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,738,222 - 10,757,954 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.099,729,983 - 9,750,175 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera97,356,596 - 7,375,693 (-)NCBICelera
Cytogenetic Map9q11NCBI
Uhrf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554954,153,898 - 4,154,611 (-)NCBIChiLan1.0ChiLan1.0
UHRF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2209,302,493 - 9,355,349 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1198,531,805 - 8,584,592 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0193,926,583 - 3,979,163 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1194,872,753 - 4,925,330 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl194,872,753 - 4,925,330 (+)Ensemblpanpan1.1panPan2
UHRF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12054,858,673 - 54,889,769 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2054,859,947 - 54,889,907 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2054,583,125 - 54,615,199 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02055,513,260 - 55,545,335 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2055,513,262 - 55,545,339 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12054,574,546 - 54,606,612 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02055,055,222 - 55,087,332 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02055,253,102 - 55,285,205 (-)NCBIUU_Cfam_GSD_1.0
Uhrf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118214,944,645 - 214,972,502 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365882,862,367 - 2,888,946 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365882,863,651 - 2,890,116 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UHRF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.164,592,362 - 4,642,179 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl64,592,919 - 4,642,445 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660813,489,316 - 3,544,391 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Uhrf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248284,898,677 - 4,929,872 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248284,898,786 - 4,929,136 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in UHRF1
525 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 9 2 5 8 2 3
Below cutoff 1 1 3 2 15 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000014764   ⟹   ENSSSCP00000014364
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl273,898,071 - 73,931,769 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000051749   ⟹   ENSSSCP00000056636
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl273,898,071 - 73,930,896 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000094299   ⟹   ENSSSCP00000075992
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl273,898,071 - 73,930,588 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000100581   ⟹   ENSSSCP00000080986
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl273,898,071 - 73,931,769 (-)Ensembl
RefSeq Acc Id: XM_005661320   ⟹   XP_005661377
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1273,898,061 - 73,931,857 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005661321   ⟹   XP_005661378
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1273,898,061 - 73,931,092 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021084038   ⟹   XP_020939697
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1273,898,061 - 73,937,727 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020939697   ⟸   XM_021084038
- UniProtKB: A0A480LXY4 (UniProtKB/TrEMBL),   A0A8D0X9J9 (UniProtKB/TrEMBL),   A0A8D0ZHJ8 (UniProtKB/TrEMBL),   A0A8D1QB89 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005661377   ⟸   XM_005661320
- UniProtKB: A0A480LXY4 (UniProtKB/TrEMBL),   A0A8D0X9J9 (UniProtKB/TrEMBL),   A0A8D0ZHJ8 (UniProtKB/TrEMBL),   A0A8D1QB89 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005661378   ⟸   XM_005661321
- UniProtKB: A0A480LXY4 (UniProtKB/TrEMBL),   A0A8D0X9J9 (UniProtKB/TrEMBL),   A0A8D0ZHJ8 (UniProtKB/TrEMBL),   A0A8D1QB89 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000056636   ⟸   ENSSSCT00000051749
RefSeq Acc Id: ENSSSCP00000014364   ⟸   ENSSSCT00000014764
RefSeq Acc Id: ENSSSCP00000075992   ⟸   ENSSSCT00000094299
RefSeq Acc Id: ENSSSCP00000080986   ⟸   ENSSSCT00000100581
Protein Domains
PHD-type   RING-type   Ubiquitin-like   YDG


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000013517 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00030050911 UniProtKB/TrEMBL
  ENSSSCG00035031769 UniProtKB/TrEMBL
  ENSSSCG00055011778 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000014764 ENTREZGENE
  ENSSSCT00000014764.5 UniProtKB/TrEMBL
  ENSSSCT00000051749 ENTREZGENE
  ENSSSCT00000051749.3 UniProtKB/TrEMBL
  ENSSSCT00000094299.1 UniProtKB/TrEMBL
  ENSSSCT00000100581.1 UniProtKB/TrEMBL
  ENSSSCT00030070937.1 UniProtKB/TrEMBL
  ENSSSCT00035042072.1 UniProtKB/TrEMBL
  ENSSSCT00055023025.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.280.10 UniProtKB/TrEMBL
  2.30.30.1150 UniProtKB/TrEMBL
  2.30.30.140 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro PUA-like_sf UniProtKB/TrEMBL
  SRA-YDG_sf UniProtKB/TrEMBL
  SRA_YDG UniProtKB/TrEMBL
  TTD_dom UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
  Ubiquitin_dom UniProtKB/TrEMBL
  Ubl_UHRF1 UniProtKB/TrEMBL
  UHRF1/2-like UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_PHD UniProtKB/TrEMBL
  Znf_PHD-finger UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/TrEMBL
KEGG Report ssc:100511003 UniProtKB/TrEMBL
NCBI Gene UHRF1 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE UHRF1 UniProtKB/TrEMBL
  PTHR14140 UniProtKB/TrEMBL
Pfam PHD UniProtKB/TrEMBL
  SAD_SRA UniProtKB/TrEMBL
  TTD UniProtKB/TrEMBL
  ubiquitin UniProtKB/TrEMBL
PROSITE UBIQUITIN_2 UniProtKB/TrEMBL
  YDG UniProtKB/TrEMBL
  ZF_PHD_2 UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
SMART PHD UniProtKB/TrEMBL
  RING UniProtKB/TrEMBL
  SRA UniProtKB/TrEMBL
  UBQ UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
  SSF57903 UniProtKB/TrEMBL
  SSF88697 UniProtKB/TrEMBL
UniProt A0A287BKE5_PIG UniProtKB/TrEMBL
  A0A480LXY4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0X9J9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0ZHJ8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1QB89 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4F9I9_PIG UniProtKB/TrEMBL
  A0A8W4FR44_PIG UniProtKB/TrEMBL
  F1S7K1_PIG UniProtKB/TrEMBL
VGNC ID VGNC:94689 ENTREZGENE