Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of APPL2 mRNA] | CTD | PMID:31150632 | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | APPL2 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of APPL2 mRNA | CTD | PMID:22079256 | 1,2-dimethylhydrazine | decreases expression | ISO | Appl2 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of APPL2 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | multiple interactions | ISO | Appl2 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of APPL2 mRNA | CTD | PMID:22206623 | 1,3,5-trinitro-1,3,5-triazinane | decreases expression | EXP | | 6480464 | cyclonite results in decreased expression of APPL2 mRNA | CTD | PMID:25559034 | 17alpha-ethynylestradiol | increases expression | ISO | Appl2 (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of APPL2 mRNA | CTD | PMID:17942748 | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of APPL2 mRNA | CTD | PMID:32145629 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | APPL2 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Appl2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to APPL2 promoter] | CTD | PMID:19654925 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Appl2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of APPL2 mRNA | CTD | PMID:21570461 | 2-hydroxypropanoic acid | decreases expression | ISO | APPL2 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of APPL2 mRNA | CTD | PMID:30851411 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of APPL2 mRNA | CTD | PMID:30047161 | aristolochic acid A | decreases expression | ISO | APPL2 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of APPL2 mRNA | CTD | PMID:33212167 | Aroclor 1254 | decreases expression | ISO | Appl2 (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of APPL2 mRNA | CTD | PMID:23650126 | arsane | multiple interactions | ISO | APPL2 (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of APPL2 mRNA | CTD | PMID:32525701 | arsenic atom | multiple interactions | ISO | APPL2 (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of APPL2 mRNA | CTD | PMID:32525701 | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of APPL2 gene | CTD | PMID:35440735 | benzo[a]pyrene | decreases expression | ISO | Appl2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of APPL2 mRNA | CTD | PMID:19770486 | benzo[a]pyrene | increases methylation | ISO | APPL2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of APPL2 promoter | CTD | PMID:27901495 | benzo[a]pyrene | decreases expression | ISO | APPL2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of APPL2 mRNA | CTD | PMID:22316170 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of APPL2 mRNA | CTD | PMID:25181051 | bisphenol A | decreases expression | ISO | Appl2 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of APPL2 mRNA | CTD | PMID:32156529 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of APPL2 mRNA | CTD | PMID:34947998 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of APPL2 mRNA | CTD | PMID:32145629 | Bisphenol B | increases expression | ISO | APPL2 (Homo sapiens) | 6480464 | bisphenol B results in increased expression of APPL2 protein | CTD | PMID:34186270 | cadmium atom | multiple interactions | ISO | APPL2 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of APPL2 mRNA | CTD | PMID:35301059 | cadmium dichloride | multiple interactions | ISO | APPL2 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of APPL2 mRNA | CTD | PMID:35301059 | carbon nanotube | decreases expression | ISO | Appl2 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | APPL2 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to APPL2 gene] | CTD | PMID:28238834 | choline | multiple interactions | ISO | Appl2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of APPL2 gene | CTD | PMID:20938992 | chromium(6+) | affects expression | ISO | Appl2 (Mus musculus) | 6480464 | chromium hexavalent ion affects the expression of APPL2 mRNA | CTD | PMID:28472532 | cisplatin | increases expression | ISO | APPL2 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of APPL2 mRNA | CTD | PMID:27392435 | cobalt dichloride | decreases expression | ISO | APPL2 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of APPL2 mRNA | CTD | PMID:19320972 | cyclosporin A | decreases expression | ISO | APPL2 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of APPL2 mRNA | CTD | PMID:20106945 | dioxygen | increases expression | ISO | Appl2 (Mus musculus) | 6480464 | Oxygen deficiency results in increased expression of APPL2 mRNA | CTD | PMID:20880076 | dioxygen | multiple interactions | ISO | Appl2 (Mus musculus) | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of APPL2 mRNA | CTD | PMID:30529165 | dorsomorphin | multiple interactions | ISO | APPL2 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of APPL2 mRNA | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | APPL2 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of APPL2 mRNA | CTD | PMID:29803840 | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of APPL2 mRNA | CTD | PMID:29391264 | ethanol | increases expression | ISO | Appl2 (Mus musculus) | 6480464 | Ethanol results in increased expression of APPL2 mRNA | CTD | PMID:30319688 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of APPL2 mRNA | CTD | PMID:24793618 | folic acid | multiple interactions | ISO | Appl2 (Mus musculus) | 6480464 | [1 more ... | CTD | PMID:20938992 and PMID:22206623 | folic acid | decreases expression | ISO | Appl2 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of APPL2 mRNA | CTD | PMID:25629700 | geldanamycin | increases expression | ISO | APPL2 (Homo sapiens) | 6480464 | geldanamycin results in increased expression of APPL2 mRNA | CTD | PMID:26705709 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of APPL2 mRNA | CTD | PMID:33387578 | isoprenaline | increases expression | ISO | Appl2 (Mus musculus) | 6480464 | Isoproterenol results in increased expression of APPL2 mRNA | CTD | PMID:20003209 | ivermectin | decreases expression | ISO | APPL2 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of APPL2 protein | CTD | PMID:32959892 | L-methionine | multiple interactions | ISO | Appl2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of APPL2 gene | CTD | PMID:20938992 | methamphetamine | increases expression | ISO | Appl2 (Mus musculus) | 6480464 | Methamphetamine results in increased expression of APPL2 mRNA | CTD | PMID:26307267 | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of APPL2 mRNA | CTD | PMID:30047161 | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of APPL2 gene | CTD | PMID:35440735 | methyl methanesulfonate | increases expression | ISO | APPL2 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of APPL2 mRNA | CTD | PMID:23649840 | paracetamol | affects expression | ISO | Appl2 (Mus musculus) | 6480464 | Acetaminophen affects the expression of APPL2 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of APPL2 mRNA | CTD | PMID:33387578 | perfluorononanoic acid | decreases expression | ISO | APPL2 (Homo sapiens) | 6480464 | perfluoro-n-nonanoic acid results in decreased expression of APPL2 mRNA | CTD | PMID:32588087 | perfluorooctanoic acid | decreases expression | EXP | | 6480464 | perfluorooctanoic acid results in decreased expression of APPL2 mRNA | CTD | PMID:35163327 | phenobarbital | decreases expression | EXP | | 6480464 | Phenobarbital results in decreased expression of APPL2 mRNA | CTD | PMID:30047161 | potassium chromate | decreases expression | ISO | APPL2 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of APPL2 mRNA | CTD | PMID:22079256 | potassium chromate | multiple interactions | ISO | APPL2 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of APPL2 mRNA | CTD | PMID:22079256 | quercetin | decreases expression | ISO | APPL2 (Homo sapiens) | 6480464 | Quercetin results in decreased expression of APPL2 mRNA | CTD | PMID:21632981 | rac-lactic acid | decreases expression | ISO | APPL2 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of APPL2 mRNA | CTD | PMID:30851411 | SB 431542 | multiple interactions | ISO | APPL2 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of APPL2 mRNA | CTD | PMID:27188386 | sodium arsenate | multiple interactions | ISO | APPL2 (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of APPL2 mRNA | CTD | PMID:32525701 | sodium arsenite | decreases expression | ISO | APPL2 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of APPL2 protein | CTD | PMID:30528433 | sodium arsenite | increases expression | ISO | Appl2 (Mus musculus) | 6480464 | sodium arsenite results in increased expression of APPL2 mRNA | CTD | PMID:36209798 | temozolomide | decreases expression | ISO | APPL2 (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of APPL2 mRNA | CTD | PMID:31758290 | tert-butyl hydroperoxide | decreases expression | ISO | APPL2 (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in decreased expression of APPL2 mRNA | CTD | PMID:15336504 | testosterone | increases expression | ISO | Appl2 (Mus musculus) | 6480464 | Testosterone deficiency results in increased expression of APPL2 mRNA | CTD | PMID:33848595 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of APPL2 mRNA | CTD | PMID:31150632 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of APPL2 mRNA] | CTD | PMID:31150632 | tetraphene | increases expression | ISO | Appl2 (Mus musculus) | 6480464 | benz(a)anthracene results in increased expression of APPL2 mRNA | CTD | PMID:26377693 | thimerosal | decreases expression | ISO | APPL2 (Homo sapiens) | 6480464 | Thimerosal results in decreased expression of APPL2 mRNA | CTD | PMID:27188386 | titanium dioxide | increases expression | ISO | Appl2 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of APPL2 mRNA | CTD | PMID:23557971 | trichloroethene | increases methylation | EXP | | 6480464 | Trichloroethylene results in increased methylation of APPL2 gene | CTD | PMID:27618143 | trichostatin A | decreases expression | ISO | APPL2 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of APPL2 mRNA | CTD | PMID:24935251 and PMID:26272509 | trichostatin A | multiple interactions | ISO | APPL2 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of APPL2 mRNA | CTD | PMID:27188386 | troglitazone | decreases expression | ISO | Appl2 (Mus musculus) | 6480464 | troglitazone results in decreased expression of APPL2 mRNA | CTD | PMID:28973697 | valproic acid | increases expression | ISO | Appl2 (Mus musculus) | 6480464 | Valproic Acid results in increased expression of APPL2 mRNA | CTD | PMID:21427059 | valproic acid | decreases expression | ISO | APPL2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of APPL2 mRNA | CTD | PMID:23179753 | vorinostat | decreases expression | ISO | APPL2 (Homo sapiens) | 6480464 | vorinostat results in decreased expression of APPL2 mRNA | CTD | PMID:27188386 | |