Or6c75 (olfactory receptor family 6 subfamily C member 75) - Rat Genome Database

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Gene: Or6c75 (olfactory receptor family 6 subfamily C member 75) Rattus norvegicus
Analyze
Symbol: Or6c75
Name: olfactory receptor family 6 subfamily C member 75
RGD ID: 1333361
Description: Predicted to enable G protein-coupled receptor activity and olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in plasma membrane; INTERACTS WITH ochratoxin A; vinclozolin; aflatoxin B1 (ortholog).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 1014; olfactory receptor gene Olr1014; olfactory receptor Olr1014; Olr1014
RGD Orthologs
Human
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr876,051,751 - 6,052,695 (+)NCBIGRCr8
mRatBN7.275,400,918 - 5,401,862 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl75,398,500 - 5,403,735 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx78,295,134 - 8,296,078 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0710,170,794 - 10,171,738 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.078,006,124 - 8,007,068 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.078,504,405 - 8,505,349 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
RGSC_v3.476,799,208 - 6,800,152 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.176,799,207 - 6,800,152 (+)NCBI
Celera73,648,109 - 3,649,053 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21873635  


Genomics

Comparative Map Data
Or6c75
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr876,051,751 - 6,052,695 (+)NCBIGRCr8
mRatBN7.275,400,918 - 5,401,862 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl75,398,500 - 5,403,735 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx78,295,134 - 8,296,078 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0710,170,794 - 10,171,738 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.078,006,124 - 8,007,068 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.078,504,405 - 8,505,349 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
RGSC_v3.476,799,208 - 6,800,152 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.176,799,207 - 6,800,152 (+)NCBI
Celera73,648,109 - 3,649,053 (+)NCBICelera
Cytogenetic Map7q11NCBI
OR6C75
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381255,362,975 - 55,369,279 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1255,362,975 - 55,369,279 (+)EnsemblGRCh38hg38GRCh38
GRCh371255,756,759 - 55,763,063 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,045,162 - 54,046,100 (+)NCBINCBI36Build 36hg18NCBI36
Build 341254,045,161 - 54,046,100NCBI
Celera1255,410,961 - 55,411,899 (+)NCBICelera
Cytogenetic Map12q13.2NCBI
HuRef1252,797,687 - 52,798,625 (+)NCBIHuRef
CHM1_11255,725,708 - 55,726,646 (+)NCBICHM1_1
T2T-CHM13v2.01255,329,536 - 55,335,853 (+)NCBIT2T-CHM13v2.0
LOC100736710
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1520,649,137 - 20,652,150 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2521,944,250 - 21,945,721 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Or6c75
3 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:526
Count of miRNA genes:234
Interacting mature miRNAs:282
Transcripts:ENSRNOT00000004472, ENSRNOT00000044697, ENSRNOT00000072123, ENSRNOT00000072708, ENSRNOT00000074059, ENSRNOT00000074567, ENSRNOT00000074969
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001000699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000114249   ⟹   ENSRNOP00000090640
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl75,398,500 - 5,403,735 (+)Ensembl
RefSeq Acc Id: NM_001000699   ⟹   NP_001000699
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr876,051,751 - 6,052,695 (+)NCBI
mRatBN7.275,400,918 - 5,401,862 (+)NCBI
Rnor_6.078,504,405 - 8,505,349 (+)NCBI
RGSC_v3.476,799,208 - 6,800,152 (+)RGD
Celera73,648,109 - 3,649,053 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001000699 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000090640
  ENSRNOP00000090640.1
Reference Protein Sequences
RefSeq Acc Id: NP_001000699   ⟸   NM_001000699
- UniProtKB: A0A8I6ADY4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000090640   ⟸   ENSRNOT00000114249
Protein Domains
G-protein coupled receptors family 1 profile

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-35149 BioCyc
Ensembl Genes ENSRNOG00000065865 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000114249 ENTREZGENE
  ENSRNOT00000114249.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
  Olfact_rcpt_6C-like UniProtKB/TrEMBL
NCBI Gene 404920 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
  OLFACTORY RECEPTOR 6C75 UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or6c75 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000065865 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8I6ADY4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or6c75  olfactory receptor family 6 subfamily C member 75  Olr1014  olfactory receptor 1014  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr1014  olfactory receptor 1014   Olr1014_predicted  olfactory receptor 1014 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr1014_predicted  olfactory receptor 1014 (predicted)      Symbol and Name status set to approved 70820 APPROVED