Acyp1 (acylphosphatase 1) - Rat Genome Database

Name: Acyp1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Acyp1 (acylphosphatase 1) Rattus norvegicus

Analyze

Symbol:

Acyp1

Name:

acylphosphatase 1

RGD ID:

1311327

Description:

Predicted to enable acylphosphatase activity. Orthologous to human ACYP1 (acylphosphatase 1); PARTICIPATES IN Leigh disease pathway; primary hyperoxaluria type 2 pathway; pyruvate decarboxylase deficiency pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

acylphosphatase 1, erythrocyte (common) type; acylphosphatase-1; LOC299203

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ACYP1 (acylphosphatase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Mus musculus (house mouse):	Acyp1 (acylphosphatase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Acyp1 (acylphosphatase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ACYP1 (acylphosphatase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ACYP1 (acylphosphatase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Acyp1 (acylphosphatase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ACYP1 (acylphosphatase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ACYP1 (acylphosphatase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Acyp1 (acylphosphatase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Acyp1 (acylphosphatase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	ACYP1 (acylphosphatase 1)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	acyp2 (acylphosphatase 2, muscle type)	Alliance	DIOPT (InParanoid\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Acyp	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	Acyp2	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG18371	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG34161	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG14022	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	acyp1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	110,650,213 - 110,663,404 (-)	NCBI		GRCr8
mRatBN7.2	6	104,919,162 - 104,932,348 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	104,919,162 - 104,932,387 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	105,088,768 - 105,095,753 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	105,387,639 - 105,394,624 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	104,757,301 - 104,764,286 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	109,097,065 - 109,110,266 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	109,097,065 - 109,104,050 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	116,446,795 - 116,459,981 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	109,320,444 - 109,327,303 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	109,323,898 - 109,337,013 (-)	NCBI
Celera	6	102,742,108 - 102,749,093 (-)	NCBI		Celera
Cytogenetic Map	6	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Developmental Disabilities (ISO)

intellectual disability (ISO)

Niemann-Pick disease type C1 (ISO)

Niemann-Pick disease type C2 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-palmitoylglycerol (ISO)

4,4'-diaminodiphenylmethane (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amiodarone (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

Brodifacoum (EXP)

cadmium dichloride (EXP)

carbamazepine (ISO)

CGP 52608 (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

dioxygen (ISO)

Enterolactone (ISO)

epoxiconazole (ISO)

ethyl methanesulfonate (ISO)

folic acid (ISO)

gentamycin (EXP)

hydrogen peroxide (ISO)

indole-3-methanol (EXP)

ivermectin (ISO)

lead(0) (ISO)

leflunomide (ISO)

methidathion (ISO)

methyl methanesulfonate (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

quercetin (ISO)

resorcinol (ISO)

resveratrol (ISO)

rotenone (EXP)

sodium arsenite (ISO)

sunitinib (ISO)

temozolomide (ISO)

tert-butyl hydroperoxide (ISO)

testosterone (EXP)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

toluene 2,4-diisocyanate (ISO)

topotecan (EXP)

trichloroethene (EXP)

triphenyl phosphate (EXP)

tungsten (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Molecular Function

acylphosphatase activity (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

Leigh disease pathway (ISO)

primary hyperoxaluria type 2 pathway (ISO)

pyruvate decarboxylase deficiency pathway (ISO)

pyruvate dehydrogenase E1 deficiency pathway (ISO)

pyruvate kinase deficiency of red cells pathway (ISO)

pyruvate metabolic pathway (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:22871113	PMID:23376485

Genomics

Comparative Map Data

Acyp1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	110,650,213 - 110,663,404 (-)	NCBI		GRCr8
mRatBN7.2	6	104,919,162 - 104,932,348 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	104,919,162 - 104,932,387 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	105,088,768 - 105,095,753 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	105,387,639 - 105,394,624 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	104,757,301 - 104,764,286 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	109,097,065 - 109,110,266 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	109,097,065 - 109,104,050 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	116,446,795 - 116,459,981 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	109,320,444 - 109,327,303 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	109,323,898 - 109,337,013 (-)	NCBI
Celera	6	102,742,108 - 102,749,093 (-)	NCBI		Celera
Cytogenetic Map	6	q31	NCBI

ACYP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	75,053,243 - 75,069,490 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	75,053,237 - 75,069,483 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	75,519,946 - 75,536,193 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	74,589,677 - 74,600,489 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	74,589,682 - 74,600,489	NCBI
Celera	14	55,557,594 - 55,568,402 (-)	NCBI		Celera
Cytogenetic Map	14	q24.3	NCBI
HuRef	14	55,688,111 - 55,698,922 (-)	NCBI		HuRef
CHM1_1	14	75,458,458 - 75,468,510 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	14	69,262,663 - 69,278,894 (-)	NCBI		T2T-CHM13v2.0

Acyp1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	85,319,172 - 85,335,257 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	85,319,172 - 85,335,212 (-)	Ensembl		GRCm39 Ensembl
GRCm38	12	85,272,398 - 85,288,438 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	85,272,398 - 85,288,438 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	86,613,348 - 86,621,385 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	86,161,509 - 86,169,538 (-)	NCBI		MGSCv36	mm8
Celera	12	86,730,048 - 86,738,085 (-)	NCBI		Celera
Cytogenetic Map	12	D1	NCBI
cM Map	12	39.62	NCBI

Acyp1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955523	499,508 - 508,273 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955523	499,508 - 507,809 (+)	NCBI	ChiLan1.0	ChiLan1.0

ACYP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	76,135,529 - 76,151,767 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	75,352,033 - 75,368,271 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	55,604,853 - 55,621,133 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	74,449,300 - 74,464,884 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

ACYP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	48,155,415 - 48,169,211 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	48,155,412 - 48,169,261 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	47,839,531 - 47,848,071 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	48,383,042 - 48,396,748 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	48,383,039 - 48,396,884 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	48,053,825 - 48,062,365 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	48,075,306 - 48,083,633 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	48,473,789 - 48,482,329 (-)	NCBI		UU_Cfam_GSD_1.0

Acyp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	27,857,355 - 27,871,991 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936488	4,196,977 - 4,211,552 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ACYP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	98,220,555 - 98,247,125 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	98,220,318 - 98,265,187 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	104,093,822 - 104,109,273 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ACYP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	52,267,734 - 52,283,724 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666053	40,498,448 - 40,514,460 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Acyp1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624734	26,619,100 - 26,638,714 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624734	26,612,509 - 26,638,491 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Acyp1
55 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	12
Count of miRNA genes:	11
Interacting mature miRNAs:	12
Transcripts:	ENSRNOT00000009086
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	10894415	110548006	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	15107216	107351382	Rat
12801471	Schws9	Schwannoma susceptibility QTL 9			nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	61747639	106747639	Rat
731173	Uae22	Urinary albumin excretion QTL 22	10.1		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	65531555	140994061	Rat
2290393	Uae37	Urinary albumin excretion QTL 37		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	65531555	140994061	Rat
1641904	Alcrsp4	Alcohol response QTL 4			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	6	67262953	112262953	Rat
1300075	Glom7	Glomerulus QTL 7	5.6	0.0000002	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	6	71201409	116201409	Rat
1331789	Rf37	Renal function QTL 37	3.224		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	6	72202632	115200186	Rat
70196	BpQTLcluster7	Blood pressure QTL cluster 7	6.82		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	72202632	117202632	Rat
724536	Uae7	Urinary albumin excretion QTL 7	3.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	72202632	130729475	Rat
1331799	Bp211	Blood pressure QTL 211	3.66407		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	72202632	130919985	Rat
1581550	Pur8	Proteinuria QTL 8			urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	6	72227641	130729205	Rat
1581563	Uae33	Urinary albumin excretion QTL 33			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	72227641	130729205	Rat
724524	Uae2	Urinary albumin excretion QTL 2	2.7	0.0005	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	73463459	109394713	Rat
737827	Hcar11	Hepatocarcinoma resistance QTL 11	4.4		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	6	82523650	110548006	Rat
1576302	Schws4	Schwannoma susceptibility QTL 4		0.0078	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	83190345	106747639	Rat
738034	Anxrr5	Anxiety related response QTL 5	5.9		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	6	84130881	129130881	Rat
10054138	Gmadr3	Adrenal mass QTL 3	3.68	0.00045	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	6	85140138	130140138	Rat
10054123	Srcrt6	Stress Responsive Cort QTL 6	2.5	0.0043	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	85140138	130140138	Rat
724513	Uae14	Urinary albumin excretion QTL 14	6.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	85311061	133478515	Rat
1300076	Glom8	Glomerulus QTL 8	7	0.000000009	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)	6	86894788	131894788	Rat
2303624	Vencon5	Ventilatory control QTL 5	4.45		respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	6	88047916	133047916	Rat
1331722	Thshl1	Thyroid stimulating hormone level QTL 1	11.7	0.0001	blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	6	89762877	106752806	Rat
1331725	Bp212	Blood pressure QTL 212	3.52475		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	93701310	128713626	Rat
61414	Pia3	Pristane induced arthritis QTL 3	4.5		joint integrity trait (VT:0010548)	post-insult time to onset of experimental arthritis (CMO:0001450)	6	94968928	137848904	Rat
12801411	Schws8	Schwannoma susceptibility QTL 8			nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	94968928	139968928	Rat
8552796	Vie3	Viral induced encephalitis QTL 3	2.6		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	6	96833997	140994061	Rat
1358355	Srcrt4	Stress Responsive Cort QTL 4	6.39		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	100364669	140994061	Rat
2313399	Anxrr28	Anxiety related response QTL 28			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	6	100671796	132340886	Rat
1331797	Bp213	Blood pressure QTL 213	3.291		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	104085867	128713626	Rat

Markers in Region

RH129328

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	104,919,271 - 104,919,456 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	109,097,175 - 109,097,359	NCBI	Rnor6.0
Rnor_5.0	6	116,459,687 - 116,459,871	UniSTS	Rnor5.0
RGSC_v3.4	6	109,320,553 - 109,320,737	UniSTS	RGSC3.4
Celera	6	102,742,218 - 102,742,402	UniSTS
RH 3.4 Map	6	742.39	UniSTS
Cytogenetic Map	6	q31	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	35	23	19	23	8	11	74	35	41	11	8
Low			22	18		18
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106746	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001199167	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001199168	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006240308	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017594098	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC114701	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473982	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM034312	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM062949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000009086 ⟹ ENSRNOP00000009086

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	104,919,162 - 104,926,096 (-)	Ensembl
Rnor_6.0 Ensembl	6	109,097,065 - 109,103,999 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000080009 ⟹ ENSRNOP00000074525

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	104,919,162 - 104,932,387 (-)	Ensembl
Rnor_6.0 Ensembl	6	109,097,065 - 109,104,050 (-)	Ensembl

RefSeq Acc Id:

NM_001106746 ⟹ NP_001100216

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	110,650,213 - 110,657,147 (-)	NCBI
mRatBN7.2	6	104,919,162 - 104,926,096 (-)	NCBI
Rnor_6.0	6	109,097,065 - 109,103,999 (-)	NCBI
Rnor_5.0	6	116,446,795 - 116,459,981 (+)	NCBI
RGSC_v3.4	6	109,320,444 - 109,327,303 (-)	RGD
Celera	6	102,742,108 - 102,749,042 (-)	NCBI

Sequence:

show sequence

CTTCGGGGCTGTACAGCGGCTAGTGGGGAAGCCCCGGAAACTCGAGTGTCCGCCGCTCGGATCA
TCCAAGTGTCAGTGGAGGGGATGACGGGCCTCATGGGGATAGGATGGATGGCGGCTTCAGGGCT
GCAAGGGTAGCGGGGTGAGCAGGTTTGAGCATGGCAGAAGGGGACACCTTGGTCTCAGTGGATT
ACGAAATTTTTGGAAAGGTTCAAGGGGTGTTTTTCCGCAAGTACACTCAGGCTGAGGGCAAAAA
GCTAGGTTTGGTGGGCTGGGTTCAGAACACCAACAGGGGCACGGTGCAAGGACAACTGCAAGGC
CCCGTCTCCAAGGTCCGCTTTATGCAGGAGTGGCTGGAGAAAAGAGGAAGTCCCAAATCTCACA
TCGACCGAGCAAACTTCAACAATGAGAAAATCATCTCAAACTTGGATTATTCAGACTTCCAAAT
TATAAAATAATGACACGAATTTTAATTTTTTCAAAGTAATCTCACTCCTTTTTTTATCGGTATA
TATAAAATAGAACGATTCTGTGCTCAGTATTAGAATTTGTTAGTAAGTTATTTTAGTTGCATGT
TTGAAAGTTACCAGGTATTACATGTATGACGAAAGACAAATGTGTACAGTTCTAACCAATAAAA
ACACATTAGAACCTCA

hide sequence

RefSeq Acc Id:

NM_001199167 ⟹ NP_001186096

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	110,650,213 - 110,657,158 (-)	NCBI
mRatBN7.2	6	104,919,162 - 104,926,107 (-)	NCBI
Rnor_6.0	6	109,097,065 - 109,104,010 (-)	NCBI
Rnor_5.0	6	116,446,795 - 116,459,981 (+)	NCBI
Celera	6	102,742,108 - 102,749,053 (-)	NCBI

Sequence:

show sequence

CTAAAGGTCTTCTTCGGGGCTGTACAGCGGCTAGTGGGGAAGCCCCGGAAACTCGAGTGTCCGC
CGCTCGGATCATCCAAGTGTTTGAGCATGGCAGAAGGGGACACCTTGGTCTCAGTGGATTACGA
AATTTTTGGAAAGGTTCAAGGGGTGTTTTTCCGCAAGTACACTCAGGCTGAGGGCAAAAAGCTA
GGTTTGGTGGGCTGGGTTCAGAACACCAACAGGGGCACGGTGCAAGGACAACTGCAAGGCCCCG
TCTCCAAGGTCCGCTTTATGCAGGAGTGGCTGGAGAAAAGAGGAAGTCCCAAATCTCACATCGA
CCGAGCAAACTTCAACAATGAGAAAATCATCTCAAACTTGGATTATTCAGACTTCCAAATTATA
AAATAATGACACGAATTTTAATTTTTTCAAAGTAATCTCACTCCTTTTTTTATCGGTATATATA
AAATAGAACGATTCTGTGCTCAGTATTAGAATTTGTTAGTAAGTTATTTTAGTTGCATGTTTGA
AAGTTACCAGGTATTACATGTATGACGAAAGACAAATGTGTACAGTTCTAACCAATAAAAACAC
ATTAGAACCTCA

hide sequence

RefSeq Acc Id:

NM_001199168 ⟹ NP_001186097

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	110,650,213 - 110,657,198 (-)	NCBI
mRatBN7.2	6	104,919,162 - 104,926,147 (-)	NCBI
Rnor_6.0	6	109,097,065 - 109,104,050 (-)	NCBI
Rnor_5.0	6	116,446,795 - 116,459,981 (+)	NCBI
Celera	6	102,742,108 - 102,749,093 (-)	NCBI

Sequence:

show sequence

ACTTCCGGAAGCGGCAGTTAGCGTGGCGCGGGCAGTTGATCTAAAGGTTTGAGCATGGCAGAAG
GGGACACCTTGGTCTCAGTGGATTACGAAATTTTTGGAAAGGTTCAAGGGGTGTTTTTCCGCAA
GTACACTCAGGCTGAGGGCAAAAAGCTAGGTTTGGTGGGCTGGGTTCAGAACACCAACAGGGGC
ACGGTGCAAGGACAACTGCAAGGCCCCGTCTCCAAGGTCCGCTTTATGCAGGAGTGGCTGGAGA
AAAGAGGAAGTCCCAAATCTCACATCGACCGAGCAAACTTCAACAATGAGAAAATCATCTCAAA
CTTGGATTATTCAGACTTCCAAATTATAAAATAATGACACGAATTTTAATTTTTTCAAAGTAAT
CTCACTCCTTTTTTTATCGGTATATATAAAATAGAACGATTCTGTGCTCAGTATTAGAATTTGT
TAGTAAGTTATTTTAGTTGCATGTTTGAAAGTTACCAGGTATTACATGTATGACGAAAGACAAA
TGTGTACAGTTCTAACCAATAAAAACACATTAGAACCTCA

hide sequence

RefSeq Acc Id:

XM_006240308 ⟹ XP_006240370

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	110,650,213 - 110,657,188 (-)	NCBI
mRatBN7.2	6	104,919,162 - 104,926,141 (-)	NCBI
Rnor_6.0	6	109,097,065 - 109,104,063 (-)	NCBI
Rnor_5.0	6	116,446,795 - 116,459,981 (+)	NCBI

Sequence:

show sequence

AGCTGCGCTCTAAACTTCCGGAAGCGGCAGTTAGCGTGGCGCGGGCAGTTGATCTAAAGGTCTT
CTTCGGGGCTGTACAGCGGCTAGTGGGGAAGCCCCGGAAACTCGAGTGTCCGCCGCTCGGATCA
TCCAAGTGTCAGTGGAGGGGATGACGGGCCTCATGGGGATAGGATGGATGGCGGCTTCAGGGCT
GCAAGGGTAGCGGGGTTTGAGCATGGCAGAAGGGGACACCTTGGTCTCAGTGGATTACGAAATT
TTTGGAAAGGTTCAAGGGGTGTTTTTCCGCAAGTACACTCAGGCTGAGGGCAAAAAGCTAGGTT
TGGTGGGCTGGGTTCAGAACACCAACAGGGGCACGGTGCAAGGACAACTGCAAGGCCCCGTCTC
CAAGGTCCGCTTTATGCAGGAGTGGCTGGAGAAAAGAGGAAGTCCCAAATCTCACATCGACCGA
GCAAACTTCAACAATGAGAAAATCATCTCAAACTTGGATTATTCAGACTTCCAAATTATAAAAT
AATGACACGAATTTTAATTTTTTCAAAGTAATCTCACTCCTTTTTTTATCGGTATATATAAAAT
AGAACGATTCTGTGCTCAGTATTAGAATTTGTTAGTAAGTTATTTTAGTTGCATGTTTGAAAGT
TACCAGGTATTACATGTATGACGAAAGACAAATGTGTACAGTTCTAACCAATAAAAACACATTA
GAACCTCA

hide sequence

RefSeq Acc Id:

XM_017594098 ⟹ XP_017449587

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	110,650,213 - 110,663,404 (-)	NCBI
mRatBN7.2	6	104,919,162 - 104,932,348 (-)	NCBI
Rnor_6.0	6	109,097,065 - 109,110,266 (-)	NCBI

Sequence:

show sequence

CACAGCTCAGATCAGCGTTGCCCTTGGGAAGGGGTTGGAGAGGTTTTTCTGGGGCTACATCAAA
GAAGAGTTTGGATTTCTCCGAGAATGATGCTCCCAGACCTTAGGGTGTGCCCTTGTCTGGAGAA
GGGTGGAGCCCTCAGATGGGCTCTGGACTCATCCCGCCCCAGGATTCGGGGGTCTGTCGGGCTA
GCGGGAGTGGGACTGCTGATCACCCTTCTGAGCACGCTGCGCTACTGCGCTCAGGCCCCAGGTT
TGAGCATGGCAGAAGGGGACACCTTGGTCTCAGTGGATTACGAAATTTTTGGAAAGGTTCAAGG
GGTGTTTTTCCGCAAGTACACTCAGGCTGAGGGCAAAAAGCTAGGTTTGGTGGGCTGGGTTCAG
AACACCAACAGGGGCACGGTGCAAGGACAACTGCAAGGCCCCGTCTCCAAGGTCCGCTTTATGC
AGGAGTGGCTGGAGAAAAGAGGAAGTCCCAAATCTCACATCGACCGAGCAAACTTCAACAATGA
GAAAATCATCTCAAACTTGGATTATTCAGACTTCCAAATTATAAAATAATGACACGAATTTTAA
TTTTTTCAAAGTAATCTCACTCCTTTTTTTATCGGTATATATAAAATAGAACGATTCTGTGCTC
AGTATTAGAATTTGTTAGTAAGTTATTTTAGTTGCATGTTTGAAAGTTACCAGGTATTACATGT
ATGACGAAAGACAAATGTGTACAGTTCTAACCAATAAAAACACATTAGAACCTCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001100216	(Get FASTA)	NCBI Sequence Viewer
	NP_001186096	(Get FASTA)	NCBI Sequence Viewer
	NP_001186097	(Get FASTA)	NCBI Sequence Viewer
	XP_006240370	(Get FASTA)	NCBI Sequence Viewer
	XP_017449587	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL81564	(Get FASTA)	NCBI Sequence Viewer
	EDL81565	(Get FASTA)	NCBI Sequence Viewer
	EDL81566	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000009086
	ENSRNOP00000009086.5
	ENSRNOP00000074525
	ENSRNOP00000074525.2

RefSeq Acc Id:	NP_001100216 ⟸ NM_001106746
- UniProtKB:	D4A6X4 (UniProtKB/TrEMBL), A6JE20 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAEGDTLVSVDYEIFGKVQGVFFRKYTQAEGKKLGLVGWVQNTNRGTVQGQLQGPVSKVRFMQE WLEKRGSPKSHIDRANFNNEKIISNLDYSDFQIIK hide sequence

RefSeq Acc Id:	NP_001186097 ⟸ NM_001199168
- UniProtKB:	D4A6X4 (UniProtKB/TrEMBL), A6JE20 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAEGDTLVSVDYEIFGKVQGVFFRKYTQAEGKKLGLVGWVQNTNRGTVQGQLQGPVSKVRFMQE WLEKRGSPKSHIDRANFNNEKIISNLDYSDFQIIK hide sequence

RefSeq Acc Id:	NP_001186096 ⟸ NM_001199167
- UniProtKB:	D4A6X4 (UniProtKB/TrEMBL), A6JE20 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAEGDTLVSVDYEIFGKVQGVFFRKYTQAEGKKLGLVGWVQNTNRGTVQGQLQGPVSKVRFMQE WLEKRGSPKSHIDRANFNNEKIISNLDYSDFQIIK hide sequence

RefSeq Acc Id:	XP_006240370 ⟸ XM_006240308
- Peptide Label:	isoform X2
- UniProtKB:	D4A6X4 (UniProtKB/TrEMBL), A6JE20 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAEGDTLVSVDYEIFGKVQGVFFRKYTQAEGKKLGLVGWVQNTNRGTVQGQLQGPVSKVRFMQE WLEKRGSPKSHIDRANFNNEKIISNLDYSDFQIIK hide sequence

RefSeq Acc Id:	XP_017449587 ⟸ XM_017594098
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2K899 (UniProtKB/TrEMBL)
- Sequence:	show sequence MMLPDLRVCPCLEKGGALRWALDSSRPRIRGSVGLAGVGLLITLLSTLRYCAQAPGLSMAEGDT LVSVDYEIFGKVQGVFFRKYTQAEGKKLGLVGWVQNTNRGTVQGQLQGPVSKVRFMQEWLEKRG SPKSHIDRANFNNEKIISNLDYSDFQIIK hide sequence

RefSeq Acc Id:

ENSRNOP00000074525 ⟸ ENSRNOT00000080009

RefSeq Acc Id:

ENSRNOP00000009086 ⟸ ENSRNOT00000009086

Protein Domains

Acylphosphatase-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A6X4-F1-model_v2	AlphaFold	D4A6X4	1-99	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694739

Promoter ID:

EPDNEW_R5264

Type:

initiation region

Name:

Acyp1_1

Description:

acylphosphatase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	109,104,038 - 109,104,098	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311327	AgrOrtholog
BioCyc Gene	G2FUF-36790	BioCyc
Ensembl Genes	ENSRNOG00000006744	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000009086	ENTREZGENE
	ENSRNOT00000009086.7	UniProtKB/TrEMBL
	ENSRNOT00000080009.2	UniProtKB/TrEMBL
Gene3D-CATH	3.30.70.100	UniProtKB/TrEMBL
InterPro	Acylphosphatase	UniProtKB/TrEMBL
	Acylphosphatase-like	UniProtKB/TrEMBL
	Acylphosphatase-like_dom_sf	UniProtKB/TrEMBL
	Acylphosphatase_CS	UniProtKB/TrEMBL
KEGG Report	rno:299203	UniProtKB/TrEMBL
NCBI Gene	299203	ENTREZGENE
PANTHER	ACYLPHOSPHATASE-1	UniProtKB/TrEMBL
	PTHR10029	UniProtKB/TrEMBL
Pfam	Acylphosphatase	UniProtKB/TrEMBL
PhenoGen	Acyp1	PhenoGen
PRINTS	ACYLPHPHTASE	UniProtKB/TrEMBL
PROSITE	ACYLPHOSPHATASE_1	UniProtKB/TrEMBL
	ACYLPHOSPHATASE_2	UniProtKB/TrEMBL
	ACYLPHOSPHATASE_3	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000006744	RatGTEx
Superfamily-SCOP	Acylphosphatase	UniProtKB/TrEMBL
UniProt	A0A0G2K899	ENTREZGENE, UniProtKB/TrEMBL
	A6JE20	ENTREZGENE, UniProtKB/TrEMBL
	D4A6X4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-01	Acyp1	acylphosphatase 1	Acyp1	acylphosphatase 1, erythrocyte (common) type	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Acyp1	acylphosphatase 1, erythrocyte (common) type	Acyp1_predicted	acylphosphatase 1, erythrocyte (common) type (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Acyp1_predicted	acylphosphatase 1, erythrocyte (common) type (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)