Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | increases expression | ISO | Smtn (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of SMTN mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | affects expression | ISO | Smtn (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of SMTN mRNA | CTD | PMID:17555576 | 17alpha-ethynylestradiol | multiple interactions | ISO | Smtn (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SMTN mRNA | CTD | PMID:17942748 | 17beta-estradiol | multiple interactions | ISO | SMTN (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in increased expression of SMTN mRNA | CTD | PMID:30165855 | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of SMTN mRNA | CTD | PMID:32145629 | 2,2',4,4'-Tetrabromodiphenyl ether | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:27291303 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Smtn (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SMTN mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SMTN mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Smtn (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SMTN mRNA | CTD | PMID:21496263 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | SMTN (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SMTN mRNA | CTD | PMID:21496263 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Smtn (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SMTN mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Smtn (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SMTN mRNA | CTD | PMID:19933214 | 2-butoxyethanol | increases expression | ISO | Smtn (Mus musculus) | 6480464 | n-butoxyethanol results in increased expression of SMTN mRNA | CTD | PMID:19812364 | 3,3',5,5'-tetrabromobisphenol A | increases expression | ISO | Smtn (Mus musculus) | 6480464 | tetrabromobisphenol A results in increased expression of SMTN mRNA | CTD | PMID:25172293 | 4,4'-sulfonyldiphenol | increases expression | ISO | Smtn (Mus musculus) | 6480464 | bisphenol S results in increased expression of SMTN mRNA | CTD | PMID:30951980 | 4-hydroxyphenyl retinamide | increases expression | ISO | Smtn (Mus musculus) | 6480464 | Fenretinide results in increased expression of SMTN mRNA | CTD | PMID:28973697 | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of SMTN mRNA | CTD | PMID:31881176 | acrolein | multiple interactions | ISO | SMTN (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of SMTN mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of SMTN mRNA | CTD | PMID:32699268 | acrylamide | affects expression | EXP | | 6480464 | Acrylamide affects the expression of SMTN mRNA | CTD | PMID:28959563 | afimoxifene | multiple interactions | ISO | SMTN (Homo sapiens) | 6480464 | afimoxifene inhibits the reaction [Estrogens results in decreased expression of SMTN mRNA] | CTD | PMID:21233418 | aflatoxin B1 | affects expression | ISO | SMTN (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of SMTN protein | CTD | PMID:20106945 | aflatoxin B1 | increases expression | ISO | SMTN (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased expression of SMTN mRNA | CTD | PMID:21641981 | alpha-pinene | multiple interactions | ISO | SMTN (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of SMTN mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of SMTN mRNA | CTD | PMID:32699268 | antirheumatic drug | increases expression | ISO | SMTN (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of SMTN mRNA | CTD | PMID:24449571 | aristolochic acid A | increases expression | ISO | SMTN (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of SMTN mRNA and aristolochic acid I results in increased expression of SMTN protein | CTD | PMID:33212167 | avobenzone | increases expression | ISO | SMTN (Homo sapiens) | 6480464 | avobenzone results in increased expression of SMTN mRNA | CTD | PMID:31016361 | benzo[a]pyrene | increases expression | ISO | Smtn (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of SMTN mRNA | CTD | PMID:22228805 | benzo[a]pyrene | increases expression | ISO | SMTN (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of SMTN mRNA | CTD | PMID:32234424 | benzo[a]pyrene | affects methylation | ISO | SMTN (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of SMTN promoter | CTD | PMID:27901495 | benzo[a]pyrene | decreases expression | ISO | Smtn (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of SMTN mRNA | CTD | PMID:23735875 | benzo[a]pyrene | decreases expression | ISO | SMTN (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of SMTN protein | CTD | PMID:32717239 | bis(2-ethylhexyl) phthalate | increases expression | ISO | SMTN (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in increased expression of SMTN mRNA | CTD | PMID:31163220 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of SMTN mRNA | CTD | PMID:25181051 | bisphenol A | decreases expression | ISO | SMTN (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of SMTN mRNA | CTD | PMID:29275510 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SMTN mRNA | CTD | PMID:30816183 more ... | bisphenol F | increases expression | ISO | Smtn (Mus musculus) | 6480464 | bisphenol F results in increased expression of SMTN mRNA | CTD | PMID:30951980 | bleomycin A2 | decreases expression | ISO | Smtn (Mus musculus) | 6480464 | Bleomycin results in decreased expression of SMTN mRNA | CTD | PMID:30825431 | bleomycin A2 | multiple interactions | ISO | Smtn (Mus musculus) | 6480464 | Cannabidiol analog inhibits the reaction [Bleomycin results in decreased expression of SMTN mRNA] and lenabasum inhibits the reaction [Bleomycin results in decreased expression of SMTN mRNA] | CTD | PMID:30825431 | C60 fullerene | increases expression | EXP | | 6480464 | fullerene C60 results in increased expression of SMTN mRNA | CTD | PMID:19167457 | cadmium dichloride | decreases expression | ISO | SMTN (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of SMTN mRNA | CTD | PMID:26472689 | caffeine | affects phosphorylation | ISO | SMTN (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of SMTN protein | CTD | PMID:35688186 | cannabidiol | multiple interactions | ISO | Smtn (Mus musculus) | 6480464 | Cannabidiol analog inhibits the reaction [Bleomycin results in decreased expression of SMTN mRNA] | CTD | PMID:30825431 | chlordecone | increases expression | ISO | Smtn (Mus musculus) | 6480464 | Chlordecone results in increased expression of SMTN mRNA | CTD | PMID:33711761 | chlorpyrifos | decreases expression | ISO | Smtn (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of SMTN mRNA | CTD | PMID:32715474 | chlorpyrifos | increases expression | ISO | Smtn (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of SMTN mRNA | CTD | PMID:37019170 | cisplatin | increases phosphorylation | ISO | Smtn (Mus musculus) | 6480464 | Cisplatin results in increased phosphorylation of SMTN protein | CTD | PMID:22006019 | cisplatin | decreases expression | EXP | | 6480464 | Cisplatin results in decreased expression of SMTN mRNA | CTD | PMID:22023808 | clofibrate | decreases expression | ISO | Smtn (Mus musculus) | 6480464 | Clofibrate results in decreased expression of SMTN mRNA | CTD | PMID:17585979 | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of SMTN mRNA | CTD | PMID:20187946 | copper(II) sulfate | increases expression | ISO | SMTN (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of SMTN mRNA | CTD | PMID:19549813 | coumarin | increases phosphorylation | ISO | SMTN (Homo sapiens) | 6480464 | coumarin results in increased phosphorylation of SMTN protein | CTD | PMID:35688186 | crocidolite asbestos | decreases methylation | ISO | SMTN (Homo sapiens) | 6480464 | Asbestos and Crocidolite results in decreased methylation of SMTN gene | CTD | PMID:29523930 | cyclosporin A | decreases expression | ISO | SMTN (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of SMTN mRNA | CTD | PMID:19159671 | cyclosporin A | increases expression | ISO | SMTN (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of SMTN mRNA | CTD | PMID:25562108 | dibutyl phthalate | increases expression | ISO | Smtn (Mus musculus) | 6480464 | Dibutyl Phthalate results in increased expression of SMTN mRNA | CTD | PMID:21266533 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of SMTN mRNA | CTD | PMID:21266533 | dicrotophos | increases expression | ISO | SMTN (Homo sapiens) | 6480464 | dicrotophos results in increased expression of SMTN mRNA | CTD | PMID:28302478 | diethyl maleate | increases expression | EXP | | 6480464 | diethyl maleate results in increased expression of SMTN mRNA | CTD | PMID:21161181 | diuron | increases expression | EXP | | 6480464 | Diuron results in increased expression of SMTN mRNA | CTD | PMID:21551480 | doxorubicin | decreases expression | ISO | SMTN (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of SMTN mRNA | CTD | PMID:29803840 | elemental selenium | increases expression | ISO | SMTN (Homo sapiens) | 6480464 | Selenium results in increased expression of SMTN mRNA | CTD | PMID:19244175 | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of SMTN mRNA | CTD | PMID:29391264 | ethyl methanesulfonate | increases expression | ISO | SMTN (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of SMTN mRNA | CTD | PMID:23649840 | formaldehyde | increases expression | ISO | SMTN (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of SMTN mRNA | CTD | PMID:23649840 | FR900359 | decreases phosphorylation | ISO | SMTN (Homo sapiens) | 6480464 | FR900359 results in decreased phosphorylation of SMTN protein | CTD | PMID:37730182 | glycidol | increases expression | EXP | | 6480464 | glycidol results in increased expression of SMTN mRNA | CTD | PMID:24915197 | inulin | multiple interactions | ISO | Smtn (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of SMTN mRNA | CTD | PMID:36331819 | isoprenaline | decreases expression | ISO | Smtn (Mus musculus) | 6480464 | Isoproterenol results in decreased expression of SMTN mRNA | CTD | PMID:20003209 | lead diacetate | decreases expression | ISO | Smtn (Mus musculus) | 6480464 | lead acetate results in decreased expression of SMTN mRNA | CTD | PMID:21829687 | methotrexate | affects expression | ISO | Smtn (Mus musculus) | 6480464 | Methotrexate affects the expression of SMTN mRNA | CTD | PMID:18502557 | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of SMTN gene | CTD | PMID:35440735 | methyl methanesulfonate | increases expression | ISO | SMTN (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of SMTN mRNA | CTD | PMID:23649840 | nitrofen | decreases expression | EXP | | 6480464 | nitrofen results in decreased expression of SMTN mRNA | CTD | PMID:33484710 | ozone | multiple interactions | ISO | SMTN (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of SMTN mRNA more ... | CTD | PMID:32699268 | paracetamol | affects expression | ISO | Smtn (Mus musculus) | 6480464 | Acetaminophen affects the expression of SMTN mRNA | CTD | PMID:17562736 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of SMTN mRNA | CTD | PMID:33387578 | paracetamol | increases expression | ISO | SMTN (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of SMTN mRNA | CTD | PMID:22230336 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of SMTN mRNA | CTD | PMID:17202762 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Smtn (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of SMTN mRNA | CTD | PMID:36331819 | phenobarbital | affects expression | ISO | Smtn (Mus musculus) | 6480464 | Phenobarbital affects the expression of SMTN mRNA | CTD | PMID:23091169 | pirinixic acid | decreases expression | ISO | Smtn (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of SMTN mRNA | CTD | PMID:17426115 | progesterone | affects expression | ISO | Smtn (Mus musculus) | 6480464 | Progesterone affects the expression of SMTN mRNA | CTD | PMID:17251523 | progesterone | decreases expression | ISO | SMTN (Homo sapiens) | 6480464 | Progesterone results in decreased expression of SMTN mRNA | CTD | PMID:21795739 | quercetin | increases expression | ISO | SMTN (Homo sapiens) | 6480464 | Quercetin results in increased expression of SMTN mRNA | CTD | PMID:21632981 | quercetin | decreases phosphorylation | ISO | SMTN (Homo sapiens) | 6480464 | Quercetin results in decreased phosphorylation of SMTN protein | CTD | PMID:35688186 | resveratrol | decreases expression | EXP | | 6480464 | resveratrol results in decreased expression of SMTN mRNA | CTD | PMID:20797428 | resveratrol | multiple interactions | ISO | SMTN (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of SMTN mRNA | CTD | PMID:23557933 | selenium atom | increases expression | ISO | SMTN (Homo sapiens) | 6480464 | Selenium results in increased expression of SMTN mRNA | CTD | PMID:19244175 | silicon dioxide | decreases expression | EXP | | 6480464 | Silicon Dioxide results in decreased expression of SMTN mRNA | CTD | PMID:22431001 | silicon dioxide | increases expression | ISO | SMTN (Homo sapiens) | 6480464 | Silicon Dioxide results in increased expression of SMTN mRNA | CTD | PMID:22300531 and PMID:25351596 | sodium arsenite | multiple interactions | ISO | SMTN (Homo sapiens) | 6480464 | sodium arsenite promotes the reaction [H3-3A protein binds to SMTN protein] | CTD | PMID:37734572 | sodium arsenite | increases expression | ISO | SMTN (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of SMTN mRNA | CTD | PMID:28595984 more ... | sunitinib | decreases expression | ISO | SMTN (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of SMTN mRNA | CTD | PMID:31533062 | tamoxifen | affects expression | ISO | Smtn (Mus musculus) | 6480464 | Tamoxifen affects the expression of SMTN mRNA | CTD | PMID:17555576 | temozolomide | decreases expression | ISO | SMTN (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of SMTN mRNA | CTD | PMID:31758290 | tert-butyl hydroperoxide | increases expression | ISO | SMTN (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in increased expression of SMTN mRNA | CTD | PMID:15336504 | tetrachloromethane | increases expression | ISO | Smtn (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of SMTN mRNA | CTD | PMID:31919559 | triptonide | decreases expression | ISO | Smtn (Mus musculus) | 6480464 | triptonide results in decreased expression of SMTN mRNA | CTD | PMID:33045310 | trovafloxacin | decreases expression | ISO | Smtn (Mus musculus) | 6480464 | trovafloxacin results in decreased expression of SMTN mRNA | CTD | PMID:35537566 | urethane | increases expression | ISO | SMTN (Homo sapiens) | 6480464 | Urethane results in increased expression of SMTN mRNA | CTD | PMID:28818685 | vitamin E | increases expression | ISO | SMTN (Homo sapiens) | 6480464 | Vitamin E results in increased expression of SMTN mRNA | CTD | PMID:19244175 | zoledronic acid | decreases expression | ISO | SMTN (Homo sapiens) | 6480464 | zoledronic acid results in decreased expression of SMTN mRNA | CTD | PMID:24714768 | |