Dusp26 (dual specificity phosphatase 26) - Rat Genome Database

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Gene: Dusp26 (dual specificity phosphatase 26) Rattus norvegicus
Analyze
Symbol: Dusp26
Name: dual specificity phosphatase 26
RGD ID: 1310090
Description: Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; p53 binding activity; and phosphoprotein phosphatase activity. Predicted to be involved in negative regulation of ERK1 and ERK2 cascade; negative regulation of transcription by RNA polymerase II; and positive regulation of cell adhesion. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human DUSP26 (dual specificity phosphatase 26); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dual specificity phosphatase 26 (putative); dual specificity protein phosphatase 26; LOC306527; MGC109288; RGD1310090; similar to 2310043K02Rik protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81667,744,830 - 67,752,673 (-)NCBIGRCr8
mRatBN7.21661,041,784 - 61,049,319 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1661,041,792 - 61,049,051 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1666,357,195 - 66,364,502 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01669,771,709 - 69,779,012 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01664,998,081 - 65,005,413 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01664,798,782 - 64,806,459 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1664,798,778 - 64,806,050 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01664,455,731 - 64,463,284 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41664,952,300 - 64,959,604 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11664,952,379 - 64,959,679 (-)NCBI
Celera1659,046,361 - 59,053,665 (-)NCBICelera
Cytogenetic Map16q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
Golgi apparatus  (ISO)
nucleoplasm  (IEA,ISO)
nucleus  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15796912   PMID:16581800   PMID:18614015   PMID:19043453   PMID:19056867   PMID:20562916  


Genomics

Comparative Map Data
Dusp26
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81667,744,830 - 67,752,673 (-)NCBIGRCr8
mRatBN7.21661,041,784 - 61,049,319 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1661,041,792 - 61,049,051 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1666,357,195 - 66,364,502 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01669,771,709 - 69,779,012 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01664,998,081 - 65,005,413 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01664,798,782 - 64,806,459 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1664,798,778 - 64,806,050 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01664,455,731 - 64,463,284 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41664,952,300 - 64,959,604 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11664,952,379 - 64,959,679 (-)NCBI
Celera1659,046,361 - 59,053,665 (-)NCBICelera
Cytogenetic Map16q12.3NCBI
DUSP26
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38833,591,330 - 33,600,023 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl833,591,330 - 33,600,023 (-)EnsemblGRCh38hg38GRCh38
GRCh37833,448,848 - 33,457,541 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36833,568,393 - 33,576,981 (-)NCBINCBI36Build 36hg18NCBI36
Celera832,398,523 - 32,407,113 (-)NCBICelera
Cytogenetic Map8p12NCBI
HuRef831,980,747 - 31,988,923 (-)NCBIHuRef
CHM1_1833,650,334 - 33,658,924 (-)NCBICHM1_1
T2T-CHM13v2.0833,862,584 - 33,871,277 (-)NCBIT2T-CHM13v2.0
Dusp26
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39831,579,555 - 31,587,074 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl831,579,499 - 31,587,075 (+)EnsemblGRCm39 Ensembl
GRCm38831,089,527 - 31,097,046 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl831,089,471 - 31,097,047 (+)EnsemblGRCm38mm10GRCm38
MGSCv37832,200,134 - 32,207,519 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36832,555,597 - 32,562,982 (+)NCBIMGSCv36mm8
Celera832,614,701 - 32,622,121 (+)NCBICelera
Cytogenetic Map8A3NCBI
cM Map817.93NCBI
Dusp26
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554639,712,954 - 9,718,959 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554639,712,943 - 9,718,959 (-)NCBIChiLan1.0ChiLan1.0
DUSP26
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2752,166,122 - 52,174,877 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1827,881,863 - 27,890,613 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0832,906,182 - 32,915,015 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1830,091,084 - 30,100,699 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl830,091,092 - 30,100,699 (-)Ensemblpanpan1.1panPan2
DUSP26
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11631,115,317 - 31,122,767 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1631,115,475 - 31,132,033 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1631,638,685 - 31,647,937 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01633,140,928 - 33,146,814 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1633,141,000 - 33,147,846 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11631,237,257 - 31,246,487 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01631,816,290 - 31,822,141 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01631,854,968 - 31,864,230 (+)NCBIUU_Cfam_GSD_1.0
Dusp26
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494354,103,079 - 54,109,849 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936766363,029 - 370,281 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936766363,172 - 370,234 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUSP26
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.21559,480,305 - 59,486,816 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DUSP26
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1831,667,984 - 31,679,040 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl831,666,691 - 31,679,058 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605210,369,786 - 10,378,220 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dusp26
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478010,368,975 - 10,375,215 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478010,368,988 - 10,376,731 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dusp26
63 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:92
Count of miRNA genes:75
Interacting mature miRNAs:90
Transcripts:ENSRNOT00000015725
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat

Markers in Region
UniSTS:235863  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21661,041,806 - 61,042,065 (+)MAPPERmRatBN7.2
Rnor_6.01664,798,805 - 64,799,063NCBIRnor6.0
Rnor_5.01664,455,754 - 64,456,012UniSTSRnor5.0
RGSC_v3.41664,952,320 - 64,952,578UniSTSRGSC3.4
Celera1659,046,381 - 59,046,639UniSTS
Cytogenetic Map16q12.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 9 62 3 2 6
Low 1 31 3 4 2 2 10 12 28 9 2
Below cutoff 2 10 46 33 15 33 2 21 10

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015725   ⟹   ENSRNOP00000015725
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1661,041,792 - 61,049,051 (-)Ensembl
Rnor_6.0 Ensembl1664,798,778 - 64,806,050 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1664,799,459 - 64,804,127 (-)Ensembl
RefSeq Acc Id: NM_001012352   ⟹   NP_001012352
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81667,744,837 - 67,752,101 (-)NCBI
mRatBN7.21661,041,787 - 61,049,051 (-)NCBI
Rnor_6.01664,798,785 - 64,806,050 (-)NCBI
Rnor_5.01664,455,731 - 64,463,284 (-)NCBI
RGSC_v3.41664,952,300 - 64,959,604 (-)RGD
Celera1659,046,361 - 59,053,665 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253232   ⟹   XP_006253294
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81667,744,830 - 67,752,673 (-)NCBI
mRatBN7.21661,041,784 - 61,049,319 (-)NCBI
Rnor_6.01664,798,782 - 64,806,459 (-)NCBI
Rnor_5.01664,455,731 - 64,463,284 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001012352 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253294 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH89954 (Get FASTA)   NCBI Sequence Viewer  
  EDM09110 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015725
  ENSRNOP00000015725.4
  ENSRNOP00055016775
  ENSRNOP00060015775
GenBank Protein Q5FVI9 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001012352   ⟸   NM_001012352
- UniProtKB: Q5FVI9 (UniProtKB/Swiss-Prot),   A6IVW2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253294   ⟸   XM_006253232
- Peptide Label: isoform X1
- UniProtKB: Q5FVI9 (UniProtKB/Swiss-Prot),   A6IVW2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015725   ⟸   ENSRNOT00000015725
Protein Domains
Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5FVI9-F1-model_v2 AlphaFold Q5FVI9 1-211 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310090 AgrOrtholog
BioCyc Gene G2FUF-11084 BioCyc
Ensembl Genes ENSRNOG00000011518 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055012224 UniProtKB/Swiss-Prot
  ENSRNOG00060011882 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015725 ENTREZGENE
  ENSRNOT00000015725.8 UniProtKB/Swiss-Prot
  ENSRNOT00055020791 UniProtKB/Swiss-Prot
  ENSRNOT00060020102 UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7312637 IMAGE-MGC_LOAD
InterPro Atypical_DUSP_famA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dual-sp_phosphatase_cat-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_dom UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:306527 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:109288 IMAGE-MGC_LOAD
NCBI Gene 306527 ENTREZGENE
PANTHER AGAP008228-PA UniProtKB/TrEMBL
  DUAL SPECIFICITY PROTEIN PHOSPHATASE 26 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45682 UniProtKB/Swiss-Prot
Pfam DSPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dusp26 PhenoGen
PRINTS ADSPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADSPHPHTASEA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011518 RatGTEx
  ENSRNOG00055012224 RatGTEx
  ENSRNOG00060011882 RatGTEx
SMART DSPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP (Phosphotyrosine protein) phosphatases II UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6IVW2 ENTREZGENE, UniProtKB/TrEMBL
  DUS26_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-12-15 Dusp26  dual specificity phosphatase 26  Dusp26  dual specificity phosphatase 26 (putative)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-27 Dusp26  dual specificity phosphatase 26 (putative)  RGD1310090  similar to 2310043K02Rik protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1310090  similar to 2310043K02Rik protein  RGD1310090_predicted  similar to 2310043K02Rik protein (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1310090_predicted  similar to 2310043K02Rik protein (predicted)  LOC306527_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC306527_predicted  similar to 2310043K02Rik protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL