Uba7 (ubiquitin-like modifier activating enzyme 7) - Rat Genome Database

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Gene: Uba7 (ubiquitin-like modifier activating enzyme 7) Rattus norvegicus
Analyze
Symbol: Uba7
Name: ubiquitin-like modifier activating enzyme 7
RGD ID: 1308323
Description: Predicted to enable ISG15 activating enzyme activity and ubiquitin-protein transferase activity. Predicted to be involved in DNA damage response; ISG15-protein conjugation; and innate immune response. Predicted to act upstream of or within modification-dependent protein catabolic process. Predicted to be active in cytoplasm. Orthologous to human UBA7 (ubiquitin like modifier activating enzyme 7); PARTICIPATES IN Parkinson's disease pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC301000; Ube1l; ubiquitin-activating enzyme E1-like; ubiquitin-like modifier-activating enzyme 7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,543,902 - 117,552,709 (+)NCBIGRCr8
mRatBN7.28108,665,289 - 108,674,097 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,665,292 - 108,674,099 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8114,291,762 - 114,300,571 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,491,085 - 112,499,894 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08110,333,725 - 110,342,534 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,754,178 - 116,766,765 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,754,178 - 116,764,126 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,108,502 - 116,121,088 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48113,244,829 - 113,253,636 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18113,264,139 - 113,272,984 (+)NCBI
Celera8107,969,920 - 107,978,739 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
chloroprene  (EXP)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (EXP)
dioxygen  (EXP)
diquat  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
ethylparaben  (ISO)
fenthion  (ISO)
fenvalerate  (EXP)
furan  (EXP)
glycidyl methacrylate  (ISO)
hydrogen peroxide  (ISO)
iron dichloride  (ISO)
lead diacetate  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
methidathion  (ISO)
N-acetyl-L-cysteine  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
paraquat  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
selenium atom  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sotorasib  (ISO)
succimer  (ISO)
sulindac sulfide  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trametinib  (ISO)
triclosan  (ISO)
Triptolide  (EXP)
urethane  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15485925   PMID:16139798   PMID:16382139   PMID:16428300   PMID:18583345   PMID:19073728  


Genomics

Comparative Map Data
Uba7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,543,902 - 117,552,709 (+)NCBIGRCr8
mRatBN7.28108,665,289 - 108,674,097 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,665,292 - 108,674,099 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8114,291,762 - 114,300,571 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,491,085 - 112,499,894 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08110,333,725 - 110,342,534 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,754,178 - 116,766,765 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,754,178 - 116,764,126 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,108,502 - 116,121,088 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48113,244,829 - 113,253,636 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18113,264,139 - 113,272,984 (+)NCBI
Celera8107,969,920 - 107,978,739 (+)NCBICelera
Cytogenetic Map8q32NCBI
UBA7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38349,805,209 - 49,813,953 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl349,805,209 - 49,813,953 (-)EnsemblGRCh38hg38GRCh38
GRCh37349,842,642 - 49,851,386 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,817,642 - 49,826,395 (-)NCBINCBI36Build 36hg18NCBI36
Build 34349,817,642 - 49,826,395NCBI
Celera349,808,165 - 49,816,714 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef349,901,687 - 49,910,450 (-)NCBIHuRef
CHM1_1349,794,699 - 49,803,452 (-)NCBICHM1_1
T2T-CHM13v2.0349,835,086 - 49,843,840 (-)NCBIT2T-CHM13v2.0
Uba7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,852,766 - 107,861,255 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9107,852,704 - 107,861,259 (+)EnsemblGRCm39 Ensembl
GRCm389107,975,567 - 107,984,056 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,975,505 - 107,984,060 (+)EnsemblGRCm38mm10GRCm38
MGSCv379107,877,898 - 107,886,387 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369107,833,668 - 107,842,157 (+)NCBIMGSCv36mm8
Celera9107,583,980 - 107,592,467 (+)NCBICelera
Cytogenetic Map9F1NCBI
cM Map959.07NCBI
Uba7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555321,695,956 - 1,706,676 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555321,697,667 - 1,706,668 (-)NCBIChiLan1.0ChiLan1.0
UBA7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2249,791,441 - 49,800,294 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1349,796,214 - 49,805,018 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0349,737,015 - 49,745,783 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1350,973,211 - 50,981,997 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl350,973,211 - 50,981,997 (-)Ensemblpanpan1.1panPan2
UBA7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,459,981 - 39,468,919 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,460,216 - 39,468,917 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2039,380,946 - 39,389,763 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02039,816,971 - 39,825,794 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2039,816,974 - 39,838,844 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12039,184,003 - 39,192,827 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02039,588,249 - 39,597,062 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02039,867,799 - 39,876,629 (+)NCBIUU_Cfam_GSD_1.0
Uba7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560264,651,699 - 64,660,747 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365291,412,194 - 1,421,197 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365291,412,196 - 1,421,216 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UBA7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1332,332,367 - 32,341,217 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11332,330,536 - 32,341,300 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,509,800 - 35,520,514 (-)NCBISscrofa10.2Sscrofa10.2susScr3
UBA7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12211,208,744 - 11,217,834 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2211,207,417 - 11,217,734 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041155,780,703 - 155,789,500 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Uba7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247303,718,573 - 3,730,097 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247303,720,516 - 3,729,586 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Uba7
29 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:148
Count of miRNA genes:101
Interacting mature miRNAs:117
Transcripts:ENSRNOT00000068295
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
631217Activ1Activity QTL 115.9voluntary movement trait (VT:0003491)number of photobeam interruptions in an experimental apparatus (CMO:0001517)8102370617108923645Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 11 5 10
Low 3 43 55 41 8 41 8 11 68 35 32 1 8
Below cutoff 6 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000068295   ⟹   ENSRNOP00000062984
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8108,665,292 - 108,674,099 (+)Ensembl
Rnor_6.0 Ensembl8116,754,178 - 116,762,985 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000084429   ⟹   ENSRNOP00000074046
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8108,665,356 - 108,674,084 (+)Ensembl
Rnor_6.0 Ensembl8116,754,205 - 116,764,126 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000097917   ⟹   ENSRNOP00000081578
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8108,665,292 - 108,674,099 (+)Ensembl
RefSeq Acc Id: NM_001393920   ⟹   NP_001380849
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,543,902 - 117,552,709 (+)NCBI
mRatBN7.28108,665,290 - 108,674,097 (+)NCBI
RefSeq Acc Id: XM_006243741   ⟹   XP_006243803
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,543,906 - 117,552,705 (+)NCBI
mRatBN7.28108,665,291 - 108,674,097 (+)NCBI
Rnor_6.08116,754,226 - 116,762,986 (+)NCBI
Rnor_5.08116,108,502 - 116,121,088 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039081230   ⟹   XP_038937158
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,543,906 - 117,552,705 (+)NCBI
mRatBN7.28108,665,289 - 108,674,097 (+)NCBI
RefSeq Acc Id: XM_039081231   ⟹   XP_038937159
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,543,906 - 117,552,705 (+)NCBI
mRatBN7.28108,665,290 - 108,674,097 (+)NCBI
RefSeq Acc Id: XM_039081232   ⟹   XP_038937160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,544,216 - 117,552,705 (+)NCBI
mRatBN7.28108,665,601 - 108,674,097 (+)NCBI
RefSeq Acc Id: XM_039081233   ⟹   XP_038937161
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,543,906 - 117,549,897 (+)NCBI
mRatBN7.28108,665,289 - 108,671,283 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_006243803   ⟸   XM_006243741
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K735 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074046   ⟸   ENSRNOT00000084429
RefSeq Acc Id: ENSRNOP00000062984   ⟸   ENSRNOT00000068295
RefSeq Acc Id: XP_038937158   ⟸   XM_039081230
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038937161   ⟸   XM_039081233
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038937159   ⟸   XM_039081231
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038937160   ⟸   XM_039081232
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000081578   ⟸   ENSRNOT00000097917
RefSeq Acc Id: NP_001380849   ⟸   NM_001393920
- UniProtKB: A0A0G2K735 (UniProtKB/TrEMBL)
Protein Domains
THIF-type NAD/FAD binding fold   Ubiquitin-activating enzyme E1 C-terminal   Ubiquitin-activating enzyme E1 FCCH   Ubiquitin-activating enzyme E1 four-helix bundle   Ubiquitin-activating enzyme SCCH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K735-F1-model_v2 AlphaFold A0A0G2K735 1-989 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696307
Promoter ID:EPDNEW_R6810
Type:multiple initiation site
Name:Uba7_1
Description:ubiquitin-like modifier activating enzyme 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08116,754,237 - 116,754,297EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308323 AgrOrtholog
BioCyc Gene G2FUF-29165 BioCyc
BioCyc Pathway PWY-7511 [protein ubiquitination] BioCyc
BioCyc Pathway Image PWY-7511 BioCyc
Ensembl Genes ENSRNOG00000029195 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068295.3 UniProtKB/TrEMBL
  ENSRNOT00000084429 ENTREZGENE
  ENSRNOT00000084429.2 UniProtKB/TrEMBL
  ENSRNOT00000097917.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.2660 UniProtKB/TrEMBL
  1.10.10.520 UniProtKB/TrEMBL
  2.40.30.180 UniProtKB/TrEMBL
  3.10.290.60 UniProtKB/TrEMBL
  3.50.50.80 UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
  Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2 UniProtKB/TrEMBL
InterPro E1_4HB UniProtKB/TrEMBL
  E1_FCCH UniProtKB/TrEMBL
  E1_FCCH_sf UniProtKB/TrEMBL
  ThiF/MoeB/HesA UniProtKB/TrEMBL
  ThiF_NAD_FAD-bd UniProtKB/TrEMBL
  Ub-activating_enz_e1_C UniProtKB/TrEMBL
  Ub-E1_IAD_1 UniProtKB/TrEMBL
  Ub_act_enz_dom_a_sf UniProtKB/TrEMBL
  UBA_E1_C_sf UniProtKB/TrEMBL
  Ubi_acti_E1_SCCH UniProtKB/TrEMBL
  Ubiquitin-activating_enz UniProtKB/TrEMBL
  Ubiquitin-activating_enzyme UniProtKB/TrEMBL
  UBQ-activ_enz_E1 UniProtKB/TrEMBL
  UBQ-activ_enz_E1-like UniProtKB/TrEMBL
  UBQ-activ_enz_E1_Cys_AS UniProtKB/TrEMBL
KEGG Report rno:301000 UniProtKB/TrEMBL
NCBI Gene 301000 ENTREZGENE
PANTHER PTHR10953 UniProtKB/TrEMBL
  UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 7 UniProtKB/TrEMBL
Pfam E1_4HB UniProtKB/TrEMBL
  E1_FCCH UniProtKB/TrEMBL
  E1_UFD UniProtKB/TrEMBL
  ThiF UniProtKB/TrEMBL
  UBA_e1_thiolCys UniProtKB/TrEMBL
PhenoGen Uba7 PhenoGen
PRINTS UBIQUITINACT UniProtKB/TrEMBL
PROSITE UBIQUITIN_ACTIVAT_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029195 RatGTEx
SMART UBA_e1_C UniProtKB/TrEMBL
Superfamily-SCOP MoeB UniProtKB/TrEMBL
UniProt A0A0G2K735 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G652_RAT UniProtKB/TrEMBL
  D3ZEU5_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-11 Uba7  ubiquitin-like modifier activating enzyme 7  Ube1l  ubiquitin-activating enzyme E1-like   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ube1l  ubiquitin-activating enzyme E1-like   Ube1l_predicted  ubiquitin-activating enzyme E1-like (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ube1l_predicted  ubiquitin-activating enzyme E1-like (predicted)      Symbol and Name status set to approved 70820 APPROVED