Ppp2r5a (protein phosphatase 2, regulatory subunit B', alpha) - Rat Genome Database

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Gene: Ppp2r5a (protein phosphatase 2, regulatory subunit B', alpha) Rattus norvegicus
Analyze
Symbol: Ppp2r5a
Name: protein phosphatase 2, regulatory subunit B', alpha
RGD ID: 1308022
Description: Predicted to enable kinase binding activity; phosphoprotein phosphatase activity; and protein phosphatase activator activity. Predicted to be involved in negative regulation of protein localization to plasma membrane and positive regulation of protein dephosphorylation. Predicted to be located in centrosome; plasma membrane; and sarcomere. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. Orthologous to human PPP2R5A (protein phosphatase 2 regulatory subunit B'alpha); PARTICIPATES IN Wnt signaling, canonical pathway; mRNA decay pathway; Wnt signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC312754; protein phosphatase 2, regulatory subunit B (B56), alpha isoform; protein phosphatase 2, regulatory subunit B', alpha isoform; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813105,462,371 - 105,506,767 (-)NCBIGRCr8
mRatBN7.213102,931,264 - 102,975,661 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13102,931,264 - 102,975,661 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13105,451,304 - 105,495,698 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013106,835,157 - 106,879,551 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013104,050,237 - 104,094,632 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013110,033,550 - 110,077,946 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13110,033,550 - 110,077,946 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013114,599,131 - 114,643,527 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413107,413,761 - 107,458,156 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113107,602,873 - 107,647,661 (-)NCBI
Celera13102,370,409 - 102,414,549 (-)NCBICelera
Cytogenetic Map13q27NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15569306   PMID:17245430   PMID:17416611   PMID:17700073   PMID:18782775   PMID:19131648   PMID:21075214   PMID:24157919  


Genomics

Comparative Map Data
Ppp2r5a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813105,462,371 - 105,506,767 (-)NCBIGRCr8
mRatBN7.213102,931,264 - 102,975,661 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13102,931,264 - 102,975,661 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13105,451,304 - 105,495,698 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013106,835,157 - 106,879,551 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013104,050,237 - 104,094,632 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013110,033,550 - 110,077,946 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13110,033,550 - 110,077,946 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013114,599,131 - 114,643,527 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413107,413,761 - 107,458,156 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113107,602,873 - 107,647,661 (-)NCBI
Celera13102,370,409 - 102,414,549 (-)NCBICelera
Cytogenetic Map13q27NCBI
PPP2R5A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381212,285,410 - 212,361,853 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1212,285,410 - 212,361,853 (+)EnsemblGRCh38hg38GRCh38
GRCh371212,458,752 - 212,535,195 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361210,525,502 - 210,601,828 (+)NCBINCBI36Build 36hg18NCBI36
Build 341208,847,273 - 208,923,599NCBI
Celera1185,685,982 - 185,760,829 (+)NCBICelera
Cytogenetic Map1q32.3NCBI
HuRef1183,135,716 - 183,210,570 (+)NCBIHuRef
CHM1_11213,731,558 - 213,808,070 (+)NCBICHM1_1
T2T-CHM13v2.01211,531,574 - 211,606,538 (+)NCBIT2T-CHM13v2.0
Ppp2r5a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391191,084,178 - 191,129,238 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1191,084,172 - 191,135,469 (-)EnsemblGRCm39 Ensembl
GRCm381191,351,981 - 191,397,041 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1191,351,975 - 191,403,272 (-)EnsemblGRCm38mm10GRCm38
MGSCv371193,175,860 - 193,220,920 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361193,052,596 - 193,097,656 (-)NCBIMGSCv36mm8
Celera1198,282,109 - 198,324,528 (-)NCBICelera
Cytogenetic Map1H6NCBI
cM Map196.28NCBI
Ppp2r5a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554065,059,826 - 5,115,312 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554065,059,826 - 5,115,312 (-)NCBIChiLan1.0ChiLan1.0
PPP2R5A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2137,044,737 - 37,117,393 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1137,009,226 - 37,081,877 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01187,853,674 - 187,926,318 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11192,716,546 - 192,788,328 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1192,716,546 - 192,788,328 (+)Ensemblpanpan1.1panPan2
PPP2R5A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1710,502,959 - 10,566,475 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl710,502,930 - 10,565,404 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha710,078,569 - 10,141,787 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0710,208,302 - 10,272,200 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl710,208,105 - 10,272,195 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1710,131,806 - 10,195,013 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0710,233,111 - 10,296,331 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0710,356,575 - 10,419,810 (+)NCBIUU_Cfam_GSD_1.0
Ppp2r5a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934463,903,654 - 63,969,401 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365571,143,101 - 1,209,807 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365571,143,936 - 1,209,719 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP2R5A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9131,003,903 - 131,076,338 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19131,003,903 - 131,075,803 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29144,051,576 - 144,124,384 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPP2R5A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12517,163,429 - 17,237,519 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2517,162,544 - 17,237,524 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605517,663,928 - 17,738,158 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp2r5a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477117,810,733 - 17,865,689 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppp2r5a
289 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:400
Count of miRNA genes:234
Interacting mature miRNAs:280
Transcripts:ENSRNOT00000000078
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat

Markers in Region
AA800651  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.213102,931,419 - 102,931,616 (+)MAPPERmRatBN7.2
mRatBN7.24162,232,974 - 162,233,171 (+)MAPPERmRatBN7.2
Rnor_6.013110,033,706 - 110,033,902NCBIRnor6.0
Rnor_6.04162,296,328 - 162,296,524NCBIRnor6.0
Rnor_5.013114,599,287 - 114,599,483UniSTSRnor5.0
Rnor_5.04227,494,546 - 227,494,742UniSTSRnor5.0
RGSC_v3.44166,002,483 - 166,002,679UniSTSRGSC3.4
RGSC_v3.413107,413,917 - 107,414,113UniSTSRGSC3.4
Celera13102,370,565 - 102,370,761UniSTS
Celera4150,931,753 - 150,931,949UniSTS
RH 3.4 Map13726.5UniSTS
Cytogenetic Map4q42UniSTS
Cytogenetic Map13q27UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 36 11 8
Low 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000000078   ⟹   ENSRNOP00000000078
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl13102,931,264 - 102,975,661 (-)Ensembl
Rnor_6.0 Ensembl13110,033,550 - 110,077,946 (-)Ensembl
RefSeq Acc Id: NM_001107891   ⟹   NP_001101361
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813105,462,371 - 105,506,767 (-)NCBI
mRatBN7.213102,931,264 - 102,975,661 (-)NCBI
Rnor_6.013110,033,550 - 110,077,946 (-)NCBI
Rnor_5.013114,599,131 - 114,643,527 (-)NCBI
RGSC_v3.413107,413,761 - 107,458,156 (-)RGD
Celera13102,370,409 - 102,414,549 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001101361 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL95003 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000000078
  ENSRNOP00000000078.4
Reference Protein Sequences
RefSeq Acc Id: NP_001101361   ⟸   NM_001107891
- UniProtKB: D3ZDI7 (UniProtKB/TrEMBL),   A6JGZ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000000078   ⟸   ENSRNOT00000000078

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZDI7-F1-model_v2 AlphaFold D3ZDI7 1-486 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699117
Promoter ID:EPDNEW_R9641
Type:initiation region
Name:Ppp2r5a_1
Description:protein phosphatase 2, regulatory subunit B', alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.013110,077,964 - 110,078,024EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308022 AgrOrtholog
BioCyc Gene G2FUF-16845 BioCyc
Ensembl Genes ENSRNOG00000000068 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000078 ENTREZGENE
  ENSRNOT00000000078.6 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  PP2A_B56 UniProtKB/TrEMBL
KEGG Report rno:312754 UniProtKB/TrEMBL
NCBI Gene 312754 ENTREZGENE
PANTHER B56 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM UniProtKB/TrEMBL
Pfam B56 UniProtKB/TrEMBL
PhenoGen Ppp2r5a PhenoGen
PIRSF PP2A_B56 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000068 RatGTEx
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
UniProt A6JGZ7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZDI7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Ppp2r5a  protein phosphatase 2, regulatory subunit B', alpha  Ppp2r5a  protein phosphatase 2, regulatory subunit B', alpha isoform  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-12-15 Ppp2r5a  protein phosphatase 2, regulatory subunit B', alpha isoform  Ppp2r5a  protein phosphatase 2, regulatory subunit B (B56), alpha isoform   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ppp2r5a  protein phosphatase 2, regulatory subunit B (B56), alpha isoform   Ppp2r5a_predicted  protein phosphatase 2, regulatory subunit B (B56), alpha isoform (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ppp2r5a_predicted  protein phosphatase 2, regulatory subunit B (B56), alpha isoform (predicted)      Symbol and Name status set to approved 70820 APPROVED