Bag3 (BAG cochaperone 3) - Rat Genome Database

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Gene: Bag3 (BAG cochaperone 3) Rattus norvegicus
Analyze
Symbol: Bag3
Name: BAG cochaperone 3
RGD ID: 1307794
Description: Predicted to enable adenyl-nucleotide exchange factor activity and protein-folding chaperone binding activity. Involved in negative regulation of apoptotic process; negative regulation of protein targeting to mitochondrion; and spinal cord development. Predicted to be located in Z disc and nucleoplasm. Predicted to be part of protein folding chaperone complex. Predicted to be active in cytosol; membrane; and nucleus. Used to study glioblastoma. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1HH and myofibrillar myopathy 6. Orthologous to human BAG3 (BAG cochaperone 3); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BAG family molecular chaperone regulator 3; Bcl2-associated athanogene 3; LOC293524
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81192,533,460 - 192,557,281 (+)NCBIGRCr8
mRatBN7.21183,103,038 - 183,126,862 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1183,102,871 - 183,126,858 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1191,453,498 - 191,477,319 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01198,639,582 - 198,663,403 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01191,309,832 - 191,333,624 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,941,258 - 199,965,191 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,941,161 - 199,965,191 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,989,244 - 207,013,177 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,781,147 - 187,804,835 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11187,931,027 - 187,954,715 (+)NCBI
Celera1180,749,355 - 180,773,125 (+)NCBICelera
Cytogenetic Map1q37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2-methoxyethanol  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
ABT-737  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
albendazole  (ISO)
all-trans-retinoic acid  (ISO)
alpha,alpha-trehalose  (ISO)
amiodarone  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
beta-carotene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
Brevetoxin B  (ISO)
Brodifacoum  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
celastrol  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dicrotophos  (ISO)
Dictamnine  (ISO)
dieldrin  (EXP)
dioxygen  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elesclomol  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
fenamidone  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
gedunin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (EXP,ISO)
hydrogen chloride  (ISO)
imidacloprid  (EXP)
ivermectin  (ISO)
kainic acid  (EXP)
ketamine  (EXP)
lactulose  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
melibiose  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metacetamol  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
morphine  (EXP)
motexafin gadolinium  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
nickel dichloride  (EXP)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
p-chloromercuribenzoic acid  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
pyrethrins  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
staurosporine  (ISO)
sulforaphane  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thiabendazole  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
Triptolide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
cytosol  (IBA,ISO)
membrane  (IBA)
nucleoplasm  (ISO)
nucleus  (IBA,ISO)
protein folding chaperone complex  (ISO)
Z disc  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification of a synaptosome-associated form of BAG3 protein. Bruno AP, etal., Cell Cycle. 2008 Oct;7(19):3104-5. Epub 2008 Oct 12.
2. Transient expression of Bis protein in midline radial glia in developing rat brainstem and spinal cord. Choi JS, etal., Cell Tissue Res. 2009 Jul;337(1):27-36. Epub 2009 May 5.
3. BAG3 protein is overexpressed in human glioblastoma and is a potential target for therapy. Festa M, etal., Am J Pathol. 2011 Jun;178(6):2504-12. Epub 2011 May 10.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Induction of Bis, a Bcl-2-binding protein, in reactive astrocytes of the rat hippocampus following kainic acid-induced seizure. Lee MY, etal., Exp Mol Med. 2002 May 31;34(2):167-71.
7. Reactive astrocytes express bis, a bcl-2-binding protein, after transient forebrain ischemia. Lee MY, etal., Exp Neurol. 2002 Jun;175(2):338-46.
8. The anti-apoptotic protein BAG-3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines. Liao Q, etal., FEBS Lett. 2001 Aug 17;503(2-3):151-7.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy. Ulbricht A, etal., Curr Biol. 2013 Mar 4;23(5):430-5. doi: 10.1016/j.cub.2013.01.064. Epub 2013 Feb 21.
Additional References at PubMed
PMID:10597216   PMID:11527400   PMID:12477932   PMID:16936253   PMID:18006506   PMID:19085932   PMID:20060297   PMID:20599823   PMID:20884878   PMID:20962586   PMID:22366786   PMID:24318877  
PMID:24675892   PMID:25212465   PMID:25468996   PMID:25904010   PMID:26159920   PMID:27381181   PMID:27383426   PMID:27756573   PMID:28144784   PMID:28755400   PMID:28941726   PMID:29484366  
PMID:30326144   PMID:30631036   PMID:30744518   PMID:30932190   PMID:31114002   PMID:31209204   PMID:33578031   PMID:33989081   PMID:34162039   PMID:34379447   PMID:35253089   PMID:35352799  
PMID:37899687   PMID:38488519  


Genomics

Comparative Map Data
Bag3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81192,533,460 - 192,557,281 (+)NCBIGRCr8
mRatBN7.21183,103,038 - 183,126,862 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1183,102,871 - 183,126,858 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1191,453,498 - 191,477,319 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01198,639,582 - 198,663,403 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01191,309,832 - 191,333,624 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,941,258 - 199,965,191 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,941,161 - 199,965,191 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,989,244 - 207,013,177 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,781,147 - 187,804,835 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11187,931,027 - 187,954,715 (+)NCBI
Celera1180,749,355 - 180,773,125 (+)NCBICelera
Cytogenetic Map1q37NCBI
BAG3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810119,651,380 - 119,677,819 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10119,651,380 - 119,677,819 (+)EnsemblGRCh38hg38GRCh38
GRCh3710121,410,892 - 121,437,331 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610121,400,872 - 121,427,321 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410121,400,871 - 121,427,317NCBI
Celera10115,141,910 - 115,168,393 (+)NCBICelera
Cytogenetic Map10q26.11NCBI
HuRef10115,040,288 - 115,066,931 (+)NCBIHuRef
CHM1_110121,695,782 - 121,722,250 (+)NCBICHM1_1
T2T-CHM13v2.010120,548,963 - 120,575,488 (+)NCBIT2T-CHM13v2.0
Bag3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397128,125,307 - 128,148,705 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7128,125,340 - 128,148,705 (+)EnsemblGRCm39 Ensembl
GRCm387128,523,583 - 128,546,981 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7128,523,616 - 128,546,981 (+)EnsemblGRCm38mm10GRCm38
MGSCv377135,667,097 - 135,690,495 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367128,314,764 - 128,355,703 (+)NCBIMGSCv36mm8
Celera7128,367,952 - 128,391,279 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map770.26NCBI
Bag3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955551446,605 - 469,207 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955551446,322 - 468,329 (+)NCBIChiLan1.0ChiLan1.0
BAG3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28131,509,777 - 131,536,781 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110131,515,147 - 131,541,828 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010116,221,747 - 116,248,692 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110119,654,366 - 119,665,964 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10119,643,963 - 119,665,964 (+)Ensemblpanpan1.1panPan2
BAG3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12829,792,612 - 29,815,466 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2829,792,777 - 29,815,138 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2829,934,645 - 29,957,491 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02830,323,229 - 30,346,844 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2830,322,795 - 30,346,516 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12829,876,932 - 29,899,733 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02829,897,755 - 29,920,635 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02830,092,215 - 30,115,061 (+)NCBIUU_Cfam_GSD_1.0
Bag3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721316,553,837 - 16,575,442 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364868,985,761 - 9,007,502 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364868,985,871 - 9,007,461 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BAG3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14129,466,905 - 129,533,987 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114129,510,240 - 129,533,998 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214141,034,569 - 141,058,597 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BAG3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19112,439,954 - 112,465,875 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9112,439,782 - 112,466,086 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604873,714,873 - 73,741,128 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bag3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473727,171,402 - 27,195,004 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473727,171,402 - 27,195,008 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bag3
172 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:87
Count of miRNA genes:74
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000027616
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1174133260196383668Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
61378Bp43Blood pressure QTL 4322.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1181746937196383668Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169112897197261052Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2325725Eae31Experimental allergic encephalomyelitis QTL 31nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1178810256188377506Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat

Markers in Region
AW532391  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,102,664 - 183,102,854 (+)MAPPERmRatBN7.2
Rnor_6.01199,940,885 - 199,941,074NCBIRnor6.0
Rnor_5.01206,988,871 - 206,989,060UniSTSRnor5.0
RGSC_v3.41187,780,774 - 187,780,963UniSTSRGSC3.4
Celera1180,748,982 - 180,749,171UniSTS
RH 3.4 Map11384.7UniSTS
Cytogenetic Map1q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 7 7 3 7 7 10 8 15 24 3 7
Low 50 34 16 34 1 1 66 20 17 8 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000027616   ⟹   ENSRNOP00000027616
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1183,102,871 - 183,126,858 (+)Ensembl
Rnor_6.0 Ensembl1199,941,161 - 199,965,191 (+)Ensembl
RefSeq Acc Id: NM_001011936   ⟹   NP_001011936
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81192,533,460 - 192,557,281 (+)NCBI
mRatBN7.21183,103,038 - 183,126,862 (+)NCBI
Rnor_6.01199,941,258 - 199,965,191 (+)NCBI
Rnor_5.01206,989,244 - 207,013,177 (+)NCBI
RGSC_v3.41187,781,147 - 187,804,835 (+)RGD
Celera1180,749,355 - 180,773,125 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001011936 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH85857 (Get FASTA)   NCBI Sequence Viewer  
  ABG23394 (Get FASTA)   NCBI Sequence Viewer  
  EDM17171 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000027616
  ENSRNOP00000027616.4
Reference Protein Sequences
RefSeq Acc Id: NP_001011936   ⟸   NM_001011936
- UniProtKB: Q5U2U8 (UniProtKB/TrEMBL),   A6IA08 (UniProtKB/TrEMBL),   Q156J1 (UniProtKB/TrEMBL),   F7EZX8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000027616   ⟸   ENSRNOT00000027616
Protein Domains
BAG   WW

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U2U8-F1-model_v2 AlphaFold Q5U2U8 1-574 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690460
Promoter ID:EPDNEW_R985
Type:initiation region
Name:Bag3_1
Description:Bcl2-associated athanogene 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R986  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01199,941,085 - 199,941,145EPDNEW
RGD ID:13690461
Promoter ID:EPDNEW_R986
Type:multiple initiation site
Name:Bag3_2
Description:Bcl2-associated athanogene 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R985  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01199,941,276 - 199,941,336EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307794 AgrOrtholog
BioCyc Gene G2FUF-57292 BioCyc
Ensembl Genes ENSRNOG00000020298 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027616 ENTREZGENE
  ENSRNOT00000027616.7 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.120 UniProtKB/TrEMBL
  2.20.70.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7190249 IMAGE-MGC_LOAD
InterPro Apoptosis_reg_Bcl-2_prot_BAG UniProtKB/TrEMBL
  BAG_chaperone_regulator UniProtKB/TrEMBL
  BAG_dom_sf UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/TrEMBL
  WW_Rsp5_WWP UniProtKB/TrEMBL
KEGG Report rno:293524 UniProtKB/TrEMBL
MGC_CLONE MGC:94584 IMAGE-MGC_LOAD
NCBI Gene 293524 ENTREZGENE
PANTHER BAG FAMILY MOLECULAR CHAPERONE REGULATOR 3 UniProtKB/TrEMBL
  PTHR12329 UniProtKB/TrEMBL
Pfam BAG UniProtKB/TrEMBL
  PF00397 UniProtKB/TrEMBL
PhenoGen Bag3 PhenoGen
PROSITE BAG UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020298 RatGTEx
SMART BAG UniProtKB/TrEMBL
  SM00456 UniProtKB/TrEMBL
Superfamily-SCOP SSF63491 UniProtKB/TrEMBL
  WW_Rsp5_WWP UniProtKB/TrEMBL
UniProt A6IA08 ENTREZGENE, UniProtKB/TrEMBL
  F7EZX8 ENTREZGENE, UniProtKB/TrEMBL
  Q156J1 ENTREZGENE, UniProtKB/TrEMBL
  Q5U2U8 ENTREZGENE
UniProt Secondary Q5U2U8 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-11-11 Bag3  BAG cochaperone 3  Bag3  Bcl2-associated athanogene 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Bag3  Bcl2-associated athanogene 3  Bag3_predicted  Bcl2-associated athanogene 3 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Bag3_predicted  Bcl2-associated athanogene 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED