Rhoh (ras homolog family member H) - Rat Genome Database

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Gene: Rhoh (ras homolog family member H) Rattus norvegicus
Analyze
Symbol: Rhoh
Name: ras homolog family member H
RGD ID: 1307623
Description: Predicted to enable several functions, including GTP binding activity; GTPase activity; and kinase inhibitor activity. Predicted to be involved in several processes, including mast cell activation; negative regulation of canonical NF-kappaB signal transduction; and positive regulation of T cell differentiation. Predicted to be located in cytoplasm and immunological synapse. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in epidermodysplasia verruciformis. Orthologous to human RHOH (ras homolog family member H); INTERACTS WITH 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC305341; MGC109123; ras homolog gene family, member H; rho-related GTP-binding protein RhoH
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81442,694,860 - 42,725,690 (-)NCBIGRCr8
mRatBN7.21442,341,135 - 42,371,971 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1442,337,751 - 42,386,369 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1442,695,015 - 42,725,936 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01443,995,052 - 44,025,974 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01442,475,045 - 42,505,966 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01443,961,756 - 43,992,587 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1443,961,756 - 43,992,587 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01443,781,206 - 43,812,028 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41445,024,482 - 45,055,940 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11445,026,872 - 45,058,331 (-)NCBI
Celera1441,494,501 - 41,525,255 (-)NCBICelera
Cytogenetic Map14p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:11809807   PMID:17028588   PMID:17119112   PMID:19124738   PMID:22850876  


Genomics

Comparative Map Data
Rhoh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81442,694,860 - 42,725,690 (-)NCBIGRCr8
mRatBN7.21442,341,135 - 42,371,971 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1442,337,751 - 42,386,369 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1442,695,015 - 42,725,936 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01443,995,052 - 44,025,974 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01442,475,045 - 42,505,966 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01443,961,756 - 43,992,587 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1443,961,756 - 43,992,587 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01443,781,206 - 43,812,028 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41445,024,482 - 45,055,940 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11445,026,872 - 45,058,331 (-)NCBI
Celera1441,494,501 - 41,525,255 (-)NCBICelera
Cytogenetic Map14p11NCBI
RHOH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38440,191,080 - 40,246,967 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl440,191,011 - 40,246,967 (+)EnsemblGRCh38hg38GRCh38
GRCh37440,192,700 - 40,248,587 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36439,874,922 - 39,922,676 (+)NCBINCBI36Build 36hg18NCBI36
Build 34440,021,167 - 40,068,419NCBI
Celera440,637,435 - 40,685,176 (+)NCBICelera
Cytogenetic Map4p14NCBI
HuRef439,515,874 - 39,569,650 (+)NCBIHuRef
CHM1_1440,191,833 - 40,245,593 (+)NCBICHM1_1
T2T-CHM13v2.0440,161,181 - 40,217,041 (+)NCBIT2T-CHM13v2.0
Rhoh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39566,018,092 - 66,054,043 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl566,018,556 - 66,054,043 (+)EnsemblGRCm39 Ensembl
GRCm38565,860,742 - 65,896,700 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl565,861,213 - 65,896,700 (+)EnsemblGRCm38mm10GRCm38
MGSCv37566,254,808 - 66,287,939 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36566,140,350 - 66,175,835 (+)NCBIMGSCv36mm8
Celera563,159,997 - 63,193,217 (+)NCBICelera
Cytogenetic Map5C3.1NCBI
cM Map533.8NCBI
Rhoh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554437,227,751 - 7,264,821 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554437,227,751 - 7,269,984 (-)NCBIChiLan1.0ChiLan1.0
RHOH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2340,381,386 - 40,430,592 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1440,573,329 - 40,622,540 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0434,517,487 - 34,569,934 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1440,374,816 - 40,420,753 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl440,419,549 - 40,420,124 (+)Ensemblpanpan1.1panPan2
RHOH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1372,272,446 - 72,277,015 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl372,276,418 - 72,276,993 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha374,822,104 - 74,825,439 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0373,040,298 - 73,043,633 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl373,039,977 - 73,089,743 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1372,309,276 - 72,312,610 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0372,459,426 - 72,462,761 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0372,843,539 - 72,846,874 (-)NCBIUU_Cfam_GSD_1.0
Rhoh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528538,574,902 - 38,615,064 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364827,689,371 - 7,723,321 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364827,721,815 - 7,723,395 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RHOH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl831,321,059 - 31,372,364 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1831,321,005 - 31,372,366 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2832,988,403 - 33,036,670 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RHOH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12710,061,316 - 10,109,124 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2710,062,014 - 10,062,589 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604756,429,868 - 56,477,900 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rhoh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476126,720,478 - 26,721,053 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476126,717,857 - 26,721,628 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rhoh
104 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:206
Count of miRNA genes:139
Interacting mature miRNAs:156
Transcripts:ENSRNOT00000003425
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143088377768757901Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143999825175582726Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat

Markers in Region
RH141876  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21442,341,178 - 42,341,358 (+)MAPPERmRatBN7.2
Rnor_6.01443,961,800 - 43,961,979NCBIRnor6.0
Rnor_5.01443,781,250 - 43,781,429UniSTSRnor5.0
RGSC_v3.41445,024,526 - 45,024,705UniSTSRGSC3.4
Celera1441,494,545 - 41,494,724UniSTS
Cytogenetic Map14p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 8 19 10
Low 1 43 49 41 41 8 10 67 35 41 1 8
Below cutoff 1 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003425   ⟹   ENSRNOP00000003425
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1442,341,135 - 42,386,369 (-)Ensembl
Rnor_6.0 Ensembl1443,961,756 - 43,992,587 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110238   ⟹   ENSRNOP00000094121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1442,337,751 - 42,372,160 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115442   ⟹   ENSRNOP00000078680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1442,340,344 - 42,346,884 (-)Ensembl
RefSeq Acc Id: NM_001013430   ⟹   NP_001013448
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81442,694,860 - 42,725,690 (-)NCBI
mRatBN7.21442,341,135 - 42,371,971 (-)NCBI
Rnor_6.01443,961,756 - 43,992,587 (-)NCBI
Rnor_5.01443,781,206 - 43,812,028 (-)NCBI
RGSC_v3.41445,024,482 - 45,055,940 (-)RGD
Celera1441,494,501 - 41,525,255 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001013448 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH91269 (Get FASTA)   NCBI Sequence Viewer  
  EDL90051 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003425
  ENSRNOP00000003425.4
  ENSRNOP00000078680.1
  ENSRNOP00000094121.1
Reference Protein Sequences
RefSeq Acc Id: NP_001013448   ⟸   NM_001013430
- UniProtKB: Q5BJZ5 (UniProtKB/TrEMBL),   A0A8I5ZLD5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003425   ⟸   ENSRNOT00000003425
RefSeq Acc Id: ENSRNOP00000094121   ⟸   ENSRNOT00000110238
RefSeq Acc Id: ENSRNOP00000078680   ⟸   ENSRNOT00000115442

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5BJZ5-F1-model_v2 AlphaFold Q5BJZ5 1-191 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699309
Promoter ID:EPDNEW_R9834
Type:initiation region
Name:Rhoh_1
Description:ras homolog family member H
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01443,992,647 - 43,992,707EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307623 AgrOrtholog
BioCyc Gene G2FUF-15755 BioCyc
Ensembl Genes ENSRNOG00000002540 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003425 ENTREZGENE
  ENSRNOT00000003425.5 UniProtKB/TrEMBL
  ENSRNOT00000110238.1 UniProtKB/TrEMBL
  ENSRNOT00000115442.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7381512 IMAGE-MGC_LOAD
InterPro P-loop_NTPase UniProtKB/TrEMBL
  Ras_GTPase UniProtKB/TrEMBL
  Small_GTP_bd UniProtKB/TrEMBL
  Small_GTPase_Rho UniProtKB/TrEMBL
KEGG Report rno:305341 UniProtKB/TrEMBL
MGC_CLONE MGC:109123 IMAGE-MGC_LOAD
NCBI Gene 305341 ENTREZGENE
PANTHER PTHR24072 UniProtKB/TrEMBL
  RHO-RELATED GTP-BINDING PROTEIN RHOH UniProtKB/TrEMBL
Pfam Ras UniProtKB/TrEMBL
PhenoGen Rhoh PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002540 RatGTEx
SMART RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8I5ZLD5 ENTREZGENE, UniProtKB/TrEMBL
  Q5BJZ5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-15 Rhoh  ras homolog family member H  Rhoh  ras homolog gene family, member H  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Rhoh  ras homolog gene family, member H  Rhoh_predicted  ras homolog gene family, member H (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Rhoh_predicted  ras homolog gene family, member H (predicted)      Symbol and Name status set to approved 70820 APPROVED