Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dichloroethane | increases expression | ISO | Plekhm3 (Mus musculus) | 6480464 | ethylene dichloride results in increased expression of PLEKHM3 mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | decreases expression | ISO | Plekhm3 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of PLEKHM3 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | multiple interactions | ISO | Plekhm3 (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of PLEKHM3 mRNA] | CTD | PMID:22206623 | 1-chloro-2,4-dinitrobenzene | increases methylation | ISO | Plekhm3 (Mus musculus) | 6480464 | Dinitrochlorobenzene results in increased methylation of PLEKHM3 promoter | CTD | PMID:24675093 | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of PLEKHM3 mRNA | CTD | PMID:29097150 | 17beta-estradiol | decreases expression | ISO | PLEKHM3 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of PLEKHM3 mRNA | CTD | PMID:31614463 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Plekhm3 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PLEKHM3 mRNA | CTD | PMID:21570461 and PMID:26377647 | aflatoxin B1 | increases expression | ISO | PLEKHM3 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased expression of PLEKHM3 mRNA | CTD | PMID:21641981 | aristolochic acid A | decreases expression | ISO | PLEKHM3 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of PLEKHM3 mRNA | CTD | PMID:33212167 | arsenite(3-) | multiple interactions | ISO | PLEKHM3 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to PLEKHM3 mRNA] | CTD | PMID:32406909 | arsenous acid | decreases expression | ISO | Plekhm3 (Mus musculus) | 6480464 | Arsenic Trioxide results in decreased expression of PLEKHM3 mRNA | CTD | PMID:35676786 | benzo[a]pyrene | decreases methylation | ISO | PLEKHM3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of PLEKHM3 3' UTR | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | Plekhm3 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of PLEKHM3 mRNA | CTD | PMID:32417428 | benzo[a]pyrene | affects methylation | ISO | PLEKHM3 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of PLEKHM3 promoter | CTD | PMID:27901495 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PLEKHM3 mRNA | CTD | PMID:25181051 | bisphenol A | decreases expression | ISO | PLEKHM3 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of PLEKHM3 mRNA | CTD | PMID:31715268 | bisphenol A | increases expression | ISO | PLEKHM3 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of PLEKHM3 mRNA | CTD | PMID:29275510 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of PLEKHM3 mRNA | CTD | PMID:30816183 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of PLEKHM3 mRNA | CTD | PMID:29097150 | bromobenzene | increases expression | EXP | | 6480464 | bromobenzene results in increased expression of PLEKHM3 mRNA | CTD | PMID:32479839 | chlorpyrifos | decreases expression | ISO | Plekhm3 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of PLEKHM3 mRNA | CTD | PMID:37019170 | chromium(6+) | affects expression | ISO | Plekhm3 (Mus musculus) | 6480464 | chromium hexavalent ion affects the expression of PLEKHM3 mRNA | CTD | PMID:28472532 | crocidolite asbestos | decreases expression | ISO | Plekhm3 (Mus musculus) | 6480464 | Asbestos and Crocidolite results in decreased expression of PLEKHM3 mRNA | CTD | PMID:29279043 | cyclosporin A | increases expression | ISO | PLEKHM3 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of PLEKHM3 mRNA | CTD | PMID:27989131 | diarsenic trioxide | decreases expression | ISO | Plekhm3 (Mus musculus) | 6480464 | Arsenic Trioxide results in decreased expression of PLEKHM3 mRNA | CTD | PMID:35676786 | dorsomorphin | multiple interactions | ISO | PLEKHM3 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | PLEKHM3 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of PLEKHM3 mRNA | CTD | PMID:29803840 | entinostat | decreases expression | ISO | PLEKHM3 (Homo sapiens) | 6480464 | entinostat results in decreased expression of PLEKHM3 mRNA | CTD | PMID:26272509 | entinostat | multiple interactions | ISO | PLEKHM3 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLEKHM3 mRNA | CTD | PMID:27188386 | ethanol | affects splicing | ISO | Plekhm3 (Mus musculus) | 6480464 | Ethanol affects the splicing of PLEKHM3 mRNA | CTD | PMID:30319688 | ethyl methanesulfonate | increases expression | ISO | PLEKHM3 (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of PLEKHM3 mRNA | CTD | PMID:23649840 | fenvalerate | increases expression | EXP | | 6480464 | fenvalerate results in increased expression of PLEKHM3 mRNA | CTD | PMID:30307764 | folic acid | multiple interactions | ISO | Plekhm3 (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of PLEKHM3 mRNA] | CTD | PMID:22206623 | folic acid | decreases expression | ISO | Plekhm3 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of PLEKHM3 mRNA | CTD | PMID:25629700 | formaldehyde | increases expression | ISO | PLEKHM3 (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of PLEKHM3 mRNA | CTD | PMID:23649840 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of PLEKHM3 mRNA | CTD | PMID:33387578 | lipopolysaccharide | multiple interactions | ISO | PLEKHM3 (Homo sapiens) | 6480464 | [S-(1 more ... | CTD | PMID:35811015 | methyl methanesulfonate | increases expression | ISO | PLEKHM3 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of PLEKHM3 mRNA | CTD | PMID:23649840 | N-ethyl-N-nitrosourea | increases mutagenesis | ISO | Plekhm3 (Mus musculus) | 6480464 | Ethylnitrosourea results in increased mutagenesis of PLEKHM3 mRNA | CTD | PMID:27776689 | panobinostat | multiple interactions | ISO | PLEKHM3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLEKHM3 mRNA | CTD | PMID:27188386 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of PLEKHM3 mRNA | CTD | PMID:33387578 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Plekhm3 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Pectins] results in increased expression of PLEKHM3 mRNA | CTD | PMID:36331819 | phenylmercury acetate | decreases expression | ISO | PLEKHM3 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of PLEKHM3 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | PLEKHM3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLEKHM3 mRNA | CTD | PMID:27188386 | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | PLEKHM3 (Homo sapiens) | 6480464 | [S-(1 more ... | CTD | PMID:35811015 | SB 431542 | multiple interactions | ISO | PLEKHM3 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | sunitinib | increases expression | ISO | PLEKHM3 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of PLEKHM3 mRNA | CTD | PMID:31533062 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of PLEKHM3 mRNA | CTD | PMID:34492290 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of PLEKHM3 mRNA | CTD | PMID:33387578 | trichostatin A | decreases expression | ISO | PLEKHM3 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of PLEKHM3 mRNA | CTD | PMID:24935251 | trichostatin A | affects expression | ISO | PLEKHM3 (Homo sapiens) | 6480464 | trichostatin A affects the expression of PLEKHM3 mRNA | CTD | PMID:28542535 | trimellitic anhydride | increases methylation | ISO | Plekhm3 (Mus musculus) | 6480464 | trimellitic anhydride results in increased methylation of PLEKHM3 promoter | CTD | PMID:24675093 | triptonide | decreases expression | ISO | Plekhm3 (Mus musculus) | 6480464 | triptonide results in decreased expression of PLEKHM3 mRNA | CTD | PMID:33045310 | tungsten | decreases expression | ISO | Plekhm3 (Mus musculus) | 6480464 | Tungsten results in decreased expression of PLEKHM3 mRNA | CTD | PMID:30912803 | urethane | increases expression | ISO | PLEKHM3 (Homo sapiens) | 6480464 | Urethane results in increased expression of PLEKHM3 mRNA | CTD | PMID:28818685 | valproic acid | affects expression | ISO | PLEKHM3 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of PLEKHM3 mRNA | CTD | PMID:25979313 | valproic acid | multiple interactions | ISO | PLEKHM3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLEKHM3 mRNA | CTD | PMID:27188386 | valproic acid | decreases expression | ISO | PLEKHM3 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of PLEKHM3 mRNA | CTD | PMID:23179753 more ... | valproic acid | increases expression | ISO | PLEKHM3 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of PLEKHM3 mRNA | CTD | PMID:24935251 and PMID:29154799 | vinclozolin | decreases expression | EXP | | 6480464 | vinclozolin results in decreased expression of PLEKHM3 mRNA | CTD | PMID:23034163 | |