PLEKHM3 (pleckstrin homology domain containing M3) - Rat Genome Database

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Gene: PLEKHM3 (pleckstrin homology domain containing M3) Chlorocebus sabaeus
Analyze
Symbol: PLEKHM3
Name: pleckstrin homology domain containing M3
RGD ID: 18501560
Description: ENCODES a protein that exhibits metal ion binding (inferred); INVOLVED IN myoblast differentiation (inferred); ASSOCIATED WITH Neurodevelopmental Disorders (ortholog); primary pulmonary hypertension (ortholog); FOUND IN cytoplasm (inferred); Golgi apparatus (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pleckstrin homology domain-containing family M member 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11093,612,617 - 93,816,814 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1093,616,714 - 93,816,476 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040105,553,005 - 105,758,658 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
PLEKHM3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11093,612,617 - 93,816,814 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1093,616,714 - 93,816,476 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040105,553,005 - 105,758,658 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
PLEKHM3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382207,821,288 - 208,025,527 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2207,821,288 - 208,025,527 (-)EnsemblGRCh38hg38GRCh38
GRCh372208,686,012 - 208,890,251 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362208,401,288 - 208,574,637 (-)NCBINCBI36Build 36hg18NCBI36
Celera2202,448,087 - 202,652,388 (-)NCBICelera
Cytogenetic Map2q33.3NCBI
HuRef2200,528,351 - 200,732,867 (-)NCBIHuRef
CHM1_12208,691,961 - 208,896,203 (-)NCBICHM1_1
T2T-CHM13v2.02208,295,515 - 208,499,792 (-)NCBIT2T-CHM13v2.0
Plekhm3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39164,828,279 - 64,995,983 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl164,825,142 - 64,995,983 (-)EnsemblGRCm39 Ensembl
GRCm38164,789,120 - 64,956,824 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl164,785,983 - 64,956,824 (-)EnsemblGRCm38mm10GRCm38
MGSCv37164,835,695 - 65,003,398 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36164,723,397 - 64,891,100 (-)NCBIMGSCv36mm8
Celera165,290,516 - 65,457,493 (-)NCBICelera
Cytogenetic Map1C2NCBI
cM Map132.76NCBI
Plekhm3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8973,659,998 - 73,819,079 (-)NCBIGRCr8
mRatBN7.2966,166,233 - 66,325,332 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl966,166,321 - 66,325,294 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0971,492,665 - 71,651,529 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl971,498,293 - 71,651,512 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0970,935,154 - 71,074,261 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4963,442,057 - 63,583,879 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1963,589,038 - 63,723,352 (-)NCBI
Celera963,571,202 - 63,730,053 (-)NCBICelera
Cytogenetic Map9q32NCBI
Plekhm3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554577,065,428 - 7,239,663 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554577,065,443 - 7,239,663 (+)NCBIChiLan1.0ChiLan1.0
PLEKHM3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213110,435,802 - 110,643,005 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B110,450,779 - 110,658,005 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B95,061,743 - 95,265,162 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B213,186,504 - 213,389,109 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B213,193,876 - 213,389,109 (-)Ensemblpanpan1.1panPan2
PLEKHM3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13716,177,125 - 16,354,641 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3716,182,819 - 16,355,003 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3717,060,085 - 17,238,333 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03716,111,878 - 16,290,825 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3716,116,080 - 16,290,796 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13716,057,489 - 16,235,714 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03716,030,442 - 16,208,662 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03716,039,805 - 16,218,067 (-)NCBIUU_Cfam_GSD_1.0
Plekhm3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303164,288,243 - 164,503,017 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366313,960,725 - 4,138,096 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366313,954,774 - 4,138,079 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLEKHM3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15110,994,410 - 111,185,324 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115110,989,123 - 111,185,928 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215122,623,253 - 122,671,379 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Plekhm3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247657,981,903 - 8,166,964 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247657,981,903 - 8,173,599 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 3 10 36
Low 33 10 24
Below cutoff

Sequence


RefSeq Acc Id: ENSCSAT00000008160   ⟹   ENSCSAP00000006311
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1093,616,714 - 93,816,476 (-)Ensembl
RefSeq Acc Id: XM_007966035   ⟹   XP_007964226
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11093,621,609 - 93,816,814 (-)NCBI
Vero_WHO_p1.0NW_023666040105,553,005 - 105,732,614 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007966037   ⟹   XP_007964228
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11093,612,617 - 93,816,801 (-)NCBI
Vero_WHO_p1.0NW_023666040105,553,007 - 105,758,658 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007966039   ⟹   XP_007964230
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11093,688,984 - 93,816,797 (-)NCBI
Vero_WHO_p1.0NW_023666040105,553,007 - 105,679,860 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038001652   ⟹   XP_037857580
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666040105,553,007 - 105,758,658 (+)NCBI
RefSeq Acc Id: XM_038001653   ⟹   XP_037857581
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666040105,553,007 - 105,751,645 (+)NCBI
RefSeq Acc Id: XP_007964228   ⟸   XM_007966037
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RCH2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007964226   ⟸   XM_007966035
- Peptide Label: isoform X2
RefSeq Acc Id: XP_007964230   ⟸   XM_007966039
- Peptide Label: isoform X3
RefSeq Acc Id: ENSCSAP00000006311   ⟸   ENSCSAT00000008160
RefSeq Acc Id: XP_037857580   ⟸   XM_038001652
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RCH2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037857581   ⟸   XM_038001653
- Peptide Label: isoform X4


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000010071 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000008160.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
InterPro PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  PLEKHM3_PH_1 UniProtKB/TrEMBL
  Zf-RING_9 UniProtKB/TrEMBL
NCBI Gene PLEKHM3 ENTREZGENE
PANTHER PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN UniProtKB/TrEMBL
  PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 3 UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/TrEMBL
  zf-RING_9 UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
SMART DUF4206 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
UniProt A0A0D9RCH2 ENTREZGENE, UniProtKB/TrEMBL