Olig3 (oligodendrocyte transcription factor 3) - Rat Genome Database

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Gene: Olig3 (oligodendrocyte transcription factor 3) Rattus norvegicus
Analyze
Symbol: Olig3
Name: oligodendrocyte transcription factor 3
RGD ID: 1305997
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and E-box binding activity. Predicted to be involved in axon development; positive regulation of transcription by RNA polymerase II; and sensory organ development. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II; spinal cord motor neuron cell fate specification; and spinal cord motor neuron migration. Predicted to be active in nucleus. Orthologous to human OLIG3 (oligodendrocyte transcription factor 3); INTERACTS WITH bisphenol A; glyphosate; 1,2-dimethylhydrazine (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC293012; oligodendrocyte transcription factor 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8115,900,881 - 15,902,953 (+)NCBIGRCr8
mRatBN7.2114,081,259 - 14,083,336 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl114,081,328 - 14,082,149 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx113,840,322 - 13,842,404 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0119,842,266 - 19,844,350 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0114,061,398 - 14,063,463 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0114,797,766 - 14,799,835 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl114,797,766 - 14,799,835 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0116,343,568 - 16,345,637 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4114,568,462 - 14,570,533 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1114,568,354 - 14,570,595 (+)NCBI
Celera112,527,890 - 12,529,961 (+)NCBICelera
Cytogenetic Map1p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15674731   PMID:15769945  


Genomics

Comparative Map Data
Olig3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8115,900,881 - 15,902,953 (+)NCBIGRCr8
mRatBN7.2114,081,259 - 14,083,336 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl114,081,328 - 14,082,149 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx113,840,322 - 13,842,404 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0119,842,266 - 19,844,350 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0114,061,398 - 14,063,463 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0114,797,766 - 14,799,835 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl114,797,766 - 14,799,835 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0116,343,568 - 16,345,637 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4114,568,462 - 14,570,533 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1114,568,354 - 14,570,595 (+)NCBI
Celera112,527,890 - 12,529,961 (+)NCBICelera
Cytogenetic Map1p12NCBI
OLIG3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386137,492,199 - 137,494,394 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6137,492,199 - 137,494,394 (-)EnsemblGRCh38hg38GRCh38
GRCh376137,813,336 - 137,815,531 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366137,855,029 - 137,857,224 (-)NCBINCBI36Build 36hg18NCBI36
Build 346137,855,028 - 137,857,224NCBI
Celera6138,553,474 - 138,555,669 (-)NCBICelera
Cytogenetic Map6q23.3NCBI
HuRef6135,375,512 - 135,377,708 (-)NCBIHuRef
CHM1_16138,075,547 - 138,077,743 (-)NCBICHM1_1
T2T-CHM13v2.06138,680,645 - 138,682,841 (-)NCBIT2T-CHM13v2.0
Olig3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391019,232,287 - 19,234,352 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1019,232,281 - 19,234,352 (+)EnsemblGRCm39 Ensembl
GRCm381019,356,539 - 19,358,604 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1019,356,533 - 19,358,604 (+)EnsemblGRCm38mm10GRCm38
MGSCv371019,076,345 - 19,078,410 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361019,045,953 - 19,048,020 (+)NCBIMGSCv36mm8
Celera1019,255,439 - 19,257,539 (+)NCBICelera
Cytogenetic Map10A3NCBI
cM Map108.33NCBI
Olig3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543621,929,086 - 21,929,904 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543621,929,086 - 21,929,904 (+)NCBIChiLan1.0ChiLan1.0
OLIG3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25157,451,637 - 157,453,843 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16155,350,945 - 155,353,151 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06135,245,422 - 135,248,355 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16139,332,779 - 139,334,975 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6139,333,938 - 139,334,756 (-)Ensemblpanpan1.1panPan2
OLIG3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1129,919,043 - 29,921,713 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl129,920,190 - 29,921,008 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha130,802,543 - 30,803,421 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0130,088,185 - 30,089,063 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1129,966,232 - 29,967,110 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0129,850,573 - 29,851,451 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0130,156,470 - 30,157,348 (-)NCBIUU_Cfam_GSD_1.0
Olig3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946125,014,379 - 125,016,661 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365604,794,747 - 4,795,565 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365604,793,595 - 4,795,781 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OLIG3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl126,800,671 - 26,801,489 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1126,800,671 - 26,801,489 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2130,151,022 - 30,151,840 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OLIG3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11335,925,356 - 35,926,211 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1335,925,373 - 35,926,194 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660408,118,234 - 8,120,420 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Olig3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624886330,068 - 330,886 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624886329,887 - 331,938 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Olig3
10 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:218
Count of miRNA genes:147
Interacting mature miRNAs:168
Transcripts:ENSRNOT00000016048
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1124744506Rat
2298546Neuinf4Neuroinflammation QTL 45.1nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1128736750Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1132356093Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1132356093Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1592587724697545Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)11148148232355910Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 10
Low 31 7
Below cutoff 2 9 26 10 19 10 7 8 20 9 13 11 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016048   ⟹   ENSRNOP00000016048
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl114,797,766 - 14,799,835 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108658   ⟹   ENSRNOP00000087458
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl114,081,328 - 14,082,149 (+)Ensembl
RefSeq Acc Id: NM_001106269   ⟹   NP_001099739
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8115,900,881 - 15,902,953 (+)NCBI
mRatBN7.2114,081,259 - 14,083,336 (+)NCBI
Rnor_6.0114,797,766 - 14,799,835 (+)NCBI
Rnor_5.0116,343,568 - 16,345,637 (+)NCBI
RGSC_v3.4114,568,462 - 14,570,533 (+)RGD
Celera112,527,890 - 12,529,961 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001099739 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93782 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000087458
  ENSRNOP00000087458.1
Reference Protein Sequences
RefSeq Acc Id: NP_001099739   ⟸   NM_001106269
- UniProtKB: D4A572 (UniProtKB/TrEMBL),   A6JPB0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016048   ⟸   ENSRNOT00000016048
RefSeq Acc Id: ENSRNOP00000087458   ⟸   ENSRNOT00000108658
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A572-F1-model_v2 AlphaFold D4A572 1-273 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305997 AgrOrtholog
BioCyc Gene G2FUF-62234 BioCyc
Ensembl Genes ENSRNOG00000012057 Ensembl
  ENSRNOG00000064127 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000108658 ENTREZGENE
  ENSRNOT00000108658.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
InterPro HLH_DNA-bd UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  Olig3 UniProtKB/TrEMBL
KEGG Report rno:293012 UniProtKB/TrEMBL
NCBI Gene 293012 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED UniProtKB/TrEMBL
  PTHR19290:SF96 UniProtKB/TrEMBL
Pfam HLH UniProtKB/TrEMBL
PhenoGen Olig3 PhenoGen
PROSITE HLH UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012057 RatGTEx
  ENSRNOG00000064127 RatGTEx
SMART HLH UniProtKB/TrEMBL
Superfamily-SCOP HLH_basic UniProtKB/TrEMBL
UniProt A6JPB0 ENTREZGENE, UniProtKB/TrEMBL
  D4A572 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Olig3  oligodendrocyte transcription factor 3   Olig3_predicted  oligodendrocyte transcription factor 3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Olig3_predicted  oligodendrocyte transcription factor 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED