Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | ISO | Diras2 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | ISO | Diras2 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of DIRAS2 mRNA | CTD | PMID:32109520 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of DIRAS2 mRNA | CTD | PMID:33387578 | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | increases expression | ISO | DIRAS2 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:26705709 | aflatoxin B1 | decreases methylation | ISO | DIRAS2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of DIRAS2 intron | CTD | PMID:30157460 | aldehydo-D-glucose | multiple interactions | ISO | Diras2 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose co-treated with Glyphosate] results in decreased expression of DIRAS2 mRNA | CTD | PMID:37567420 | all-trans-retinoic acid | multiple interactions | ISO | Diras2 (Mus musculus) | 6480464 | [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of DIRAS2 mRNA | CTD | PMID:36189433 | all-trans-retinoic acid | increases expression | ISO | Diras2 (Mus musculus) | 6480464 | Tretinoin results in increased expression of DIRAS2 mRNA | CTD | PMID:36189433 | arsane | increases expression | ISO | DIRAS2 (Homo sapiens) | 6480464 | Arsenic results in increased expression of DIRAS2 mRNA | CTD | PMID:36861143 | arsenic atom | increases expression | ISO | DIRAS2 (Homo sapiens) | 6480464 | Arsenic results in increased expression of DIRAS2 mRNA | CTD | PMID:36861143 | atrazine | increases expression | ISO | DIRAS2 (Homo sapiens) | 6480464 | Atrazine results in increased expression of DIRAS2 mRNA | CTD | PMID:22378314 | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of DIRAS2 gene | CTD | PMID:35440735 | benzo[a]pyrene | multiple interactions | ISO | Diras2 (Mus musculus) | 6480464 | Benzo(a)pyrene promotes the reaction [AHR protein binds to DIRAS2 promoter] | CTD | PMID:19654925 | benzo[a]pyrene | affects methylation | ISO | DIRAS2 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of DIRAS2 5' UTR | CTD | PMID:27901495 | benzo[a]pyrene | increases methylation | ISO | DIRAS2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of DIRAS2 promoter | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | DIRAS2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of DIRAS2 mRNA | CTD | PMID:22316170 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of DIRAS2 mRNA | CTD | PMID:25181051 more ... | bisphenol A | multiple interactions | ISO | DIRAS2 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of DIRAS2 gene | CTD | PMID:31601247 | bisphenol F | decreases expression | ISO | Diras2 (Mus musculus) | 6480464 | bisphenol F results in decreased expression of DIRAS2 mRNA | CTD | PMID:30951980 | cadmium atom | multiple interactions | ISO | Diras2 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of DIRAS2 mRNA | CTD | PMID:37325564 | cadmium dichloride | multiple interactions | ISO | Diras2 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of DIRAS2 mRNA | CTD | PMID:37325564 | carbon nanotube | decreases expression | ISO | Diras2 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | DIRAS2 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to DIRAS2 gene] | CTD | PMID:28238834 | chlorpyrifos | decreases expression | ISO | Diras2 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of DIRAS2 mRNA | CTD | PMID:37019170 | cyclosporin A | increases expression | ISO | DIRAS2 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of DIRAS2 mRNA | CTD | PMID:20106945 | D-glucose | multiple interactions | ISO | Diras2 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose co-treated with Glyphosate] results in decreased expression of DIRAS2 mRNA | CTD | PMID:37567420 | dexamethasone | increases expression | ISO | Diras2 (Mus musculus) | 6480464 | Dexamethasone results in increased expression of DIRAS2 mRNA | CTD | PMID:22733784 | dibutyl phthalate | increases expression | ISO | Diras2 (Mus musculus) | 6480464 | Dibutyl Phthalate results in increased expression of DIRAS2 mRNA | CTD | PMID:21266533 | dimethylarsinic acid | multiple interactions | ISO | Diras2 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of DIRAS2 mRNA | CTD | PMID:34876320 | dorsomorphin | multiple interactions | ISO | DIRAS2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DIRAS2 mRNA | CTD | PMID:27188386 | ethanol | affects splicing | ISO | Diras2 (Mus musculus) | 6480464 | Ethanol affects the splicing of DIRAS2 mRNA | CTD | PMID:30319688 | ethanol | affects expression | ISO | Diras2 (Mus musculus) | 6480464 | Ethanol affects the expression of DIRAS2 mRNA | CTD | PMID:30319688 | fonofos | increases methylation | ISO | DIRAS2 (Homo sapiens) | 6480464 | Fonofos results in increased methylation of DIRAS2 promoter | CTD | PMID:22847954 | fructose | multiple interactions | ISO | Diras2 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose co-treated with Glyphosate] results in decreased expression of DIRAS2 mRNA | CTD | PMID:37567420 | fulvestrant | multiple interactions | ISO | DIRAS2 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of DIRAS2 gene | CTD | PMID:31601247 | glucose | multiple interactions | ISO | Diras2 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose co-treated with Glyphosate] results in decreased expression of DIRAS2 mRNA | CTD | PMID:37567420 | glyphosate | multiple interactions | ISO | Diras2 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose co-treated with Glyphosate] results in decreased expression of DIRAS2 mRNA | CTD | PMID:37567420 | lipopolysaccharide | multiple interactions | ISO | DIRAS2 (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of DIRAS2 mRNA | CTD | PMID:35811015 | methylarsonic acid | multiple interactions | ISO | Diras2 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of DIRAS2 mRNA | CTD | PMID:34876320 | mono(2-ethylhexyl) phthalate | increases expression | ISO | Diras2 (Mus musculus) | 6480464 | mono-(2-ethylhexyl)phthalate results in increased expression of DIRAS2 mRNA | CTD | PMID:36189433 | mono(2-ethylhexyl) phthalate | multiple interactions | ISO | Diras2 (Mus musculus) | 6480464 | [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of DIRAS2 mRNA | CTD | PMID:36189433 | ozone | multiple interactions | ISO | Diras2 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of DIRAS2 mRNA and [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of DIRAS2 mRNA | CTD | PMID:34911549 | parathion | increases methylation | ISO | DIRAS2 (Homo sapiens) | 6480464 | Parathion results in increased methylation of DIRAS2 promoter | CTD | PMID:22847954 | PCB138 | multiple interactions | ISO | Diras2 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | phenylmercury acetate | multiple interactions | ISO | DIRAS2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DIRAS2 mRNA | CTD | PMID:27188386 | pirinixic acid | multiple interactions | ISO | DIRAS2 (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of DIRAS2 mRNA | CTD | PMID:19710929 | resveratrol | multiple interactions | ISO | DIRAS2 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of DIRAS2 mRNA | CTD | PMID:23557933 | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | DIRAS2 (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of DIRAS2 mRNA | CTD | PMID:35811015 | SB 431542 | multiple interactions | ISO | DIRAS2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DIRAS2 mRNA | CTD | PMID:27188386 | sodium arsenate | multiple interactions | ISO | Diras2 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of DIRAS2 mRNA | CTD | PMID:34876320 | sodium arsenite | increases expression | ISO | Diras2 (Mus musculus) | 6480464 | sodium arsenite results in increased expression of DIRAS2 mRNA | CTD | PMID:37682722 | sodium arsenite | multiple interactions | ISO | Diras2 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of DIRAS2 mRNA | CTD | PMID:34876320 | terbufos | increases methylation | ISO | DIRAS2 (Homo sapiens) | 6480464 | terbufos results in increased methylation of DIRAS2 promoter | CTD | PMID:22847954 | tetraphene | decreases expression | ISO | Diras2 (Mus musculus) | 6480464 | benz(a)anthracene results in decreased expression of DIRAS2 mRNA | CTD | PMID:26377693 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of DIRAS2 mRNA | CTD | PMID:33387578 | valproic acid | decreases methylation | ISO | DIRAS2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of DIRAS2 gene | CTD | PMID:29154799 | valproic acid | increases expression | ISO | DIRAS2 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of DIRAS2 mRNA | CTD | PMID:24383497 more ... | |