Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (1->4)-beta-D-glucan | multiple interactions | ISO | Ep400 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of EP400 mRNA | CTD | PMID:36331819 | 17alpha-ethynylestradiol | multiple interactions | ISO | Ep400 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EP400 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | increases expression | ISO | Ep400 (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of EP400 mRNA | CTD | PMID:17942748 | 17beta-estradiol | increases expression | ISO | EP400 (Homo sapiens) | 6480464 | Estradiol results in increased expression of EP400 mRNA | CTD | PMID:31614463 | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | ISO | Ep400 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | ISO | Ep400 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Ep400 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EP400 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of EP400 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of EP400 mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Ep400 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of EP400 mRNA | CTD | PMID:21570461 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 6-dinitrotoluene affects the expression of EP400 mRNA | CTD | PMID:21346803 | 2-hydroxypropanoic acid | increases expression | ISO | EP400 (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of EP400 mRNA | CTD | PMID:30851411 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | EP400 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of EP400 mRNA more ... | CTD | PMID:28628672 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | EP400 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of EP400 mRNA | CTD | PMID:28628672 | 4-amino-2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 4-amino-2 and 6-dinitrotoluene affects the expression of EP400 mRNA | CTD | PMID:21346803 | 5-fluorouracil | multiple interactions | ISO | EP400 (Homo sapiens) | 6480464 | TP53 protein affects the reaction [Fluorouracil results in decreased expression of EP400 mRNA] | CTD | PMID:15016801 | acrolein | multiple interactions | ISO | EP400 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of EP400 mRNA more ... | CTD | PMID:32699268 and PMID:32845096 | aflatoxin B1 | increases expression | ISO | Ep400 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of EP400 mRNA | CTD | PMID:19770486 | aflatoxin B1 | increases methylation | ISO | EP400 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of EP400 intron | CTD | PMID:30157460 | alpha-pinene | multiple interactions | ISO | EP400 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of EP400 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased expression of EP400 mRNA | CTD | PMID:32699268 | aristolochic acid A | decreases expression | ISO | EP400 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of EP400 mRNA | CTD | PMID:33212167 | arsenite(3-) | multiple interactions | ISO | EP400 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to EP400 mRNA] | CTD | PMID:32406909 | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of EP400 gene | CTD | PMID:35440735 | benzo[a]pyrene | increases expression | ISO | Ep400 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of EP400 mRNA | CTD | PMID:20504355 | benzo[a]pyrene | affects methylation | ISO | EP400 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of EP400 promoter | CTD | PMID:27901495 | benzo[a]pyrene | decreases methylation | ISO | Ep400 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased methylation of EP400 exon and Benzo(a)pyrene results in decreased methylation of EP400 intron | CTD | PMID:27901495 | benzo[a]pyrene | decreases expression | ISO | EP400 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of EP400 mRNA | CTD | PMID:26238291 | benzo[e]pyrene | increases methylation | ISO | EP400 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of EP400 intron | CTD | PMID:30157460 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of EP400 mRNA | CTD | PMID:25181051 | bisphenol A | decreases methylation | ISO | EP400 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of EP400 gene | CTD | PMID:31601247 | bisphenol A | multiple interactions | ISO | EP400 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of EP400 mRNA | CTD | PMID:28628672 | bisphenol F | multiple interactions | ISO | EP400 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of EP400 mRNA | CTD | PMID:28628672 | butanal | decreases expression | ISO | EP400 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of EP400 mRNA | CTD | PMID:26079696 | cadmium atom | multiple interactions | ISO | EP400 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of EP400 mRNA | CTD | PMID:35301059 | cadmium dichloride | decreases expression | ISO | EP400 (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of EP400 mRNA | CTD | PMID:25596134 | cadmium dichloride | multiple interactions | ISO | EP400 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of EP400 mRNA | CTD | PMID:35301059 | caffeine | decreases phosphorylation | ISO | EP400 (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of EP400 protein | CTD | PMID:35688186 | chloroacetaldehyde | decreases expression | ISO | EP400 (Homo sapiens) | 6480464 | chloroacetaldehyde results in decreased expression of EP400 mRNA | CTD | PMID:25596134 | chlorpyrifos | decreases expression | ISO | Ep400 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of EP400 mRNA | CTD | PMID:37019170 | cidofovir anhydrous | decreases expression | ISO | EP400 (Homo sapiens) | 6480464 | Cidofovir results in decreased expression of EP400 mRNA | CTD | PMID:25596134 | cisplatin | decreases expression | ISO | EP400 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of EP400 mRNA | CTD | PMID:25596134 | clodronic acid | decreases expression | ISO | EP400 (Homo sapiens) | 6480464 | Clodronic Acid results in decreased expression of EP400 mRNA | CTD | PMID:25596134 | cobalt dichloride | affects expression | ISO | EP400 (Homo sapiens) | 6480464 | cobaltous chloride affects the expression of EP400 mRNA alternative form | CTD | PMID:19320972 | copper(II) sulfate | increases expression | ISO | EP400 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of EP400 mRNA | CTD | PMID:19549813 | coumarin | affects phosphorylation | ISO | EP400 (Homo sapiens) | 6480464 | coumarin affects the phosphorylation of EP400 protein | CTD | PMID:35688186 | cyclosporin A | decreases methylation | ISO | EP400 (Homo sapiens) | 6480464 | Cyclosporine results in decreased methylation of EP400 promoter | CTD | PMID:27989131 | deoxynivalenol | decreases phosphorylation | ISO | Ep400 (Mus musculus) | 6480464 | deoxynivalenol results in decreased phosphorylation of EP400 protein | CTD | PMID:23352502 | dexamethasone | multiple interactions | ISO | EP400 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of EP400 mRNA more ... | CTD | PMID:28628672 | dicrotophos | increases expression | ISO | EP400 (Homo sapiens) | 6480464 | dicrotophos results in increased expression of EP400 mRNA | CTD | PMID:28302478 | dioxygen | decreases expression | ISO | EP400 (Homo sapiens) | 6480464 | Oxygen deficiency results in decreased expression of EP400 mRNA | CTD | PMID:25596134 | epoxiconazole | decreases expression | ISO | Ep400 (Mus musculus) | 6480464 | epoxiconazole results in decreased expression of EP400 mRNA | CTD | PMID:35436446 | ethanol | affects splicing | ISO | Ep400 (Mus musculus) | 6480464 | Ethanol affects the splicing of EP400 mRNA | CTD | PMID:30319688 | fenofibrate | decreases expression | EXP | | 6480464 | Fenofibrate results in decreased expression of EP400 mRNA | CTD | PMID:25596134 | fenthion | decreases expression | ISO | Ep400 (Mus musculus) | 6480464 | Fenthion results in decreased expression of EP400 mRNA | CTD | PMID:34813904 | formaldehyde | decreases expression | ISO | EP400 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of EP400 mRNA | CTD | PMID:23649840 | FR900359 | affects phosphorylation | ISO | EP400 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of EP400 protein | CTD | PMID:37730182 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of EP400 mRNA | CTD | PMID:33387578 | glyphosate | affects methylation | EXP | | 6480464 | Glyphosate affects the methylation of EP400 gene | CTD | PMID:35440735 | ifosfamide | decreases expression | ISO | EP400 (Homo sapiens) | 6480464 | Ifosfamide results in decreased expression of EP400 mRNA | CTD | PMID:25596134 | indometacin | multiple interactions | ISO | EP400 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of EP400 mRNA more ... | CTD | PMID:28628672 | metformin | affects expression | EXP | | 6480464 | Metformin affects the expression of EP400 mRNA | CTD | PMID:25596134 | methamphetamine | increases expression | ISO | Ep400 (Mus musculus) | 6480464 | Methamphetamine results in increased expression of EP400 mRNA | CTD | PMID:26307267 | methapyrilene | increases methylation | ISO | EP400 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of EP400 intron | CTD | PMID:30157460 | methidathion | affects expression | ISO | Ep400 (Mus musculus) | 6480464 | methidathion affects the expression of EP400 mRNA | CTD | PMID:34813904 | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of EP400 gene | CTD | PMID:35440735 | methylmercury chloride | increases expression | ISO | EP400 (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of EP400 mRNA | CTD | PMID:28001369 | ozone | multiple interactions | ISO | EP400 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of EP400 mRNA more ... | CTD | PMID:32699268 and PMID:32845096 | paracetamol | affects expression | ISO | Ep400 (Mus musculus) | 6480464 | Acetaminophen affects the expression of EP400 mRNA | CTD | PMID:17562736 | parathion | increases expression | ISO | Ep400 (Mus musculus) | 6480464 | Parathion results in increased expression of EP400 mRNA | CTD | PMID:34813904 | PCB138 | multiple interactions | ISO | Ep400 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Ep400 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of EP400 mRNA and [perfluorooctane sulfonic acid co-treated with Pectins] results in decreased expression of EP400 mRNA | CTD | PMID:36331819 | propiconazole | decreases expression | ISO | Ep400 (Mus musculus) | 6480464 | propiconazole results in decreased expression of EP400 mRNA | CTD | PMID:21278054 | quercetin | increases phosphorylation | ISO | EP400 (Homo sapiens) | 6480464 | Quercetin results in increased phosphorylation of EP400 protein | CTD | PMID:35688186 | rac-lactic acid | increases expression | ISO | EP400 (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of EP400 mRNA | CTD | PMID:30851411 | sodium arsenite | affects expression | ISO | EP400 (Homo sapiens) | 6480464 | sodium arsenite affects the expression of EP400 mRNA | CTD | PMID:29319823 | sunitinib | increases expression | ISO | EP400 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of EP400 mRNA | CTD | PMID:31533062 | tamoxifen | decreases expression | ISO | Ep400 (Mus musculus) | 6480464 | Tamoxifen results in decreased expression of EP400 mRNA | CTD | PMID:17555576 | thapsigargin | increases expression | ISO | Ep400 (Mus musculus) | 6480464 | Thapsigargin results in increased expression of EP400 protein | CTD | PMID:24648495 | thimerosal | decreases expression | ISO | EP400 (Homo sapiens) | 6480464 | Thimerosal results in decreased expression of EP400 mRNA | CTD | PMID:27188386 | topotecan | decreases expression | EXP | | 6480464 | Topotecan results in decreased expression of EP400 mRNA | CTD | PMID:25729387 | torcetrapib | increases expression | ISO | EP400 (Homo sapiens) | 6480464 | torcetrapib results in increased expression of EP400 mRNA | CTD | PMID:23228038 | trichloroethene | increases methylation | EXP | | 6480464 | Trichloroethylene results in increased methylation of EP400 gene | CTD | PMID:27618143 | triptonide | increases expression | ISO | Ep400 (Mus musculus) | 6480464 | triptonide results in increased expression of EP400 mRNA | CTD | PMID:33045310 | troglitazone | decreases expression | ISO | Ep400 (Mus musculus) | 6480464 | troglitazone results in decreased expression of EP400 mRNA | CTD | PMID:28973697 | tungsten | decreases expression | ISO | Ep400 (Mus musculus) | 6480464 | Tungsten results in decreased expression of EP400 mRNA | CTD | PMID:30912803 | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of EP400 mRNA | CTD | PMID:23034163 | vorinostat | decreases expression | ISO | EP400 (Homo sapiens) | 6480464 | vorinostat results in decreased expression of EP400 mRNA | CTD | PMID:27188386 | zoledronic acid | decreases expression | ISO | EP400 (Homo sapiens) | 6480464 | zoledronic acid results in decreased expression of EP400 mRNA | CTD | PMID:25596134 | | 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