Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [APC protein affects the susceptibility to 1 and 2-Dimethylhydrazine] which results in increased expression of SOCS6 mRNA | CTD | PMID:27840820 | 1,2-dimethylhydrazine | decreases expression | ISO | Socs6 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of SOCS6 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | increases expression | ISO | Socs6 (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of SOCS6 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | multiple interactions | ISO | Socs6 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SOCS6 mRNA | CTD | PMID:17942748 | 17beta-estradiol | increases expression | ISO | SOCS6 (Homo sapiens) | 6480464 | Estradiol results in increased expression of SOCS6 mRNA | CTD | PMID:20106945 | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | ISO | Socs6 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:31388691 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Socs6 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SOCS6 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SOCS6 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Socs6 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SOCS6 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of SOCS6 mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Socs6 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SOCS6 mRNA | CTD | PMID:19770486 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of SOCS6 mRNA | CTD | PMID:21346803 | 2-palmitoylglycerol | increases expression | ISO | SOCS6 (Homo sapiens) | 6480464 | 2-palmitoylglycerol results in increased expression of SOCS6 mRNA | CTD | PMID:37199045 | acrolein | multiple interactions | ISO | SOCS6 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of SOCS6 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of SOCS6 mRNA | CTD | PMID:32699268 | alpha-pinene | multiple interactions | ISO | SOCS6 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of SOCS6 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of SOCS6 mRNA | CTD | PMID:32699268 | amiodarone | increases expression | ISO | SOCS6 (Homo sapiens) | 6480464 | Amiodarone results in increased expression of SOCS6 mRNA | CTD | PMID:19774075 | aristolochic acid A | decreases expression | ISO | SOCS6 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of SOCS6 mRNA | CTD | PMID:33212167 | benzo[a]pyrene | increases expression | ISO | Socs6 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of SOCS6 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | affects methylation | ISO | SOCS6 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of SOCS6 promoter | CTD | PMID:27901495 | benzo[a]pyrene | multiple interactions | ISO | Socs6 (Mus musculus) | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of SOCS6 mRNA] | CTD | PMID:22228805 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | SOCS6 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:20018196 | benzo[a]pyrene diol epoxide I | affects expression | ISO | SOCS6 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:20382639 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of SOCS6 gene | CTD | PMID:28505145 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SOCS6 mRNA | CTD | PMID:34947998 | bisphenol A | affects expression | ISO | SOCS6 (Homo sapiens) | 6480464 | bisphenol A affects the expression of SOCS6 mRNA | CTD | PMID:30903817 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of SOCS6 mRNA | CTD | PMID:30816183 | cadmium atom | multiple interactions | ISO | SOCS6 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SOCS6 mRNA | CTD | PMID:35301059 | cadmium dichloride | multiple interactions | ISO | SOCS6 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SOCS6 mRNA | CTD | PMID:35301059 | caffeine | decreases phosphorylation | ISO | SOCS6 (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of SOCS6 protein | CTD | PMID:35688186 | carbamazepine | affects expression | ISO | SOCS6 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of SOCS6 mRNA | CTD | PMID:24752500 | choline | multiple interactions | ISO | Socs6 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SOCS6 gene | CTD | PMID:20938992 | cisplatin | decreases expression | ISO | SOCS6 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of SOCS6 mRNA | CTD | PMID:27392435 | copper(II) sulfate | increases expression | ISO | SOCS6 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of SOCS6 mRNA | CTD | PMID:19549813 | cycloheximide | increases expression | ISO | Socs6 (Mus musculus) | 6480464 | Cycloheximide results in increased expression of SOCS6 mRNA | CTD | PMID:23237828 | cyclosporin A | decreases expression | ISO | Socs6 (Mus musculus) | 6480464 | Cyclosporine results in decreased expression of SOCS6 mRNA | CTD | PMID:19770486 | cyclosporin A | increases expression | ISO | SOCS6 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of SOCS6 mRNA | CTD | PMID:20106945 and PMID:25562108 | diclofenac | affects expression | ISO | SOCS6 (Homo sapiens) | 6480464 | Diclofenac affects the expression of SOCS6 mRNA | CTD | PMID:24752500 | dorsomorphin | multiple interactions | ISO | SOCS6 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOCS6 mRNA | CTD | PMID:27188386 | doxorubicin | affects expression | ISO | SOCS6 (Homo sapiens) | 6480464 | Doxorubicin affects the expression of SOCS6 mRNA | CTD | PMID:29803840 | epoxiconazole | decreases expression | ISO | Socs6 (Mus musculus) | 6480464 | epoxiconazole results in decreased expression of SOCS6 mRNA | CTD | PMID:35436446 | fenofibrate | increases expression | ISO | Socs6 (Mus musculus) | 6480464 | Fenofibrate results in increased expression of SOCS6 mRNA | CTD | PMID:21318169 | fenofibrate | multiple interactions | ISO | Socs6 (Mus musculus) | 6480464 | PPARA protein affects the reaction [Fenofibrate results in increased expression of SOCS6 mRNA] | CTD | PMID:21318169 | folic acid | multiple interactions | ISO | Socs6 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SOCS6 gene | CTD | PMID:20938992 | formaldehyde | decreases expression | ISO | SOCS6 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of SOCS6 mRNA | CTD | PMID:20655997 | FR900359 | decreases phosphorylation | ISO | SOCS6 (Homo sapiens) | 6480464 | FR900359 results in decreased phosphorylation of SOCS6 protein | CTD | PMID:37730182 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of SOCS6 mRNA | CTD | PMID:33387578 | L-methionine | multiple interactions | ISO | Socs6 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SOCS6 gene | CTD | PMID:20938992 | leflunomide | increases expression | ISO | SOCS6 (Homo sapiens) | 6480464 | leflunomide results in increased expression of SOCS6 mRNA | CTD | PMID:28988120 | methidathion | decreases expression | ISO | Socs6 (Mus musculus) | 6480464 | methidathion results in decreased expression of SOCS6 mRNA | CTD | PMID:34813904 | ozone | multiple interactions | ISO | SOCS6 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of SOCS6 mRNA more ... | CTD | PMID:32699268 | paracetamol | affects expression | ISO | Socs6 (Mus musculus) | 6480464 | Acetaminophen affects the expression of SOCS6 mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | ISO | SOCS6 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of SOCS6 mRNA | CTD | PMID:22230336 | pentachlorophenol | increases expression | ISO | Socs6 (Mus musculus) | 6480464 | Pentachlorophenol results in increased expression of SOCS6 mRNA | CTD | PMID:23892564 | phenobarbital | affects expression | ISO | SOCS6 (Homo sapiens) | 6480464 | Phenobarbital affects the expression of SOCS6 mRNA | CTD | PMID:19159669 | phenobarbital | affects expression | ISO | Socs6 (Mus musculus) | 6480464 | Phenobarbital affects the expression of SOCS6 mRNA | CTD | PMID:23091169 | pyrogallol | increases expression | ISO | Socs6 (Mus musculus) | 6480464 | Pyrogallol results in increased expression of SOCS6 mRNA | CTD | PMID:20362636 | quercetin | decreases expression | ISO | SOCS6 (Homo sapiens) | 6480464 | Quercetin results in decreased expression of SOCS6 mRNA | CTD | PMID:21632981 | SB 431542 | multiple interactions | ISO | SOCS6 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOCS6 mRNA | CTD | PMID:27188386 | silver atom | decreases expression | ISO | Socs6 (Mus musculus) | 6480464 | Silver results in decreased expression of SOCS6 mRNA | CTD | PMID:27131904 | silver(0) | decreases expression | ISO | Socs6 (Mus musculus) | 6480464 | Silver results in decreased expression of SOCS6 mRNA | CTD | PMID:27131904 | Soman | increases expression | EXP | | 6480464 | Soman results in increased expression of SOCS6 mRNA | CTD | PMID:19281266 | tert-butyl hydroperoxide | increases expression | ISO | SOCS6 (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in increased expression of SOCS6 mRNA | CTD | PMID:15336504 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of SOCS6 mRNA | CTD | PMID:34492290 | trichostatin A | decreases expression | ISO | SOCS6 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of SOCS6 mRNA | CTD | PMID:26272509 | trichostatin A | multiple interactions | ISO | SOCS6 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOCS6 mRNA | CTD | PMID:27188386 | triptonide | increases expression | ISO | Socs6 (Mus musculus) | 6480464 | triptonide results in increased expression of SOCS6 mRNA | CTD | PMID:33045310 | urethane | decreases expression | ISO | SOCS6 (Homo sapiens) | 6480464 | Urethane results in decreased expression of SOCS6 mRNA | CTD | PMID:28818685 | valproic acid | affects expression | ISO | Socs6 (Mus musculus) | 6480464 | Valproic Acid affects the expression of SOCS6 mRNA | CTD | PMID:17963808 | valproic acid | affects expression | ISO | SOCS6 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of SOCS6 mRNA | CTD | PMID:25979313 | valproic acid | increases methylation | ISO | SOCS6 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of SOCS6 gene | CTD | PMID:29154799 | valproic acid | decreases expression | ISO | SOCS6 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of SOCS6 mRNA | CTD | PMID:23179753 more ... | |