Socs6 (suppressor of cytokine signaling 6) - Rat Genome Database

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Gene: Socs6 (suppressor of cytokine signaling 6) Chinchilla lanigera
Analyze
Symbol: Socs6
Name: suppressor of cytokine signaling 6
RGD ID: 9040908
Description: INVOLVED IN intracellular glucose homeostasis (ortholog); negative regulation of T cell activation (ortholog); proteasomal protein catabolic process (ortholog); PARTICIPATES IN insulin signaling pathway; Jak-Stat signaling pathway; ASSOCIATED WITH chromosome 18q deletion syndrome (ortholog); intestinal volvulus (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN immunological synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540253,852,510 - 53,876,245 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540253,847,859 - 53,876,245 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Socs6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540253,852,510 - 53,876,245 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540253,847,859 - 53,876,245 (+)NCBIChiLan1.0ChiLan1.0
SOCS6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381870,289,045 - 70,330,199 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1870,289,045 - 70,330,199 (+)EnsemblGRCh38hg38GRCh38
GRCh371867,956,281 - 67,997,435 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361866,107,117 - 66,148,414 (+)NCBINCBI36Build 36hg18NCBI36
Build 341866,107,242 - 66,145,328NCBI
Celera1864,803,527 - 64,844,775 (+)NCBICelera
Cytogenetic Map18q22.2NCBI
HuRef1864,675,129 - 64,716,511 (+)NCBIHuRef
CHM1_11867,951,383 - 67,992,682 (+)NCBICHM1_1
T2T-CHM13v2.01870,504,115 - 70,545,262 (+)NCBIT2T-CHM13v2.0
Socs6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391888,883,293 - 88,912,623 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1888,683,348 - 88,945,605 (-)EnsemblGRCm39 Ensembl
GRCm381888,865,169 - 88,894,364 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1888,665,224 - 88,927,481 (-)EnsemblGRCm38mm10GRCm38
MGSCv371889,037,272 - 89,063,599 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361889,002,071 - 89,028,400 (-)NCBIMGSCv36mm8
Celera1890,595,043 - 90,615,952 (-)NCBICelera
Cytogenetic Map18E4NCBI
cM Map1858.66NCBI
Socs6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81884,386,587 - 84,413,927 (-)NCBIGRCr8
mRatBN7.21882,111,866 - 82,139,193 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1882,111,827 - 82,139,219 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1884,181,347 - 84,199,267 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01884,854,573 - 84,872,495 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01882,722,714 - 82,740,644 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01885,962,729 - 85,981,125 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1885,962,729 - 85,980,833 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01885,005,240 - 85,023,344 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41885,722,868 - 85,725,214 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11885,796,321 - 85,798,793 (-)NCBI
Celera1880,666,098 - 80,684,203 (-)NCBICelera
Cytogenetic Map18q13NCBI
SOCS6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21787,817,792 - 87,861,022 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11873,510,442 - 73,578,231 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01863,666,761 - 63,710,085 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11866,957,394 - 67,000,015 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1866,994,489 - 66,996,096 (+)Ensemblpanpan1.1panPan2
SOCS6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.118,078,500 - 8,117,651 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl18,082,389 - 8,083,996 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha19,053,320 - 9,127,874 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.017,914,975 - 7,954,235 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl17,914,977 - 7,954,284 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.117,900,976 - 7,975,745 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.017,889,975 - 7,929,220 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.018,099,778 - 8,139,047 (-)NCBIUU_Cfam_GSD_1.0
Socs6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494421,889,210 - 21,907,684 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936964174,165 - 179,813 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOCS6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1152,593,653 - 152,636,650 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11152,593,647 - 152,636,645 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21168,991,451 - 168,993,887 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SOCS6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1189,445,820 - 9,488,125 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl189,449,740 - 9,451,347 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606016,327,085 - 16,369,287 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Socs6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480610,921,204 - 10,949,108 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000018642   ⟹   ENSCLAP00000018461
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540253,852,510 - 53,876,245 (+)Ensembl
RefSeq Acc Id: XM_005373056   ⟹   XP_005373113
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540253,852,510 - 53,876,245 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005373057   ⟹   XP_005373114
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540253,847,859 - 53,876,245 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005373113 (Get FASTA)   NCBI Sequence Viewer  
  XP_005373114 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000018461
  ENSCLAP00000018461.1
Reference Protein Sequences
RefSeq Acc Id: XP_005373114   ⟸   XM_005373057
- UniProtKB: A0A8C2YRR6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005373113   ⟸   XM_005373056
- UniProtKB: A0A8C2YRR6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000018461   ⟸   ENSCLAT00000018642
Protein Domains
SH2   SOCS box


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000012662 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000018642 ENTREZGENE
  ENSCLAT00000018642.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
  SOCS box UniProtKB/TrEMBL
InterPro SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SOCS6_SH2 UniProtKB/TrEMBL
  SOCS6_SOCS UniProtKB/TrEMBL
  SOCS_box UniProtKB/TrEMBL
  SOCS_box-like_dom_sf UniProtKB/TrEMBL
NCBI Gene Socs6 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT UniProtKB/TrEMBL
  SUPPRESSOR OF CYTOKINE SIGNALING 6 UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
  SOCS_box UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/TrEMBL
  SOCS UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
  SOCS UniProtKB/TrEMBL
  SOCS_box UniProtKB/TrEMBL
Superfamily-SCOP SSF158235 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A8C2YRR6 ENTREZGENE, UniProtKB/TrEMBL