Plekhg5 (pleckstrin homology and RhoGEF domain containing G5) - Rat Genome Database

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Gene: Plekhg5 (pleckstrin homology and RhoGEF domain containing G5) Rattus norvegicus
Analyze
Symbol: Plekhg5
Name: pleckstrin homology and RhoGEF domain containing G5
RGD ID: 1303132
Description: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including endothelial cell chemotaxis; positive regulation of canonical NF-kappaB signal transduction; and regulation protein catabolic process at presynapse. Predicted to be located in several cellular components, including cell-cell junction; lamellipodium; and presynapse. Predicted to be active in axon; endocytic vesicle; and plasma membrane. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate C and autosomal recessive distal hereditary motor neuronopathy 4. Orthologous to human PLEKHG5 (pleckstrin homology and RhoGEF domain containing G5); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; azoxystrobin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: neuronal RhoA GEF protein; PH domain-containing family G member 5; pleckstrin homology domain containing, family G (with RhoGef domain) member 5; pleckstrin homology domain-containing family G member 5; Tech; transcript highly enriched in cortex and hippocampus
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85167,860,730 - 167,904,229 (+)NCBIGRCr8
mRatBN7.25162,577,999 - 162,621,518 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5162,578,071 - 162,621,513 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5165,281,116 - 165,324,436 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05167,102,520 - 167,145,861 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05167,064,724 - 167,108,066 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05169,244,778 - 169,288,310 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5169,244,778 - 169,288,309 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05172,803,041 - 172,846,761 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45169,301,095 - 169,344,134 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15169,311,282 - 169,354,321 (+)NCBI
Celera5160,810,630 - 160,853,658 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IBA)
cell-cell junction  (ISO,ISS)
cytoplasm  (ISO,ISS)
endocytic vesicle  (IBA,ISO,ISS)
lamellipodium  (ISO,ISS)
perinuclear region of cytoplasm  (IEA)
plasma membrane  (IBA,ISO)
presynapse  (ISO)
synapse  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. A PDZ-binding motif as a critical determinant of Rho guanine exchange factor function and cell phenotype. Liu M and Horowitz A, Mol Biol Cell. 2006 Apr;17(4):1880-7. Epub 2006 Feb 8.
3. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Matsuda A, etal., Oncogene 2003 May 22;22(21):3307-18.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15686487   PMID:18537874   PMID:21543326   PMID:22322975   PMID:29084947  


Genomics

Comparative Map Data
Plekhg5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85167,860,730 - 167,904,229 (+)NCBIGRCr8
mRatBN7.25162,577,999 - 162,621,518 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5162,578,071 - 162,621,513 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5165,281,116 - 165,324,436 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05167,102,520 - 167,145,861 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05167,064,724 - 167,108,066 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05169,244,778 - 169,288,310 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5169,244,778 - 169,288,309 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05172,803,041 - 172,846,761 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45169,301,095 - 169,344,134 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15169,311,282 - 169,354,321 (+)NCBI
Celera5160,810,630 - 160,853,658 (+)NCBICelera
Cytogenetic Map5q36NCBI
PLEKHG5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3816,467,122 - 6,520,092 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl16,467,122 - 6,520,074 (-)EnsemblGRCh38hg38GRCh38
GRCh3716,526,152 - 6,580,152 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3616,448,739 - 6,502,656 (-)NCBINCBI36Build 36hg18NCBI36
Celera15,640,600 - 5,693,925 (-)NCBICelera
Cytogenetic Map1p36.31NCBI
HuRef15,673,695 - 5,727,849 (-)NCBIHuRef
CHM1_116,514,665 - 6,568,791 (-)NCBICHM1_1
T2T-CHM13v2.015,992,764 - 6,045,736 (-)NCBIT2T-CHM13v2.0
Plekhg5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394152,156,890 - 152,199,855 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4152,156,955 - 152,199,857 (+)EnsemblGRCm39 Ensembl
GRCm384152,072,433 - 152,115,404 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4152,072,498 - 152,115,400 (+)EnsemblGRCm38mm10GRCm38
MGSCv374151,470,828 - 151,489,509 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364150,940,519 - 150,959,200 (+)NCBIMGSCv36mm8
Celera4154,383,207 - 154,401,930 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map482.86NCBI
Plekhg5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554866,107,024 - 6,121,356 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554866,099,654 - 6,121,805 (+)NCBIChiLan1.0ChiLan1.0
PLEKHG5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21221,707,604 - 221,760,746 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11220,349,975 - 220,402,801 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v015,228,681 - 5,259,554 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.116,481,341 - 6,511,652 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl16,481,782 - 6,535,643 (-)Ensemblpanpan1.1panPan2
PLEKHG5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1560,321,453 - 60,347,393 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl560,321,465 - 60,348,088 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha560,331,033 - 60,357,773 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0560,537,129 - 60,563,846 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl560,532,155 - 60,570,971 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1560,536,427 - 60,563,129 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0560,403,196 - 60,429,897 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0560,804,787 - 60,831,497 (-)NCBIUU_Cfam_GSD_1.0
Plekhg5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505830,770,105 - 30,801,791 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366231,255,096 - 1,279,349 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366231,255,350 - 1,279,310 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLEKHG5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl667,321,534 - 67,362,838 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1667,316,818 - 67,373,787 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2662,274,608 - 62,319,169 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLEKHG5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120125,223,074 - 125,276,115 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20125,244,593 - 125,275,676 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605429,271,045 - 29,331,768 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plekhg5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248184,990,808 - 5,009,788 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248184,990,321 - 5,010,308 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Plekhg5
268 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:268
Count of miRNA genes:173
Interacting mature miRNAs:197
Transcripts:ENSRNOT00000064841
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat

Markers in Region
D5Got294  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25162,579,873 - 162,579,979 (+)MAPPERmRatBN7.2
Rnor_6.05169,246,581 - 169,246,684NCBIRnor6.0
Rnor_5.05172,804,844 - 172,804,947UniSTSRnor5.0
RGSC_v3.45169,302,770 - 169,302,873UniSTSRGSC3.4
Celera5160,812,433 - 160,812,536UniSTS
Cytogenetic Map5q36UniSTS
RH141643  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25162,621,241 - 162,621,421 (+)MAPPERmRatBN7.2
Rnor_6.05169,288,038 - 169,288,217NCBIRnor6.0
Rnor_5.05172,846,489 - 172,846,668UniSTSRnor5.0
RGSC_v3.45169,343,862 - 169,344,041UniSTSRGSC3.4
Celera5160,853,386 - 160,853,565UniSTS
RH 3.4 Map51140.0UniSTS
Cytogenetic Map5q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 16 5 3 3 3 42 21 31 10
Low 3 27 52 38 16 38 8 11 32 14 10 1 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000064841   ⟹   ENSRNOP00000059729
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5162,578,071 - 162,621,513 (+)Ensembl
Rnor_6.0 Ensembl5169,244,778 - 169,288,309 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000082586   ⟹   ENSRNOP00000074776
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5162,607,074 - 162,621,513 (+)Ensembl
Rnor_6.0 Ensembl5169,274,785 - 169,287,448 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000084487   ⟹   ENSRNOP00000071902
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5162,592,417 - 162,621,513 (+)Ensembl
Rnor_6.0 Ensembl5169,259,283 - 169,287,918 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107438   ⟹   ENSRNOP00000093604
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5162,602,578 - 162,621,513 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118143   ⟹   ENSRNOP00000088309
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5162,582,480 - 162,621,513 (+)Ensembl
RefSeq Acc Id: NM_001415855   ⟹   NP_001402784
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85167,885,275 - 167,904,229 (+)NCBI
mRatBN7.25162,602,563 - 162,621,518 (+)NCBI
RefSeq Acc Id: NM_001415856   ⟹   NP_001402785
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85167,875,172 - 167,904,229 (+)NCBI
mRatBN7.25162,592,460 - 162,621,518 (+)NCBI
RefSeq Acc Id: NM_201272   ⟹   NP_958429
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85167,860,794 - 167,904,229 (+)NCBI
mRatBN7.25162,578,071 - 162,621,518 (+)NCBI
Rnor_6.05169,244,778 - 169,288,310 (+)NCBI
Rnor_5.05172,803,041 - 172,846,761 (+)NCBI
RGSC_v3.45169,301,095 - 169,344,134 (+)RGD
Celera5160,810,630 - 160,853,658 (+)RGD
Sequence:
RefSeq Acc Id: XM_039109734   ⟹   XP_038965662
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85167,875,169 - 167,904,229 (+)NCBI
mRatBN7.25162,592,506 - 162,621,514 (+)NCBI
RefSeq Acc Id: XM_039109735   ⟹   XP_038965663
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85167,864,442 - 167,904,229 (+)NCBI
mRatBN7.25162,582,076 - 162,621,514 (+)NCBI
RefSeq Acc Id: XM_039109738   ⟹   XP_038965666
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85167,860,730 - 167,904,229 (+)NCBI
mRatBN7.25162,577,999 - 162,621,514 (+)NCBI
RefSeq Acc Id: XM_039109739   ⟹   XP_038965667
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85167,875,327 - 167,904,229 (+)NCBI
mRatBN7.25162,592,606 - 162,621,514 (+)NCBI
RefSeq Acc Id: XM_039109740   ⟹   XP_038965668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85167,896,164 - 167,904,229 (+)NCBI
mRatBN7.25162,613,452 - 162,621,514 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_958429   ⟸   NM_201272
- Peptide Label: isoform 3
- UniProtKB: Q6RFZ7 (UniProtKB/Swiss-Prot),   A0A0G2K8X8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071902   ⟸   ENSRNOT00000084487
RefSeq Acc Id: ENSRNOP00000074776   ⟸   ENSRNOT00000082586
RefSeq Acc Id: ENSRNOP00000059729   ⟸   ENSRNOT00000064841
RefSeq Acc Id: XP_038965666   ⟸   XM_039109738
- Peptide Label: isoform X3
- UniProtKB: Q6RFZ7 (UniProtKB/Swiss-Prot),   A0A0G2K8X8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965663   ⟸   XM_039109735
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A5Z3 (UniProtKB/TrEMBL),   A0A0G2K8X8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965662   ⟸   XM_039109734
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K8X8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965667   ⟸   XM_039109739
- Peptide Label: isoform X3
- UniProtKB: Q6RFZ7 (UniProtKB/Swiss-Prot),   A0A0G2K8X8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965668   ⟸   XM_039109740
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000093604   ⟸   ENSRNOT00000107438
RefSeq Acc Id: ENSRNOP00000088309   ⟸   ENSRNOT00000118143
RefSeq Acc Id: NP_001402785   ⟸   NM_001415856
- Peptide Label: isoform 2
- UniProtKB: A0A0G2K1M4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001402784   ⟸   NM_001415855
- Peptide Label: isoform 1
- UniProtKB: A0A8I6AJ37 (UniProtKB/TrEMBL)
Protein Domains
DH   PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6RFZ7-F1-model_v2 AlphaFold Q6RFZ7 1-1039 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694300
Promoter ID:EPDNEW_R4822
Type:initiation region
Name:Plekhg5_1
Description:pleckstrin homology and RhoGEF domain containing G5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05169,259,257 - 169,259,317EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303132 AgrOrtholog
BioCyc Gene G2FUF-39022 BioCyc
Ensembl Genes ENSRNOG00000022694 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064841 ENTREZGENE
  ENSRNOT00000064841.3 UniProtKB/Swiss-Prot
  ENSRNOT00000082586.2 UniProtKB/TrEMBL
  ENSRNOT00000084487 ENTREZGENE
  ENSRNOT00000084487.2 UniProtKB/TrEMBL
  ENSRNOT00000107438 ENTREZGENE
  ENSRNOT00000107438.1 UniProtKB/TrEMBL
  ENSRNOT00000118143.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PKHG5/7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:310999 UniProtKB/Swiss-Prot
NCBI Gene 310999 ENTREZGENE
PANTHER PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13217 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Plekhg5 PhenoGen
PROSITE DH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022694 RatGTEx
SMART RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48065 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K1M4 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K8X8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A5Z3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AJ37 ENTREZGENE, UniProtKB/TrEMBL
  PKHG5_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-30 Plekhg5  pleckstrin homology and RhoGEF domain containing G5  Plekhg5  pleckstrin homology domain containing, family G (with RhoGef domain) member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Plekhg5  pleckstrin homology domain containing, family G (with RhoGef domain) member 5  Tech  neuronal RhoA GEF protein  Symbol and Name updated 1299863 APPROVED
2005-02-14 Tech  neuronal RhoA GEF protein      Symbol and Name status set to provisional 70820 PROVISIONAL