Plekhg5 (pleckstrin homology and RhoGEF domain containing G5) - Rat Genome Database

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Gene: Plekhg5 (pleckstrin homology and RhoGEF domain containing G5) Chinchilla lanigera
Analyze
Symbol: Plekhg5
Name: pleckstrin homology and RhoGEF domain containing G5
RGD ID: 8786214
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN endothelial cell chemotaxis (ortholog); endothelial cell migration (ortholog); positive regulation of canonical NF-kappaB signal transduction (ortholog); ASSOCIATED WITH autosomal dominant distal hereditary motor neuronopathy 14 (ortholog); autosomal recessive distal hereditary motor neuronopathy 4 (ortholog); Charcot-Marie-Tooth disease recessive intermediate C (ortholog); FOUND IN cell-cell junction (ortholog); cytoplasm (ortholog); endocytic vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pleckstrin homology domain containing, family G (with RhoGef domain) member 5; pleckstrin homology domain-containing family G member 5
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554866,107,024 - 6,121,356 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554866,099,654 - 6,121,805 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Plekhg5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554866,107,024 - 6,121,356 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554866,099,654 - 6,121,805 (+)NCBIChiLan1.0ChiLan1.0
PLEKHG5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3816,467,122 - 6,520,092 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl16,467,122 - 6,520,074 (-)EnsemblGRCh38hg38GRCh38
GRCh3716,526,152 - 6,580,152 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3616,448,739 - 6,502,656 (-)NCBINCBI36Build 36hg18NCBI36
Celera15,640,600 - 5,693,925 (-)NCBICelera
Cytogenetic Map1p36.31NCBI
HuRef15,673,695 - 5,727,849 (-)NCBIHuRef
CHM1_116,514,665 - 6,568,791 (-)NCBICHM1_1
T2T-CHM13v2.015,992,764 - 6,045,736 (-)NCBIT2T-CHM13v2.0
Plekhg5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394152,156,890 - 152,199,855 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4152,156,955 - 152,199,857 (+)EnsemblGRCm39 Ensembl
GRCm384152,072,433 - 152,115,404 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4152,072,498 - 152,115,400 (+)EnsemblGRCm38mm10GRCm38
MGSCv374151,470,828 - 151,489,509 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364150,940,519 - 150,959,200 (+)NCBIMGSCv36mm8
Celera4154,383,207 - 154,401,930 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map482.86NCBI
Plekhg5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85167,860,730 - 167,904,229 (+)NCBIGRCr8
mRatBN7.25162,577,999 - 162,621,518 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5162,578,071 - 162,621,513 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5165,281,116 - 165,324,436 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05167,102,520 - 167,145,861 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05167,064,724 - 167,108,066 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05169,244,778 - 169,288,310 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5169,244,778 - 169,288,309 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05172,803,041 - 172,846,761 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45169,301,095 - 169,344,134 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15169,311,282 - 169,354,321 (+)NCBI
Celera5160,810,630 - 160,853,658 (+)NCBICelera
Cytogenetic Map5q36NCBI
PLEKHG5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21221,707,604 - 221,760,746 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11220,349,975 - 220,402,801 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v015,228,681 - 5,259,554 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.116,481,341 - 6,511,652 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl16,481,782 - 6,535,643 (-)Ensemblpanpan1.1panPan2
PLEKHG5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1560,321,453 - 60,347,393 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl560,321,465 - 60,348,088 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha560,331,033 - 60,357,773 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0560,537,129 - 60,563,846 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl560,532,155 - 60,570,971 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1560,536,427 - 60,563,129 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0560,403,196 - 60,429,897 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0560,804,787 - 60,831,497 (-)NCBIUU_Cfam_GSD_1.0
Plekhg5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505830,770,105 - 30,801,791 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366231,255,096 - 1,279,349 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366231,255,350 - 1,279,310 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLEKHG5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl667,321,534 - 67,362,838 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1667,316,818 - 67,373,787 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2662,274,608 - 62,319,169 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLEKHG5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120125,223,074 - 125,276,115 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20125,244,593 - 125,275,676 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605429,271,045 - 29,331,768 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plekhg5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248184,990,808 - 5,009,788 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248184,990,321 - 5,010,308 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000009477   ⟹   ENSCLAP00000009348
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554866,107,024 - 6,121,356 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000009478   ⟹   ENSCLAP00000009349
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554866,107,087 - 6,121,110 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000009479   ⟹   ENSCLAP00000009350
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554866,107,268 - 6,121,110 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000009480   ⟹   ENSCLAP00000009351
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554866,107,699 - 6,121,110 (+)Ensembl
RefSeq Acc Id: XM_005404088   ⟹   XP_005404145
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554866,099,661 - 6,121,110 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013504284   ⟹   XP_013359738
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554866,099,654 - 6,121,805 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013504285   ⟹   XP_013359739
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554866,107,023 - 6,121,805 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013504286   ⟹   XP_013359740
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554866,102,370 - 6,121,805 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013504288   ⟹   XP_013359742
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554866,107,021 - 6,121,110 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005404145   ⟸   XM_005404088
- Peptide Label: isoform X2
- UniProtKB: A0A8C2V3A5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013359738   ⟸   XM_013504284
- Peptide Label: isoform X1
- UniProtKB: A0A8C2V3A5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013359740   ⟸   XM_013504286
- Peptide Label: isoform X4
- UniProtKB: A0A8C2V3A5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013359742   ⟸   XM_013504288
- Peptide Label: isoform X5
- UniProtKB: A0A8C2YME3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013359739   ⟸   XM_013504285
- Peptide Label: isoform X3
- UniProtKB: A0A8C2YME6 (UniProtKB/TrEMBL),   A0A8C2YME3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000009351   ⟸   ENSCLAT00000009480
RefSeq Acc Id: ENSCLAP00000009348   ⟸   ENSCLAT00000009477
RefSeq Acc Id: ENSCLAP00000009349   ⟸   ENSCLAT00000009478
RefSeq Acc Id: ENSCLAP00000009350   ⟸   ENSCLAT00000009479
Protein Domains
DH   PH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000006493 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000009477 ENTREZGENE
  ENSCLAT00000009477.1 UniProtKB/TrEMBL
  ENSCLAT00000009478 ENTREZGENE
  ENSCLAT00000009478.1 UniProtKB/TrEMBL
  ENSCLAT00000009479.1 UniProtKB/TrEMBL
  ENSCLAT00000009480.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  PKHG5/7 UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
NCBI Gene Plekhg5 ENTREZGENE
PANTHER PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 5 UniProtKB/TrEMBL
  PTHR13217 UniProtKB/TrEMBL
Pfam RhoGEF UniProtKB/TrEMBL
PROSITE DH_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
SMART RhoGEF UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF48065 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A8C2V3A5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2V954_CHILA UniProtKB/TrEMBL
  A0A8C2YME3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YME6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Plekhg5  pleckstrin homology and RhoGEF domain containing G5    pleckstrin homology domain containing, family G (with RhoGef domain) member 5  Symbol and/or name change 5135510 APPROVED