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Gene: Unc5c (unc-5 netrin receptor C) Rattus norvegicus

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Symbol:

Unc5c

Name:

unc-5 netrin receptor C

RGD ID:

735109

Description:

Predicted to enable netrin receptor activity involved in chemorepulsion; protein kinase binding activity; and tubulin binding activity. Predicted to be involved in chemorepulsion of axon; dorsal root ganglion development; and netrin-activated signaling pathway. Predicted to act upstream of or within several processes, including nervous system development; positive regulation of apoptotic process; and regulation of neuron migration. Predicted to be located in several cellular components, including filopodium; growth cone; and lamellipodium. Orthologous to human UNC5C (unc-5 netrin receptor C); INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; androgen antagonist.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

netrin receptor UNC5C; protein unc-5 homolog C; unc-5 homolog 3; unc-5 homolog C; unc-5 homolog C (C. elegans)

RGD Orthologs

Alliance Orthologs

More Info

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More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	UNC5C (unc-5 netrin receptor C)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Unc5c (unc-5 netrin receptor C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Unc5c (unc-5 netrin receptor C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	UNC5C (unc-5 netrin receptor C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	UNC5C (unc-5 netrin receptor C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Unc5c (unc-5 netrin receptor C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	UNC5C (unc-5 netrin receptor C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	UNC5C (unc-5 netrin receptor C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Unc5c (unc-5 netrin receptor C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Unc5c (unc-5 netrin receptor C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	UNC5C (unc-5 netrin receptor C)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Unc5c (unc-5 netrin receptor C)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	unc5c (unc-5 netrin receptor C)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	unc5c (unc-5 netrin receptor C)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:ch73-72b7.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:ch73-72b7.1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	unc-5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	unc-5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	unc-5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	unc-5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	unc5c	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	unc5c	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Allele / Splice:

Unc5c^hob ; Unc5c^cvd

Genetic Models:

HOB-Unc5c^hob/Snk ; F344.CVD-Unc5c^cvd/Kyo

Is Marker For:

Strains: HOB-Unc5c^hob/Snk ; CVD/Opu ; HOB/Snk ; F344.CVD-Unc5c^cvd/Kyo

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	232,854,352 - 233,208,482 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	232,846,262 - 233,208,482 (+)	Ensembl				GRCr8
mRatBN7.2	2	230,180,353 - 230,535,219 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	230,180,951 - 230,535,217 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	237,924,292 - 238,290,667 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	235,817,330 - 236,183,687 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	230,681,978 - 231,048,343 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	247,045,813 - 247,397,483 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	247,248,407 - 247,397,483 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	265,573,406 - 265,926,229 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	239,365,109 - 239,721,231 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	222,239,483 - 222,591,078 (+)	NCBI		Celera
RGSC_v3.1	2	239,351,848 - 239,707,971 (+)	NCBI
Cytogenetic Map	2	q44	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

renal cell carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

androgen antagonist (EXP)

aristolochic acid A (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

Butylparaben (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

cisplatin (ISO)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

diazinon (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

enzacamene (EXP)

ethanol (ISO)

etoposide (ISO)

folic acid (ISO)

fulvestrant (ISO)

furan (EXP)

glyphosate (EXP,ISO)

ketamine (EXP)

kojic acid (ISO)

lipopolysaccharide (ISO)

nickel atom (ISO)

okadaic acid (ISO)

ozone (ISO)

panobinostat (ISO)

paracetamol (EXP)

perfluorohexanesulfonic acid (ISO)

phenylmercury acetate (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

Soman (EXP)

spermine (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

valproic acid (EXP,ISO)

vancomycin (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anterior/posterior axon guidance (ISO)

apoptotic process (IEA)

axon guidance (IBA,IEA,ISO,ISS)

brain development (ISO)

chemorepulsion of axon (IEA,ISO,ISS)

dorsal root ganglion development (IEA,ISO,ISS)

netrin-activated signaling pathway (IEA,ISO)

positive regulation of apoptotic process (ISO)

regulation of cell migration (ISO)

signal transduction (IEA)

Cellular Component

axon (IEA,ISO,ISS)

cell surface (IEA)

dendrite (IEA,ISO,ISS)

filopodium (IEA,ISO,ISS)

growth cone (IEA,ISO,ISS)

lamellipodium (IEA,ISO,ISS)

membrane (IEA)

neuron projection (IEA)

neuronal cell body (IEA,ISO,ISS)

plasma membrane (IEA,ISO,ISS)

synapse (IEA)

Molecular Function

netrin receptor activity (IBA,IEA,ISO)

netrin receptor activity involved in chemorepulsion (IEA,ISO,ISS)

protein binding (ISO)

protein kinase binding (IEA,ISO)

tubulin binding (IEA,ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

absent cerebellum vermis (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat neurological mutations cerebellar vermis defect and hobble are caused by mutations in the netrin-1 receptor gene Unc5h3.	Kuramoto T, etal., Brain Res Mol Brain Res 2004 Mar 30;122(2):103-8.
4.	Rat mutations cvd and hob with cerebellar malformations map to chromosome 2.	Kuwamura M, etal., Exp Anim 2004 Jan;53(1):21-6.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:1401878	PMID:9126743	PMID:9389662	PMID:9550145	PMID:10818148	PMID:10964959	PMID:11387206	PMID:18077458	PMID:18479186	PMID:22685302	PMID:23144223	PMID:25419706
PMID:27068745	PMID:28483977

Genomics

Comparative Map Data

Unc5c
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	232,854,352 - 233,208,482 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	232,846,262 - 233,208,482 (+)	Ensembl				GRCr8
mRatBN7.2	2	230,180,353 - 230,535,219 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	230,180,951 - 230,535,217 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	237,924,292 - 238,290,667 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	235,817,330 - 236,183,687 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	230,681,978 - 231,048,343 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	247,045,813 - 247,397,483 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	247,248,407 - 247,397,483 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	265,573,406 - 265,926,229 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	239,365,109 - 239,721,231 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	222,239,483 - 222,591,078 (+)	NCBI		Celera
RGSC_v3.1	2	239,351,848 - 239,707,971 (+)	NCBI
Cytogenetic Map	2	q44	NCBI

UNC5C
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	95,162,504 - 95,548,973 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	95,162,504 - 95,549,206 (-)	Ensembl			hg38	GRCh38
GRCh37	4	96,083,655 - 96,470,124 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	96,308,712 - 96,689,185 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	4	96,446,866 - 96,827,340	NCBI
Celera	4	93,380,311 - 93,766,978 (-)	NCBI		Celera
Cytogenetic Map	4	q22.3	NCBI
HuRef	4	91,820,282 - 92,206,879 (-)	NCBI		HuRef
CHM1_1	4	96,060,693 - 96,447,078 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	98,477,165 - 98,864,110 (-)	NCBI		T2T-CHM13v2.0

Unc5c
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	141,171,360 - 141,540,685 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	141,170,977 - 141,540,685 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	3	141,465,564 - 141,834,924 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	141,465,216 - 141,834,924 (+)	Ensembl			mm10	GRCm38
MGSCv37	3	141,128,528 - 141,497,886 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	3	141,402,951 - 141,772,309 (+)	NCBI		MGSCv36	mm8
Celera	3	147,889,997 - 148,247,699 (+)	NCBI		Celera
Cytogenetic Map	3	H1	NCBI
cM Map	3	65.57	NCBI

Unc5c
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955405	5,797,590 - 5,950,544 (-)	Ensembl
ChiLan1.0	NW_004955405	5,791,286 - 6,049,952 (-)	NCBI	ChiLan1.0	ChiLan1.0

UNC5C
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	93,198,579 - 93,586,730 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	93,477,466 - 93,865,726 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	87,527,262 - 87,921,351 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	98,198,831 - 98,589,857 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	98,205,554 - 98,587,888 (-)	Ensembl			panPan2	panpan1.1

UNC5C
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	32	17,981,286 - 18,333,111 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	32	17,987,464 - 18,333,602 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	32	23,609,404 - 23,959,891 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	32	18,164,222 - 18,513,849 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	32	18,167,485 - 18,513,818 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	32	18,134,124 - 18,485,245 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	32	17,955,873 - 18,306,960 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	32	21,584,814 - 21,936,742 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Unc5c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405301	23,396,564 - 23,746,350 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936687	2,607,112 - 2,756,094 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936687	2,600,635 - 2,951,407 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

UNC5C
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	124,142,030 - 124,530,603 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	8	124,149,364 - 124,533,755 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

UNC5C
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	43,405,666 - 43,786,436 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666037	21,777,546 - 22,164,042 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Unc5c
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624757	23,151,485 - 23,537,706 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624757	23,145,200 - 23,537,812 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Unc5c
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	3	18,968,702 - 19,320,865 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Unc5c
2547 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	90
Count of miRNA genes:	74
Interacting mature miRNAs:	82
Transcripts:	ENSRNOT00000050330
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331734	Bp204	Blood pressure QTL 204	3.61192		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	170656145	239614549	Rat
631501	Bp101	Blood pressure QTL 101	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	205135267	250135267	Rat
1598813	Memor9	Memory QTL 9	2.7		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	202029709	236904960	Rat
2307174	Activ3	Activity QTL 3	4.83	0.000058	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	2	210956252	251712708	Rat
8693697	Alc36	Alcohol consumption QTL 36	2	0.592	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	2	219814164	239320906	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	143344967	251712708	Rat
1298075	Scl17	Serum cholesterol level QTL 17	3.4		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	214404877	251712708	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	143344967	251712708	Rat
1300126	Bp175	Blood pressure QTL 175	3.46		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	204795005	249795005	Rat
7207484	Bss108	Bone structure and strength QTL 108	5.3		femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	2	214404877	251712708	Rat
2313073	Bmd75	Bone mineral density QTL 75	4.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	2	218051934	251712708	Rat
61398	Bp50	Blood pressure QTL 50	4.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	192287802	237287802	Rat
7207482	Bss107	Bone structure and strength QTL 107	7		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	2	214404877	251712708	Rat
2317752	Glom23	Glomerulus QTL 23	3.6		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	2	196140964	251540988	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	205135267	250135267	Rat
1549836	Bss2	Bone structure and strength QTL 2	7.5		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	2	214404877	251712708	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	2	205135267	250135267	Rat
1359031	Bp275	Blood pressure QTL 275			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	188565047	233565047	Rat
1331767	Hrtrt12	Heart rate QTL 12	3.373		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	221088977	243501206	Rat
2293833	Kiddil8	Kidney dilation QTL 8	2.9		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	220274283	249795005	Rat
1598835	Anxrr18	Anxiety related response QTL 18	2.98		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	2	203664411	248664411	Rat
7207490	Bss111	Bone structure and strength QTL 111	6.4		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	2	214404877	251712708	Rat
8693622	Alc26	Alcohol consumption QTL 26	2.4	0.667	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	2	223810546	243965570	Rat
61366	Iddm3	Insulin dependent diabetes mellitus QTL 3	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	192287802	237287802	Rat
2293844	Kiddil7	Kidney dilation QTL 7	3.5		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	220274283	249795005	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	151869660	251712708	Rat

Markers in Region

D2Rat296

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	230,469,531 - 230,469,773 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	247,331,943 - 247,332,273	NCBI	Rnor6.0
Rnor_5.0	2	265,860,605 - 265,860,935	UniSTS	Rnor5.0
RGSC_v3.4	2	239,654,588 - 239,654,790	RGD	RGSC3.4
RGSC_v3.4	2	239,654,589 - 239,654,790	UniSTS	RGSC3.4
Celera	2	222,525,569 - 222,525,770	UniSTS
RGSC_v3.1	2	239,641,328 - 239,641,530	RGD
SHRSP x BN Map	2	98.7698	RGD
SHRSP x BN Map	2	98.7698	UniSTS
Cytogenetic Map	2	q44	UniSTS

RH138265

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	230,533,052 - 230,533,210 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	247,395,319 - 247,395,476	NCBI	Rnor6.0
Rnor_5.0	2	265,924,063 - 265,924,220	UniSTS	Rnor5.0
RGSC_v3.4	2	239,719,067 - 239,719,224	UniSTS	RGSC3.4
Celera	2	222,588,914 - 222,589,071	UniSTS
RH 3.4 Map	2	1581.1	UniSTS
Cytogenetic Map	2	q44	UniSTS

AU049740

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	230,203,710 - 230,203,853 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	247,068,459 - 247,068,601	NCBI	Rnor6.0
Rnor_5.0	2	265,596,052 - 265,596,194	UniSTS	Rnor5.0
RGSC_v3.4	2	239,387,756 - 239,387,898	UniSTS	RGSC3.4
Celera	2	222,262,140 - 222,262,282	UniSTS
Cytogenetic Map	2	q44	UniSTS

Unc5c

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	2	233,207,657 - 233,208,079 (+)	Marker Load Pipeline
mRatBN7.2	2	230,534,393 - 230,534,816 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	247,396,660 - 247,397,082	NCBI	Rnor6.0
Rnor_5.0	2	265,925,404 - 265,925,826	UniSTS	Rnor5.0
RGSC_v3.4	2	239,720,408 - 239,720,830	UniSTS	RGSC3.4
Celera	2	222,590,255 - 222,590,677	UniSTS
Cytogenetic Map	2	q44	UniSTS

Related Rat Strains

The following Strains have been annotated to Unc5c

CVD/Opu F344.CVD-Unc5c^cvd/Kyo HOB-Unc5c^hob/Snk HOB/Snk

Genetic Models

This gene Unc5c is modified in the following models/strains:

HOB-Unc5c^hob/Snk F344.CVD-Unc5c^cvd/Kyo

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	11	67	151	86	85	54	25	54	6	273	124	11	130	71	92	31	16	16

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001415084	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_199407	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039102727	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039102728	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039102729	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB118026	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473952	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000050330 ⟹ ENSRNOP00000050380

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	233,109,679 - 233,208,482 (+)	Ensembl
mRatBN7.2 Ensembl	2	230,436,411 - 230,535,217 (+)	Ensembl
Rnor_6.0 Ensembl	2	247,299,433 - 247,391,299 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000082287 ⟹ ENSRNOP00000068741

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	233,056,912 - 233,208,482 (+)	Ensembl
mRatBN7.2 Ensembl	2	230,383,654 - 230,535,217 (+)	Ensembl
Rnor_6.0 Ensembl	2	247,248,407 - 247,397,483 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000093785 ⟹ ENSRNOP00000095040

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	232,846,262 - 233,208,482 (+)	Ensembl
mRatBN7.2 Ensembl	2	230,448,646 - 230,535,217 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000106798 ⟹ ENSRNOP00000090774

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	232,854,268 - 233,208,482 (+)	Ensembl
mRatBN7.2 Ensembl	2	230,180,951 - 230,535,217 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000108186 ⟹ ENSRNOP00000089543

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	232,854,268 - 233,208,482 (+)	Ensembl
mRatBN7.2 Ensembl	2	230,180,951 - 230,535,217 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000116804 ⟹ ENSRNOP00000087486

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	232,854,268 - 233,208,482 (+)	Ensembl
mRatBN7.2 Ensembl	2	230,434,570 - 230,535,217 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000120185 ⟹ ENSRNOP00000088490

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	232,854,467 - 233,208,482 (+)	Ensembl
mRatBN7.2 Ensembl	2	230,181,214 - 230,535,217 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000165460 ⟹ ENSRNOP00000105184

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	233,107,956 - 233,202,434 (+)	Ensembl

RefSeq Acc Id:

NM_001415084 ⟹ NP_001402013

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	232,854,352 - 233,208,482 (+)	NCBI
mRatBN7.2	2	230,181,099 - 230,535,219 (+)	NCBI

RefSeq Acc Id:

NM_199407 ⟹ NP_955439

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	232,854,352 - 233,208,482 (+)	NCBI
mRatBN7.2	2	230,181,099 - 230,535,219 (+)	NCBI
Rnor_6.0	2	247,045,813 - 247,397,483 (+)	NCBI
Rnor_5.0	2	265,573,406 - 265,926,229 (+)	NCBI
RGSC_v3.4	2	239,365,109 - 239,721,231 (+)	RGD
Celera	2	222,239,483 - 222,591,078 (+)	RGD

Sequence:

show sequence

CCTTGGAGAAAGTGGAGTGTGGCGCTCCGGCTGCTGTTATTTCTCAGGACTGCCTGGCGGTGGC
CGGATCTAGCCTCCTGCCCGGCGGGGCTTTCTGCTGTTTGCGCGTCTCCTGGTGGCGTTACCCT
TCCCCGCACACCTCTGCCGACGATGAGGAAAGGTCTGAGGGCGACAGCGGCCCGCTGCGGACTG
GGACTAGGATACTTGCTGCAGATGCTTGTGTTACCTGCCCTGGCCCTGCTCAGCGCCAGTGGCA
CCGGCTCGGCCGCTCAAGATGATGACTTTTTCCATGAACTCCCAGAAACCTTTCCATCAGACCC
ACCTGAGCCATTACCACACTTTCTCATTGAGCCCGAGGAAGCTTACATTGTGAAGAACAAGCCT
GTGAACCTGTATTGTAAAGCCAGCCCTGCCACCCAGATCTACTTCAAGTGCAACAGCGAATGGG
TTCATCAGAAGGACCACGTAGTAGACGAGAGGGTAGATGAAACCTCCGGTCTCATTGTGAGAGA
AGTGAGCATTGAGATTTCACGCCAGCAGGTGGAGGAACTGTTCGGGCCTGAAGATTACTGGTGC
CAGTGTGTGGCCTGGAGCTCAGCGGGCACTACGAAGAGTCGGAAGGCATACGTGCGCATTGCGT
ATCTGCGGAAGACATTTGAGCAGGAACCCTTGGGAAAAGAAGTGTCCTTGGAGCAGGAAGTGTT
ACTCCAGTGCCGGCCACCTGAAGGGATCCCAATGGCTGAGGTGGAGTGGCTAAAGAATGAAGAC
ATAATTGATCCTGTCGAAGATCGGAATTTTTATATCACTATCGATCACAACCTGATCATCAAGC
AGGCACGACTCTCAGATACAGCGAATTATACCTGTGTTGCCAAAAACATTGTTGCCAAGAGGAA
AAGCACCACAGCCACCGTCATCGTGTATGTTAATGGTGGCTGGTCCACCTGGGCAGAATGGTCT
GTGTGTAACAGCCGCTGTGGGCGAGGATATCAGAAACGCACAAGAACCTGCACCAACCCAGCCC
CCCTCAATGGTGGGGCCTTCTGCGAGGGGCAGAGTGTACAGAAAATAGCATGCACCACGTTATG
CCCAGTGGATGGCAGGTGGACTTCGTGGAGCAAATGGTCAACTTGTGGGACTGAGTGCACCCAC
TGGCGGAGGAGGGAGTGTACAGCACCAGCCCCCAAGAACGGGGGTAAGGACTGTGATGGCCTGG
TCCTCCAATCCAAGAACTGCACCGATGGGCTGTGCATGCAGGCTGCTCCTGACTCAGATGACGT
TGCTCTCTACGTTGGGATTGTGATCGCTGTAACCGTTTGTCTGGCAATCACTGTTGTGGTGGCC
CTGTTCGTGTATCGCAAGAACCACCGTGACTTTGAGTCTAATATCATTGACTCCTCAGCACTCA
ATGGCGGCTTTCAGCCTGTGAACATCAAGGCTGCCAGACAAGATCTCCTGGCAGTACCCCCGGA
TCTCACCTCAGCTGCAGCCATGTACAGGGGACCCGTCTATGCTCTCCATGATGTCTCAGACAAA
ATCCCAATGACCAATTCTCCAATTCTAGACCCACTGCCCAATTTGAAAATCAAAGTGTACAACA
GCTCAGGTGCTGTCACTCCTCAGGACGACCTTGCTGAGTTCTCATCCAAGCTGTCACCCCAGAT
GACCCAATCCTTGCTAGAGAATGAGGCCCTGAACCTGAAGAACCAGAGTCTCGCAAGACAGACT
GACCCATCCTGCACAGCGTTTGGCACCTTCAACTCCCTGGGCGGTCACCTCATCATCCCTAATT
CAGGAGTAAGCTTGCTGATTCCCGCTGGGGCCATTCCTCAGGGGAGAGTCTATGAAATGTATGT
GACTGTACACAGGAAAGAAAATATGAGGCCCCCCATGGAAGACTCTCAGACCCTGCTGACCCCT
GTGGTGAGCTGTGGGCCTCCTGGAGCTCTGTTGACCCGTCCTGTCATCCTCACTCTGCATCACT
GTGCAGACCCTAACACCGAGGACTGGAAGATCCAGCTCAAAAACCAGGCAGTGCAGGGACAGTG
GGAGGATGTTGTGGTTGTTGGAGAGGAAAACTTCACAACCCCCTGTTACATTCAGCTGGATGCA
GAGGCTTGCCATATTCTCACGGAGAACCTCAGTACCTATGCCCTGGTTGGGCAGTCCACCACCA
AAGCAGCTGCCAAGCGTCTGAAGCTGGCCATCTTTGGGCCCCTCTGCTGCTCTTCCCTGGAGTA
TAGCATCAGAGTCTACTGCCTGGATGACACACAGGATGCCCTGAAGGAAGTTCTACAACTGGAA
AGGCAAATGGGAGGACAGCTCCTAGAAGAACCCAAGGCTCTTCATTTTAAAGGCAGCATCCACA
ACCTGCGCCTCTCAATTCATGACATCACCCATTCCCTCTGGAAGAGCAAATTGCTGGCTAAGTA
TCAGGAAATTCCATTTTACCACATCTGGAGTGGCTCTCAAAGAAACCTCCACTGTACCTTCACT
CTGGAAAGACTCAGCCTAAACACAGTAGAGCTGGTTTGCAAACTCTGTGTGCGGCAGGTTGAAG
GAGAAGGGCAGATCTTCCAGCTCAACTGTACTGTGTCAGAGGAACCTACTGGTATCGATTTGCC
TCTCCTGGACCCTGCTAGCACCATTACCACTGTCACTGGACCAAGTGCTTTCAGCATCCCTCTT
CCTATCCGGCAGAAGCTATGTAGCAGCCTGGATGCCCCCCAAACAAGAGGCCATGACTGGAGGA
TGCTGGCCCACAAACTTAACCTGGACAGGTACTTGAATTACTTTGCCACCAAATCGAGCCCGAC
TGGCGTAATCCTGGATCTCTGGGAAGCACAGAACTTCCCCGATGGAAACCTGAGCATGCTGGCA
GCCGTCCTGGAAGAAATGGGAAGACACGAAACCGTAGTGTCCTTGGCAGCAGAAGGTCAGTATT
GACCACACCGGAACCGACACTGAAGGACAAAATTACACAGGGAGTCTGTGTTCAGGGGAACCAC
ATCTGAGGAGGAAATCCAGATAGGACCAAGGCGCTTTACAGGCAAGATGGCAACAGGAAACGTG
GGGGACAGATACAACCACCAAGGTACACGCCCACTTCATTCGGACAGTACCACCACGGGAGCTA
AGGAAAACAATGTGTAAATTTGTACCTTGAATTTAACAATCAATCTAATTTTCTCTTCATTGGG
CTGTATGCTGTATGGTACAGGATCTTACAGTTTCCTAGGAAACGCTTTATATTGCTATCCAGAT
GTATGGATAAACTTTCTTAACAAACCCAGTTTCTACAAATGTTGTTTACATCAAATTGGACAGG
GATGCAGACGCTGTCCATGGCTCGTTCTATTTTTGTTCAGATCATTTGAAGTTGAAGCTGTGGA
CGGTTGATTGTGTCTATTTCAGATTAGTAATTTACAGAGAAATCACAGACTTTTTGCTACAAAT
TGTGTACATCGAGTGTCTCAGATAATCTTCCCATCAGTGTTCTGTTTCTGAAACTTGTTGGACC
AGTATTGCCATTGGTATCAGGGAAGTGGAGAATCTCAATGTAAAGGAGAAATTGCTAAAATTCC
TTACGTGATGGGGGGGCCCGGTCGGTGTCCTTTGGGAACAACCTTTGCTGTGGTATTACAGGGA
AGGTAGCGACTCAGGTCCCTCCACACAAACATTTCTGTGTCACGTGTGTGTTTGTAATAAGCAA
TTTCAAGTGTTTTTTGAAAAAGTATTATCATTATTACTGATGATTATCACAACTATTCTAGTGA
AAAGATTTTTCTTTTGTTTTAGTTAGCAATACTGTTAGTGTTTGGTGTTGACTGGGCCTGCCTC
CCTTTCTTGCCTAAAGAGGTGGGATATGGTCACCAGTTTAGTTCAATAGCTTTTGCTTCCTTGA
CCTTTGACCTACTATTCTGTGGTGGAAAAGACAAAAATGCTCAGTGGCTATGTCTGCTCTTTCA
GCTTGCTTGGTCAGAGCCTTTCTCCTCTTGCTCTTATCATGAGGAGAGTTCTCTATGTAAAGTT
CATTTACTTTTGTGGCTGTCTTTCTGGGAGGCAGTGGGACTGTGGGTAACAGTGAACTAGGAAT
CAGGAAAAGTTATCCTTGTGAAGTTGGTCACTGTCTGGCTGTGTGACTTTGGGGAGAACCCTGA
GAGTCACTGGAGCTCATTGTCCTTCTATGTAAACAATGGAGACCAGATCATCTCAAGGTTCCAG
CATGCTGATATCCCATTGGGATATCATCAGCCTTTTACATCTTGCAGGCAGGATTGACTTGAAA
GGGGGATGACTTCAACATGCATTTATTTGTTTGCCTTTGTCTTTGTATCATCGTTGCATGATGT
TCACCGAGAGAGGGCATCCTTTTCTTATTGTCTTGACCTCTAGTGGGGCCCTACCCTCCAGCCG
ACCAACTAATTGTAAATTCTACTTTACCCATTTATTGATCTCTAGATCTCAAGACCATTTCTAC
TAAAAGCCCATGCAGCTGAAGGACTCGGTACCATTTTTCTTCCTTTATTAATCTTTGCTTTAAT
AATATGCAGTTGTATTTACAGCCTTTTATTATCCCTTTAACCCTATAAAATGTTGTACATACCA
CAAGTTCTCCTTGGGACCATCTTGGTTTTGGTTTGTTTGTTTCTTTGGGGCTTTTTGTTGTTGT
TGTTTTGTTTTGTTTTGTTTTTGATATAGGAACTCCATTCAGCAGATGGTGAATGAAAACTTAG
CAACCCCATAGTTACAGTTGCAGTTAAATAGGAAGCACCCGTGTCCTTAAGTCAGAGACTTCAA
AATGTGGCTGTGGTATACTTTGGGGCTGGAAGTATCCAGGTTGCTGAGTGGATTCCAGTTGGGA
ATCGTTTTGCCTAATGCTCCCTCCAATTCTTTTACTTCCTGATACTCTCCGTCCCTTCCACTGT
AGTCATTAAGGAACCATGGAAACAGTTGCGGAGACTTCCTTCACGGTGTTTTTCTTCTCTTTCA
GAGATGTATCCTCCAATCTCTCTAACCTCATTCATATGTAAGACTCCTGGTTCCACTGGTGGTG
GGAGGCGAATTCTATACTCCTATGAAAGCCCAGTGGCTGATGTCTAGAACTATGAGTTTGTTTG
AATTTTTAAGAGTTTGATAGATATTCTTAAAAAGCAAGAGGAAGAAAGACAGTCATTGCTGCCT
CTTGAAACAAAGGTGTGGATGTTCCTCTTCGCTACTTGGATTTTGGAACCATCCAAGTAATCCA
AACTGAGAGATCTTGACTGGATATTCTGTGTAACTTCAATGCTTTGTGCTAAGTCAAGAGAGAC
AAACATGTTGCTGTTCTGGATAATTTATCCTAAAAACCCGTTAAGTAACCATCATAGACATACT
GAATATAACCAAAGCAACATTATTGAGTCTTTTCAGAGTCCTCATGTTCAAGCATCTAGAGATA
CTGGCTTTTCTATTCAGACTCTCACAACAGGAAAAGGAAACATTACTGATATCTTATGAAGGAA
TCATTTGTCATAAAACTACTTTTCTGTCATGCGAATGACAGTTTCCAAACTAGAACATACCAAA
CATCAAATAATTTCCTCTTAAGCAGTCTGCTCTTTCTCCTTAGGAAGAAAATAATAGTTGTTAG
ATTGCTGCTTTCCAACACACCAGGTTCACCTGGCATAGTTCATTTTAGAGGGAGCTTCATCATC
ACCTCTGTGGCATGTCTGACTTCTACAGAGCTTCTGAGGAAAGCCTTGCTTGCTCTGGGTGGGT
TAAAAAAAACTAATTATTTGTGCATGGTGCCATCTAGTGGCCTGCCACATAGTTACTCAATTTT
ACATACAGCTTACAAAAAGTTGACAGTTAAGTACCTGTGGAGTTTGACATAACATTTGTGACAG
ACGTGGGGGAATTTACCCACGTGCGTAACTCTCTTATTCTCATATTCTTCAGTTAAATCATCTA
TTCCACAATTTTCTGGGTATATTACCTCATCAAATTACTCATTCACACCTTAAGTTATTTTCTA
GTAATAGACATATATGGAATCTATATTAAAAAGTCTCTGAAAGTTGTCATTCTTTATTTATGAA
TGCCATTGGGTTTTGCATATTTTAAATCTTTTAATTCCAAAACATTAACTTTTAGAAGCATAAG
CTCTAGTCACAAAGAAGCCCCCCTGTCCACCATCTCCACATACATATACAAACGCATGGCATCC
CCTTTGGGGTTTTGTTATTTGATTTACTATTTTGATATATATTCTTACTAGGTATTCCAGAACA
CCCTCAAATCCATCACCCTATTGCCCCTGCCTCTCTCATGTGGTGGGAGTTTAAGTATGTACCA
TAGACCTGCTTCAACCTGCTCTGCATCTGGAAATGAGAGTCCTGTGTCTATGGATGTGGGAGTT
GTGGCTGTTAATCAAGGTGATACTCTTTCAATGAAGTAGACTTTCTGAGATCAGGAATCTAACG
CTCCATGACCTCATCTTATTGTTATGACATTAATTCAAATGGGCTTGAGTACATGAGTAGAAGG
GTGTGTCAAGAAAGTCACAGCCCAAACATCTTCAAAGCACTCACATTGTCTCTGCTACACAAGA
ACTTCATCCTGACCTGAGCAAATTAATCTCTTCGGGGAAAGAATAATTTGGGAGATGAGAGGTC
CAAGATCAAAGTATAGCATTAGCTATTTTCACATATGCTATGAGTCTATAGATTTTAATTATTC
CACTATCAAAGAGTAGAGACATTCTTGAGGGAAAAGTTGTCATAGCTATATTTAGGATCCTCTA
GGAAACAGGTATTAAAGACATTTCTTCTAAAAGTGTTTGAAAAGGAAACCTTCAGAGGGTGGGA
TTTAGACAGTTCATATCTGGAGCAGGGTAGATGGTTGCTACATCTCTGTGTGTCTCCGATGAGG
ACTTGGCAGCTGTGATCCTGCATCATTCACACCTCCATAGCCACAGGACAAAGGAGAGCTTATA
AGGTTGATGTCCTGCCCCAGAATCCATACATATGCCTACAGTCTGTGCTCTGGAGCCAATCAGT
GTAGAAGGATGTTGAACAATATGAGAGAACAAGTAGAAAAGATTGACTTGTTGCGAGTCTCCAA
GATGAACATGAATTTGAGCTGAGTAATTGCTCCAGAAAAGAGATCCATTCAGAGATAGATACTA
ATGCAAGTCCAAGGCCAGGGTGGCAAAGGAGGGACTACAGAAACACAGTGGGGGGTGGAATTAG
GCTTGAGATGCCTTTTCTGAGAAGCTTTGTAAATCAGAACACCATTGTTCAAATCAGTCATTTG
TAAAGATGATAATGGCCAATGAGCATCTTATTTTATAGATCCAAAAGAAAAATATTTTTATTAT
TATTCTCAAGATAATAAAACTGGTTTTGCCTTCTGAGTGCCTCGTGGGACCAACTATCTTATTC
CTTTAGTTTTGTATTGTTTTTGTATTTTTAAAGCATACTGAGCTGACATTGACTTATAACTCTT
ACAACTCTCTGTACAACAGAGTACTGTTTCTCTGCCCCAAGAGATCCGATTGTACCACCTCTGC
AACAGTTACCTGAGAATTTCCTGATGTAATTGGGACTATGAGGAATACATTTATTATGTTCATA
TGGGCTAAGTAAGCCATATGAAGTTATGTTTCCCAAAATCTGACACTTATGTAAGCTTTGTTAA
ATGAGTAGAGATGGCCTGCATGTACCTGGGTGGAGTATCTCGTCAAACTAACAGTGTGGTTGTG
AATCCTTTAGTCCTTTTGAACAAATGGTTGCCCTTTTTTCCTGAAAACCTATTGCAATGGTCTT
CAGAAAGTCCAGTGGGCTTGGCTGCTTCCTTTATTGATCTGTGGTGGGATATTAACGGGCTTAT
TCAACCAAAGGTATTTTCAGAGGCCTATTTCAGTATGGCTGGGGTATCCTCAGGACAAATAAGA
CATACTCCATAAACATGCTAGCAGGTAAAGCCAATGAAATGTAAGAGGTGACCTGCAAGTCTTC
AGTATACACAACTATGAAGGAATCTATCCCAAGAATTACCAGAATCCTAAATTGGAAGCTCCTG
CCATATATCAGGACCGTCATGGCCAACCCCACTAGTTGTTAAGCAGAAAACCAGGGACTGTCCT
GAGATACAATCAGCTGTCCACCAGCCATGTTATTTACTACGGTACACCAGCTTTTTATATATCA
TTTGGGAACCTGTGCTAGAGCAGAATTATAAATTGCAGGCTATCATACTGTATGACCCATTTTA
AATAAGCCTAAACTCCATGTCATCCTTACATGCCAAAGGCCTAATGCCATGGAGCCCGATGACA
CCCAGCCATGGTGACTGAACTGTGGGCTGGTTGTCCTGATGGGCAGCCTAAGGGACGAGCTCTC
TGCCTTTGATCTTCACTCAGCATGAAGATGTGGCAACATCAAAGCATCATGATGAGCCCTGTGC
TATGTTAAAGCAATTTTAAGATGGCGTACGAAACAAATTCACAGCTAGTAGAACATACCTTTGC
CCTTTCTGTGTTCCTAAAGTCATCAATGGCACCCATAACTGCACATATATGGATTCAGACATTT
TTTTCTCCAGATTATTGGAAAGAAAGAAGAGCCAGTTAAACACATGACTTGCGTTCTTTCTTTC
ACTTGTTCCTAGTCCTACTATGGGTATTGATGCCCTTACCTTTCAGACAATGTATTTAGCCAAG
TTGCAGGGAATATCATTACTCTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGT
GTGTTAGATGTCACAGTGTTGTGTGTATTAAGCTTAATGTTGAGCTGTAAGGAACCAGTCATCT
TCCTCCTTGTTCTAAAGAAGAAAACCCATATTCATCAGAGAACAATCCCCAGCTTGCTGCTAAA
AAGAGGCTGGGTCACCCTCCTGCTGTCTTCTTTGGACCAGGTCAACTTCAGAAGTATCAGGTTG
AAATTTTAAGCTCTGTCAGTTTTTTTTTTCCCTTCTTTTAGCAAAACAACATGACCTTGGCTTC
CCAGATATGGAACCCTTCCTTCCTTTGTTACAGAATTCTGTCTTGCTGTATCTTCTATGCAATT
CCTTTTCTAATGACCCCTAGTGGCTGAGGAGTGCTCTGCAGCACTCCGCTTGTCGCCTTGCTGT
GCGGTGGAGGTGAGGGATACCAGCTTTGGGTGTGCCTCTTTTCTCTCCCTGGTTGCCTCTCACC
CAATTTTCCTGCAGTCCCCTTGGTTTGTAAATTGCCTGCATTTACTCTGTCAGCCAACGTGTAC
AAATGTAAGAAAGAATTTTTAAACAGGTAATAAATTATATTTATAAGC

hide sequence

RefSeq Acc Id:

XM_039102727 ⟹ XP_038958655

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	233,082,689 - 233,208,482 (+)	NCBI
mRatBN7.2	2	230,409,416 - 230,535,219 (+)	NCBI

RefSeq Acc Id:

XM_039102728 ⟹ XP_038958656

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	233,107,905 - 233,208,482 (+)	NCBI
mRatBN7.2	2	230,433,704 - 230,535,219 (+)	NCBI

RefSeq Acc Id:

XM_039102729 ⟹ XP_038958657

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	233,107,963 - 233,208,482 (+)	NCBI
mRatBN7.2	2	230,434,701 - 230,535,219 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001402013	(Get FASTA)	NCBI Sequence Viewer
	NP_955439	(Get FASTA)	NCBI Sequence Viewer
	XP_038958655	(Get FASTA)	NCBI Sequence Viewer
	XP_038958656	(Get FASTA)	NCBI Sequence Viewer
	XP_038958657	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAD05181	(Get FASTA)	NCBI Sequence Viewer
	EDL82340	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000050380
	ENSRNOP00000089543
	ENSRNOP00000090774
	ENSRNOP00000105184
GenBank Protein	Q761X5	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_955439 ⟸ NM_199407
- Peptide Label:	isoform 2 precursor
- UniProtKB:	Q761X5 (UniProtKB/Swiss-Prot), A0A8I6AAJ4 (UniProtKB/TrEMBL), A6HW54 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDDFFHELPETFPSDPPEPLPHF LIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHVVDERVDETSGLIVREVSIEISR QQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPE GIPMAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVI VYVNGGWSTWAEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWT SWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQAAPDSDDVALYVGIV IAVTVCLAITVVVALFVYRKNHRDFESNIIDSSALNGGFQPVNIKAARQDLLAVPPDLTSAAAM YRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNSSGAVTPQDDLAEFSSKLSPQMTQSLLEN EALNLKNQSLARQTDPSCTAFGTFNSLGGHLIIPNSGVSLLIPAGAIPQGRVYEMYVTVHRKEN MRPPMEDSQTLLTPVVSCGPPGALLTRPVILTLHHCADPNTEDWKIQLKNQAVQGQWEDVVVVG EENFTTPCYIQLDAEACHILTENLSTYALVGQSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCL DDTQDALKEVLQLERQMGGQLLEEPKALHFKGSIHNLRLSIHDITHSLWKSKLLAKYQEIPFYH IWSGSQRNLHCTFTLERLSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPAST ITTVTGPSAFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLW EAQNFPDGNLSMLAAVLEEMGRHETVVSLAAEGQY hide sequence

Ensembl Acc Id:

ENSRNOP00000068741 ⟸ ENSRNOT00000082287

Ensembl Acc Id:

ENSRNOP00000050380 ⟸ ENSRNOT00000050330

RefSeq Acc Id:	XP_038958655 ⟸ XM_039102727
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6GH52 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038958656 ⟸ XM_039102728
- Peptide Label:	isoform X2
- UniProtKB:	F1LM73 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038958657 ⟸ XM_039102729
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I6A7B2 (UniProtKB/TrEMBL), F1LM73 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000088490 ⟸ ENSRNOT00000120185

Ensembl Acc Id:

ENSRNOP00000087486 ⟸ ENSRNOT00000116804

Ensembl Acc Id:

ENSRNOP00000095040 ⟸ ENSRNOT00000093785

Ensembl Acc Id:

ENSRNOP00000089543 ⟸ ENSRNOT00000108186

Ensembl Acc Id:

ENSRNOP00000090774 ⟸ ENSRNOT00000106798

RefSeq Acc Id:	NP_001402013 ⟸ NM_001415084
- Peptide Label:	isoform 1 precursor
- UniProtKB:	Q761X5 (UniProtKB/Swiss-Prot), A0A8I6AEG2 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000105184 ⟸ ENSRNOT00000165460

Protein Domains

Death Ig-like Ig-like C2-type TSP type-1 ZU5

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q761X5-F1-model_v2	AlphaFold	Q761X5	1-931	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:735109	AgrOrtholog
BioCyc Gene	G2FUF-51003	BioCyc
Ensembl Genes	ENSRNOG00000029071	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000050330	ENTREZGENE
	ENSRNOT00000106798	ENTREZGENE
	ENSRNOT00000108186	ENTREZGENE
	ENSRNOT00000165460	ENTREZGENE
Gene3D-CATH	1.10.533.10	UniProtKB/Swiss-Prot
	2.20.100.10	UniProtKB/Swiss-Prot
	2.60.220.30	UniProtKB/Swiss-Prot
	2.60.40.10	UniProtKB/Swiss-Prot
InterPro	DEATH-like_dom_sf	UniProtKB/Swiss-Prot
	Death_domain	UniProtKB/Swiss-Prot
	Death_UNC5C	UniProtKB/Swiss-Prot
	Ig-like_dom	UniProtKB/Swiss-Prot
	Ig-like_dom_sf	UniProtKB/Swiss-Prot
	Ig-like_fold	UniProtKB/Swiss-Prot
	Ig_I-set	UniProtKB/Swiss-Prot
	Ig_sub	UniProtKB/Swiss-Prot
	Ig_sub2	UniProtKB/Swiss-Prot
	TSP1_rpt	UniProtKB/Swiss-Prot
	TSP1_rpt_sf	UniProtKB/Swiss-Prot
	UNC5	UniProtKB/Swiss-Prot
	UPA	UniProtKB/Swiss-Prot
	ZU5_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:362049	UniProtKB/Swiss-Prot
NCBI Gene	362049	ENTREZGENE
PANTHER	NETRIN RECEPTOR UNC5C	UniProtKB/Swiss-Prot
	PTHR12582	UniProtKB/Swiss-Prot
Pfam	Death	UniProtKB/Swiss-Prot
	I-set	UniProtKB/Swiss-Prot
	TSP_1	UniProtKB/Swiss-Prot
	UPA	UniProtKB/Swiss-Prot
	ZU5	UniProtKB/Swiss-Prot
PhenoGen	Unc5c	PhenoGen
PRINTS	TSP1REPEAT	UniProtKB/Swiss-Prot
PROSITE	IG_LIKE	UniProtKB/Swiss-Prot
	TSP1	UniProtKB/Swiss-Prot
	ZU5	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000029071	RatGTEx
SMART	DEATH	UniProtKB/Swiss-Prot
	IGc2	UniProtKB/Swiss-Prot
	SM00409	UniProtKB/Swiss-Prot
	TSP1	UniProtKB/Swiss-Prot
	ZU5	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF47986	UniProtKB/Swiss-Prot
	SSF48726	UniProtKB/Swiss-Prot
	SSF82895	UniProtKB/Swiss-Prot
UniProt	A0A0G2JTK0_RAT	UniProtKB/TrEMBL
	A0A8I6A7B2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AAJ4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AEG2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6APK1_RAT	UniProtKB/TrEMBL
	A0A8I6GH52	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LTI4_RAT	UniProtKB/TrEMBL
	A6HW54	ENTREZGENE, UniProtKB/TrEMBL
	F1LM73	ENTREZGENE, UniProtKB/TrEMBL
	Q761X5	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-06-26	Unc5c	unc-5 netrin receptor C	Unc5c	unc-5 homolog C (C. elegans)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Unc5c	unc-5 homolog C (C. elegans)			Symbol and Name status set to approved	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Mammalian Phenotype