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# | Reference Title | Reference Citation |
1. | Rat neurological mutations cerebellar vermis defect and hobble are caused by mutations in the netrin-1 receptor gene Unc5h3. | Kuramoto T, etal., Brain Res Mol Brain Res 2004 Mar 30;122(2):103-8. |
2. | Rat mutations cvd and hob with cerebellar malformations map to chromosome 2. | Kuwamura M, etal., Exp Anim 2004 Jan;53(1):21-6. |
3. | Strains registered by the National Bio Resource Project for the Rat in Japan | Personal Communication with NBRP |
4. | RGD Strain RSO annotation pipeline | RGD Automated Pipelines |
Note Type | Note | Reference |
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strain_characteristics | Abnormal behavior with a swaying gait due to hind-leg paralysis is observed at 2-3 weeks after birth. Reproductivity of affected (hob/hob) males is extremely low. Pathological examination on the cerebellum shows flat shape, vermis defect, partially invaginated molecular layer, and ectopic Purkinje cells. The hob is allelic to the cvd on the Unc5h3 locus. | 1302733 |
strain_other | Predicted to have truncated Unc5c protein that is expressed in the brain. | 1302733 |
strain_reproduction | Maintained by brother-sister matings between hob/+ males and hob/hob females. Good breeding performance. | 1302733 |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2017-04-05 | HOB-Unc5chob/Snk | hobble rat | HOB-Unc5c+Snk | hobble rat | Symbol updated | 68687 | APPROVED |
2010-06-08 | HOB-Unc5c+Snk | hobble rat | HOB-Unc5c+/Snk | hobble rat | Symbol and/or name change | 68913 | APPROVED |