Strain Report - Rat Genome Database

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Strain: HOB-Unc5chob/Snk

Symbol: HOB-Unc5chob/Snk
Strain: HOB-Unc5chob
Substrain: Snk
Full Name: hobble rat
RGD ID: 1554302
Citation ID: RRID:RGD_1554302
Ontology ID: RS:0000486
Alleles: Unc5chob;   Unc5c
Also Known As: HOB (hob/+); HOB-Unc5c+Snk; HOB-Unc5chob/Snk; HOB-Unc5c^[hob]/Snk
Type: mutant
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: Homozygous hobble rats that were taken from the inbred hobble rat colony.
Coat Color: Albino
Inbred Generations: F25
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22230,180,353 - 230,535,219RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.02247,045,813 - 247,397,483RGD_MAPPER_PIPELINERnor6.0
Rnor_5.02265,573,406 - 265,926,229RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.42239,365,109 - 239,721,231RGD_MAPPER_PIPELINERGSC3.4





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Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
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Clinical Measurement
heart rate
systolic blood pressure
body weight
body temperature
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
hematocrit
mean corpuscular volume
plasma glucose level
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
plasma alkaline phosphatase activity level
plasma total protein level
plasma albumin level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart weight to body weight ratio
both kidneys wet weight
lung wet weight
urine potassium level
urine sodium level
brain weight to body weight ratio
both kidneys wet weight as percentage of body weight
liver weight as percentage of body weight
spleen weight to body weight ratio
brain wet weight
lung weight to body weight ratio
liver wet weight
both adrenal glands wet weight
spleen wet weight
both testes wet weight
activated partial thromboplastin time
prothrombin time
timed urine volume
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
total plasma calcium level
urine chloride level
plasma creatinine level
plasma triglyceride level
plasma total cholesterol level
plasma urea nitrogen level
both adrenal glands weight to body weight ratio
plasma high density lipoprotein cholesterol level
plasma low density lipoprotein cholesterol level
both testes wet weight to body weight ratio
urine sodium excretion rate to body weight ratio
timed urine volume to body weight ratio
urine chloride excretion rate to body weight ratio
urine potassium excretion rate to body weight ratio
plasma total bilirubin level
blood segmented neutrophil count to total leukocyte count ratio
blood band neutrophil count to total leukocyte count ratio
non-specified leukocyte count to total leukocyte count ratio
plasma albumin to plasma total protein ratio

References

References - curated
# Reference Title Reference Citation
1. Rat neurological mutations cerebellar vermis defect and hobble are caused by mutations in the netrin-1 receptor gene Unc5h3. Kuramoto T, etal., Brain Res Mol Brain Res 2004 Mar 30;122(2):103-8.
2. Rat mutations cvd and hob with cerebellar malformations map to chromosome 2. Kuwamura M, etal., Exp Anim 2004 Jan;53(1):21-6.
3. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Abnormal behavior with a swaying gait due to hind-leg paralysis is observed at 2-3 weeks after birth. Reproductivity of affected (hob/hob) males is extremely low. Pathological examination on the cerebellum shows flat shape, vermis defect, partially invaginated molecular layer, and ectopic Purkinje cells. The hob is allelic to the cvd on the Unc5h3 locus. 1302733
strain_other Predicted to have truncated Unc5c protein that is expressed in the brain. 1302733
strain_reproduction Maintained by brother-sister matings between hob/+ males and hob/hob females. Good breeding performance. 1302733

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-04-05 HOB-Unc5chob/Snk  hobble rat  HOB-Unc5c+Snk  hobble rat  Symbol updated 68687 APPROVED
2010-06-08 HOB-Unc5c+Snk  hobble rat  HOB-Unc5c+/Snk  hobble rat  Symbol and/or name change 68913 APPROVED