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Gene: Dusp7 (dual specificity phosphatase 7) Rattus norvegicus

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Symbol:

Dusp7

Name:

dual specificity phosphatase 7

RGD ID:

735026

Description:

Predicted to enable MAP kinase tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; and protein tyrosine/threonine phosphatase activity. Predicted to be involved in negative regulation of ERK1 and ERK2 cascade and signal transduction. Predicted to be active in cytosol. Orthologous to human DUSP7 (dual specificity phosphatase 7); PARTICIPATES IN mitogen activated protein kinase signaling pathway; INTERACTS WITH 2-amino-2-deoxy-D-glucopyranose; 3-chloropropane-1,2-diol; 4,4'-sulfonyldiphenol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

dual specificity protein phosphatase 7; dual specificity protein phosphatase MKP-X; MAP kinase phosphatase; mkp-X

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DUSP7 (dual specificity phosphatase 7)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Dusp7 (dual specificity phosphatase 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dusp7 (dual specificity phosphatase 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DUSP7 (dual specificity phosphatase 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DUSP7 (dual specificity phosphatase 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DUSP7 (dual specificity phosphatase 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DUSP7 (dual specificity phosphatase 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dusp7 (dual specificity phosphatase 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Dusp7 (dual specificity phosphatase 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	DUSP7 (dual specificity phosphatase 7)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Dusp7 (dual specificity phosphatase 7)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dusp7 (dual specificity phosphatase 7)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	MSG5	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Mkp3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	lip-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	lip-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	dusp7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	115,888,091 - 115,895,126 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	115,887,892 - 115,895,126 (+)	Ensembl				GRCr8
mRatBN7.2	8	107,009,369 - 107,016,404 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	107,008,528 - 107,016,404 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	112,632,332 - 112,639,365 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	110,831,503 - 110,838,534 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	108,674,294 - 108,681,327 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	115,069,095 - 115,076,130 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	115,069,095 - 115,076,130 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	114,436,772 - 114,443,807 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	111,510,358 - 111,515,989 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	106,321,745 - 106,328,777 (+)	NCBI		Celera
RGSC_v3.1	8	111,530,229 - 111,535,444 (+)	NCBI
Cytogenetic Map	8	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(S)-amphetamine (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-amino-2-deoxy-D-glucopyranose (EXP)

2-hydroxypropanoic acid (ISO)

2-palmitoylglycerol (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

acrolein (ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucosamine (EXP)

alpha-pinene (ISO)

amitrole (EXP)

ammonium chloride (EXP)

ampicillin (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

beta-D-glucosamine (EXP)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

C60 fullerene (EXP)

cadmium dichloride (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

cefaloridine (EXP)

chlorpyrifos (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

diarsenic trioxide (ISO)

diazinon (ISO)

Dibutyl phosphate (ISO)

dicrotophos (ISO)

doxorubicin (ISO)

ethanol (ISO)

folic acid (ISO)

glyphosate (EXP)

Licochalcone B (ISO)

lipopolysaccharide (ISO)

mercury dichloride (EXP)

methimazole (EXP)

N-methylformamide (ISO)

nickel atom (ISO)

nitrates (ISO)

okadaic acid (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

potassium chromate (ISO)

rac-lactic acid (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

testosterone (ISO)

thimerosal (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

troglitazone (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of ERK1 and ERK2 cascade (IBA)

negative regulation of MAP kinase activity (ISO)

peptidyl-tyrosine dephosphorylation (ISO)

Cellular Component

cytoplasm (IBA,IEA)

cytosol (IBA,IEA,ISO)

Molecular Function

hydrolase activity (IEA)

MAP kinase tyrosine phosphatase activity (IBA)

MAP kinase tyrosine/serine/threonine phosphatase activity (IBA,IEA,ISO)

phosphoprotein phosphatase activity (IEA)

protein binding (ISO)

protein serine/threonine phosphatase activity (IEA)

protein tyrosine phosphatase activity (IEA)

protein tyrosine/threonine phosphatase activity (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

mitogen activated protein kinase signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase.	Muda M, etal., J Biol Chem 1996 Feb 23;271(8):4319-26.
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9788880	PMID:26435497

Genomics

Comparative Map Data

Dusp7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	115,888,091 - 115,895,126 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	115,887,892 - 115,895,126 (+)	Ensembl				GRCr8
mRatBN7.2	8	107,009,369 - 107,016,404 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	107,008,528 - 107,016,404 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	112,632,332 - 112,639,365 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	110,831,503 - 110,838,534 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	108,674,294 - 108,681,327 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	115,069,095 - 115,076,130 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	115,069,095 - 115,076,130 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	114,436,772 - 114,443,807 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	111,510,358 - 111,515,989 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	106,321,745 - 106,328,777 (+)	NCBI		Celera
RGSC_v3.1	8	111,530,229 - 111,535,444 (+)	NCBI
Cytogenetic Map	8	q32	NCBI

DUSP7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	52,048,919 - 52,056,571 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	52,048,919 - 52,056,571 (-)	Ensembl			hg38	GRCh38
GRCh37	3	52,082,935 - 52,090,587 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	52,059,799 - 52,065,329 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	3	52,059,870 - 52,065,269	NCBI
Celera	3	52,062,259 - 52,069,785 (-)	NCBI		Celera
Cytogenetic Map	3	p21.2	NCBI
HuRef	3	52,146,055 - 52,153,134 (-)	NCBI		HuRef
CHM1_1	3	52,035,473 - 52,042,994 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	52,081,823 - 52,089,474 (-)	NCBI		T2T-CHM13v2.0

Dusp7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	106,245,831 - 106,252,923 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	106,245,831 - 106,252,923 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	106,368,560 - 106,375,724 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	106,368,632 - 106,375,724 (+)	Ensembl			mm10	GRCm38
MGSCv37	9	106,270,963 - 106,278,055 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	106,226,733 - 106,233,822 (+)	NCBI		MGSCv36	mm8
MGSCv36	9	107,157,107 - 107,167,680 (+)	NCBI		MGSCv36	mm8
Celera	9	105,996,040 - 106,003,059 (+)	NCBI		Celera
Cytogenetic Map	9	F1	NCBI
cM Map	9	57.46	NCBI

Dusp7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955532	3,685,137 - 3,691,933 (-)	Ensembl
ChiLan1.0	NW_004955532	3,685,137 - 3,691,933 (-)	NCBI	ChiLan1.0	ChiLan1.0

DUSP7
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	52,043,185 - 52,050,712 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	52,047,955 - 52,055,470 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	51,990,115 - 51,997,627 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	53,219,167 - 53,226,491 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	53,219,167 - 53,226,491 (-)	Ensembl			panPan2	panpan1.1

DUSP7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	37,676,077 - 37,682,003 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	37,657,725 - 37,665,000 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	38,026,800 - 38,034,077 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	37,942,727 - 38,034,072 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	37,390,441 - 37,397,715 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	37,798,934 - 37,806,209 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	38,084,030 - 38,091,307 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

DUSP7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	34,199,409 - 34,206,649 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	13	34,199,404 - 34,210,621 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	37,396,095 - 37,404,952 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DUSP7
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	13,416,262 - 13,423,736 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	13,416,287 - 13,423,661 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666041	153,480,091 - 153,487,666 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dusp7
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	5,858,480 - 5,865,806 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624730	5,858,838 - 5,865,657 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Dusp7
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	8	97,670,276 - 97,677,403 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Dusp7
53 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	288
Count of miRNA genes:	174
Interacting mature miRNAs:	197
Transcripts:	ENSRNOT00000014770
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	105462581	132782436	Rat
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	82352698	127352698	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	61019838	121662124	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	49849908	118871671	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	80768445	125768445	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	80768445	125768445	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	70041301	121080908	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	68690349	119799881	Rat
10450865	Bw175	Body weight QTL 175	4.1		total fat pad mass (VT:0015008)	adipose tissue molecular composition measurement (CMO:0000484)	8	84192326	129192326	Rat
724539	Cm19	Cardiac mass QTL 19	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	8	103375781	129871912	Rat
738011	Anxrr9	Anxiety related response QTL 9	6.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	8	102413464	132782436	Rat
8693654	Alc32	Alcohol consumption QTL 32	2	0.755	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	8	97492344	116428905	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	55428333	127966348	Rat
634332	Pia18	Pristane induced arthritis QTL 18	4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	84192326	132782436	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	85348065	130348065	Rat
631217	Activ1	Activity QTL 1	15.9		voluntary movement trait (VT:0003491)	number of photobeam interruptions in an experimental apparatus (CMO:0001517)	8	111249511	117802327	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	79394435	132782436	Rat
2313400	Anxrr25	Anxiety related response QTL 25			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	8	98145073	122898010	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	80768445	125768445	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	80768445	125768445	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	91340911	131690273	Rat

Markers in Region

RH133148

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	107,015,044 - 107,016,278 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	115,074,771 - 115,076,004	NCBI	Rnor6.0
Rnor_5.0	8	114,442,448 - 114,443,681	UniSTS	Rnor5.0
RGSC_v3.4	8	111,516,034 - 111,517,267	UniSTS	RGSC3.4
Celera	8	106,327,412 - 106,328,651	UniSTS
RH 3.4 Map	8	1153.5	UniSTS
Cytogenetic Map	8	q32	UniSTS

RH143715

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	107,008,675 - 107,008,818 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	115,068,402 - 115,068,544	NCBI	Rnor6.0
Rnor_5.0	8	114,436,079 - 114,436,221	UniSTS	Rnor5.0
RGSC_v3.4	8	111,509,748 - 111,509,890	UniSTS	RGSC3.4
Celera	8	106,321,086 - 106,321,228	UniSTS
RH 3.4 Map	8	1138.69	UniSTS
Cytogenetic Map	8	q32	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	164	91	90	59	92	59	6	356	192	11	143	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001100547	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ211633	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X94186	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000014770 ⟹ ENSRNOP00000014770

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	115,887,892 - 115,895,126 (+)	Ensembl
mRatBN7.2 Ensembl	8	107,008,528 - 107,016,404 (+)	Ensembl
Rnor_6.0 Ensembl	8	115,069,095 - 115,076,130 (+)	Ensembl

RefSeq Acc Id:

NM_001100547 ⟹ NP_001094017

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	115,888,091 - 115,895,126 (+)	NCBI
mRatBN7.2	8	107,009,369 - 107,016,404 (+)	NCBI
Rnor_6.0	8	115,069,095 - 115,076,130 (+)	NCBI
Rnor_5.0	8	114,436,772 - 114,443,807 (+)	NCBI
Celera	8	106,321,745 - 106,328,777 (+)	NCBI

Sequence:

show sequence

ATGAAAAACCAGCTCCGCGGGCCCCCAGTGCGGGCGCACATGTCGACTTCGGGGGCGGCGGCGG
CTGGGGGCACCCGGGCGGGGTCGGAGCCCGGTGCGGGATCTGGGTCCAGCGCAGGCATCGGAGC
TGGAGCGACGACGGGAGCGGGGGCCATGCCCTGCAAGAGCGCCGAGTGGCTGCAGGAGGAGCTG
GAGGCGCGCGGTGGCGCGTCCCTGCTGCTGCTGGATTGCCGGCCGCACGAGCTCTTCGAATCGT
CGCACATTGAGACGGCCATCAACCTGGCCATCCCGGGTCTCATGCTGCGCCGCCTGCGCAAAGG
CAACCTGCCCATCCGCTCCATCATTCCCAACCATGCCGACAAGGAGCGCTTCGCCACGCGCTGC
AAGGCGGCCACCGTGCTGCTTTACGACGAGGCCACGGCTGAGTGGCAGCCCGAGCCCGGCGCCC
CCGCCTCGGTTCTCGGCCTGCTCCTGCAGAAGCTGCGAGACGACGGCTGCCAGGCCTACTACCT
CCAAGGTGGTTTCAACAAGTTCCAGACGGAATACTCAGAGCATTGTGAGACTAATGTGGACAGC
TCGTCCTCCCCGAGTGGCTCGCCGCCCACCTCCGTGCTGGGCTTGGGGGGCCTGCGCATCAGCT
CTGACTGCTCAGATGGAGAGTCAGACCGGGAGCTGCCCAGCAGTGCCACTGAGTCGGATGGCAG
CCCTGTGCCATCCAGCCAGCCAGCCTTTCCGGTCCAGATCCTGCCCTACCTCTACCTCGGCTGT
GCCAAGGACTCTACCAACCTGGATGTACTTGGCAAGTACGGCATCAAATATATCCTCAATGTCA
CACCCAACCTGCCCAATGCCTTTGAGCACGGTGGTGAGTTCACCTACAAGCAAATCCCCATCTC
TGACCACTGGAGCCAGAACCTCTCTCAGTTCTTCCCCGAGGCCATCAGCTTCATTGATGAAGCC
CGCTCCAAGAAGTGCGGTGTCTTGGTGCACTGCTTAGCAGGCATCAGCCGTTCAGTGACCGTTA
CCGTAGCCTACCTGATGCAGAAGATGAACCTGTCCCTCAACGACGCCTACGACTTCGTTAAGAG
GAAAAAGTCTAACATCTCACCCAACTTCAACTTCATGGGGCAGCTGCTGGACTTTGAGCGGACG
CTGGGCCTCAGCAGCCCGTGCGACAACCACACACCCAGTGAACAGCTCTACTTCTCCACACCCA
CCAACCATAACCTGTTTCCGATCAACACGCTCGAGTCCACGTGAGGCCTGATGCGCTCGAATAG
GCGCAGCACCAGGGTCTCCCAGCCCTCCACAGGGCCTGGTGAGGGGCCCTAGCCTGCTGCCCCT
TCTGGCTTGAAGAACCCACAGATGTCACCTGTGTCCGGAGAACCAGGCTGAGCAGTGGCCGAGC
TCCCATGCCATCCTGTGCAGGACCCACAGCAAGGCCGCCTGTGATAGCACTTGCCAGATGGCCT
CAGCTTTCCAGACATGTTGCCGAAGTGAGCGTTGGCCTCAGCTTGCAGACTTGTGGCTTGGGGG
CCAGCGGGGCCTTGTCTCTGCCCCAGGACATCCATTCTGCTGATGGCCCAGCCAATCTGGCAAT
TTTTAAAGACATATCCACAAACCTGAGTTTGCTACTTTTAGCAGGTAAATCCGAGCTCCCTGGA
GCAGTGTTCAGGCTCTCCTTGGTTTTTCTTTTCTTTTCCTTCCTTCCTTCCTTCCTTCCTTTCT
TTTTTTTTTTTTTTTTTTTAACAAAAAGTGTTATTTTTCAGGCTAAATGCAACAACGGATTGTA
TAAACCAATATTTCACCCCCTTTCTTAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAG
AGAGGTGTTCTCCGTTTCTTTTCTCGTTTCAAAAAGAAAACCATCGCTGTATTTTGTTTTCTGT
GGAAAAGGCAAACCCCGTGTTCTTGACCAAGTGCATTTTGCACGTGTGCGAAGTGAAGTCTGTT
TTCCCAGCAGGCCATTCTTGAAGGGTGAGTCGTAGCTTTCCAGGCATAAGGACCCTGGTTACAC
CATCTCCTACCCGTGGTCCTGCCAGCTCAGTGCCACATTTGCACGAGCCAGTTGCTGTGAGCTG
TGCCTGGTGGGCACCAGTGGTCTTTGTGTTGTATGCTCTCCTGCCAACCTTCTGAGAGTCCTGC
AGACCTCTCTGCCAAGTCCTACTGGAGGTGGTGCTGCAGGGGAGTGCCAAGCAGTAGCATCAGC
CATCTGGGCTCAGCTCCTCAGAGGGCTGGGCCCTGGCCCTTTTATAAATTACCCACCACTTCTG
TCCTCATCTCTGTCTCTTAACTGGGAATAGAGGCCCACAGTACCTGAGTAAAGCACTTCCCAGC
CCCTCATCTCTGCTGTAGATTCCGTCTAGGTCCACTCCCAGCCCCCTTGTCCAGGTGCACACCT
GCCCTGGCCTGTGTTGCCCAGGCCTTTTCCATGCAGGCAACTTAACACCTATTGCGTGCGGCAC
CAAGAGACGGGGCAGGTGGGGCAAGGACTGGCCAGTGGGAGTGTGAAGCTACCACCCACCCCAG
TATCCATAGCACAAAGCCACGGGCTCCATAATGCTCCTTCGGTTTCATTGCTTCTCAAGCCTTG
GTTCTCACCAGGCACCATGAGGACCAAGAAGTGCTGAGGGGGACCTGCACCCCCAGTGGGCAGT
GACTGAGGCCACAGAAACTCCACACCACCATATCTTACCTCACAGGGGTGGTTTTCAGGGATTC
TTTAGGGAAGCAGTTTAAAATCTTGCCACAGTTGAGAAATTGACAAAAAAACTTCTACTTTGTA
CATTGTATGTTCTCGTGTTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCT
CACTCATTTTTAAAAAGAAAATCCAGAAAGGTGTATCAGATCAGAGTGTAAATGACAGTATATC
AGAGGGTGGCCAGTTTTGCTTTAAGATCTTATGAAGGAAAGTTTGTGACCCTACATACATACAT
ACATACATACATACGTACACACACAAACACACACACACATACACACATATATATATAGGTCCCG
AGCTAGCATGGGACTTTGTTTATATTGCAAATAAATATTATTTTTTCTTTAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001094017	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	CAA63896	(Get FASTA)	NCBI Sequence Viewer
	EDL77319	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000014770
	ENSRNOP00000014770.5
GenBank Protein	Q63340	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001094017 ⟸ NM_001100547

- UniProtKB:

Q63340 (UniProtKB/Swiss-Prot), F1M7V9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKNQLRGPPVRAHMSTSGAAAAGGTRAGSEPGAGSGSSAGIGAGATTGAGAMPCKSAEWLQEEL
EARGGASLLLLDCRPHELFESSHIETAINLAIPGLMLRRLRKGNLPIRSIIPNHADKERFATRC
KAATVLLYDEATAEWQPEPGAPASVLGLLLQKLRDDGCQAYYLQGGFNKFQTEYSEHCETNVDS
SSSPSGSPPTSVLGLGGLRISSDCSDGESDRELPSSATESDGSPVPSSQPAFPVQILPYLYLGC
AKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEA
RSKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERT
LGLSSPCDNHTPSEQLYFSTPTNHNLFPINTLEST

hide sequence

Ensembl Acc Id:

ENSRNOP00000014770 ⟸ ENSRNOT00000014770

Protein Domains

Rhodanese Tyrosine-protein phosphatase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q63340-F1-model_v2	AlphaFold	Q63340	1-419	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696247

Promoter ID:

EPDNEW_R6771

Type:

single initiation site

Name:

Dusp7_1

Description:

dual specificity phosphatase 7

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	115,069,182 - 115,069,242	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:735026	AgrOrtholog
BioCyc Gene	G2FUF-29241	BioCyc
Ensembl Genes	ENSRNOG00000010789	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000014770	ENTREZGENE
	ENSRNOT00000014770.8	UniProtKB/Swiss-Prot
Gene3D-CATH	3.40.250.10	UniProtKB/Swiss-Prot
	3.90.190.10	UniProtKB/Swiss-Prot
InterPro	Dual-sp_phosphatase_cat-dom	UniProtKB/Swiss-Prot
	MKP	UniProtKB/Swiss-Prot
	Prot-tyrosine_phosphatase-like	UniProtKB/Swiss-Prot
	Rhodanese-like_dom	UniProtKB/Swiss-Prot
	Rhodanese-like_dom_sf	UniProtKB/Swiss-Prot
	TYR_PHOSPHATASE_dom	UniProtKB/Swiss-Prot
	TYR_PHOSPHATASE_DUAL_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:300980	UniProtKB/Swiss-Prot
NCBI Gene	300980	ENTREZGENE
PANTHER	DUAL SPECIFICITY PROTEIN PHOSPHATASE	UniProtKB/Swiss-Prot
	DUAL SPECIFICITY PROTEIN PHOSPHATASE 7	UniProtKB/Swiss-Prot
Pfam	DSPc	UniProtKB/Swiss-Prot
	Rhodanese	UniProtKB/Swiss-Prot
PhenoGen	Dusp7	PhenoGen
PIRSF	MAPK_Ptase	UniProtKB/Swiss-Prot
PRINTS	MAPKPHPHTASE	UniProtKB/Swiss-Prot
PROSITE	RHODANESE_3	UniProtKB/Swiss-Prot
	TYR_PHOSPHATASE_2	UniProtKB/Swiss-Prot
	TYR_PHOSPHATASE_DUAL	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000010789	RatGTEx
SMART	DSPc	UniProtKB/Swiss-Prot
	RHOD	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF52799	UniProtKB/Swiss-Prot
	SSF52821	UniProtKB/Swiss-Prot
UniProt	DUS7_RAT	UniProtKB/Swiss-Prot
	F1M7V9	ENTREZGENE
	Q63340	ENTREZGENE
UniProt Secondary	F1M7V9	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Dusp7	dual specificity phosphatase 7			Symbol and Name status set to approved	1299863	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in lung, heart, brain, and kidney, but not significantly in skeletal muscle or testis	728656

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)