Oprk1 (opioid receptor, kappa 1) - Rat Genome Database

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Gene: Oprk1 (opioid receptor, kappa 1) Rattus norvegicus
Analyze
Symbol: Oprk1
Name: opioid receptor, kappa 1
RGD ID: 69426
Description: Enables receptor serine/threonine kinase binding activity. Involved in several processes, including behavioral response to cocaine; conditioned place preference; and regulation of secretion by cell. Located in several cellular components, including T-tubule; perikaryon; and sarcoplasmic reticulum. Is active in postsynaptic membrane; presynaptic membrane; and synaptic vesicle membrane. Used to study heroin dependence; myocardial infarction; and withdrawal disorder. Biomarker of alcohol use disorder; congestive heart failure; fetal alcohol spectrum disorder; and withdrawal disorder. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; drug dependence (multiple); neonatal abstinence syndrome; and opioid abuse. Orthologous to human OPRK1 (opioid receptor kappa 1); PARTICIPATES IN nalbuphine pharmacodynamics pathway; INTERACTS WITH (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin; (R)-noradrenaline; (R,R)-tramadol.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: K-OR-1; kappa-type opioid receptor; KOR-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8518,657,866 - 18,675,671 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl518,657,871 - 18,675,671 (-)EnsemblGRCr8
mRatBN7.2513,860,016 - 13,877,823 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl513,860,021 - 13,877,823 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx516,035,098 - 16,052,904 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0517,669,824 - 17,687,612 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0517,369,783 - 17,387,591 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0513,742,655 - 13,760,460 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl513,744,658 - 13,760,305 (-)Ensemblrn6Rnor6.0
Rnor_5.0518,519,763 - 18,534,188 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4514,040,848 - 14,055,273 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera513,240,420 - 13,258,214 (-)NCBICelera
RGSC_v3.1514,037,659 - 14,055,460 (-)NCBI
Cytogenetic Map5q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin  (EXP)
(R)-noradrenaline  (EXP)
(R,R)-tramadol  (EXP)
(S)-nicotine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2-naphthylamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
7-Hydroxymitragynine  (ISO)
acetylmethadol  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
Azoxymethane  (ISO)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP)
bisphenol F  (ISO)
buprenorphine  (EXP,ISO)
butorphanol  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
celastrol  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cocaine  (EXP,ISO)
codeine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
cycloheximide  (ISO)
dextran sulfate  (ISO)
dextromethorphan  (EXP)
dextropropoxyphene  (EXP)
dextrorphan  (EXP)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
dopamine  (EXP)
dorsomorphin  (ISO)
DPDPE  (EXP)
dynorphin A  (EXP,ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
Ethylketocyclazocine  (EXP)
etonitazene  (EXP)
fentanyl  (EXP)
fenvalerate  (EXP)
folic acid  (ISO)
fomepizole  (ISO)
gedunin  (ISO)
gentamycin  (EXP)
hydrocodone  (EXP)
Levallorphan  (EXP)
Levorphanol  (EXP)
magnesium atom  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
mercury atom  (EXP)
mercury(0)  (EXP)
methadone  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
Mitragynine  (ISO)
morphine  (EXP,ISO)
Nalmefene  (ISO)
naloxone  (EXP)
naltrexone  (EXP)
nicotine  (ISO)
Norbinaltorphimine  (EXP,ISO)
oxycodone  (EXP)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (EXP)
paynantheine  (ISO)
pentetrazol  (ISO)
picrotoxin  (EXP)
progesterone  (ISO)
SB 431542  (ISO)
serotonin  (EXP)
tapentadol  (EXP)
thioglycolic acid  (EXP)
titanium dioxide  (ISO)
tramadol  (EXP)
trichostatin A  (ISO)
U50488  (ISO)
U69593  (EXP,ISO)
valproic acid  (EXP,ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Stress, kappa manipulations, and aversive effects of ethanol in adolescent and adult male rats. Anderson RI, etal., Neuroscience. 2013 Sep 26;249:214-22. doi: 10.1016/j.neuroscience.2012.12.028. Epub 2012 Dec 29.
2. Tyrosine phosphorylation of the kappa -opioid receptor regulates agonist efficacy. Appleyard SM, etal., J Biol Chem. 2000 Dec 8;275(49):38281-5.
3. The endogenous opioid system in human alcoholics: molecular adaptations in brain areas involved in cognitive control of addiction. Bazov I, etal., Addict Biol. 2013 Jan;18(1):161-9. doi: 10.1111/j.1369-1600.2011.00366.x. Epub 2011 Sep 28.
4. Kappa opioid receptor activation of p38 MAPK is GRK3- and arrestin-dependent in neurons and astrocytes. Bruchas MR, etal., J Biol Chem. 2006 Jun 30;281(26):18081-9. Epub 2006 Apr 28.
5. Dysregulation of Nociceptin/Orphanin FQ and Dynorphin Systems in the Extended Amygdala of Alcohol Preferring Marchigian Sardinian (msP) Rats. Caputi FF, etal., Int J Mol Sci. 2021 Feb 28;22(5):2448. doi: 10.3390/ijms22052448.
6. Formation of mu-/kappa-opioid receptor heterodimer is sex-dependent and mediates female-specific opioid analgesia. Chakrabarti S, etal., Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20115-9. doi: 10.1073/pnas.1009923107. Epub 2010 Nov 1.
7. G protein coupled receptor kinase-2 upregulation causes ¿-opioid receptor desensitization in diabetic heart. Chen X, etal., Biochem Biophys Res Commun. 2017 Jan 22;482(4):658-664. doi: 10.1016/j.bbrc.2016.11.090. Epub 2016 Nov 16.
8. Molecular cloning of a rat kappa opioid receptor reveals sequence similarities to the mu and delta opioid receptors. Chen Y, etal., Biochem J 1993 Nov 1;295 ( Pt 3):625-8.
9. Opioid system genes in alcoholism: a case-control study in Croatian population. Cupic B, etal., Neuropeptides. 2013 Oct;47(5):315-9. doi: 10.1016/j.npep.2013.08.002. Epub 2013 Aug 28.
10. Different alcohol exposures induce selective alterations on the expression of dynorphin and nociceptin systems related genes in rat brain. D'Addario C, etal., Addict Biol. 2013 May;18(3):425-33. doi: 10.1111/j.1369-1600.2011.00326.x. Epub 2011 Apr 20.
11. Kappa opioid receptors in the rostral ventromedial medulla of male and female rats. Drake CT, etal., J Comp Neurol. 2007 Jan 20;500(3):465-76.
12. Maladaptive behavioral regulation in alcohol dependence: Role of kappa-opioid receptors in the bed nucleus of the stria terminalis. Erikson CM, etal., Neuropharmacology. 2018 Sep 15;140:162-173. doi: 10.1016/j.neuropharm.2018.07.034. Epub 2018 Jul 31.
13. Electrical and manual acupuncture stimulation affect oestrous cyclicity and neuroendocrine function in an 5alpha-dihydrotestosterone-induced rat polycystic ovary syndrome model. Feng Y, etal., Exp Physiol. 2012 May;97(5):651-62. doi: 10.1113/expphysiol.2011.063131. Epub 2012 Feb 15.
14. Increased locomotor response to amphetamine induced by the repeated administration of the selective kappa-opioid receptor agonist U-69593. Fuentealba JA, etal., Synapse. 2007 Sep;61(9):771-7.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. The expression of opioid genes in non-classical reward areas depends on early life conditions and ethanol intake. Granholm L, etal., Brain Res. 2017 Aug 1;1668:36-45. doi: 10.1016/j.brainres.2017.05.006. Epub 2017 May 13.
18. Repeated stress exposure causes strain-dependent shifts in the behavioral economics of cocaine in rats. Groblewski PA, etal., Addict Biol. 2015 Mar;20(2):297-301. doi: 10.1111/adb.12123. Epub 2014 Feb 15.
19. The effect of kappa opioid receptor antagonism on energy expenditure in the obese Zucker rat. Jarosz PA Biol Res Nurs. 2007 Apr;8(4):294-9.
20. Dynorphin A, kappa opioid receptors and the antinociceptive efficacy of asimadoline in streptozotocin-induced diabetic rats. Jolivalt CG, etal., Diabetologia. 2006 Nov;49(11):2775-85. Epub 2006 Aug 19.
21. kappa -opioid receptor agonists modulate visceral nociception at a novel, peripheral site of action. Joshi SK, etal., J Neurosci. 2000 Aug 1;20(15):5874-9.
22. OPRD1 rs569356 polymorphism has an effect on plasma norbuprenorphine levels and dose/kg-normalized norbuprenorphine values in individuals with opioid use disorder. Kaya-Akyüzlü D, etal., Environ Toxicol Pharmacol. 2023 Jun;100:104143. doi: 10.1016/j.etap.2023.104143. Epub 2023 May 3.
23. Morphine withdrawal precipitated by specific mu, delta or kappa opioid receptor antagonists: a c-Fos protein study in the rat central nervous system. Le Guen S, etal., Eur J Neurosci. 2003 Jun;17(11):2425-37. doi: 10.1046/j.1460-9568.2003.02678.x.
24. Differential coupling of mu-, delta-, and kappa-opioid receptors to G alpha16-mediated stimulation of phospholipase C. Lee JW, etal., J Neurochem. 1998 May;70(5):2203-11.
25. Morphine-6beta-glucuronide-induced hyperphagia: characterization of opioid action by selective antagonists and antisense mapping in rats. Leventhal L, etal., J Pharmacol Exp Ther. 1998 Nov;287(2):538-44.
26. Molecular cloning and expression of a rat kappa opioid receptor. Li S, etal., Biochem J 1993 Nov 1;295 ( Pt 3):629-33.
27. Medial dorsal hypothalamus mediates the inhibition of reward seeking after extinction. Marchant NJ, etal., J Neurosci. 2010 Oct 20;30(42):14102-15. doi: 10.1523/JNEUROSCI.4079-10.2010.
28. Phosphorylation of a carboxyl-terminal serine within the kappa-opioid receptor produces desensitization and internalization. McLaughlin JP, etal., J Biol Chem. 2003 Sep 5;278(36):34631-40. Epub 2003 Jun 18.
29. Cloning and pharmacological characterization of a rat kappa opioid receptor. Meng F, etal., Proc Natl Acad Sci U S A 1993 Nov 1;90(21):9954-8.
30. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
31. Cloning and expression of a cDNA for the rat kappa-opioid receptor. Minami M, etal., FEBS Lett 1993 Aug 30;329(3):291-5.
32. dynorphin-kappa opioid receptor signaling partly mediates estrogen negative feedback effect on LH pulses in female rats. Mostari P, etal., J Reprod Dev. 2013;59(3):266-72. Epub 2013 Feb 8.
33. An analysis of genetic association in opioid dependence susceptibility. Nagaya D, etal., J Clin Pharm Ther. 2018 Feb;43(1):80-86. doi: 10.1111/jcpt.12585. Epub 2017 Jun 27.
34. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
35. cDNA cloning and pharmacological characterization of an opioid receptor with high affinities for kappa-subtype-selective ligands. Nishi M, etal., FEBS Lett 1993 Sep 6;330(1):77-80.
36. Association of opioid receptor gene polymorphisms with drinking severity and impulsivity related to alcohol use disorder in a Korean population. Park CI, etal., CNS Neurosci Ther. 2020 Jan;26(1):30-38. doi: 10.1111/cns.13138. Epub 2019 Apr 19.
37. Effect of exogenous kappa-opioid receptor activation in rat model of myocardial infarction. Peart JN, etal., J Cardiovasc Pharmacol. 2004 Mar;43(3):410-5.
38. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
39. GOA pipeline RGD automated data pipeline
40. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
41. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
42. Downregulation of kappa opioid receptor mRNA levels by chronic ethanol and repetitive cocaine in rat ventral tegmentum and nucleus accumbens. Rosin A, etal., Neurosci Lett. 1999 Nov 5;275(1):1-4.
43. Bi-phasic intensity-dependent opioid-mediated neural amplitude changes in the chinchilla cochlea: partial blockade by an N-Methyl-D-Aspartate (NMDA)-receptor antagonist. Sahley TL, etal., Eur J Pharmacol. 2008 Feb 2;580(1-2):100-15. Epub 2007 Oct 25.
44. The kappa opioid receptor antagonist JDTic attenuates alcohol seeking and withdrawal anxiety. Schank JR, etal., Addict Biol. 2012 May;17(3):634-47. doi: 10.1111/j.1369-1600.2012.00455.x.
45. Long-term antagonism of κ opioid receptors prevents escalation of and increased motivation for heroin intake. Schlosburg JE, etal., J Neurosci. 2013 Dec 4;33(49):19384-92. doi: 10.1523/JNEUROSCI.1979-13.2013.
46. Neurobehavioral and transcriptional effects of acrylamide in juvenile rats. Seale SM, etal., Pharmacol Biochem Behav. 2012 Mar;101(1):77-84. doi: 10.1016/j.pbb.2011.12.006. Epub 2011 Dec 16.
47. A role for kappa-, but not mu-opioid, receptor activation in acute food deprivation-induced reinstatement of heroin seeking in rats. Sedki F, etal., Addict Biol. 2014 Apr 13. doi: 10.1111/adb.12133.
48. Evaluation of dynorphin and kappa-opioid receptor level in the human blood lymphocytes and plasma: Possible role as a biomarker in severe opioid use disorder. Shahkarami K, etal., Drug Alcohol Depend. 2019 Dec 1;205:107638. doi: 10.1016/j.drugalcdep.2019.107638. Epub 2019 Nov 2.
49. Dynorphin A(1-17)-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats. Silva RM, etal., J Pharmacol Exp Ther. 2002 May;301(2):513-8.
50. Major coexpression of kappa-opioid receptors and the dopamine transporter in nucleus accumbens axonal profiles. Svingos AL, etal., Synapse. 2001 Dec 1;42(3):185-92. doi: 10.1002/syn.10005.
51. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
52. Behavioral meaningful opioidergic stimulation activates kappa receptor gene expression. Teodorov E, etal., Braz J Med Biol Res. 2012 Oct;45(10):982-7. Epub 2012 May 31.
53. Treatment with steroid hormones and morphine alters general activity, sexual behavior, and opioid gene expression in female rats. Teodorov E, etal., Life Sci. 2014 May 28;104(1-2):47-54. doi: 10.1016/j.lfs.2014.03.021. Epub 2014 Mar 31.
54. Preliminary study of the effects of morphine treatment on opioid receptor gene expression in brain structures of the female rat. Teodorov E, etal., Neuroscience. 2006 Sep 1;141(3):1225-31. Epub 2006 Jun 6.
55. Upregulation of the kappa opioidergic system in left ventricular rat myocardium in response to volume overload: Adaptive changes of the cardiac kappa opioid system in heart failure. Treskatsch S, etal., Pharmacol Res. 2015 Dec;102:33-41. doi: 10.1016/j.phrs.2015.09.005. Epub 2015 Sep 10.
56. Regulation of kappa-opioid receptor mRNA level by cyclic AMP and growth factors in cultured rat glial cells. Tryoen-Toth P, etal., Brain Res Mol Brain Res. 1998 Mar 30;55(1):141-50.
57. Chronic nicotine-induced changes in gene expression of delta and kappa-opioid receptors and their endogenous ligands in the mesocorticolimbic system of the rat. Ugur M, etal., Synapse. 2017 Sep;71(9). doi: 10.1002/syn.21985. Epub 2017 May 29.
58. Variations in opioid receptor genes in neonatal abstinence syndrome. Wachman EM, etal., Drug Alcohol Depend. 2015 Oct 1;155:253-9. doi: 10.1016/j.drugalcdep.2015.07.001. Epub 2015 Jul 8.
59. Prenatal ethanol induces an anxiety phenotype and alters expression of dynorphin & nociceptin/orphanin FQ genes. Wille-Bille A, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jul 13;85:77-88. doi: 10.1016/j.pnpbp.2018.04.005. Epub 2018 Apr 18.
60. Inhibitory effects of processed Aconiti tuber on morphine-induced conditioned place preference in rats. Wu G, etal., J Ethnopharmacol. 2011 Jun 14;136(1):254-9. doi: 10.1016/j.jep.2011.04.041. Epub 2011 Apr 28.
61. Association of the kappa-opioid system with alcohol dependence. Xuei X, etal., Mol Psychiatry. 2006 Nov;11(11):1016-24. doi: 10.1038/sj.mp.4001882. Epub 2006 Aug 22.
62. Structure and expression of a rat kappa opioid receptor gene. Yakovlev AG, etal., J Biol Chem 1995 Mar 24;270(12):6421-4.
63. Analyses of polymorphisms of intron 2 of OPRK1 (kappa-opioid receptor gene) in association with opioid and cocaine dependence diagnoses in an African-American population. Yuferov V, etal., Neurosci Lett. 2022 Jan 18;768:136364. doi: 10.1016/j.neulet.2021.136364. Epub 2021 Nov 26.
64. Alterations in kappa opioid receptor mRNA levels in the paraventricular nucleus of the hypothalamus by stress and sex steroids. Yukhananov RY and Handa RJ, Neuroreport. 1996 Jul 8;7(10):1690-4.
65. The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk. Zhang H, etal., Mol Psychiatry. 2008 May;13(5):531-43. doi: 10.1038/sj.mp.4002035. Epub 2007 Jul 10.
66. κ Opioid Receptor 1 Single Nucleotide Polymorphisms were Associated with the Methadone Dosage. Zhang Q, etal., Genet Test Mol Biomarkers. 2020 Jan;24(1):17-23. doi: 10.1089/gtmb.2019.0159.
67. Effect of PDYN and OPRK1 polymorphisms on the risk of alcohol use disorder and the intensity of depressive symptoms. Özkan-Kotiloğlu S, etal., Alcohol Alcohol. 2023 Jul 10;58(4):404-414. doi: 10.1093/alcalc/agad036.
Additional References at PubMed
PMID:7624359   PMID:8755601   PMID:9463367   PMID:9915326   PMID:10385123   PMID:11726686   PMID:12842289   PMID:12855366   PMID:14580956   PMID:15467355   PMID:15778854   PMID:15950775  
PMID:16130146   PMID:17167054   PMID:17980907   PMID:18500486   PMID:19009591   PMID:19217659   PMID:19462402   PMID:19545549   PMID:19567249   PMID:19924112   PMID:20435099   PMID:20574683  
PMID:20653037   PMID:21338616   PMID:21531393   PMID:21723305   PMID:21849544   PMID:22072818   PMID:22316281   PMID:22437504   PMID:22487769   PMID:22735633   PMID:22796630   PMID:23212453  
PMID:23402995   PMID:23838631   PMID:23877505   PMID:24219160   PMID:24957331   PMID:24978951   PMID:25013167   PMID:25641629   PMID:26086860   PMID:26635353   PMID:26860203   PMID:27226238  
PMID:27523794   PMID:27899527   PMID:28163104   PMID:28531297   PMID:28987634   PMID:32948219   PMID:33444637   PMID:33546289   PMID:33908346   PMID:34016793   PMID:36272558   PMID:36764577  
PMID:37455648   PMID:39151827   PMID:39155080  


Genomics

Comparative Map Data
Oprk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8518,657,866 - 18,675,671 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl518,657,871 - 18,675,671 (-)EnsemblGRCr8
mRatBN7.2513,860,016 - 13,877,823 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl513,860,021 - 13,877,823 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx516,035,098 - 16,052,904 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0517,669,824 - 17,687,612 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0517,369,783 - 17,387,591 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0513,742,655 - 13,760,460 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl513,744,658 - 13,760,305 (-)Ensemblrn6Rnor6.0
Rnor_5.0518,519,763 - 18,534,188 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4514,040,848 - 14,055,273 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera513,240,420 - 13,258,214 (-)NCBICelera
RGSC_v3.1514,037,659 - 14,055,460 (-)NCBI
Cytogenetic Map5q12NCBI
OPRK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38853,225,724 - 53,251,637 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl853,225,724 - 53,251,637 (-)Ensemblhg38GRCh38
GRCh37854,138,284 - 54,164,197 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36854,300,829 - 54,326,747 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34854,304,325 - 54,326,525NCBI
Celera850,129,111 - 50,155,030 (-)NCBICelera
Cytogenetic Map8q11.23NCBI
HuRef849,605,704 - 49,631,623 (-)NCBIHuRef
CHM1_1854,189,898 - 54,215,806 (-)NCBICHM1_1
T2T-CHM13v2.0853,602,209 - 53,628,122 (-)NCBIT2T-CHM13v2.0
Oprk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915,658,673 - 5,676,357 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15,658,689 - 5,676,354 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3815,588,450 - 5,606,134 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15,588,466 - 5,606,131 (+)Ensemblmm10GRCm38
MGSCv3715,578,574 - 5,592,947 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3615,578,574 - 5,592,947 (+)NCBIMGSCv36mm8
Celera15,572,638 - 5,587,007 (+)NCBICelera
Cytogenetic Map1A1NCBI
cM Map11.89NCBI
Oprk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545412,744,765 - 12,752,226 (-)Ensembl
ChiLan1.0NW_00495545412,741,577 - 12,751,282 (-)NCBIChiLan1.0ChiLan1.0
OPRK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2768,862,192 - 68,888,090 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1844,587,073 - 44,612,962 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0849,650,844 - 49,677,494 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1847,030,643 - 47,056,577 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl847,029,313 - 47,056,577 (-)EnsemblpanPan2panpan1.1
OPRK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1295,022,270 - 5,054,223 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl295,025,786 - 5,051,919 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha295,465,554 - 5,491,602 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0295,094,906 - 5,125,355 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl295,094,910 - 5,125,386 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1295,025,124 - 5,051,183 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0295,246,074 - 5,272,177 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0295,327,765 - 5,353,862 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Oprk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530374,479,528 - 74,505,054 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936496280,558 - 305,904 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936496280,593 - 305,900 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OPRK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl477,399,183 - 77,426,879 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1477,399,298 - 77,429,025 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2484,469,581 - 84,499,310 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OPRK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1849,337,308 - 49,364,724 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl849,341,427 - 49,362,947 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603992,601,556 - 92,627,383 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Oprk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247352,301,101 - 2,325,684 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247352,301,248 - 2,325,678 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Oprk1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11140,878,397 - 140,894,005 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Oprk1
216 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:658
Count of miRNA genes:294
Interacting mature miRNAs:360
Transcripts:ENSRNOT00000010254
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)51373115343590997Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5862723052665523Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51460607859606078Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51757663362576633Rat
1578774Tcas8Tongue tumor susceptibility QTL 83.47tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)51570745160707451Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5692228237468560Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51748608062486080Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
631827Alc4Alcohol consumption QTL 43.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)51297048025683802Rat
2303577Gluco47Glucose level QTL 473blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51652001961520019Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)51748608062486080Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5862723053627230Rat

Markers in Region
D5Wox26  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2513,861,313 - 13,861,507 (+)MAPPERmRatBN7.2
Rnor_6.0513,743,953 - 13,744,146NCBIRnor6.0
Rnor_5.0518,517,868 - 18,518,061UniSTSRnor5.0
RGSC_v3.4514,038,953 - 14,039,146UniSTSRGSC3.4
Celera513,241,718 - 13,241,911UniSTS
Cytogenetic Map5q12UniSTS
RH94595  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2513,860,572 - 13,860,771 (+)MAPPERmRatBN7.2
Rnor_6.0513,743,212 - 13,743,410NCBIRnor6.0
Rnor_5.0518,517,127 - 18,517,325UniSTSRnor5.0
RGSC_v3.4514,038,212 - 14,038,410UniSTSRGSC3.4
Celera513,240,977 - 13,241,175UniSTS
Cytogenetic Map5q12UniSTS
BF403255  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2513,860,189 - 13,860,395 (+)MAPPERmRatBN7.2
Rnor_6.0513,742,829 - 13,743,034NCBIRnor6.0
Rnor_5.0518,516,744 - 18,516,949UniSTSRnor5.0
RGSC_v3.4514,037,829 - 14,038,034UniSTSRGSC3.4
Celera513,240,594 - 13,240,799UniSTS
Cytogenetic Map5q12UniSTS
Oprk1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2513,867,261 - 13,867,388 (+)MAPPERmRatBN7.2
Rnor_6.0513,749,901 - 13,750,027NCBIRnor6.0
Rnor_5.0518,523,816 - 18,523,942UniSTSRnor5.0
RGSC_v3.4514,044,901 - 14,045,027UniSTSRGSC3.4
Celera513,247,666 - 13,247,792UniSTS
Cytogenetic Map5q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
6 3 40 137 55 52 30 12 30 5 133 64 4 130 30 66 22 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000010254   ⟹   ENSRNOP00000010255
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl518,657,871 - 18,675,671 (-)Ensembl
mRatBN7.2 Ensembl513,860,021 - 13,877,823 (-)Ensembl
Rnor_6.0 Ensembl513,744,658 - 13,760,305 (-)Ensembl
RefSeq Acc Id: NM_001318742   ⟹   NP_001305671
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8518,657,866 - 18,675,671 (-)NCBI
mRatBN7.2513,860,016 - 13,877,823 (-)NCBI
Rnor_6.0513,742,655 - 13,760,460 (-)NCBI
Celera513,240,420 - 13,258,214 (-)NCBI
Sequence:
RefSeq Acc Id: NM_017167   ⟹   NP_058863
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8518,657,866 - 18,675,671 (-)NCBI
mRatBN7.2513,860,016 - 13,877,823 (-)NCBI
Rnor_6.0513,742,655 - 13,760,460 (-)NCBI
Rnor_5.0518,519,763 - 18,534,188 (-)NCBI
RGSC_v3.4514,040,848 - 14,055,273 (-)RGD
Celera513,240,420 - 13,258,214 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039109359   ⟹   XP_038965287
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8518,657,866 - 18,675,409 (-)NCBI
mRatBN7.2513,860,016 - 13,877,486 (-)NCBI
RefSeq Acc Id: NP_058863   ⟸   NM_017167
- Peptide Label: isoform 1
- UniProtKB: P34975 (UniProtKB/Swiss-Prot),   A6JFI3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001305671   ⟸   NM_001318742
- Peptide Label: isoform 1x
- Sequence:
Ensembl Acc Id: ENSRNOP00000010255   ⟸   ENSRNOT00000010254
RefSeq Acc Id: XP_038965287   ⟸   XM_039109359
- Peptide Label: isoform X1
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P34975-F1-model_v2 AlphaFold P34975 1-380 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69426 AgrOrtholog
BioCyc Gene G2FUF-42160 BioCyc
Ensembl Genes ENSRNOG00000007647 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010254 ENTREZGENE
  ENSRNOT00000010254.4 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Kappa_opi_rcpt UniProtKB/Swiss-Prot
  Opioid_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:29335 UniProtKB/Swiss-Prot
NCBI Gene 29335 ENTREZGENE
PANTHER KAPPA-TYPE OPIOID RECEPTOR UniProtKB/Swiss-Prot
  NEUROPEPTIDES RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Oprk1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  KAPPAOPIOIDR UniProtKB/Swiss-Prot
  OPIOIDR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007647 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
TIGR TC206180
UniProt A6JFI3 ENTREZGENE, UniProtKB/TrEMBL
  OPRK_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Oprk1  opioid receptor, kappa 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process involved in cardiovascular regulation, feeding behavior, fluid balance, modulation of anti-nociception, and temperature control 729017