Hsd3b2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2) - Rat Genome Database

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Gene: Hsd3b2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2) Rattus norvegicus
Analyze
Symbol: Hsd3b2
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
RGD ID: 67377
Description: Enables 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity and steroid Delta-isomerase activity. Involved in several processes, including Leydig cell differentiation; response to corticosterone; and steroid hormone biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytoplasm. Biomarker of hyperprolactinemia and hypertension. Human ortholog(s) of this gene implicated in hypospadias. Orthologous to human HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3 beta-hydroxysteroid dehydrogenase 6; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type IV; 3-beta-HSD IV; Hsd3b1; Hsd3b2l1; Hsd3b6; Hydroxy-delta-5-steroid dehydrogenase 3 beta- and steroid delta-isomerase; hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6; hydroxysteroid dehydrogenase-6 delta<5>-3-beta; hydroxysteroid dehydrogenase-6, delta<5>-3-beta; LOC108348086; MGC109236
RGD Orthologs
Human
Chinchilla
Bonobo
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82188,784,614 - 188,812,535 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2188,784,614 - 188,790,569 (-)EnsemblGRCr8
mRatBN7.22186,095,897 - 186,105,354 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2186,095,897 - 186,101,852 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2193,745,518 - 193,754,936 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02191,547,554 - 191,557,003 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02186,378,092 - 186,387,510 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02200,712,895 - 200,722,429 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2202,341,422 - 202,350,929 (-)Ensemblrn6Rnor6.0
Rnor_5.02221,794,088 - 221,803,545 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42193,337,342 - 193,346,799 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2178,571,952 - 178,581,409 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R,R,R)-alpha-tocopherol  (EXP)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenol  (ISO)
2,4-Dihydroxybenzophenone  (EXP)
2,6-dibromophenol  (ISO)
2-bromophenol  (ISO)
2-methoxyethanol  (EXP)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-dihydroxybenzoic acid  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-nitro-m-cresol  (ISO)
8-Br-cAMP  (ISO)
Acetyl tributyl citrate  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP)
alternariol  (ISO)
ammonium chloride  (EXP)
apigenin  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzofurans  (ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
carbamazepine  (ISO)
chlorohydrocarbon  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cortisol  (ISO)
cypermethrin  (EXP,ISO)
daidzein  (ISO)
decabromodiphenyl ether  (EXP)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl phthalate  (ISO)
difenoconazole  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
doxorubicin  (ISO)
enniatin  (ISO)
enzacamene  (EXP)
fenitrothion  (EXP)
furan  (EXP)
galaxolide  (ISO)
gamma-hexachlorocyclohexane  (ISO)
hexachlorophene  (EXP)
imidacloprid  (EXP)
ketoconazole  (ISO)
lamotrigine  (ISO)
levetiracetam  (ISO)
linuron  (EXP)
mercury dichloride  (EXP)
metyrapone  (ISO)
Mitotane  (ISO)
mycotoxin  (ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
niclosamide  (ISO)
octreotide  (EXP)
okadaic acid  (ISO)
oxybenzone  (EXP)
pasireotide  (EXP)
perflubron  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
pioglitazone  (ISO)
prochloraz  (ISO)
progesterone  (EXP,ISO)
prostaglandin E2  (ISO)
quercetin  (EXP)
sodium arsenite  (EXP)
sodium dichromate  (EXP)
sulpiride  (EXP)
Tesaglitazar  (EXP)
thioacetamide  (EXP)
topiramate  (ISO)
torcetrapib  (ISO)
trans-cinnamic acid  (ISO)
tributylstannane  (ISO)
triclosan  (EXP)
triphenylstannane  (ISO)
Triptolide  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
valproic acid  (ISO)
zearalenone  (EXP)
zinc oxide  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Opposite effects of prolactin and corticosterone on the expression and activity of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase in rat skin. Couet J, etal., J Invest Dermatol. 1994 Jul;103(1):60-4.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Increased expression of 3 beta-hydroxysteroid dehydrogenase mRNA in dorsal root ganglion neurons of adult rats following peripheral nerve injury. Hashimoto N, etal., Neurosci Lett 2003 Apr 3;340(1):45-8.
5. Gonadotropin stimuli increase adrenodoxin immunoreactivity in the mitochondria of rat ovarian cells. Izumi S and Mitani F, Acta Histochem. 2005;107(4):269-77. Epub 2005 Sep 1.
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Semicomprehensive Analysis of the Postnatal Age-Related Changes in the mRNA Expression of Sex Steroidogenic Enzymes and Sex Steroid Receptors in the Male Rat Hippocampus. Kimoto T, etal., Endocrinology. 2010 Nov 3.
8. Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells. Lachance Y, etal., J Biol Chem 1990 Nov 25;265(33):20469-75.
9. Endogenous ouabain: upregulation of steroidogenic genes in hypertensive hypothalamus but not adrenal. Murrell JR, etal., Circulation. 2005 Aug 30;112(9):1301-8. Epub 2005 Aug 22.
10. Biochemical effects of gestational coexposure to lead and cadmium on reproductive performance, placenta, and ovary. Nampoothiri LP and Gupta S, J Biochem Mol Toxicol. 2008 Sep;22(5):337-44.
11. Regulation of expression of male-specific rat liver microsomal 3 beta-hydroxysteroid dehydrogenase. Naville D, etal., Mol Endocrinol 1991 Aug;5(8):1090-100.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Leydig cell re-generation and expression of cell signaling molecules in the germ cell-free testis. O'Shaughnessy PJ, etal., Reproduction. 2008 Jun;135(6):851-8.
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Payne AH and Hales DB, Endocr Rev. 2004 Dec;25(6):947-70.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
18. GOA pipeline RGD automated data pipeline
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Polymorphism in exon 4 of the human 3 beta-hydroxysteroid dehydrogenase type I gene (HSD3B1) and blood pressure. Rosmond R, etal., Biochem Biophys Res Commun. 2002 Apr 26;293(1):629-32.
21. Structure and tissue-specific expression of a novel member of the rat 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) family. The exclusive 3 beta-HSD gene expression in the skin. Simard J, etal., J Biol Chem 1993 Sep 15;268(26):19659-68.
22. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
23. Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms. Viollet B, etal., J Biol Chem 1996 Jan 19;271(3):1405-15.
24. Characterization of rat 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase cDNAs and differential tissue-specific expression of the corresponding mRNAs in steroidogenic and peripheral tissues. Zhao HF, etal., J Biol Chem 1991 Jan 5;266(1):583-93.
Additional References at PubMed
PMID:1944309   PMID:12477932   PMID:15489334   PMID:17257522   PMID:19071209  


Genomics

Comparative Map Data
Hsd3b2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82188,784,614 - 188,812,535 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2188,784,614 - 188,790,569 (-)EnsemblGRCr8
mRatBN7.22186,095,897 - 186,105,354 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2186,095,897 - 186,101,852 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2193,745,518 - 193,754,936 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02191,547,554 - 191,557,003 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02186,378,092 - 186,387,510 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02200,712,895 - 200,722,429 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2202,341,422 - 202,350,929 (-)Ensemblrn6Rnor6.0
Rnor_5.02221,794,088 - 221,803,545 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42193,337,342 - 193,346,799 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2178,571,952 - 178,581,409 (-)NCBICelera
Cytogenetic Map2q34NCBI
HSD3B2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381119,414,931 - 119,423,034 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1119,413,725 - 119,423,035 (+)Ensemblhg38GRCh38
GRCh371119,957,554 - 119,965,657 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361119,759,296 - 119,767,174 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341119,669,814 - 119,677,693NCBI
Celera1118,188,369 - 118,196,423 (+)NCBICelera
Cytogenetic Map1p12NCBI
HuRef1117,816,103 - 117,824,157 (+)NCBIHuRef
CHM1_11120,073,104 - 120,081,190 (+)NCBICHM1_1
T2T-CHM13v2.01119,428,182 - 119,436,213 (+)NCBIT2T-CHM13v2.0
Hsd3b2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543522,414,605 - 22,421,682 (+)NCBIChiLan1.0ChiLan1.0
HSD3B2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21112,031,114 - 112,039,643 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11111,634,957 - 111,643,532 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0183,130,065 - 83,156,996 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11118,128,493 - 118,153,124 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1118,128,493 - 118,153,124 (-)EnsemblpanPan2panpan1.1
HSD3B2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11756,552,945 - 56,561,062 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1756,552,945 - 56,561,062 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1756,201,670 - 56,209,794 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01757,425,539 - 57,433,679 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1757,425,539 - 57,433,679 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11756,461,835 - 56,469,954 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01756,493,794 - 56,501,741 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01757,083,743 - 57,091,866 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0

Variants

.
Variants in Hsd3b2
265 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:121
Count of miRNA genes:68
Interacting mature miRNAs:74
Transcripts:ENSRNOT00000026306, ENSRNOT00000056172, ENSRNOT00000068511
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2188565047233565047Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
7488929Bp366Blood pressure QTL 3660.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2187663373195783351Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat

Markers in Region
RH128688  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22186,169,892 - 186,170,042 (+)MAPPERmRatBN7.2
Rnor_6.02200,756,587 - 200,756,736NCBIRnor6.0
Rnor_5.02220,223,694 - 220,223,843UniSTSRnor5.0
RGSC_v3.42193,500,945 - 193,501,094UniSTSRGSC3.4
Celera2178,651,862 - 178,652,011UniSTS
RH 3.4 Map21261.2UniSTS
Cytogenetic Map2q34UniSTS
RH131337  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22186,095,922 - 186,096,079 (+)MAPPERmRatBN7.2
Rnor_6.02202,341,443 - 202,341,599NCBIRnor6.0
Rnor_6.02200,712,921 - 200,713,077NCBIRnor6.0
Rnor_5.02221,794,114 - 221,794,270UniSTSRnor5.0
Rnor_5.02220,180,003 - 220,180,159UniSTSRnor5.0
RGSC_v3.42193,337,368 - 193,337,524UniSTSRGSC3.4
Celera2178,571,978 - 178,572,134UniSTS
RH 3.4 Map21263.4UniSTS
Cytogenetic Map2q34UniSTS
RH139877  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22186,139,789 - 186,139,977 (+)MAPPERmRatBN7.2
mRatBN7.22186,171,600 - 186,171,788 (+)MAPPERmRatBN7.2
Rnor_6.02200,758,285 - 200,758,472NCBIRnor6.0
Rnor_5.02220,225,287 - 220,225,474UniSTSRnor5.0
RGSC_v3.42193,502,653 - 193,502,840UniSTSRGSC3.4
Celera2178,653,570 - 178,653,757UniSTS
Celera2178,615,849 - 178,616,036UniSTS
RH 3.4 Map21261.2UniSTS
Cytogenetic Map2q34UniSTS
HSD3B  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22186,096,288 - 186,096,462 (+)MAPPERmRatBN7.2
Rnor_6.02202,341,809 - 202,341,982NCBIRnor6.0
Rnor_6.02200,713,287 - 200,713,460NCBIRnor6.0
Rnor_5.02220,180,369 - 220,180,542UniSTSRnor5.0
Rnor_5.02221,794,480 - 221,794,653UniSTSRnor5.0
RGSC_v3.42193,337,734 - 193,337,907UniSTSRGSC3.4
Celera2178,572,344 - 178,572,517UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 8 42 51 41 26 8 26 6 92 37 1 21 14 47 15 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000026306   ⟹   ENSRNOP00000026306
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2188,784,614 - 188,790,569 (-)Ensembl
mRatBN7.2 Ensembl2186,095,897 - 186,101,852 (-)Ensembl
Rnor_6.0 Ensembl2202,341,422 - 202,350,929 (-)Ensembl
RefSeq Acc Id: NM_017265   ⟹   NP_058961
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82188,784,614 - 188,794,069 (-)NCBI
mRatBN7.22186,095,897 - 186,105,354 (-)NCBI
Rnor_6.02200,712,895 - 200,722,429 (-)NCBI
Rnor_5.02221,794,088 - 221,803,545 (-)NCBI
RGSC_v3.42193,337,342 - 193,346,799 (-)RGD
Celera2178,571,952 - 178,581,409 (-)RGD
Sequence:
RefSeq Acc Id: XM_063281672   ⟹   XP_063137742
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82188,784,614 - 188,812,534 (-)NCBI
RefSeq Acc Id: XM_063281673   ⟹   XP_063137743
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82188,784,614 - 188,812,142 (-)NCBI
RefSeq Acc Id: XM_063281674   ⟹   XP_063137744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82188,784,614 - 188,812,534 (-)NCBI
RefSeq Acc Id: XM_063281675   ⟹   XP_063137745
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82188,784,614 - 188,803,394 (-)NCBI
RefSeq Acc Id: XM_063281676   ⟹   XP_063137746
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82188,784,614 - 188,812,535 (-)NCBI
RefSeq Acc Id: XM_063281677   ⟹   XP_063137747
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82188,784,614 - 188,812,534 (-)NCBI
RefSeq Acc Id: XM_063281678   ⟹   XP_063137748
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82188,784,614 - 188,812,535 (-)NCBI
RefSeq Acc Id: NP_058961   ⟸   NM_017265
- UniProtKB: Q5FVK0 (UniProtKB/Swiss-Prot),   Q62878 (UniProtKB/Swiss-Prot),   A6K3E0 (UniProtKB/TrEMBL),   F1LNS3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026306   ⟸   ENSRNOT00000026306
RefSeq Acc Id: XP_063137748   ⟸   XM_063281678
- Peptide Label: isoform X1
- UniProtKB: Q62878 (UniProtKB/Swiss-Prot),   Q5FVK0 (UniProtKB/Swiss-Prot),   A6K3E0 (UniProtKB/TrEMBL),   F1LNS3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137746   ⟸   XM_063281676
- Peptide Label: isoform X1
- UniProtKB: Q62878 (UniProtKB/Swiss-Prot),   Q5FVK0 (UniProtKB/Swiss-Prot),   A6K3E0 (UniProtKB/TrEMBL),   F1LNS3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137747   ⟸   XM_063281677
- Peptide Label: isoform X1
- UniProtKB: Q62878 (UniProtKB/Swiss-Prot),   Q5FVK0 (UniProtKB/Swiss-Prot),   A6K3E0 (UniProtKB/TrEMBL),   F1LNS3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137744   ⟸   XM_063281674
- Peptide Label: isoform X1
- UniProtKB: Q62878 (UniProtKB/Swiss-Prot),   Q5FVK0 (UniProtKB/Swiss-Prot),   A6K3E0 (UniProtKB/TrEMBL),   F1LNS3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137742   ⟸   XM_063281672
- Peptide Label: isoform X1
- UniProtKB: Q62878 (UniProtKB/Swiss-Prot),   Q5FVK0 (UniProtKB/Swiss-Prot),   A6K3E0 (UniProtKB/TrEMBL),   F1LNS3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137743   ⟸   XM_063281673
- Peptide Label: isoform X1
- UniProtKB: Q62878 (UniProtKB/Swiss-Prot),   Q5FVK0 (UniProtKB/Swiss-Prot),   A6K3E0 (UniProtKB/TrEMBL),   F1LNS3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137745   ⟸   XM_063281675
- Peptide Label: isoform X1
- UniProtKB: Q62878 (UniProtKB/Swiss-Prot),   Q5FVK0 (UniProtKB/Swiss-Prot),   A6K3E0 (UniProtKB/TrEMBL),   F1LNS3 (UniProtKB/TrEMBL)
Protein Domains
3-beta hydroxysteroid dehydrogenase/isomerase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62878-F1-model_v2 AlphaFold Q62878 1-373 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:67377 AgrOrtholog
BioCyc Gene G2FUF-51909 BioCyc
Ensembl Genes ENSRNOG00000019441 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026306 ENTREZGENE
  ENSRNOT00000026306.6 UniProtKB/Swiss-Prot
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7309637 IMAGE-MGC_LOAD
InterPro 3Beta_OHSteriod_DH/Estase UniProtKB/Swiss-Prot
  Lipid_A_modif_metabolic_enz UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:29632 UniProtKB/Swiss-Prot
MGC_CLONE MGC:109236 IMAGE-MGC_LOAD
NCBI Gene 29632 ENTREZGENE
PANTHER BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA UniProtKB/Swiss-Prot
  EPIMERASE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
Pfam 3Beta_HSD UniProtKB/Swiss-Prot
PhenoGen Hsd3b2 PhenoGen
RatGTEx ENSRNOG00000019441 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot
TIGR TC219828
UniProt 3BHS4_RAT UniProtKB/Swiss-Prot
  A6K3E0 ENTREZGENE, UniProtKB/TrEMBL
  F1LNS3 ENTREZGENE, UniProtKB/TrEMBL
  Q5FVK0 ENTREZGENE
  Q62878 ENTREZGENE
UniProt Secondary Q5FVK0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Hsd3b2  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2  LOC108348086  3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4  Data merged from RGD:11496463 737654 PROVISIONAL
2016-08-02 LOC108348086  3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4      Symbol and Name status set to provisional 70820 PROVISIONAL
2015-08-18 Hsd3b2  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2  Hsd3b2l1  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1  Name and Symbol changed 629549 APPROVED
2015-08-18 Hsd3b2l1  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1  Hsd3b1  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1  Symbol changed 629549 APPROVED
2010-11-02 Hsd3b1  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1  Hsd3b6  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-12-18 Hsd3b6  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6  Hsd3b1  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2002-06-10 Hsd3b1  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1      Name updated 70584 APPROVED
2001-10-23 Hsd3b1  hydroxysteroid dehydrogenase-6, delta<5>-3-beta      Name updated 68916 PENDING

RGD Curation Notes
Note Type Note Reference
gene_function contains both 3 beta-hydroxysteroid dehydrogenase and delta 5-delta 4-isomerase activities 632870
gene_protein 42-kDa protein 632870