Sla (src-like adaptor) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Sla (src-like adaptor) Rattus norvegicus
Analyze
Symbol: Sla
Name: src-like adaptor
RGD ID: 631373
Description: Predicted to enable epidermal growth factor receptor binding activity and phosphotyrosine residue binding activity. Predicted to be involved in regulation of MAPK cascade and signal transduction. Predicted to be located in endosome. Predicted to be part of COP9 signalosome. Predicted to be active in cytoplasm; nucleoplasm; and plasma membrane. Orthologous to human SLA (Src like adaptor); PARTICIPATES IN platelet-derived growth factor signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: SLAP-1; Slap1; src-like-adapter; src-like-adapter protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87100,423,467 - 100,473,840 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7100,424,169 - 100,473,684 (-)EnsemblGRCr8
mRatBN7.2798,534,431 - 98,584,810 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl798,535,368 - 98,584,648 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7100,295,615 - 100,345,148 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07102,497,284 - 102,546,821 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07102,416,627 - 102,466,162 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07107,585,055 - 107,604,950 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7107,584,118 - 107,634,335 (-)Ensemblrn6Rnor6.0
Rnor_5.07107,517,379 - 107,537,284 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47104,153,028 - 104,202,272 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera795,087,623 - 95,107,518 (-)NCBICelera
RGSC_v3.17104,187,257 - 104,236,502 (-)NCBI
Cytogenetic Map7q33NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
bathocuproine disulfonic acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
cycloheximide  (ISO)
cylindrospermopsin  (ISO)
cytarabine  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
glycidol  (EXP)
hypochlorous acid  (ISO)
ionomycin  (ISO)
isotretinoin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
paracetamol  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pyrrolidine dithiocarbamate  (ISO)
resveratrol  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
tacrolimus hydrate  (ISO)
tamibarotene  (ISO)
tebuconazole  (ISO)
testosterone  (EXP,ISO)
titanium dioxide  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zebularine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Restricted expression of Slap-1 in the rodent cerebral cortex. Alifragis P, etal., Gene Expr Patterns 2003 Aug;3(4):437-40.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Sla
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87100,423,467 - 100,473,840 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7100,424,169 - 100,473,684 (-)EnsemblGRCr8
mRatBN7.2798,534,431 - 98,584,810 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl798,535,368 - 98,584,648 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7100,295,615 - 100,345,148 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07102,497,284 - 102,546,821 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07102,416,627 - 102,466,162 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07107,585,055 - 107,604,950 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7107,584,118 - 107,634,335 (-)Ensemblrn6Rnor6.0
Rnor_5.07107,517,379 - 107,537,284 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47104,153,028 - 104,202,272 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera795,087,623 - 95,107,518 (-)NCBICelera
RGSC_v3.17104,187,257 - 104,236,502 (-)NCBI
Cytogenetic Map7q33NCBI
SLA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388133,036,728 - 133,102,602 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8133,036,728 - 133,102,912 (-)Ensemblhg38GRCh38
GRCh378134,048,973 - 134,114,846 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368134,118,155 - 134,184,479 (-)NCBIBuild 36Build 36hg18NCBI36
Build 348134,118,155 - 134,141,628NCBI
Celera8130,226,336 - 130,292,597 (-)NCBICelera
Cytogenetic Map8q24.22NCBI
HuRef8129,368,758 - 129,435,010 (-)NCBIHuRef
CHM1_18134,089,636 - 134,155,921 (-)NCBICHM1_1
T2T-CHM13v2.08134,160,152 - 134,225,947 (-)NCBIT2T-CHM13v2.0
Sla
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391566,652,713 - 66,703,921 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1566,652,668 - 66,703,678 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381566,780,819 - 66,831,829 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1566,780,819 - 66,831,829 (-)Ensemblmm10GRCm38
MGSCv371566,612,426 - 66,663,391 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361566,610,533 - 66,661,498 (-)NCBIMGSCv36mm8
Celera1568,313,400 - 68,364,521 (-)NCBICelera
Cytogenetic Map15D2NCBI
cM Map1529.3NCBI
Sla
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554617,622,501 - 7,653,782 (-)Ensembl
ChiLan1.0NW_0049554617,622,501 - 7,643,008 (-)NCBIChiLan1.0ChiLan1.0
SLA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27150,425,866 - 150,492,000 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18125,940,457 - 126,006,515 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08129,690,546 - 129,757,660 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18132,666,411 - 132,732,669 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8132,666,411 - 132,732,669 (-)EnsemblpanPan2panpan1.1
SLA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11329,503,304 - 29,590,679 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1329,504,867 - 29,569,773 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1329,477,307 - 29,564,622 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01329,859,189 - 29,946,631 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1329,860,732 - 29,926,000 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11329,585,790 - 29,673,356 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01329,687,899 - 29,773,789 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01330,036,353 - 30,122,339 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sla
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244053038,784,853 - 8,838,894 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647016,232,602 - 16,264,982 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647016,232,614 - 16,264,982 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl48,189,232 - 8,247,388 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.148,166,829 - 8,247,396 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.248,087,278 - 8,167,827 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18127,466,230 - 127,504,344 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8127,468,048 - 127,504,325 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603912,574,726 - 12,641,317 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sla
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473522,892,713 - 22,950,355 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473522,929,467 - 22,949,471 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Sla
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11240,894,223 - 240,944,866 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sla
603 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:24
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000007982
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)771103011106126789Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
1298525Cm1Cardiac mass QTL 12.7heart mass (VT:0007028)heart wet weight (CMO:0000069)756625161101625161Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
1331723Bw25Body weight QTL 253.348body mass (VT:0001259)body weight (CMO:0000012)796700404111672180Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)755498584105834451Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)763889858108889858Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)762963207107963207Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)763889858108889858Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
Sla  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2798,536,185 - 98,536,281 (+)MAPPERmRatBN7.2
Rnor_6.07107,585,873 - 107,585,968NCBIRnor6.0
Rnor_5.07107,518,197 - 107,518,292UniSTSRnor5.0
RGSC_v3.47104,153,846 - 104,153,941UniSTSRGSC3.4
Celera795,088,441 - 95,088,536UniSTS
Cytogenetic Map7q33UniSTS
RH141175  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2798,535,184 - 98,535,387 (+)MAPPERmRatBN7.2
Rnor_6.07107,584,872 - 107,585,074NCBIRnor6.0
Rnor_5.07107,517,196 - 107,517,398UniSTSRnor5.0
RGSC_v3.47104,152,845 - 104,153,047UniSTSRGSC3.4
Celera795,087,440 - 95,087,642UniSTS
RH 3.4 Map7683.2UniSTS
Cytogenetic Map7q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000087116   ⟹   ENSRNOP00000072624
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7100,424,169 - 100,473,684 (-)Ensembl
mRatBN7.2 Ensembl798,535,368 - 98,584,600 (-)Ensembl
Rnor_6.0 Ensembl7107,585,055 - 107,634,287 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088752   ⟹   ENSRNOP00000075482
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl798,535,368 - 98,555,347 (-)Ensembl
Rnor_6.0 Ensembl7107,585,577 - 107,616,038 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7107,585,921 - 107,604,981 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093523   ⟹   ENSRNOP00000076267
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7100,425,079 - 100,444,383 (-)Ensembl
mRatBN7.2 Ensembl798,540,552 - 98,584,648 (-)Ensembl
Rnor_6.0 Ensembl7107,590,239 - 107,634,335 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093672   ⟹   ENSRNOP00000076294
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7107,584,118 - 107,634,287 (-)Ensembl
RefSeq Acc Id: NM_178097   ⟹   NP_835198
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87100,424,169 - 100,473,684 (-)NCBI
mRatBN7.2798,535,133 - 98,584,648 (-)NCBI
Rnor_6.07107,585,055 - 107,604,950 (-)NCBI
Rnor_5.07107,517,379 - 107,537,284 (-)NCBI
RGSC_v3.47104,153,028 - 104,202,272 (-)RGD
Celera795,087,623 - 95,107,518 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079357   ⟹   XP_038935285
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87100,423,467 - 100,473,840 (-)NCBI
mRatBN7.2798,534,431 - 98,584,810 (-)NCBI
RefSeq Acc Id: XM_063263691   ⟹   XP_063119761
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87100,423,467 - 100,444,388 (-)NCBI
RefSeq Acc Id: NP_835198   ⟸   NM_178097
- UniProtKB: A0A1W2Q6L4 (UniProtKB/TrEMBL),   A0A0G2K3G1 (UniProtKB/TrEMBL),   A6HRR8 (UniProtKB/TrEMBL),   A0A0G2KAQ1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072624   ⟸   ENSRNOT00000087116
Ensembl Acc Id: ENSRNOP00000076267   ⟸   ENSRNOT00000093523
Ensembl Acc Id: ENSRNOP00000076294   ⟸   ENSRNOT00000093672
Ensembl Acc Id: ENSRNOP00000075482   ⟸   ENSRNOT00000088752
RefSeq Acc Id: XP_038935285   ⟸   XM_039079357
- Peptide Label: isoform X2
- UniProtKB: A6HRR9 (UniProtKB/TrEMBL),   A0A0G2KAQ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119761   ⟸   XM_063263691
- Peptide Label: isoform X1
- UniProtKB: A0A0G2KAQ1 (UniProtKB/TrEMBL)
Protein Domains
SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P59622-F1-model_v2 AlphaFold P59622 1-312 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695371
Promoter ID:EPDNEW_R5889
Type:initiation region
Name:Sla_1
Description:src-like adaptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07107,605,005 - 107,605,065EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631373 AgrOrtholog
BioCyc Gene G2FUF-33120 BioCyc
Ensembl Genes ENSRNOG00000056714 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000087116 ENTREZGENE
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
InterPro Grb2-like UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
  SLAP_SH2 UniProtKB/Swiss-Prot
  SLAP_SH3 UniProtKB/Swiss-Prot
KEGG Report rno:338477 UniProtKB/Swiss-Prot
NCBI Gene 338477 ENTREZGENE
PANTHER PROTEIN ENHANCER OF SEVENLESS 2B UniProtKB/Swiss-Prot
Pfam SH2 UniProtKB/Swiss-Prot
  SH3_1 UniProtKB/Swiss-Prot
PhenoGen Sla PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot
PROSITE SH2 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000056714 RatGTEx
SMART SH2 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot
UniProt A0A0G2K3G1 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2KAQ1 ENTREZGENE
  A0A1W2Q6I5_RAT UniProtKB/TrEMBL
  A0A1W2Q6L4 ENTREZGENE
  A6HRR8 ENTREZGENE, UniProtKB/TrEMBL
  A6HRR9 ENTREZGENE, UniProtKB/TrEMBL
  P59622 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-11 Sla  src-like adaptor      Symbol and Name status set to approved 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression speifically expressed by deeper layer neurons and by neurons of layers II/III in the developing cortex 1302297