Sgpl1 (sphingosine-1-phosphate lyase 1) - Rat Genome Database

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Gene: Sgpl1 (sphingosine-1-phosphate lyase 1) Rattus norvegicus
Analyze
Symbol: Sgpl1
Name: sphingosine-1-phosphate lyase 1
RGD ID: 628599
Description: Predicted to enable sphinganine-1-phosphate aldolase activity. Predicted to be involved in apoptotic signaling pathway; fatty acid metabolic process; and sphingolipid metabolic process. Predicted to act upstream of or within several processes, including face morphogenesis; gonad development; and steroid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in nephrotic syndrome type 14. Orthologous to human SGPL1 (sphingosine-1-phosphate lyase 1); PARTICIPATES IN Fabry disease pathway; Gaucher's disease pathway; Krabbe disease pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: S1PL; SP-lyase 1; Spgl1; sphingosine phosphate lyase 1; sphingosine-1-phosphate aldolase; spl; SPL 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82029,590,652 - 29,637,064 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2029,592,721 - 29,667,753 (-)EnsemblGRCr8
mRatBN7.22029,047,793 - 29,094,209 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2029,047,796 - 29,094,084 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2030,065,894 - 30,110,041 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02029,452,195 - 29,496,346 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02030,194,650 - 30,238,806 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02030,699,936 - 30,769,178 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2030,699,872 - 30,749,940 (-)Ensemblrn6Rnor6.0
Rnor_5.02032,497,280 - 32,543,188 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42028,459,734 - 28,505,017 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2030,483,317 - 30,527,561 (-)NCBICelera
RGSC_v3.12028,473,533 - 28,518,817 (-)NCBI
Cytogenetic Map20q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (ISO)
aflatoxin B1  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
carbon nanotube  (ISO)
chromium(3+) trichloride  (ISO)
cyproconazole  (ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dieldrin  (EXP)
dioxygen  (ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fipronil  (EXP)
FR900359  (ISO)
gentamycin  (EXP)
graphite  (EXP)
inulin  (ISO)
ivermectin  (ISO)
onapristone  (EXP)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
propiconazole  (EXP,ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Subcellular localization and membrane topology of sphingosine-1-phosphate lyase in rat liver. Van Veldhoven PP and Mannaerts GP, J Biol Chem 1991 Jul 5;266(19):12502-7.
Additional References at PubMed
PMID:14570870   PMID:17143286   PMID:19056881   PMID:24809814   PMID:25630683   PMID:28165339   PMID:29070677   PMID:33450132  


Genomics

Comparative Map Data
Sgpl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82029,590,652 - 29,637,064 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2029,592,721 - 29,667,753 (-)EnsemblGRCr8
mRatBN7.22029,047,793 - 29,094,209 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2029,047,796 - 29,094,084 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2030,065,894 - 30,110,041 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02029,452,195 - 29,496,346 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02030,194,650 - 30,238,806 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02030,699,936 - 30,769,178 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2030,699,872 - 30,749,940 (-)Ensemblrn6Rnor6.0
Rnor_5.02032,497,280 - 32,543,188 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42028,459,734 - 28,505,017 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2030,483,317 - 30,527,561 (-)NCBICelera
RGSC_v3.12028,473,533 - 28,518,817 (-)NCBI
Cytogenetic Map20q11NCBI
SGPL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381070,815,948 - 70,881,184 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1070,815,905 - 70,958,701 (+)Ensemblhg38GRCh38
GRCh371072,575,704 - 72,640,941 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361072,245,722 - 72,309,873 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341072,245,721 - 72,309,871NCBI
Celera1065,857,672 - 65,923,231 (+)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1066,569,390 - 66,634,948 (+)NCBIHuRef
CHM1_11072,858,499 - 72,923,730 (+)NCBICHM1_1
T2T-CHM13v2.01071,685,760 - 71,750,988 (+)NCBIT2T-CHM13v2.0
Sgpl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391060,934,421 - 60,983,463 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1060,934,421 - 60,983,482 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381061,098,642 - 61,147,684 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1061,098,642 - 61,147,703 (-)Ensemblmm10GRCm38
MGSCv371060,561,390 - 60,610,413 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361060,493,999 - 60,542,956 (-)NCBIMGSCv36mm8
Celera1062,199,269 - 62,248,215 (-)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.14NCBI
Sgpl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543720,488,330 - 20,547,171 (-)Ensembl
ChiLan1.0NW_00495543720,489,641 - 20,547,105 (-)NCBIChiLan1.0ChiLan1.0
SGPL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2882,966,349 - 83,030,587 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11082,971,702 - 83,039,487 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01067,286,349 - 67,351,574 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11069,812,082 - 69,876,444 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1069,812,092 - 69,876,438 (+)EnsemblpanPan2panpan1.1
SGPL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1421,666,264 - 21,717,476 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl421,660,939 - 21,715,155 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha421,795,341 - 21,851,669 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0421,939,185 - 21,995,525 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl421,944,334 - 21,995,521 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1421,834,799 - 21,891,148 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0422,040,063 - 22,096,345 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0422,392,266 - 22,448,632 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sgpl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721359,357,640 - 59,407,321 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365217,848,972 - 7,900,041 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365217,850,370 - 7,899,998 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SGPL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1473,724,100 - 73,781,800 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11473,696,902 - 73,781,830 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21479,572,301 - 79,628,480 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SGPL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1960,425,703 - 60,487,196 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl960,424,305 - 60,487,146 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604821,148,927 - 21,211,740 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sgpl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247544,844,552 - 4,886,709 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247544,844,472 - 4,889,006 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Sgpl1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11826,934,031 - 26,980,027 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sgpl1
147 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:32
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000065127
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202668936256021148Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804392029865039Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)202074558556021148Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202668936256021148Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202679235356021148Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)201224324249189476Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202668936256021148Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202668936256021148Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000065127   ⟹   ENSRNOP00000059089
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2030,702,005 - 30,749,940 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084391   ⟹   ENSRNOP00000070983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2029,592,721 - 29,667,753 (-)Ensembl
mRatBN7.2 Ensembl2029,047,796 - 29,094,084 (-)Ensembl
Rnor_6.0 Ensembl2030,699,872 - 30,748,784 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000134454   ⟹   ENSRNOP00000102422
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2029,592,721 - 29,637,061 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000151642   ⟹   ENSRNOP00000104811
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2029,592,721 - 29,617,676 (-)Ensembl
RefSeq Acc Id: NM_173116   ⟹   NP_775139
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82029,592,721 - 29,636,878 (-)NCBI
mRatBN7.22029,049,862 - 29,094,023 (-)NCBI
Rnor_6.02030,702,005 - 30,749,940 (-)NCBI
Rnor_5.02032,497,280 - 32,543,188 (-)NCBI
RGSC_v3.42028,459,734 - 28,505,017 (-)RGD
Celera2030,483,317 - 30,527,561 (-)RGD
Sequence:
RefSeq Acc Id: XM_008772871   ⟹   XP_008771093
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82029,590,652 - 29,637,064 (-)NCBI
mRatBN7.22029,047,793 - 29,094,209 (-)NCBI
Rnor_6.02030,699,936 - 30,749,948 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008772872   ⟹   XP_008771094
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82029,590,652 - 29,636,876 (-)NCBI
mRatBN7.22029,047,793 - 29,094,022 (-)NCBI
Rnor_6.02030,699,936 - 30,749,839 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039098466   ⟹   XP_038954394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82029,590,652 - 29,636,974 (-)NCBI
mRatBN7.22029,047,793 - 29,094,119 (-)NCBI
RefSeq Acc Id: XM_063278988   ⟹   XP_063135058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82029,590,652 - 29,636,925 (-)NCBI
RefSeq Acc Id: NP_775139   ⟸   NM_173116
- UniProtKB: Q8CHN6 (UniProtKB/Swiss-Prot),   A0A8L2R514 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771093   ⟸   XM_008772871
- Peptide Label: isoform X1
- UniProtKB: A0A8L2R514 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771094   ⟸   XM_008772872
- Peptide Label: isoform X2
- UniProtKB: Q8CHN6 (UniProtKB/Swiss-Prot),   A0A8L2R514 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000059089   ⟸   ENSRNOT00000065127
Ensembl Acc Id: ENSRNOP00000070983   ⟸   ENSRNOT00000084391
RefSeq Acc Id: XP_038954394   ⟸   XM_039098466
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063135058   ⟸   XM_063278988
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000104811   ⟸   ENSRNOT00000151642
Ensembl Acc Id: ENSRNOP00000102422   ⟸   ENSRNOT00000134454

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CHN6-F1-model_v2 AlphaFold Q8CHN6 1-568 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701600
Promoter ID:EPDNEW_R12123
Type:multiple initiation site
Name:Sgpl1_1
Description:sphingosine-1-phosphate lyase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02030,749,961 - 30,750,021EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628599 AgrOrtholog
BioCyc Gene G2FUF-3729 BioCyc
Ensembl Genes ENSRNOG00000000565 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000134454 ENTREZGENE
Gene3D-CATH 3.40.640.10 UniProtKB/Swiss-Prot
  3.90.1150.10 UniProtKB/Swiss-Prot
  6.10.140.2150 UniProtKB/Swiss-Prot
InterPro GrpII_AminoAcid_Decarb UniProtKB/Swiss-Prot
  PyrdxlP-dep_de-COase UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase_dom1 UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase_major UniProtKB/Swiss-Prot
KEGG Report rno:286896 UniProtKB/Swiss-Prot
NCBI Gene 286896 ENTREZGENE
PANTHER PTHR42735 UniProtKB/Swiss-Prot
  SPHINGOSINE-1-PHOSPHATE LYASE 1 UniProtKB/Swiss-Prot
Pfam Pyridoxal_deC UniProtKB/Swiss-Prot
PhenoGen Sgpl1 PhenoGen
RatGTEx ENSRNOG00000000565 RatGTEx
Superfamily-SCOP SSF53383 UniProtKB/Swiss-Prot
UniProt A0A8L2R514 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LIV1_RAT UniProtKB/TrEMBL
  A0ABK0LL68_RAT UniProtKB/TrEMBL
  A6K3Y7_RAT UniProtKB/TrEMBL
  Q8CHN6 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-17 Sgpl1  sphingosine-1-phosphate lyase 1  Sgpl1  sphingosine phosphate lyase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-17 Sgpl1  sphingosine phosphate lyase 1  Spgl1  sphingosine-1-phosphate lyase 1  Symbol and Name updated 1303942 APPROVED
2003-02-27 Spgl1  sphingosine-1-phosphate lyase 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the microsomal fraction 727205