Gene: Sgpl1 (sphingosine phosphate lyase 1)
Mus musculus |
| Symbol: |
Sgpl1
|
| Name: |
sphingosine phosphate lyase 1
|
| Description: |
ENCODES a protein that exhibits carboxy-lyase activity (inferred); catalytic activity (inferred); lyase activity (inferred); INVOLVED IN androgen metabolic process; estrogen metabolic process; face morphogenesis; PARTICIPATES IN sphingosine 1-phosphate signaling pathway; sphingolipid metabolic pathway; ASSOCIATED WITH abnormal blood vessel morphology; abnormal bone marrow morphology; abnormal cell migration; FOUND IN endoplasmic reticulum (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane |
| Type: |
protein-coding
|
| RefSeq Status: |
VALIDATED
|
| Also known as: |
AI428538; D10Xrf456; mSPL; OTTMUSP00000042252; OTTMUSP00000042253; OTTMUSP00000042256; S1PL; SP-lyase 1; sphingosine-1-phosphate aldolase; sphingosine-1-phosphate lyase 1; Spl; SPL 1
|
| Orthologs: |
Homo sapiens : SGPL1
(sphingosine-1-phosphate lyase 1)
HGNC
Rattus norvegicus : Sgpl1
(sphingosine-1-phosphate lyase 1)
|
| Latest Assembly: |
Mouse Genome Assembly Build 37
|
| Position: |
| Map | Chr | Position | Strand | Source |
|---|
Mouse Genome Assembly GRCm38 | 10 | 61,098,642 - 61,147,665 | - | NCBI | Mouse cM Map | 10 | 32.14 | | NCBI | Mouse Celera Assembly | 10 | 62,199,269 - 62,248,215 | - | NCBI | Mouse Genome Assembly Build 37 | 10 | 60,561,390 - 60,610,413 | - | NCBI | Mouse Genome Assembly Build 36.1 | 10 | 60,561,390 - 60,610,347 | - | NCBI | Mouse Cytogenetic Map | 10 | B4 | | NCBI |
|
| Model |
|
 Gene-Chemical Interaction Annotations
| 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of SGPL1 mRNA | CTD | PMID:22467019 | | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:628599 | 6480464 | AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of SGPL1 mRNA] | CTD | PMID:21215274 | | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of SGPL1 mRNA | CTD | PMID:21570461 | | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:628599 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SGPL1 mRNA | CTD | PMID:21215274 | | 2,4-dinitrotoluene | affects expression | ISO | RGD:628599 | 6480464 | 2,4-dinitrotoluene affects the expression of SGPL1 mRNA | CTD | PMID:21346803 | | 2,6-dinitrotoluene | affects expression | ISO | RGD:628599 | 6480464 | 2,6-dinitrotoluene affects the expression of SGPL1 mRNA | CTD | PMID:21346803 | | 4,4'-diaminodiphenylmethane | increases expression | EXP | | 6480464 | 4,4'-diaminodiphenylmethane results in increased expression of SGPL1 mRNA | CTD | PMID:18648102 | | 4-hydroxynon-2-enal | increases expression | EXP | | 6480464 | 4-hydroxy-2-nonenal results in increased expression of SGPL1 mRNA | CTD | PMID:19191707 | | ammonium chloride | affects expression | ISO | RGD:628599 | 6480464 | Ammonium Chloride affects the expression of SGPL1 mRNA | CTD | PMID:16483693 | | paracetamol | decreases expression | ISO | RGD:1347742 | 6480464 | Acetaminophen results in decreased expression of SGPL1 mRNA | CTD | PMID:21420995 | | phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of SGPL1 mRNA | CTD | PMID:19482888 PMID:19270015 | | phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of SGPL1 mRNA | CTD | PMID:19270015 more ... | | phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of SGPL1 mRNA | CTD | PMID:19270015 PMID:19482888 | | propiconazole | increases expression | EXP | | 6480464 | propiconazole results in increased expression of SGPL1 mRNA | CTD | PMID:21278054 | | propiconazole | increases expression | EXP | | 6480464 | propiconazole results in increased expression of SGPL1 mRNA | CTD | PMID:21278054 PMID:22334560 | |
 Gene Ontology Annotations
Biological Process
| androgen metabolic process | | IMP | MGI:MGI:3526851 | 2290270 | MGI:MGI:3820330|PMID:19056881 | MGI | MGI:MGI:3820330 PMID:19056881 | | apoptotic process | | ISO | UniProtKB:O95470 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 | | carboxylic acid metabolic process | | IEA | InterPro:IPR002129 | 2290270 | MGI:MGI:2152098 | UniProtKB | MGI:MGI:2152098 | | ceramide metabolic process | | ISO | UniProtKB:O95470 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 | | estrogen metabolic process | | IMP | MGI:MGI:3526851 | 2290270 | MGI:MGI:3820330|PMID:19056881 | MGI | MGI:MGI:3820330 PMID:19056881 | | face morphogenesis | | IMP | MGI:MGI:3526851 | 2290270 | MGI:MGI:3696608|PMID:17143286 | MGI | MGI:MGI:3696608 PMID:17143286 | | female gonad development | | IMP | MGI:MGI:3526851 | 2290270 | MGI:MGI:3820330|PMID:19056881 | MGI | MGI:MGI:3820330 PMID:19056881 | | fibroblast migration | | IMP | MGI:MGI:3526851 | 2290270 | MGI:MGI:3696608|PMID:17143286 | MGI | MGI:MGI:3696608 PMID:17143286 | | hemopoiesis | | IMP | MGI:MGI:3526851 | 2290270 | MGI:MGI:3696608|PMID:17143286 | MGI | MGI:MGI:3696608 PMID:17143286 | | kidney development | | IMP | MGI:MGI:3526851 | 2290270 | MGI:MGI:3696608|PMID:17143286 | MGI | MGI:MGI:3696608 PMID:17143286 | | Leydig cell differentiation | | IMP | MGI:MGI:3526851 | 2290270 | MGI:MGI:3820330|PMID:19056881 | MGI | MGI:MGI:3820330 PMID:19056881 | | lipid metabolic process | | IEA | UniProtKB-KW:KW-0443 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 | | luteinization | | IMP | MGI:MGI:3526851 | 2290270 | MGI:MGI:3820330|PMID:19056881 | MGI | MGI:MGI:3820330 PMID:19056881 | | nitrogen compound metabolic process | | IMP | MGI:MGI:3526851 | 2290270 | MGI:MGI:3696608|PMID:17143286 | MGI | MGI:MGI:3696608 PMID:17143286 | | palate development | | IMP | MGI:MGI:3526851 | 2290270 | MGI:MGI:3696608|PMID:17143286 | MGI | MGI:MGI:3696608 PMID:17143286 | | platelet-derived growth factor receptor signaling pathway | | IMP | MGI:MGI:3526851 | 2290270 | MGI:MGI:3696608|PMID:17143286 | MGI | MGI:MGI:3696608 PMID:17143286 | | post-embryonic development | | IMP | MGI:MGI:3526851 | 2290270 | MGI:MGI:3696608|PMID:17143286 | MGI | MGI:MGI:3696608 PMID:17143286 | | regulation of multicellular organism growth | | IMP | MGI:MGI:3526851 | 2290270 | MGI:MGI:3696608|PMID:17143286 | MGI | MGI:MGI:3696608 PMID:17143286 | | skeletal system morphogenesis | | IMP | MGI:MGI:3526851 | 2290270 | MGI:MGI:3696608|PMID:17143286 | MGI | MGI:MGI:3696608 PMID:17143286 | | spermatogenesis | | IMP | MGI:MGI:3526851 | 2290270 | MGI:MGI:3820330|PMID:19056881 | MGI | MGI:MGI:3820330 PMID:19056881 | | sphingolipid metabolic process | | IEA | UniProtKB-KW:KW-0746 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 | | vasculogenesis | | IMP | MGI:MGI:3526851 | 2290270 | MGI:MGI:3696608|PMID:17143286 | MGI | MGI:MGI:3696608 PMID:17143286 | |
| 1301787 | Bsc1_m | brain size control 1 (mouse) | | | Not determined | | 10 | 58143880 | 92144007 | Mouse |
| 1301380 | Cia8_m | collagen induced arthritis QTL 8 (mouse) | | | Not determined | | 10 | 57337186 | 91337351 | Mouse |
| 1558776 | Artmd1_m | arthropathy in MRL and DBA/1 mice 1 (mouse) | | | Not determined | | 10 | 55139307 | 89139418 | Mouse |
| 1301003 | Lmblgq4_m | limb length QTL 4 (mouse) | | | Not determined | | 10 | 50718408 | 84718557 | Mouse |
| 1300882 | Ath17_m | atherosclerosis 17 (mouse) | | | Not determined | | 10 | 50718408 | 84718557 | Mouse |
| 4141577 | Bmd38_m | bone mineral density 38 (mouse) | | | Not determined | | 10 | 50718408 | 84718557 | Mouse |
| 1301502 | Eae17_m | susceptibility to experimental allergic encephalomyelitis 17 (mouse) | | | Not determined | | 10 | 50718408 | 84718557 | Mouse |
| 1357737 | Hpcr2_m | hepatocarcinogen resistance 2 (mouse) | | | Not determined | | 10 | 49475191 | 83475366 | Mouse |
| 1301966 | Lifespan2_m | life span 2 (mouse) | | | Not determined | | 10 | 49475191 | 83475366 | Mouse |
| 4142169 | Pbwg16_m | postnatal body weight growth 16 (mouse) | | | Not determined | | 10 | 49475156 | 83475381 | Mouse |
| 1357742 | Jckm1_m | juvenile cystic kidney modifier 1 (mouse) | | | Not determined | | 10 | 49475156 | 83475381 | Mouse |
| 1300597 | Skull14_m | skull morphology 14 (mouse) | | | Not determined | | 10 | 49475156 | 83475381 | Mouse |
| 1301386 | Sysbp1_m | systolic blood pressure 1 (mouse) | | | Not determined | | 10 | 49475156 | 83475381 | Mouse |
| 1301561 | Chab2_m | cholesterol absorption 2 (mouse) | | | Not determined | | 10 | 49329535 | 83329679 | Mouse |
| 1357784 | Arti2_m | age related thymic involution 2 (mouse) | | | Not determined | | 10 | 49329535 | 83329679 | Mouse |
| 1302150 | Bbaa18_m | B.burgdorferi-associated arthritis 18 (mouse) | | | Not determined | | 10 | 48964981 | 82965126 | Mouse |
| 1302035 | Lmb4_m | lupus in MRL and B6 F2 cross (mouse) | | | Not determined | | 10 | 47906889 | 81907087 | Mouse |
| 4141159 | Phl2_m | progressive hearing loss 2 (mouse) | | | Not determined | | 10 | 47818209 | 69739569 | Mouse |
| 1300588 | Daq5_m | directional asymmetry QTL 5 (mouse) | | | Not determined | | 10 | 34337110 | 68337258 | Mouse |
| 1300907 | Daq4_m | directional asymmetry QTL 4 (mouse) | | | Not determined | | 10 | 34337110 | 68337258 | Mouse |
| 1357558 | Bmch4_m | bone mechanical trait 4 (mouse) | | | Not determined | | 10 | 31420846 | 65420994 | Mouse |
| 1301520 | Uvbi1_m | UVB induced immunosuppression 1 (mouse) | | | Not determined | | 10 | 30818209 | 64818340 | Mouse |
| 1300898 | Cfid_m | cystic fibrosis intestinal distress (mouse) | | | Not determined | | 10 | 29564113 | 63564193 | Mouse |