Pou2f1 (POU class 2 homeobox 1) - Rat Genome Database

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Gene: Pou2f1 (POU class 2 homeobox 1) Rattus norvegicus
Analyze
Symbol: Pou2f1
Name: POU class 2 homeobox 1
RGD ID: 621689
Description: Enables chromatin binding activity; signaling receptor binding activity; and transcription cis-regulatory region binding activity. Involved in liver regeneration and negative regulation of miRNA transcription. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Orthologous to human POU2F1 (POU class 2 homeobox 1); PARTICIPATES IN forkhead class A signaling pathway; RNA polymerase III transcription pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: NF-A1; oct-1; octamer-binding protein 1; octamer-binding transcription factor 1; OTF-1; POU domain, class 2, transcription factor 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81380,653,602 - 80,796,279 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1380,663,714 - 80,796,356 (-)EnsemblGRCr8
mRatBN7.21378,120,617 - 78,263,306 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1378,130,685 - 78,263,363 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1380,748,808 - 80,881,315 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01382,052,678 - 82,185,143 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01379,299,826 - 79,432,306 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01384,075,316 - 84,217,368 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1384,083,632 - 84,217,366 (-)Ensemblrn6Rnor6.0
Rnor_5.01388,957,996 - 89,095,123 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41381,607,326 - 81,739,958 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1377,841,488 - 77,973,453 (-)NCBICelera
RGSC_v3.11381,639,808 - 81,649,784 (-)NCBI
Cytogenetic Map13q23NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,5-hexanedione  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-naphthylamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acetazolamide  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP)
clofibrate  (ISO)
cobalt dichloride  (ISO)
coenzyme Q10  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dorsomorphin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenbuconazole  (ISO)
formaldehyde  (ISO)
gallic acid  (ISO)
indometacin  (ISO)
ionomycin  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
Lasiocarpine  (ISO)
lead(II) chloride  (ISO)
lipopolysaccharide  (ISO)
methyl methanesulfonate  (ISO)
monocrotaline  (ISO)
nicotine  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP)
riddelliine  (ISO)
rifampicin  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription. Dumay-Odelot H, etal., Cell Cycle. 2010 Sep 15;9(18):3687-99. Epub 2010 Sep 1.
2. Regulation of the rat CYP4A2 gene promoter by c-Jun and octamer binding protein-1. Fiala-Beer E, etal., Int J Biochem Cell Biol. 2007;39(6):1235-47. Epub 2007 Apr 1.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Functional interaction between Oct-1 and retinoid X receptor. Kakizawa T, etal., J Biol Chem. 1999 Jul 2;274(27):19103-8.
6. The POU-domain protein Oct-1 is widely expressed in adult rat organs. Kambe F, etal., Biochim Biophys Acta 1993 Jan 23;1171(3):307-10.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. A novel transcriptional element which regulates expression of the CYP2D4 gene by Oct-1 and YY-1 binding. Mizuno D, etal., Biochim Biophys Acta 2003 Jun 19;1627(2-3):121-8.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus. Shakib K, etal., Proteomics. 2005 Jul;5(11):2819-38.
15. Oct-1 transcription factor is a negative regulator of rat CYP1A1 expression via an octamer sequence in its negative regulatory element. Sterling K and Bresnick E, Mol Pharmacol. 1996 Feb;49(2):329-37.
16. Rat DNA sequence associated with a complex form of DNA polymerase alpha in nonregenerating liver interacts with a ubiquitous transcription/replication factor Oct-1. Timchenko NA, etal., Biomed Sci. 1991;2(6):595-600.
17. Negative feedback regulation between microRNA let-7g and LOX-1 mediated hypoxia-induced PASMCs proliferation. Zhang WF, etal., Biochem Biophys Res Commun. 2017 Jul 8;488(4):655-663. doi: 10.1016/j.bbrc.2017.01.073. Epub 2017 Jan 18.
Additional References at PubMed
PMID:1677182   PMID:1690859   PMID:7945330   PMID:7969117   PMID:8131747   PMID:8960364   PMID:9199328   PMID:9242494   PMID:9738004   PMID:10329190   PMID:10541551   PMID:11380252  
PMID:11891224   PMID:11937630   PMID:11997177   PMID:12782656   PMID:14729276   PMID:15024082   PMID:15138251   PMID:15252056   PMID:15326124   PMID:15613485   PMID:16002402   PMID:16735694  
PMID:17140559   PMID:19617623   PMID:24368669   PMID:37592110  


Genomics

Comparative Map Data
Pou2f1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81380,653,602 - 80,796,279 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1380,663,714 - 80,796,356 (-)EnsemblGRCr8
mRatBN7.21378,120,617 - 78,263,306 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1378,130,685 - 78,263,363 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1380,748,808 - 80,881,315 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01382,052,678 - 82,185,143 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01379,299,826 - 79,432,306 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01384,075,316 - 84,217,368 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1384,083,632 - 84,217,366 (-)Ensemblrn6Rnor6.0
Rnor_5.01388,957,996 - 89,095,123 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41381,607,326 - 81,739,958 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1377,841,488 - 77,973,453 (-)NCBICelera
RGSC_v3.11381,639,808 - 81,649,784 (-)NCBI
Cytogenetic Map13q23NCBI
POU2F1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381167,220,885 - 167,427,345 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1167,220,876 - 167,427,345 (+)Ensemblhg38GRCh38
GRCh371167,190,122 - 167,396,582 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361165,456,767 - 165,651,966 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341163,921,800 - 164,116,982NCBI
Celera1140,299,593 - 140,494,792 (+)NCBICelera
Cytogenetic Map1q24.2NCBI
HuRef1138,436,084 - 138,642,676 (+)NCBIHuRef
CHM1_11168,612,566 - 168,819,039 (+)NCBICHM1_1
T2T-CHM13v2.01166,572,283 - 166,778,684 (+)NCBIT2T-CHM13v2.0
Pou2f1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391165,692,719 - 165,830,318 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1165,692,723 - 165,830,247 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381165,865,150 - 166,002,749 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1165,865,154 - 166,002,678 (-)Ensemblmm10GRCm38
MGSCv371167,805,603 - 167,932,765 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361167,712,147 - 167,839,290 (-)NCBIMGSCv36mm8
Celera1168,321,320 - 168,447,672 (-)NCBICelera
Cytogenetic Map1H2.3NCBI
cM Map173.21NCBI
Pou2f1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554629,553,415 - 9,710,188 (-)Ensembl
ChiLan1.0NW_0049554629,545,122 - 9,710,190 (-)NCBIChiLan1.0ChiLan1.0
POU2F1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2182,336,082 - 82,545,017 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1182,004,570 - 82,213,522 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01142,653,296 - 142,860,572 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11146,439,518 - 146,645,441 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1146,439,581 - 146,633,921 (+)EnsemblpanPan2panpan1.1
POU2F1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1730,975,303 - 31,162,288 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl730,986,181 - 31,162,246 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha730,514,309 - 30,701,250 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0730,796,626 - 30,983,731 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl730,807,446 - 30,984,164 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1730,635,299 - 30,822,385 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0730,667,196 - 30,854,171 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0730,905,692 - 31,092,637 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pou2f1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344100,760,463 - 100,833,093 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648118,617,572 - 18,678,183 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648118,607,212 - 18,679,828 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POU2F1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl483,596,269 - 83,776,430 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1483,592,051 - 83,776,465 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2491,261,062 - 91,451,596 (-)NCBISscrofa10.2Sscrofa10.2susScr3
POU2F1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12561,599,803 - 61,800,615 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2561,611,330 - 61,654,173 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605563,335,365 - 63,537,158 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pou2f1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248265,334,366 - 5,493,821 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248265,334,365 - 5,501,421 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pou2f1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11044,968,725 - 45,107,130 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pou2f1
723 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:199
Count of miRNA genes:144
Interacting mature miRNAs:158
Transcripts:ENSRNOT00000047488
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat

Markers in Region
RH136721  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21378,188,116 - 78,188,246 (+)MAPPERmRatBN7.2
Rnor_6.01384,142,192 - 84,142,321NCBIRnor6.0
Rnor_5.01389,020,747 - 89,020,876UniSTSRnor5.0
RGSC_v3.41381,663,942 - 81,664,071UniSTSRGSC3.4
Celera1377,898,364 - 77,898,493UniSTS
Cytogenetic Map13q23UniSTS
BF401612  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21378,193,746 - 78,193,844 (+)MAPPERmRatBN7.2
Rnor_6.01384,147,826 - 84,147,923NCBIRnor6.0
Rnor_5.01389,026,381 - 89,026,478UniSTSRnor5.0
RGSC_v3.41381,669,880 - 81,669,977UniSTSRGSC3.4
Celera1377,903,994 - 77,904,091UniSTS
RH 3.4 Map13476.9UniSTS
Cytogenetic Map13q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
17 13 76 198 91 90 59 134 59 6 437 251 20 178 102 108 31 34 34

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001100639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005492196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005492197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005492198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_595497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D12978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV214198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U17013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000047488   ⟹   ENSRNOP00000044416
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1380,663,823 - 80,796,356 (-)Ensembl
mRatBN7.2 Ensembl1378,130,839 - 78,263,363 (-)Ensembl
Rnor_6.0 Ensembl1384,083,806 - 84,217,332 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087096   ⟹   ENSRNOP00000072711
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1380,663,714 - 80,730,458 (-)Ensembl
mRatBN7.2 Ensembl1378,130,685 - 78,263,261 (-)Ensembl
Rnor_6.0 Ensembl1384,083,632 - 84,217,366 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115647   ⟹   ENSRNOP00000092131
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1380,663,823 - 80,796,300 (-)Ensembl
mRatBN7.2 Ensembl1378,130,839 - 78,244,103 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118670   ⟹   ENSRNOP00000094292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1380,663,823 - 80,796,243 (-)Ensembl
mRatBN7.2 Ensembl1378,130,839 - 78,263,261 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000126850   ⟹   ENSRNOP00000098938
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1380,663,823 - 80,796,356 (-)Ensembl
RefSeq Acc Id: NM_001100639   ⟹   NP_001094109
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,663,811 - 80,796,243 (-)NCBI
mRatBN7.21378,130,827 - 78,263,261 (-)NCBI
Rnor_6.01384,083,794 - 84,217,332 (-)NCBI
Rnor_5.01388,957,996 - 89,095,123 (-)NCBI
RGSC_v3.41381,607,326 - 81,739,958 (-)RGD
Celera1377,841,488 - 77,973,453 (-)RGD
Sequence:
RefSeq Acc Id: XM_008769599   ⟹   XP_008767821
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,653,602 - 80,796,279 (-)NCBI
mRatBN7.21378,120,617 - 78,263,306 (-)NCBI
Rnor_6.01384,083,781 - 84,217,368 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598656   ⟹   XP_017454145
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,653,602 - 80,796,225 (-)NCBI
mRatBN7.21378,120,617 - 78,263,255 (-)NCBI
Rnor_6.01384,083,781 - 84,171,188 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039090298   ⟹   XP_038946226
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,653,602 - 80,796,225 (-)NCBI
mRatBN7.21378,120,617 - 78,263,255 (-)NCBI
RefSeq Acc Id: XM_039090301   ⟹   XP_038946229
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,653,602 - 80,796,225 (-)NCBI
mRatBN7.21378,120,617 - 78,263,255 (-)NCBI
RefSeq Acc Id: XM_039090304   ⟹   XP_038946232
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,653,602 - 80,796,241 (-)NCBI
mRatBN7.21378,120,617 - 78,263,263 (-)NCBI
RefSeq Acc Id: XM_063271989   ⟹   XP_063128059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,653,602 - 80,796,198 (-)NCBI
RefSeq Acc Id: XM_063271990   ⟹   XP_063128060
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,653,602 - 80,747,718 (-)NCBI
RefSeq Acc Id: XM_063271991   ⟹   XP_063128061
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,653,602 - 80,796,199 (-)NCBI
RefSeq Acc Id: XR_005492196
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,653,602 - 80,796,279 (-)NCBI
mRatBN7.21378,120,617 - 78,263,306 (-)NCBI
RefSeq Acc Id: XR_005492197
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,653,602 - 80,796,279 (-)NCBI
mRatBN7.21378,120,617 - 78,263,306 (-)NCBI
RefSeq Acc Id: XR_005492198
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,653,602 - 80,796,279 (-)NCBI
mRatBN7.21378,120,617 - 78,263,306 (-)NCBI
RefSeq Acc Id: XR_595497
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,653,602 - 80,796,279 (-)NCBI
mRatBN7.21378,120,617 - 78,263,306 (-)NCBI
Rnor_6.01384,075,316 - 84,217,368 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001094109   ⟸   NM_001100639
- UniProtKB: F1LRD7 (UniProtKB/TrEMBL),   A6IDI7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767821   ⟸   XM_008769599
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K3N5 (UniProtKB/TrEMBL),   A6IDI6 (UniProtKB/TrEMBL),   F1LRD7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454145   ⟸   XM_017598656
- Peptide Label: isoform X3
- UniProtKB: F1LRD7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000044416   ⟸   ENSRNOT00000047488
Ensembl Acc Id: ENSRNOP00000072711   ⟸   ENSRNOT00000087096
RefSeq Acc Id: XP_038946232   ⟸   XM_039090304
- Peptide Label: isoform X3
- UniProtKB: F1LRD7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946229   ⟸   XM_039090301
- Peptide Label: isoform X3
- UniProtKB: F1LRD7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946226   ⟸   XM_039090298
- Peptide Label: isoform X3
- UniProtKB: F1LRD7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000094292   ⟸   ENSRNOT00000118670
Ensembl Acc Id: ENSRNOP00000092131   ⟸   ENSRNOT00000115647
RefSeq Acc Id: XP_063128061   ⟸   XM_063271991
- Peptide Label: isoform X4
- UniProtKB: F1LRD7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128059   ⟸   XM_063271989
- Peptide Label: isoform X1
- UniProtKB: F1LRD7 (UniProtKB/TrEMBL),   A0A8I6AEY3 (UniProtKB/TrEMBL),   A6IDI8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128060   ⟸   XM_063271990
- Peptide Label: isoform X3
- UniProtKB: F1LRD7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000098938   ⟸   ENSRNOT00000126850
Protein Domains
Homeobox   POU-specific

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P31503-F1-model_v2 AlphaFold P31503 1-632 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698965
Promoter ID:EPDNEW_R9490
Type:single initiation site
Name:Pou2f1_1
Description:POU class 2 homeobox 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01384,217,337 - 84,217,397EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621689 AgrOrtholog
BioCyc Gene G2FUF-17555 BioCyc
Ensembl Genes ENSRNOG00000003581 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000047488 ENTREZGENE
  ENSRNOT00000087096 ENTREZGENE
  ENSRNOT00000115647 ENTREZGENE
Gene3D-CATH 1.10.260.40 UniProtKB/Swiss-Prot
  Homeodomain-like UniProtKB/Swiss-Prot
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot
  Homeobox_CS UniProtKB/Swiss-Prot
  Homeobox_dom UniProtKB/Swiss-Prot
  Lambda_DNA-bd_dom_sf UniProtKB/Swiss-Prot
  POU UniProtKB/Swiss-Prot
  POU2F1_C UniProtKB/Swiss-Prot
  POU_dom UniProtKB/Swiss-Prot
  POU_domain_TF UniProtKB/Swiss-Prot
  TF_octamer UniProtKB/Swiss-Prot
KEGG Report rno:171068 UniProtKB/Swiss-Prot
NCBI Gene 171068 ENTREZGENE
PANTHER POU DOMAIN UniProtKB/Swiss-Prot
  POU DOMAIN, CLASS 2, TRANSCRIPTION FACTOR 1 UniProtKB/Swiss-Prot
Pfam Homeodomain UniProtKB/Swiss-Prot
  Pou UniProtKB/Swiss-Prot
  POU2F1_C UniProtKB/Swiss-Prot
PhenoGen Pou2f1 PhenoGen
PRINTS OCTAMER UniProtKB/Swiss-Prot
  POUDOMAIN UniProtKB/Swiss-Prot
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot
  HOMEOBOX_2 UniProtKB/Swiss-Prot
  POU_1 UniProtKB/Swiss-Prot
  POU_2 UniProtKB/Swiss-Prot
  POU_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003581 RatGTEx
SMART HOX UniProtKB/Swiss-Prot
  POU UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot
  SSF47413 UniProtKB/Swiss-Prot
UniProt A0A0G2K3N5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AEY3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AHE9_RAT UniProtKB/TrEMBL
  A0ABK0LD23_RAT UniProtKB/TrEMBL
  A6IDI6 ENTREZGENE, UniProtKB/TrEMBL
  A6IDI7 ENTREZGENE, UniProtKB/TrEMBL
  A6IDI8 ENTREZGENE, UniProtKB/TrEMBL
  A6IDI9_RAT UniProtKB/TrEMBL
  A6IDJ0_RAT UniProtKB/TrEMBL
  A6IDJ2_RAT UniProtKB/TrEMBL
  A6IDJ3_RAT UniProtKB/TrEMBL
  F1LRD7 ENTREZGENE, UniProtKB/TrEMBL
  P31503 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q62719 UniProtKB/Swiss-Prot
  Q63387 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Pou2f1  POU domain, class 2, transcription factor 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Pou2f1  POU domain, class 2, transcription factor 1      Symbol and Name status set to provisional 70820 PROVISIONAL