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Gene: Rfc2 (replication factor C subunit 2) Rattus norvegicus

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Symbol:

Rfc2

Name:

replication factor C subunit 2

RGD ID:

621198

Description:

Predicted to enable enzyme binding activity. Predicted to contribute to DNA clamp loader activity and single-stranded DNA helicase activity. Predicted to be involved in DNA repair; DNA-templated DNA replication; and positive regulation of DNA-directed DNA polymerase activity. Predicted to be part of Ctf18 RFC-like complex and DNA replication factor C complex. Predicted to be active in nucleus. Orthologous to human RFC2 (replication factor C subunit 2); PARTICIPATES IN mismatch repair pathway; nucleotide excision repair pathway; DNA replication pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

activator 1 subunit C2; MGC95315; replication factor C (activator 1) 2; replication factor C (activator 1) 2 (40kD)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RFC2 (replication factor C subunit 2)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Rfc2 (replication factor C (activator 1) 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rfc2 (replication factor C subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RFC2 (replication factor C subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RFC2 (replication factor C subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rfc2 (replication factor C subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RFC2 (replication factor C subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RFC2 (replication factor C subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rfc2 (replication factor C subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Rfc2 (replication factor C subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	RFC2 (replication factor C subunit 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rfc2 (replication factor C (activator 1) 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rfc2 (replication factor C (activator 1) 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	RFC4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	RfC4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	rfc-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	rfc2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	rfc2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	27,756,920 - 27,770,049 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	27,756,922 - 27,770,025 (-)	Ensembl				GRCr8
mRatBN7.2	12	22,120,449 - 22,133,576 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	22,120,010 - 22,133,557 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	23,263,632 - 23,276,828 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	23,874,713 - 23,887,909 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	22,941,263 - 22,954,609 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	25,130,375 - 25,143,480 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	25,130,377 - 25,143,480 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	27,130,769 - 27,143,874 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	23,185,550 - 23,198,655 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	23,884,376 - 23,897,525 (-)	NCBI		Celera
RGSC_v3.1	12	23,046,380 - 23,053,601 (-)	NCBI
Cytogenetic Map	12	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP,ISO)

2,2'-Methylenebis(4-methyl-6-tert-butylphenol) (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3-dimethoxynaphthalene-1,4-dione (ISO)

2-hydroxypropanoic acid (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

actinomycin D (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

ammonium chloride (EXP)

antimony(0) (ISO)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (ISO)

caffeine (ISO)

calcitriol (ISO)

cannabidiol (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

chromium atom (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

clotrimazole (EXP)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (EXP)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP,ISO)

dioxygen (ISO)

dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate (ISO)

Enterolactone (ISO)

enzyme inhibitor (ISO)

epoxiconazole (ISO)

flutamide (EXP)

folic acid (ISO)

glyphosate (ISO)

ivermectin (ISO)

Lasiocarpine (ISO)

methimazole (EXP)

methyl methanesulfonate (ISO)

monocrotaline (ISO)

N(4)-hydroxycytidine (ISO)

N-methyl-4-phenylpyridinium (EXP)

N-nitrosodiethylamine (ISO)

nimesulide (EXP)

nitrates (ISO)

Nutlin-3 (ISO)

oxaliplatin (EXP)

paracetamol (EXP,ISO)

perfluorooctanoic acid (ISO)

piperonyl butoxide (EXP)

pirinixic acid (ISO)

piroxicam (ISO)

potassium dichromate (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

riddelliine (ISO)

rotenone (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

sunitinib (ISO)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

thapsigargin (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

topotecan (EXP)

trimellitic anhydride (ISO)

triphenyl phosphate (ISO)

troglitazone (ISO)

trovafloxacin (ISO)

urethane (ISO)

valdecoxib (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

DNA repair (IBA)

DNA replication (IEA)

DNA-templated DNA replication (IBA,IEA,ISO)

positive regulation of DNA-directed DNA polymerase activity (ISO,ISS)

Cellular Component

Ctf18 RFC-like complex (IEA,ISO,ISS)

DNA replication factor C complex (IBA,IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA,IEA)

Molecular Function

ATP binding (IEA)

ATP hydrolysis activity (IEA)

DNA binding (IEA)

DNA clamp loader activity (IBA,IEA,ISO,ISS)

enzyme binding (IEA,ISO)

nucleotide binding (IEA)

protein binding (ISO)

single-stranded DNA helicase activity (IEA,ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

DNA replication pathway (IEA)

mismatch repair pathway (IEA,ISO)

nucleotide excision repair pathway (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Expression of replication factor C 40-kDa subunit is down-regulated during neonatal development in rat ventricular myocardium.	Chim SS, etal., J Cell Biochem 2000 Jun 12;78(4):533-40.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Replication clamps and clamp loaders.	Hedglin M, etal., Cold Spring Harb Perspect Biol. 2013 Apr 1;5(4):a010165. doi: 10.1101/cshperspect.a010165.
4.	Mechanisms and functions of DNA mismatch repair.	Li GM Cell Res. 2008 Jan;18(1):85-98.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
8.	GOA pipeline	RGD automated data pipeline
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:9488738	PMID:12477932	PMID:12930902	PMID:24115439

Genomics

Comparative Map Data

Rfc2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	27,756,920 - 27,770,049 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	27,756,922 - 27,770,025 (-)	Ensembl				GRCr8
mRatBN7.2	12	22,120,449 - 22,133,576 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	22,120,010 - 22,133,557 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	23,263,632 - 23,276,828 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	23,874,713 - 23,887,909 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	22,941,263 - 22,954,609 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	25,130,375 - 25,143,480 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	25,130,377 - 25,143,480 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	27,130,769 - 27,143,874 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	23,185,550 - 23,198,655 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	23,884,376 - 23,897,525 (-)	NCBI		Celera
RGSC_v3.1	12	23,046,380 - 23,053,601 (-)	NCBI
Cytogenetic Map	12	q12	NCBI

RFC2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	74,231,502 - 74,254,399 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	74,223,231 - 74,254,458 (-)	Ensembl			hg38	GRCh38
GRCh37	7	73,645,832 - 73,668,729 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	73,283,768 - 73,306,674 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	7	73,090,484 - 73,113,389	NCBI
Celera	7	69,125,398 - 69,148,304 (-)	NCBI		Celera
Cytogenetic Map	7	q11.23	NCBI
HuRef	7	69,527,267 - 69,550,345 (-)	NCBI		HuRef
CHM1_1	7	73,790,894 - 73,813,879 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	75,433,796 - 75,456,693 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	72,978,904 - 73,001,860 (-)	NCBI

Rfc2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	134,611,544 - 134,627,182 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	134,610,220 - 134,630,659 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	134,582,690 - 134,598,328 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	134,581,366 - 134,601,805 (+)	Ensembl			mm10	GRCm38
MGSCv37	5	135,058,560 - 135,074,198 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	134,867,317 - 134,882,955 (+)	NCBI		MGSCv36	mm8
Celera	5	131,590,738 - 131,606,377 (+)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	74.68	NCBI

Rfc2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955456	13,659,157 - 13,671,181 (+)	Ensembl
ChiLan1.0	NW_004955456	13,659,122 - 13,671,405 (+)	NCBI	ChiLan1.0	ChiLan1.0

RFC2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	90,644,647 - 90,667,307 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	138,909,280 - 138,931,940 (+)	NCBI		NHGRI_mPanPan1
PanPan1.1	7	81,378,937 - 81,401,937 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	81,378,937 - 81,401,937 (-)	Ensembl			panPan2	panpan1.1

RFC2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	6,119,203 - 6,159,293 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	6,119,164 - 6,160,886 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	7,819,017 - 7,857,620 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	5,935,190 - 5,973,800 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	5,951,322 - 5,974,387 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	5,926,219 - 5,964,926 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	5,873,708 - 5,912,408 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	6,037,183 - 6,075,802 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Rfc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	130,756,864 - 130,772,906 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936543	3,263,878 - 3,279,667 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936543	3,263,661 - 3,273,178 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RFC2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	11,373,492 - 11,392,695 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	3	11,373,489 - 11,392,690 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	11,056,709 - 11,068,698 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RFC2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	8,818,606 - 8,846,929 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	8,818,650 - 8,847,865 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666070	7,734,642 - 7,758,689 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rfc2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	13,737,310 - 13,748,821 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624740	13,737,225 - 13,748,876 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Rfc2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	19,462,495 - 19,475,493 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Rfc2
92 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	306
Count of miRNA genes:	182
Interacting mature miRNAs:	203
Transcripts:	ENSRNOT00000001989
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	24805022	52308831	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
2306789	Ean6	Experimental allergic neuritis QTL 6	4.9		nervous system integrity trait (VT:0010566)	experimental autoimmune neuritis severity score (CMO:0001528)	12	1	29775522	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7411643	Foco20	Food consumption QTL 20		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	25989355	52308831	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	3489416	48489416	Rat
1331739	Hrtrt14	Heart rate QTL 14	3.56232		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	12	1	38687564	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	18473041	52308831	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	15264248	52308831	Rat
61331	Eau2	Experimental allergic uveoretinitis QTL 2		0.0005	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	12	1	33700600	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
2293684	Bmd26	Bone mineral density QTL 26	4.4	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	12	1	38635130	Rat
6893681	Bw109	Body weight QTL 109	2.3	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	12	1	28133365	Rat
1302792	Scl21	Serum cholesterol level QTL 21	3.8	0.0011	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	12	12233000	30490641	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	17464979	46784661	Rat
1300174	Bw15	Body weight QTL 15	2.93		body mass (VT:0001259)	body weight loss (CMO:0001399)	12	1	28606299	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	16187438	52308831	Rat
1331787	Rf41	Renal function QTL 41	2.998		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	12	1	33700556	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	16135029	52308831	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	51213550	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
61416	Pia4	Pristane induced arthritis QTL 4	8.4		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	12	18749469	36488809	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
7387292	Kidm42	Kidney mass QTL 42	3.03	0.0004	kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	12	1	41361854	Rat
61421	Cia12	Collagen induced arthritis QTL 12	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	18749469	34312613	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	2747694	47747694	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	18473041	52308831	Rat
2303568	Bw88	Body weight QTL 88	3		body mass (VT:0001259)	body weight (CMO:0000012)	12	1	28606299	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	3087180	48087180	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	16135029	52308831	Rat
2293086	Iddm30	Insulin dependent diabetes mellitus QTL 30	3.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	7901625	33938215	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
1331755	Bp219	Blood pressure QTL 219	3.041		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	33700556	Rat

Markers in Region

RH133356

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	12	27,757,117 - 27,757,311 (+)	Marker Load Pipeline
mRatBN7.2	12	22,120,646 - 22,120,840 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	25,130,573 - 25,130,766	NCBI	Rnor6.0
Rnor_5.0	12	27,130,967 - 27,131,160	UniSTS	Rnor5.0
RGSC_v3.4	12	23,185,748 - 23,185,941	UniSTS	RGSC3.4
Celera	12	23,884,574 - 23,884,767	UniSTS
RH 3.4 Map	12	353.1	UniSTS
Cytogenetic Map	12	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	164	91	90	59	92	59	6	356	192	11	143	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053786	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005491587	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC091000	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC135741	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF208499	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC082110	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ294700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ294701	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000001989 ⟹ ENSRNOP00000001989

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	27,756,922 - 27,770,025 (-)	Ensembl
mRatBN7.2 Ensembl	12	22,120,461 - 22,133,526 (-)	Ensembl
Rnor_6.0 Ensembl	12	25,130,377 - 25,143,480 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000094282 ⟹ ENSRNOP00000077503

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	27,756,922 - 27,770,025 (-)	Ensembl
mRatBN7.2 Ensembl	12	22,120,010 - 22,133,557 (-)	Ensembl

RefSeq Acc Id:

NM_053786 ⟹ NP_446238

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	27,756,920 - 27,770,025 (-)	NCBI
mRatBN7.2	12	22,120,449 - 22,133,554 (-)	NCBI
Rnor_6.0	12	25,130,375 - 25,143,480 (-)	NCBI
Rnor_5.0	12	27,130,769 - 27,143,874 (-)	NCBI
RGSC_v3.4	12	23,185,550 - 23,198,655 (-)	RGD
Celera	12	23,884,376 - 23,897,525 (-)	RGD

Sequence:

show sequence

GGCGGAGCTTCGGGTGGCGGGAAGAGCAGGCACCGGAATGGAGGTTCAGGAGAGCGGCAGTGGC
TCGGCTGAGAGTGGGACGCAGGAGCCCTCGCCTGTCCCCAGCAAGACCACCGGCCACTACGAGC
TGCCGTGGGTTGAAAAATACAGACCAGTGAAGCTCAATGAAATAGTGGGAAACGAAGACACTGT
GAGCAGGCTGGAGGTCTTTGCAAGAGAAGGCAATGTACCCAATATCATCATCGCTGGCCCTCCA
GGAACTGGCAAGACAACCAGCATCCTCTGCTTGGCGAGAGCGCTGCTGGGCCCGGCCCTGAAGG
ATGCAGTTCTGGAACTCAATGCGTCCAACGACAGGGGCATCGATGTGGTAAGGAATAAAATCAA
AATGTTCGCCCAGCAGAAAGTCACCCTTCCCAAGGGCCGACACAAGATCATCATTCTGGATGAG
GCAGACAGCATGACGGATGGTGCCCAGCAGGCCCTCAGGAGAACCATGGAAATCTACTCCAAAA
CGACTCGCTTCGCTCTGGCTTGTAATGCTTCAGACAAAATCATAGAGCCCATCCAGTCCCGCTG
TGCGGTGCTCCGCTACACCAAGCTCACCGATGCACAGGTCCTCAGCAGGCTCATGAATGTCATC
GAGAAGGAAAAAGTGCCATACACAGATGACGGCCTGGAAGCCATCATTTTCACAGCCCAGGGAG
ACATGCGCCAGGCTCTGAACAACTTGCAGTCCACCTTCTCAGGATTTGGCTATATCAACAGCGA
GAATGTATTCAAGGTCTGTGACGAGCCCCACCCCCTGCTGGTGAAGGAGATGATCCAGCACTGT
GTGGACGCCAACATTGATGAGGCCTATAAGATTCTTGCTCACCTGTGGCACCTGGGCTACTCGC
CAGAAGATGTCATCGGCAATATTTTCCGTGTGTGTAAAACCTTCCCAATGGCTGAATACTTGAA
ACTGGAGTTCATCAAGGAGATTGGATACACCCACATGAAAGTGGCCGAAGGAGTGAACTCCCTG
CTGCAGATGGCCGGGCTCCTGGCCAGGCTGTGTCAGAAGACCATGGCTCCGGTGGCCAGCTGAC
TTGAGACGCCCTTCACTAATGGAATTAGGAGAATCCTTGTCGCCGAGACACTGATGTTCCAGCT
TTCCACTTGTGGGAGAAGTGCCTTAGCCTTTGCTAGAACATGCTCTGTTTTTCTTCTGTGAGAA
TAGGGTCTCTTGTAGCCCAGGCTGACATTGAACTCCTGACCTCCCTCCCAGCTCTGCCTGCCGA
GTACTAGAGTCACAGGTGTGTGTCCTGCTTGCTTTATGCAGGACTACGGATGGAGCCCACAGCT
TGTGCTTGTCAGCTGGGCGACAGTGAGAGACTGAGCTCTGGAAGATTTCCTCATGGCTACCGAT
ACACGTCTGCTCTTCAGTGTGTGAATATGGCCTCAGGCCCTGGACATGGGCATGGTGGGAAAGC
TTTGACCTCCTCAGTCTTGTTGTAGCTGATAAAGCCTTTGGATGTTTGTCTTTGAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XR_005491587

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	27,758,334 - 27,770,049 (-)	NCBI
mRatBN7.2	12	22,120,449 - 22,133,576 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_446238	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF21015	(Get FASTA)	NCBI Sequence Viewer
	AAH82110	(Get FASTA)	NCBI Sequence Viewer
	EDM13423	(Get FASTA)	NCBI Sequence Viewer
	EDM13424	(Get FASTA)	NCBI Sequence Viewer
	EDM13425	(Get FASTA)	NCBI Sequence Viewer
	EDM13426	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000077503
	ENSRNOP00000077503.1
GenBank Protein	Q641W4	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_446238 ⟸ NM_053786

- UniProtKB:

Q641W4 (UniProtKB/Swiss-Prot), A6J0I4 (UniProtKB/TrEMBL), A0A8L2Q0Z2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEVQESGSGSAESGTQEPSPVPSKTTGHYELPWVEKYRPVKLNEIVGNEDTVSRLEVFAREGNV
PNIIIAGPPGTGKTTSILCLARALLGPALKDAVLELNASNDRGIDVVRNKIKMFAQQKVTLPKG
RHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQ
VLSRLMNVIEKEKVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGYINSENVFKVCDEPHPL
LVKEMIQHCVDANIDEAYKILAHLWHLGYSPEDVIGNIFRVCKTFPMAEYLKLEFIKEIGYTHM
KVAEGVNSLLQMAGLLARLCQKTMAPVAS

hide sequence

Ensembl Acc Id:

ENSRNOP00000001989 ⟸ ENSRNOT00000001989

Ensembl Acc Id:

ENSRNOP00000077503 ⟸ ENSRNOT00000094282

Protein Domains

AAA+ ATPase ATPase AAA-type core Replication factor C C-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q641W4-F1-model_v2	AlphaFold	Q641W4	1-349	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698569

Promoter ID:

EPDNEW_R9094

Type:

initiation region

Name:

Rfc2_1

Description:

replication factor C subunit 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	25,143,453 - 25,143,513	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621198	AgrOrtholog
BioCyc Gene	G2FUF-19579	BioCyc
Ensembl Genes	ENSRNOG00000001457	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000094282	ENTREZGENE
	ENSRNOT00000094282.1	UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.8.60	UniProtKB/Swiss-Prot
	1.20.272.10	UniProtKB/Swiss-Prot
	3.40.50.300	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7135071	IMAGE-MGC_LOAD
InterPro	AAA+_ATPase	UniProtKB/Swiss-Prot
	ATPase_AAA_core	UniProtKB/Swiss-Prot
	DNA_pol3_clamp-load_cplx_C	UniProtKB/Swiss-Prot
	DNA_Rep/Repair_Clamp_Loader	UniProtKB/Swiss-Prot
	P-loop_NTPase	UniProtKB/Swiss-Prot
	Rep_factorC_C	UniProtKB/Swiss-Prot
	RFC_lid	UniProtKB/Swiss-Prot
KEGG Report	rno:116468	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:95315	IMAGE-MGC_LOAD
NCBI Gene	116468	ENTREZGENE
PANTHER	REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT	UniProtKB/Swiss-Prot
	REPLICATION FACTOR C SUBUNIT 2	UniProtKB/Swiss-Prot
Pfam	AAA	UniProtKB/Swiss-Prot
	Rep_fac_C	UniProtKB/Swiss-Prot
PhenoGen	Rfc2	PhenoGen
RatGTEx	ENSRNOG00000001457	RatGTEx
SMART	AAA	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF48019	UniProtKB/Swiss-Prot
	SSF52540	UniProtKB/Swiss-Prot
UniProt	A0A8L2Q0Z2	ENTREZGENE, UniProtKB/TrEMBL
	A6J0I4	ENTREZGENE, UniProtKB/TrEMBL
	A6J0I5_RAT	UniProtKB/TrEMBL
	A6J0I7_RAT	UniProtKB/TrEMBL
	Q641W4	ENTREZGENE
	Q9QXI2_RAT	UniProtKB/TrEMBL
	RFC2_RAT	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-16	Rfc2	replication factor C subunit 2	Rfc2	replication factor C (activator 1) 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Rfc2	replication factor C (activator 1) 2		replication factor C (activator 1) 2 (40kD)	Name updated	1299863	APPROVED
2002-08-07	Rfc2	replication factor C (activator 1) 2 (40kD)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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RGD Manual Annotations

Imported Annotations - KEGG (archival)