Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Clstn2 | Rat | 1,2-dichloroethane | decreases expression | ISO | Clstn2 (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of CLSTN2 mRNA | CTD | PMID:28960355 | Clstn2 | Rat | 1,2-dimethylhydrazine | increases expression | ISO | Clstn2 (Mus musculus) | 6480464 | 1,2-Dimethylhydrazine results in increased expression of CLSTN2 mRNA | CTD | PMID:22206623 | Clstn2 | Rat | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of CLSTN2 mRNA | CTD | PMID:20068009 | Clstn2 | Rat | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of CLSTN2 mRNA | CTD | PMID:17010207 | Clstn2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Clstn2 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of CLSTN2 gene | CTD | PMID:21212295 | Clstn2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases methylation | ISO | Clstn2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased methylation of CLSTN2 gene | CTD | PMID:21212295 | Clstn2 | Rat | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | increases expression | ISO | CLSTN2 (Homo sapiens) | 6480464 | 2,2',4,4',5-brominated diphenyl ether results in increased expression of CLSTN2 mRNA | CTD | PMID:26705709 | Clstn2 | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | CLSTN2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ... | CTD | PMID:28628672 | Clstn2 | Rat | 4,4'-diaminodiphenylmethane | decreases expression | ISO | Clstn2 (Mus musculus) | 6480464 | 4,4'-diaminodiphenylmethane results in decreased expression of CLSTN2 mRNA | CTD | PMID:18648102 | Clstn2 | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of CLSTN2 mRNA | CTD | PMID:24780913 | Clstn2 | Rat | aflatoxin B1 | decreases methylation | ISO | CLSTN2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of CLSTN2 gene | CTD | PMID:27153756 | Clstn2 | Rat | aflatoxin B1 | increases methylation | ISO | CLSTN2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of CLSTN2 exon | CTD | PMID:30157460 | Clstn2 | Rat | all-trans-retinoic acid | multiple interactions | ISO | CLSTN2 (Homo sapiens) | 6480464 | [Arsenic Trioxide co-treated with Tretinoin] results in decreased expression of CLSTN2 mRNA | CTD | PMID:38179723 | Clstn2 | Rat | aristolochic acid A | decreases expression | ISO | CLSTN2 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of CLSTN2 mRNA | CTD | PMID:33212167 | Clstn2 | Rat | arsenous acid | multiple interactions | ISO | CLSTN2 (Homo sapiens) | 6480464 | [Arsenic Trioxide co-treated with Tretinoin] results in decreased expression of CLSTN2 mRNA | CTD | PMID:38179723 | Clstn2 | Rat | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of CLSTN2 gene | CTD | PMID:35440735 | Clstn2 | Rat | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of CLSTN2 mRNA | CTD | PMID:21839799 | Clstn2 | Rat | benzo[a]pyrene | increases methylation | ISO | Clstn2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased methylation of CLSTN2 intron | CTD | PMID:27901495 | Clstn2 | Rat | benzo[a]pyrene | increases methylation | ISO | CLSTN2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of CLSTN2 exon; Benzo(a)pyrene results in increased methylation of CLSTN2 more ... | CTD | PMID:27901495 | Clstn2 | Rat | benzo[a]pyrene | multiple interactions | ISO | Clstn2 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of more ... | CTD | PMID:27858113 | Clstn2 | Rat | benzo[b]fluoranthene | multiple interactions | ISO | Clstn2 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of more ... | CTD | PMID:27858113 | Clstn2 | Rat | benzo[e]pyrene | increases methylation | ISO | CLSTN2 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of CLSTN2 exon | CTD | PMID:30157460 | Clstn2 | Rat | bis(2-ethylhexyl) phthalate | decreases expression | ISO | Clstn2 (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in decreased expression of CLSTN2 mRNA | CTD | PMID:34319233 | Clstn2 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of CLSTN2 mRNA | CTD | PMID:25181051 | Clstn2 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of CLSTN2 mRNA | CTD | PMID:30816183|PMID:32528016|PMID:34947998 | Clstn2 | Rat | bisphenol A | increases expression | ISO | Clstn2 (Mus musculus) | 6480464 | bisphenol A results in increased expression of CLSTN2 mRNA | CTD | PMID:30951980 | Clstn2 | Rat | bisphenol A | multiple interactions | ISO | CLSTN2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ... | CTD | PMID:28628672 | Clstn2 | Rat | bisphenol AF | decreases expression | EXP | | 6480464 | bisphenol AF results in decreased expression of CLSTN2 mRNA | CTD | PMID:39938710 | Clstn2 | Rat | Butylbenzyl phthalate | increases methylation | ISO | Clstn2 (Mus musculus) | 6480464 | butylbenzyl phthalate results in increased methylation of CLSTN2 intron | CTD | PMID:28392331 | Clstn2 | Rat | cadmium dichloride | increases expression | ISO | CLSTN2 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of CLSTN2 mRNA | CTD | PMID:38568856 | Clstn2 | Rat | cefaloridine | decreases expression | EXP | | 6480464 | Cephaloridine results in decreased expression of CLSTN2 mRNA | CTD | PMID:18500788 | Clstn2 | Rat | CGP 52608 | multiple interactions | ISO | CLSTN2 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to CLSTN2 gene] | CTD | PMID:28238834 | Clstn2 | Rat | chlorpyrifos | decreases expression | ISO | Clstn2 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of CLSTN2 mRNA | CTD | PMID:37019170 | Clstn2 | Rat | chrysene | multiple interactions | ISO | Clstn2 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of more ... | CTD | PMID:27858113 | Clstn2 | Rat | crocidolite asbestos | decreases expression | ISO | Clstn2 (Mus musculus) | 6480464 | Asbestos, Crocidolite results in decreased expression of CLSTN2 mRNA | CTD | PMID:29279043 | Clstn2 | Rat | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of CLSTN2 mRNA | CTD | PMID:26577399 | Clstn2 | Rat | DDT | decreases expression | EXP | | 6480464 | DDT results in decreased expression of CLSTN2 mRNA | CTD | PMID:30207508 | Clstn2 | Rat | dexamethasone | multiple interactions | ISO | CLSTN2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ... | CTD | PMID:28628672 | Clstn2 | Rat | diarsenic trioxide | multiple interactions | ISO | CLSTN2 (Homo sapiens) | 6480464 | [Arsenic Trioxide co-treated with Tretinoin] results in decreased expression of CLSTN2 mRNA | CTD | PMID:38179723 | Clstn2 | Rat | diethylstilbestrol | increases expression | EXP | | 6480464 | Diethylstilbestrol results in increased expression of CLSTN2 mRNA | CTD | PMID:17010207 | Clstn2 | Rat | diquat | decreases expression | ISO | Clstn2 (Mus musculus) | 6480464 | Diquat results in decreased expression of CLSTN2 mRNA | CTD | PMID:36851058 | Clstn2 | Rat | dorsomorphin | multiple interactions | ISO | CLSTN2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression more ... | CTD | PMID:27188386 | Clstn2 | Rat | doxorubicin | decreases expression | ISO | CLSTN2 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of CLSTN2 mRNA | CTD | PMID:29803840 | Clstn2 | Rat | endosulfan | increases expression | EXP | | 6480464 | Endosulfan results in increased expression of CLSTN2 mRNA | CTD | PMID:29391264 | Clstn2 | Rat | ethanol | affects splicing | ISO | Clstn2 (Mus musculus) | 6480464 | Ethanol affects the splicing of CLSTN2 mRNA | CTD | PMID:30319688 | Clstn2 | Rat | ethanol | increases expression | ISO | Clstn2 (Mus musculus) | 6480464 | Ethanol results in increased expression of CLSTN2 mRNA | CTD | PMID:30319688 | Clstn2 | Rat | fentanyl | affects expression | EXP | | 6480464 | Fentanyl affects the expression of CLSTN2 mRNA | CTD | PMID:36032789 | Clstn2 | Rat | fonofos | increases methylation | ISO | CLSTN2 (Homo sapiens) | 6480464 | Fonofos results in increased methylation of CLSTN2 promoter | CTD | PMID:22847954 | Clstn2 | Rat | formaldehyde | increases expression | ISO | CLSTN2 (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of CLSTN2 mRNA | CTD | PMID:28937961 | Clstn2 | Rat | glyphosate | affects methylation | EXP | | 6480464 | Glyphosate affects the methylation of CLSTN2 gene | CTD | PMID:35440735 | Clstn2 | Rat | GW 4064 | decreases expression | ISO | Clstn2 (Mus musculus) | 6480464 | GW 4064 results in decreased expression of CLSTN2 mRNA | CTD | PMID:26655953 | Clstn2 | Rat | indometacin | multiple interactions | ISO | CLSTN2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ... | CTD | PMID:28628672 | Clstn2 | Rat | lead(0) | affects expression | ISO | CLSTN2 (Homo sapiens) | 6480464 | Lead affects the expression of CLSTN2 mRNA | CTD | PMID:28903495 | Clstn2 | Rat | lipopolysaccharide | decreases methylation | ISO | Clstn2 (Mus musculus) | 6480464 | Lipopolysaccharides results in decreased methylation of CLSTN2 gene | CTD | PMID:21212295 | Clstn2 | Rat | lipopolysaccharide | multiple interactions | ISO | Clstn2 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of CLSTN2 gene | CTD | PMID:21212295 | Clstn2 | Rat | methapyrilene | increases methylation | ISO | CLSTN2 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of CLSTN2 exon | CTD | PMID:30157460 | Clstn2 | Rat | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of CLSTN2 gene | CTD | PMID:35440735 | Clstn2 | Rat | methylmercury chloride | increases expression | ISO | CLSTN2 (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of CLSTN2 mRNA | CTD | PMID:28001369 | Clstn2 | Rat | Muraglitazar | decreases expression | EXP | | 6480464 | muraglitazar results in decreased expression of CLSTN2 mRNA | CTD | PMID:21515302 | Clstn2 | Rat | N-methyl-4-phenylpyridinium | decreases expression | ISO | CLSTN2 (Homo sapiens) | 6480464 | 1-Methyl-4-phenylpyridinium results in decreased expression of CLSTN2 mRNA | CTD | PMID:24810058 | Clstn2 | Rat | N-methylformamide | increases expression | ISO | Clstn2 (Mus musculus) | 6480464 | methylformamide analog results in increased expression of CLSTN2 mRNA; methylformamide results in increased expression of more ... | CTD | PMID:17040096 | Clstn2 | Rat | nickel atom | decreases expression | ISO | CLSTN2 (Homo sapiens) | 6480464 | Nickel results in decreased expression of CLSTN2 mRNA | CTD | PMID:25583101 | Clstn2 | Rat | okadaic acid | decreases expression | ISO | CLSTN2 (Homo sapiens) | 6480464 | Okadaic Acid results in decreased expression of CLSTN2 mRNA | CTD | PMID:38832940 | Clstn2 | Rat | ozone | multiple interactions | ISO | Clstn2 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased more ... | CTD | PMID:27106289|PMID:34911549 | Clstn2 | Rat | panobinostat | multiple interactions | ISO | CLSTN2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression more ... | CTD | PMID:27188386 | Clstn2 | Rat | panobinostat | increases expression | ISO | CLSTN2 (Homo sapiens) | 6480464 | panobinostat results in increased expression of CLSTN2 mRNA | CTD | PMID:26272509 | Clstn2 | Rat | parathion | increases methylation | ISO | CLSTN2 (Homo sapiens) | 6480464 | Parathion results in increased methylation of CLSTN2 promoter | CTD | PMID:22847954 | Clstn2 | Rat | phenobarbital | affects methylation | ISO | Clstn2 (Mus musculus) | 6480464 | Phenobarbital affects the methylation of CLSTN2 gene | CTD | PMID:19233941 | Clstn2 | Rat | phenylmercury acetate | multiple interactions | ISO | CLSTN2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Clstn2 | Rat | pirinixic acid | decreases expression | ISO | Clstn2 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of CLSTN2 mRNA | CTD | PMID:20813756 | Clstn2 | Rat | progesterone | increases expression | EXP | | 6480464 | Progesterone results in increased expression of CLSTN2 mRNA | CTD | PMID:20726854 | Clstn2 | Rat | progesterone | increases expression | ISO | Clstn2 (Mus musculus) | 6480464 | Progesterone results in increased expression of CLSTN2 mRNA | CTD | PMID:22238285 | Clstn2 | Rat | SB 431542 | multiple interactions | ISO | CLSTN2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression more ... | CTD | PMID:27188386 | Clstn2 | Rat | silicon dioxide | decreases expression | EXP | | 6480464 | Silicon Dioxide results in decreased expression of CLSTN2 mRNA | CTD | PMID:34779285 | Clstn2 | Rat | sodium arsenite | affects methylation | ISO | CLSTN2 (Homo sapiens) | 6480464 | sodium arsenite affects the methylation of CLSTN2 gene | CTD | PMID:28589171 | Clstn2 | Rat | sodium arsenite | increases expression | ISO | CLSTN2 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of CLSTN2 mRNA | CTD | PMID:29301061 | Clstn2 | Rat | sulforaphane | decreases expression | ISO | Clstn2 (Mus musculus) | 6480464 | sulforaphane results in decreased expression of CLSTN2 mRNA | CTD | PMID:30529165 | Clstn2 | Rat | terbufos | increases methylation | ISO | CLSTN2 (Homo sapiens) | 6480464 | terbufos results in increased methylation of CLSTN2 promoter | CTD | PMID:22847954 | Clstn2 | Rat | Tesaglitazar | decreases expression | EXP | | 6480464 | tesaglitazar results in decreased expression of CLSTN2 mRNA | CTD | PMID:21515302 | Clstn2 | Rat | tetraphene | multiple interactions | ISO | Clstn2 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of more ... | CTD | PMID:27858113 | Clstn2 | Rat | titanium dioxide | affects expression | ISO | Clstn2 (Mus musculus) | 6480464 | titanium dioxide affects the expression of CLSTN2 mRNA | CTD | PMID:23557971 | Clstn2 | Rat | titanium dioxide | decreases methylation | ISO | Clstn2 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of CLSTN2 gene | CTD | PMID:35295148 | Clstn2 | Rat | titanium dioxide | increases methylation | ISO | Clstn2 (Mus musculus) | 6480464 | titanium dioxide results in increased methylation of CLSTN2 promoter | CTD | PMID:35295148 | Clstn2 | Rat | titanium dioxide | decreases expression | ISO | Clstn2 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of CLSTN2 mRNA | CTD | PMID:29264374 | Clstn2 | Rat | tremolite asbestos | decreases expression | ISO | Clstn2 (Mus musculus) | 6480464 | tremolite results in decreased expression of CLSTN2 mRNA | CTD | PMID:29279043 | Clstn2 | Rat | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of CLSTN2 mRNA | CTD | PMID:33387578 | Clstn2 | Rat | trichostatin A | increases expression | ISO | CLSTN2 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of CLSTN2 mRNA | CTD | PMID:26272509 | Clstn2 | Rat | trichostatin A | multiple interactions | ISO | CLSTN2 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Clstn2 | Rat | triclosan | increases expression | ISO | CLSTN2 (Homo sapiens) | 6480464 | Triclosan results in increased expression of CLSTN2 mRNA | CTD | PMID:30510588 | Clstn2 | Rat | troglitazone | decreases expression | EXP | | 6480464 | troglitazone results in decreased expression of CLSTN2 mRNA | CTD | PMID:21515302 | Clstn2 | Rat | valproic acid | affects expression | ISO | CLSTN2 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of CLSTN2 mRNA | CTD | PMID:25979313 | Clstn2 | Rat | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of CLSTN2 mRNA | CTD | PMID:29427782 | Clstn2 | Rat | valproic acid | multiple interactions | ISO | CLSTN2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Clstn2 | Rat | valproic acid | increases expression | ISO | CLSTN2 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of CLSTN2 mRNA | CTD | PMID:23179753|PMID:24383497|PMID:26272509|PMID:28001369 | Clstn2 | Rat | venlafaxine hydrochloride | decreases expression | EXP | | 6480464 | Venlafaxine Hydrochloride results in decreased expression of CLSTN2 mRNA | CTD | PMID:25423262 | Clstn2 | Rat | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of CLSTN2 mRNA | CTD | PMID:19015723 | | 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