RGD Reference Report - The calsyntenins--a family of postsynaptic membrane proteins with distinct neuronal expression patterns. - Rat Genome Database

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The calsyntenins--a family of postsynaptic membrane proteins with distinct neuronal expression patterns.

Authors: Hintsch, G  Zurlinden, A  Meskenaite, V  Steuble, M  Fink-Widmer, K  Kinter, J  Sonderegger, P 
Citation: Hintsch G, etal., Mol Cell Neurosci 2002 Nov;21(3):393-409.
RGD ID: 632523
Pubmed: PMID:12498782   (View Abstract at PubMed)

We have identified two novel postsynaptic membrane proteins that are highly similar to calsyntenin-1 in their extracellular parts but vary considerably in their cytoplasmic segment. Calsyntenin-1 has recently been identified in our lab as a postsynaptic membrane protein with a highly acidic cytoplasmic segment with putative Ca(2+)-binding capacity (Vogt et al., 2001, Mol. Cell. Neurosci. 17: 151-166). Based on their structural similarity to calsyntenin-1, we have called the novel proteins calsyntenin-2 and -3, respectively. By immunoelectron microscopy, the calsyntenin protein family was localized in the postsynaptic membrane of excitatory central nervous system (CNS) synapses. In situ hybridization analysis revealed that calsyntenin-1 was abundant in most neurons of the CNS with relatively little variation in its expression level. Calsyntenin-2 and -3 expressions varied much more with highest levels in GABAergic neurons. Based on their distinct expression patterns and the differences in their cytoplasmic segments, we suggest a cell-type-specific functional role for the three calsyntenins in excitatory synaptic transmission.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
chemical synaptic transmission  NAS 632523; 632523 RGD 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
postsynaptic membrane  IDA 632523; 632523 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Clstn2  (calsyntenin 2)
Clstn3  (calsyntenin 3)

Objects referenced in this article
Gene Clstn1 calsyntenin 1 Mus musculus
Gene Clstn3 calsyntenin 3 Mus musculus

Additional Information