Nlgn2 (neuroligin 2) - Rat Genome Database

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Gene: Nlgn2 (neuroligin 2) Rattus norvegicus
Analyze
Symbol: Nlgn2
Name: neuroligin 2
RGD ID: 621118
Description: Enables cell adhesion mediator activity. Involved in several processes, including positive regulation of protein localization; presynapse organization; and regulation of synapse assembly. Acts upstream of or within synapse organization. Located in several cellular components, including dendritic shaft; inhibitory synapse; and postsynaptic membrane. Is active in GABA-ergic synapse and postsynaptic specialization membrane. Biomarker of sciatic neuropathy and status epilepticus. Orthologous to human NLGN2 (neuroligin 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: neuroligin-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,042,175 - 55,056,578 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1055,043,185 - 55,056,578 (-)EnsemblGRCr8
mRatBN7.21054,544,461 - 54,557,854 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,544,588 - 54,558,434 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1059,206,968 - 59,220,379 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,695,535 - 58,708,946 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,203,207 - 54,216,624 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,431,586 - 56,444,847 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,431,573 - 56,444,847 (-)Ensemblrn6Rnor6.0
Rnor_5.01056,176,705 - 56,189,966 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41056,646,081 - 56,678,060 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1053,698,870 - 53,712,041 (-)NCBICelera
RGSC_v3.11056,659,705 - 56,691,680 (-)NCBI
Cytogenetic Map10q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell adhesion  (IEA)
gephyrin clustering involved in postsynaptic density assembly  (IEA,ISO,ISS)
inhibitory synapse assembly  (IEA,ISO)
insulin metabolic process  (IDA)
jump response  (IMP)
locomotory exploration behavior  (IEA,ISO,ISS)
modulation of chemical synaptic transmission  (ISO,ISS)
neuromuscular process controlling balance  (IEA,ISO,ISS)
neuron cell-cell adhesion  (IDA,IEA)
neurotransmitter-gated ion channel clustering  (ISO)
positive regulation of cell population proliferation  (IDA)
positive regulation of dendritic spine development  (IEA,IMP)
positive regulation of excitatory postsynaptic potential  (IEA,ISO,ISS)
positive regulation of inhibitory postsynaptic potential  (IEA,IMP,ISO)
positive regulation of insulin secretion  (IDA,IEA,IMP,ISO)
positive regulation of protein localization to synapse  (IEA,IMP,ISO)
positive regulation of synapse assembly  (IDA,IEA)
positive regulation of synaptic transmission, GABAergic  (IEA,ISO,ISS)
positive regulation of synaptic transmission, glutamatergic  (IEA,ISO,ISS)
positive regulation of synaptic vesicle clustering  (IEA,ISO)
positive regulation of t-SNARE clustering  (IDA)
postsynaptic density protein 95 clustering  (IEA,ISO,ISS)
postsynaptic membrane assembly  (IEA,ISO,ISS)
postsynaptic specialization assembly  (IEA,ISO)
presynapse assembly  (ISO)
presynaptic membrane assembly  (IDA,IEA,ISO)
protein localization to cell surface  (ISO)
protein localization to synapse  (IEA,ISO,ISS)
regulation of membrane potential  (IEA)
regulation of nervous system process  (IEA)
regulation of presynapse assembly  (IDA,IMP)
regulation of respiratory gaseous exchange by nervous system process  (ISO,ISS)
regulation of signal transduction  (IEA)
sensory perception of pain  (IEA,ISO,ISS)
social behavior  (IMP)
synapse assembly  (IDA,IMP)
synapse organization  (IDA)
synaptic transmission, GABAergic  (ISO)
terminal button organization  (IMP)
thigmotaxis  (IMP)

Cellular Component
axon  (IEA,ISO)
cell surface  (IDA,IEA,ISO)
dendrite  (IDA,IEA,ISO)
dendritic shaft  (IDA)
dendritic spine  (IEA)
dopaminergic synapse  (IEA,ISO)
excitatory synapse  (IDA)
GABA-ergic synapse  (IDA,IEA,IMP,ISO)
glycinergic synapse  (IEA,ISO)
inhibitory synapse  (IDA)
membrane  (IEA)
plasma membrane  (IDA,IEA,ISO)
postsynaptic membrane  (IDA,IEA)
postsynaptic specialization membrane  (IBA,IDA,IEA,IMP,ISO)
presynaptic membrane  (IEA)
ribbon synapse  (IDA)
synapse  (IDA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Multiple N-linked glycosylation sites critically modulate the synaptic abundance of neuroligin isoforms. Benner O, etal., J Biol Chem. 2023 Dec;299(12):105361. doi: 10.1016/j.jbc.2023.105361. Epub 2023 Oct 20.
2. Control of excitatory and inhibitory synapse formation by neuroligins. Chih B, etal., Science. 2005 Feb 25;307(5713):1324-8. Epub 2005 Jan 27.
3. Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism. Chubykin AA, etal., J Biol Chem. 2005 Jun 10;280(23):22365-74. Epub 2005 Mar 29.
4. Expression of neurexin ligands, the neuroligins and the neurexophilins, in the developing and adult rodent olfactory bulb. Clarris HJ, etal., Int J Dev Biol 2002;46(4):649-52.
5. Unexpected association of the "inhibitory" neuroligin 2 with excitatory PSD95 in neuropathic pain. Dolique T, etal., Pain. 2013 Nov;154(11):2529-46. doi: 10.1016/j.pain.2013.07.035. Epub 2013 Jul 25.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Synaptic imbalance, stereotypies, and impaired social interactions in mice with altered neuroligin 2 expression. Hines RM, etal., J Neurosci. 2008 Jun 11;28(24):6055-67. doi: 10.1523/JNEUROSCI.0032-08.2008.
9. Structures, alternative splicing, and neurexin binding of multiple neuroligins. Ichtchenko K, etal., J Biol Chem 1996 Feb 2;271(5):2676-82.
10. Altered synaptic properties during integration of adult-born hippocampal neurons following a seizure insult. Jackson J, etal., PLoS One. 2012;7(4):e35557. doi: 10.1371/journal.pone.0035557. Epub 2012 Apr 23.
11. Postsynaptic scaffolding molecules modulate the localization of neuroligins. Levinson JN, etal., Neuroscience. 2010 Feb 3;165(3):782-93. doi: 10.1016/j.neuroscience.2009.11.016. Epub 2009 Nov 13.
12. An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers. Linhoff MW, etal., Neuron. 2009 Mar 12;61(5):734-49. doi: 10.1016/j.neuron.2009.01.017.
13. Proteomic Analysis of Unbounded Cellular Compartments: Synaptic Clefts. Loh KH, etal., Cell. 2016 Aug 25;166(5):1295-1307.e21. doi: 10.1016/j.cell.2016.07.041.
14. Synaptic localization of neuroligin 2 in the rodent retina: comparative study with the dystroglycan-containing complex. Lui L, etal., J Neurosci Res. 2010 Mar;88(4):837-49. doi: 10.1002/jnr.22258.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin. Poulopoulos A, etal., Neuron. 2009 Sep 10;63(5):628-42. doi: 10.1016/j.neuron.2009.08.023.
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons. Scheiffele P, etal., Cell. 2000 Jun 9;101(6):657-69.
21. Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion. Suckow AT, etal., Endocrinology. 2008 Dec;149(12):6006-17. Epub 2008 Aug 28.
22. Transcellular neuroligin-2 interactions enhance insulin secretion and are integral to pancreatic beta cell function. Suckow AT, etal., J Biol Chem. 2012 Jun 8;287(24):19816-26. doi: 10.1074/jbc.M111.280537. Epub 2012 Apr 23.
23. Neuroligin 2 is exclusively localized to inhibitory synapses. Varoqueaux F, etal., Eur J Cell Biol. 2004 Sep;83(9):449-56.
24. GARLH Family Proteins Stabilize GABAA Receptors at Synapses. Yamasaki T, etal., Neuron. 2017 Mar 8;93(5):1138-1152.e6. doi: 10.1016/j.neuron.2017.02.023.
25. Down-regulation of mRNAs for synaptic adhesion molecules neuroligin-2 and -3 and synCAM1 in spinal motoneurons after axotomy. Zelano J, etal., J Comp Neurol. 2007 Jul 10;503(2):308-18.
Additional References at PubMed
PMID:9647694   PMID:11329178   PMID:15458844   PMID:15620359   PMID:15740699   PMID:16982420   PMID:17336090   PMID:17582332   PMID:18250328   PMID:19016888   PMID:21424692   PMID:21532576  
PMID:22871113   PMID:22960622   PMID:23426688   PMID:23451101   PMID:24213355   PMID:24613359   PMID:25565602   PMID:26152839   PMID:27035941   PMID:27805570   PMID:29715511   PMID:30602588  
PMID:30790215   PMID:37955815  


Genomics

Comparative Map Data
Nlgn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,042,175 - 55,056,578 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1055,043,185 - 55,056,578 (-)EnsemblGRCr8
mRatBN7.21054,544,461 - 54,557,854 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,544,588 - 54,558,434 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1059,206,968 - 59,220,379 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,695,535 - 58,708,946 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,203,207 - 54,216,624 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,431,586 - 56,444,847 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,431,573 - 56,444,847 (-)Ensemblrn6Rnor6.0
Rnor_5.01056,176,705 - 56,189,966 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41056,646,081 - 56,678,060 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1053,698,870 - 53,712,041 (-)NCBICelera
RGSC_v3.11056,659,705 - 56,691,680 (-)NCBI
Cytogenetic Map10q24NCBI
NLGN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38177,404,653 - 7,419,860 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl177,404,874 - 7,419,860 (+)Ensemblhg38GRCh38
GRCh37177,311,164 - 7,323,179 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,252,226 - 7,263,903 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34177,252,225 - 7,263,903NCBI
Celera177,337,380 - 7,349,064 (+)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef177,205,598 - 7,217,206 (+)NCBIHuRef
CHM1_1177,320,590 - 7,332,275 (+)NCBICHM1_1
T2T-CHM13v2.0177,308,683 - 7,323,908 (+)NCBIT2T-CHM13v2.0
Nlgn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,713,949 - 69,728,610 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,713,948 - 69,728,610 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381169,823,123 - 69,837,784 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,823,122 - 69,837,784 (-)Ensemblmm10GRCm38
MGSCv371169,636,625 - 69,648,351 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361169,639,318 - 69,651,044 (-)NCBIMGSCv36mm8
Celera1177,384,083 - 77,395,807 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.89NCBI
Nlgn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554679,504,974 - 9,520,059 (-)Ensembl
ChiLan1.0NW_0049554679,504,974 - 9,520,059 (-)NCBIChiLan1.0ChiLan1.0
NLGN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21915,001,795 - 15,016,817 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11716,967,475 - 16,982,617 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,438,853 - 7,454,014 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1177,425,927 - 7,438,504 (+)NCBIPanPan1.1PanPan1.1panPan2
NLGN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,338,602 - 32,351,546 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl532,340,335 - 32,352,412 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha532,476,574 - 32,491,676 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0532,444,141 - 32,459,248 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,446,860 - 32,457,104 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,409,378 - 32,424,482 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,368,131 - 32,383,214 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,545,377 - 32,560,482 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nlgn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560247,218,152 - 47,230,462 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936595692,334 - 704,602 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936595692,340 - 704,650 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NLGN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,781,510 - 6,796,304 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl166,784,642 - 6,794,419 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605914,612,269 - 14,627,070 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nlgn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478610,022,717 - 10,034,624 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478610,019,307 - 10,034,624 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Nlgn2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1949,429,906 - 49,444,694 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nlgn2
81 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:184
Count of miRNA genes:104
Interacting mature miRNAs:117
Transcripts:ENSRNOT00000056871, ENSRNOT00000056872
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104748901769161158Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105216243375582749Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1578762Toxo1Toxoplasma gondii resistance QTL 1brain integrity trait (VT:0010579)percentage of study population displaying Toxoplasma gondii brain cysts at a point in time (CMO:0002028)105269900459876693Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105429622767476781Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
1354585Eae18aExperimental allergic encephalomyelitis QTL 18a7.50.0004nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)105429622758944345Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 82 59 6 346 182 11 139 81 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000056872   ⟹   ENSRNOP00000053713
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1055,043,185 - 55,056,578 (-)Ensembl
mRatBN7.2 Ensembl1054,544,588 - 54,557,854 (-)Ensembl
Rnor_6.0 Ensembl1056,431,573 - 56,444,847 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1056,437,578 - 56,441,502 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092662   ⟹   ENSRNOP00000075845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1055,043,185 - 55,053,817 (-)Ensembl
mRatBN7.2 Ensembl1054,544,588 - 54,558,434 (-)Ensembl
Rnor_6.0 Ensembl1056,431,586 - 56,444,847 (-)Ensembl
RefSeq Acc Id: NM_053992   ⟹   NP_446444
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,043,185 - 55,056,578 (-)NCBI
mRatBN7.21054,544,461 - 54,557,854 (-)NCBI
Rnor_6.01056,431,586 - 56,444,847 (-)NCBI
Rnor_5.01056,176,705 - 56,189,966 (-)NCBI
RGSC_v3.41056,646,081 - 56,678,060 (-)RGD
Celera1053,698,870 - 53,712,041 (-)RGD
Sequence:
RefSeq Acc Id: XM_063268317   ⟹   XP_063124387
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,042,175 - 55,054,776 (-)NCBI
RefSeq Acc Id: XM_063268318   ⟹   XP_063124388
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,042,175 - 55,056,405 (-)NCBI
RefSeq Acc Id: NP_446444   ⟸   NM_053992
- Peptide Label: precursor
- UniProtKB: Q62888 (UniProtKB/Swiss-Prot),   F1LQ41 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075845   ⟸   ENSRNOT00000092662
Ensembl Acc Id: ENSRNOP00000053713   ⟸   ENSRNOT00000056872
RefSeq Acc Id: XP_063124388   ⟸   XM_063268318
- Peptide Label: isoform X2
- UniProtKB: F1LQ41 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124387   ⟸   XM_063268317
- Peptide Label: isoform X1
- UniProtKB: Q62888 (UniProtKB/Swiss-Prot),   F1LQ41 (UniProtKB/TrEMBL)
Protein Domains
Carboxylesterase type B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62888-F1-model_v2 AlphaFold Q62888 1-836 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697327
Promoter ID:EPDNEW_R7852
Type:single initiation site
Name:Nlgn2_1
Description:neuroligin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01056,444,780 - 56,444,840EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621118 AgrOrtholog
BioCyc Gene G2FUF-24511 BioCyc
Ensembl Genes ENSRNOG00000015430 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000056872 ENTREZGENE
  ENSRNOT00000056872.6 UniProtKB/Swiss-Prot
  ENSRNOT00000092662 ENTREZGENE
  ENSRNOT00000092662.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot
InterPro AB_hydrolase UniProtKB/Swiss-Prot
  CarbesteraseB UniProtKB/Swiss-Prot
  Carboxylesterase_B_CS UniProtKB/Swiss-Prot
  Neuroligin/BSAL UniProtKB/Swiss-Prot
  Nlgn UniProtKB/Swiss-Prot
KEGG Report rno:117096 UniProtKB/Swiss-Prot
NCBI Gene 117096 ENTREZGENE
PANTHER NEUROLIGIN UniProtKB/Swiss-Prot
Pfam COesterase UniProtKB/Swiss-Prot
PhenoGen Nlgn2 PhenoGen
PRINTS NEUROLIGIN UniProtKB/Swiss-Prot
PROSITE CARBOXYLESTERASE_B_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015430 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot
UniProt A0A0U1RRX0_RAT UniProtKB/TrEMBL
  A6HFU2_RAT UniProtKB/TrEMBL
  F1LQ41 ENTREZGENE, UniProtKB/TrEMBL
  NLGN2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Nlgn2  neuroligin 2      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Nlgn2  neuroligin 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains an esterase homology domain, a highly conserved single transmembrane region, and a short cytoplasmic domain 729051
gene_physical_interaction binds to beta-neurexins 729051