Adgrl1 (adhesion G protein-coupled receptor L1) - Rat Genome Database

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Gene: Adgrl1 (adhesion G protein-coupled receptor L1) Rattus norvegicus
Analyze
Symbol: Adgrl1
Name: adhesion G protein-coupled receptor L1
RGD ID: 620768
Description: Enables cell adhesion molecule binding activity; toxic substance binding activity; and transmembrane signaling receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within positive regulation of synapse assembly. Located in growth cone; plasma membrane; and synapse. Is active in glutamatergic synapse and presynaptic membrane. Orthologous to human ADGRL1 (adhesion G protein-coupled receptor L1); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: calcium-independent alpha-latrotoxin receptor 1; CIRL-1; CL1BA; latrophilin 1; latrophilin-1; Lphn1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81941,107,162 - 41,148,752 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1941,109,117 - 41,148,896 (-)EnsemblGRCr8
mRatBN7.21924,202,405 - 24,244,137 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1924,204,360 - 24,244,139 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1931,025,506 - 31,065,123 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01931,679,912 - 31,719,528 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01933,902,636 - 33,942,265 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01925,029,037 - 25,069,146 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,029,037 - 25,069,142 (+)Ensemblrn6Rnor6.0
Rnor_5.01936,021,693 - 36,047,251 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41925,891,157 - 25,931,128 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1923,752,024 - 23,791,544 (-)NCBICelera
RGSC_v3.11925,895,986 - 25,935,954 (-)NCBI
Cytogenetic Map19q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
bisphenol F  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
chlordecone  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
crocidolite asbestos  (ISO)
DDE  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
dicrotophos  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
folic acid  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
L-ascorbic acid  (EXP)
lead(0)  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nicotine  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
axon  (IBA,IDA,IEA)
glutamatergic synapse  (IDA,IEP,IMP)
growth cone  (IDA,IEA)
membrane  (IEA)
neuron projection  (IDA,IEA)
plasma membrane  (IBA,IDA,IEA)
presynaptic membrane  (IBA,IDA,IEA,IEP,IMP)
synapse  (IDA,IEA)
synaptic membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Involvement of the calcium-independent receptor for alpha-latrotoxin in brain ischemia. Bin Sun H, etal., Brain Res Mol Brain Res. 2002 Aug 15;104(2):246-9.
2. Isolation and biochemical characterization of a Ca2+-independent alpha-latrotoxin-binding protein. Davletov BA, etal., J Biol Chem 1996 Sep 20;271(38):23239-45.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. alpha-Latrotoxin stimulates exocytosis by the interaction with a neuronal G-protein-coupled receptor. Krasnoperov VG, etal., Neuron 1997 Jun;18(6):925-37.
6. The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins. Kreienkamp HJ, etal., J Biol Chem. 2000 Oct 20;275(42):32387-90.
7. Alpha-latrotoxin receptor, latrophilin, is a novel member of the secretin family of G protein-coupled receptors. Lelianova VG, etal., J Biol Chem 1997 Aug 22;272(34):21504-8.
8. The latrophilin family: multiply spliced G protein-coupled receptors with differential tissue distribution. Matsushita H, etal., FEBS Lett 1999 Jan 29;443(3):348-52.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Norepinephrine exocytosis stimulated by alpha-latrotoxin requires both external and stored Ca2+ and is mediated by latrophilin, G proteins and phospholipase C. Rahman MA, etal., Philos Trans R Soc Lond B Biol Sci. 1999 Feb 28;354(1381):379-86.
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities. Silva JP, etal., Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12113-8. doi: 10.1073/pnas.1019434108. Epub 2011 Jul 1.
14. The G protein-coupled receptor CL1 interacts directly with proteins of the Shank family. Tobaben S, etal., J Biol Chem 2000 Nov 17;275(46):36204-10.
Additional References at PubMed
PMID:9830014   PMID:9920906   PMID:12270923   PMID:19161337   PMID:22262843   PMID:22871113   PMID:24613359   PMID:32996461  


Genomics

Comparative Map Data
Adgrl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81941,107,162 - 41,148,752 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1941,109,117 - 41,148,896 (-)EnsemblGRCr8
mRatBN7.21924,202,405 - 24,244,137 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1924,204,360 - 24,244,139 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1931,025,506 - 31,065,123 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01931,679,912 - 31,719,528 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01933,902,636 - 33,942,265 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01925,029,037 - 25,069,146 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,029,037 - 25,069,142 (+)Ensemblrn6Rnor6.0
Rnor_5.01936,021,693 - 36,047,251 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41925,891,157 - 25,931,128 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1923,752,024 - 23,791,544 (-)NCBICelera
RGSC_v3.11925,895,986 - 25,935,954 (-)NCBI
Cytogenetic Map19q11NCBI
ADGRL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381914,147,743 - 14,206,169 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1914,147,743 - 14,206,204 (-)Ensemblhg38GRCh38
GRCh371914,258,555 - 14,316,981 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361914,119,549 - 14,177,997 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341914,119,549 - 14,177,997NCBI
Celera1914,152,822 - 14,211,284 (-)NCBICelera
Cytogenetic Map19p13.12NCBI
HuRef1913,829,970 - 13,888,419 (-)NCBIHuRef
CHM1_11914,258,980 - 14,317,433 (-)NCBICHM1_1
T2T-CHM13v2.01914,274,383 - 14,332,836 (-)NCBIT2T-CHM13v2.0
Adgrl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,626,598 - 84,668,583 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl884,626,734 - 84,668,583 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38883,900,098 - 83,941,954 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl883,900,105 - 83,941,954 (+)Ensemblmm10GRCm38
MGSCv37886,423,997 - 86,465,853 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36886,790,818 - 86,830,082 (+)NCBIMGSCv36mm8
Celera888,192,529 - 88,234,715 (+)NCBICelera
Cytogenetic Map8C2NCBI
cM Map840.22NCBI
Adgrl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541532,846,161 - 32,883,617 (-)Ensembl
ChiLan1.0NW_00495541532,849,066 - 32,883,628 (-)NCBIChiLan1.0ChiLan1.0
ADGRL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22019,079,713 - 19,138,721 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11918,081,534 - 18,140,492 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01913,713,395 - 13,772,360 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11914,439,730 - 14,475,877 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1914,439,730 - 14,475,877 (-)EnsemblpanPan2panpan1.1
ADGRL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12048,316,909 - 48,383,783 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2048,339,945 - 48,381,667 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2048,192,793 - 48,258,299 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02048,836,078 - 48,901,545 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2048,858,591 - 48,899,602 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12048,047,337 - 48,112,760 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02048,473,880 - 48,537,373 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02048,716,611 - 48,782,111 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Adgrl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118207,531,905 - 207,560,180 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366592,794,520 - 2,822,848 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366592,794,520 - 2,822,795 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADGRL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl264,997,159 - 65,044,298 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1264,997,159 - 65,046,509 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2265,300,262 - 65,321,420 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADGRL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1612,782,202 - 12,795,742 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660746,800,557 - 6,863,556 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adgrl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249011,374,300 - 1,418,068 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249011,376,295 - 1,418,126 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Adgrl1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11716,334,661 - 16,376,281 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Adgrl1
197 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:915
Count of miRNA genes:190
Interacting mature miRNAs:230
Transcripts:ENSRNOT00000041025, ENSRNOT00000043971, ENSRNOT00000045699
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)19574806450748064Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)193128753251431640Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)194072709254856850Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)194072709254856850Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)194072709254856850Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)193009938347207961Rat

Markers in Region
D19Got21  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21924,233,287 - 24,233,495 (-)MAPPERmRatBN7.2
Rnor_6.01925,039,533 - 25,039,740NCBIRnor6.0
Rnor_5.01936,017,638 - 36,017,845UniSTSRnor5.0
RGSC_v3.41925,920,562 - 25,920,769RGDRGSC3.4
RGSC_v3.41925,920,562 - 25,920,769UniSTSRGSC3.4
Celera1923,780,835 - 23,781,042UniSTS
RGSC_v3.11925,925,388 - 25,925,595RGD
Cytogenetic Map19q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001431366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_022962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF081144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF081145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF081146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF081147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF111099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U72487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U78105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000043971   ⟹   ENSRNOP00000045873
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1941,109,117 - 41,131,194 (-)Ensembl
mRatBN7.2 Ensembl1924,204,360 - 24,226,458 (-)Ensembl
Rnor_6.0 Ensembl1925,043,680 - 25,068,275 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000045699   ⟹   ENSRNOP00000043269
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1941,109,123 - 41,148,752 (-)Ensembl
mRatBN7.2 Ensembl1924,204,366 - 24,243,995 (-)Ensembl
Rnor_6.0 Ensembl1925,029,037 - 25,069,142 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098082   ⟹   ENSRNOP00000091684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1941,109,117 - 41,126,399 (-)Ensembl
mRatBN7.2 Ensembl1924,204,363 - 24,229,278 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101340   ⟹   ENSRNOP00000085538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1941,109,120 - 41,148,896 (-)Ensembl
mRatBN7.2 Ensembl1924,204,363 - 24,244,139 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101400   ⟹   ENSRNOP00000089805
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1941,109,117 - 41,123,047 (-)Ensembl
mRatBN7.2 Ensembl1924,204,360 - 24,233,906 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103294   ⟹   ENSRNOP00000086387
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1941,109,123 - 41,148,752 (-)Ensembl
mRatBN7.2 Ensembl1924,204,363 - 24,233,906 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113469   ⟹   ENSRNOP00000090901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1941,109,120 - 41,148,896 (-)Ensembl
mRatBN7.2 Ensembl1924,204,363 - 24,244,139 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115789   ⟹   ENSRNOP00000079689
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1941,109,120 - 41,125,103 (-)Ensembl
mRatBN7.2 Ensembl1924,204,360 - 24,217,452 (-)Ensembl
RefSeq Acc Id: NM_022962   ⟹   NP_075251
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81941,109,119 - 41,148,752 (-)NCBI
mRatBN7.21924,204,362 - 24,243,995 (-)NCBI
Rnor_6.01925,029,037 - 25,069,146 (+)NCBI
Rnor_5.01936,021,693 - 36,047,251 (+)NCBI
RGSC_v3.41925,891,157 - 25,931,128 (-)RGD
Celera1923,752,024 - 23,791,544 (-)RGD
Sequence:
RefSeq Acc Id: XM_039097964   ⟹   XP_038953892
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81941,107,162 - 41,148,697 (-)NCBI
mRatBN7.21924,202,405 - 24,243,989 (-)NCBI
RefSeq Acc Id: XM_039097965   ⟹   XP_038953893
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81941,107,162 - 41,148,697 (-)NCBI
mRatBN7.21924,202,405 - 24,243,989 (-)NCBI
RefSeq Acc Id: XM_039097966   ⟹   XP_038953894
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81941,107,162 - 41,148,697 (-)NCBI
mRatBN7.21924,202,405 - 24,243,941 (-)NCBI
RefSeq Acc Id: XM_039097967   ⟹   XP_038953895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81941,107,162 - 41,148,697 (-)NCBI
mRatBN7.21924,202,405 - 24,244,137 (-)NCBI
RefSeq Acc Id: XM_039097968   ⟹   XP_038953896
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81941,107,162 - 41,125,103 (-)NCBI
mRatBN7.21924,202,405 - 24,220,344 (-)NCBI
RefSeq Acc Id: XM_039097969   ⟹   XP_038953897
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81941,107,162 - 41,125,103 (-)NCBI
mRatBN7.21924,202,405 - 24,220,344 (-)NCBI
RefSeq Acc Id: XM_039097971   ⟹   XP_038953899
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81941,107,162 - 41,125,080 (-)NCBI
mRatBN7.21924,202,405 - 24,220,335 (-)NCBI
RefSeq Acc Id: XM_063278273   ⟹   XP_063134343
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81941,107,162 - 41,120,970 (-)NCBI
RefSeq Acc Id: NP_075251   ⟸   NM_022962
- Peptide Label: precursor
- UniProtKB: A0A8I6AG63 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000043269   ⟸   ENSRNOT00000045699
Ensembl Acc Id: ENSRNOP00000045873   ⟸   ENSRNOT00000043971
RefSeq Acc Id: XP_038953895   ⟸   XM_039097967
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038953893   ⟸   XM_039097965
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038953892   ⟸   XM_039097964
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038953894   ⟸   XM_039097966
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AG63 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953897   ⟸   XM_039097969
- Peptide Label: isoform X6
- UniProtKB: A0A8I6G3M0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953896   ⟸   XM_039097968
- Peptide Label: isoform X5
- UniProtKB: A0A8I6G3M0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953899   ⟸   XM_039097971
- Peptide Label: isoform X7
- UniProtKB: A0A8I6AB35 (UniProtKB/TrEMBL),   A6IYC7 (UniProtKB/TrEMBL),   A0A8I6G3M0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000079689   ⟸   ENSRNOT00000115789
Ensembl Acc Id: ENSRNOP00000086387   ⟸   ENSRNOT00000103294
Ensembl Acc Id: ENSRNOP00000089805   ⟸   ENSRNOT00000101400
Ensembl Acc Id: ENSRNOP00000091684   ⟸   ENSRNOT00000098082
Ensembl Acc Id: ENSRNOP00000085538   ⟸   ENSRNOT00000101340
Ensembl Acc Id: ENSRNOP00000090901   ⟸   ENSRNOT00000113469
RefSeq Acc Id: XP_063134343   ⟸   XM_063278273
- Peptide Label: isoform X7
- UniProtKB: A0A8I6AB35 (UniProtKB/TrEMBL),   A6IYC7 (UniProtKB/TrEMBL),   A0A8I6G3M0 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 2 profile   GAIN-B   Olfactomedin-like   SUEL-type lectin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88917-F1-model_v2 AlphaFold O88917 1-1515 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620768 AgrOrtholog
BioCyc Gene G2FUF-6034 BioCyc
Ensembl Genes ENSRNOG00000029134 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000045699 ENTREZGENE
  ENSRNOT00000098082 ENTREZGENE
  ENSRNOT00000103294 ENTREZGENE
  ENSRNOT00000115789 ENTREZGENE
Gene3D-CATH 1.25.40.610 UniProtKB/Swiss-Prot
  2.60.120.740 UniProtKB/Swiss-Prot
  2.60.220.50 UniProtKB/Swiss-Prot
  4.10.1240.10 UniProtKB/Swiss-Prot
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GAIN_B UniProtKB/Swiss-Prot
  GAIN_dom_N UniProtKB/Swiss-Prot
  GAIN_dom_sf UniProtKB/Swiss-Prot
  GPCR_2-like UniProtKB/Swiss-Prot
  GPCR_2_extracell_dom_sf UniProtKB/Swiss-Prot
  GPCR_2_extracellular_dom UniProtKB/Swiss-Prot
  GPCR_2_latrophilin UniProtKB/Swiss-Prot
  GPCR_2_latrophilin_rcpt_C UniProtKB/Swiss-Prot
  GPCR_2_secretin-like UniProtKB/Swiss-Prot
  GPCR_2_secretin-like_CS UniProtKB/Swiss-Prot
  GPS UniProtKB/Swiss-Prot
  Latrophilin-1 UniProtKB/Swiss-Prot
  Lectin_gal-bd_dom UniProtKB/Swiss-Prot
  Lectin_gal-bd_sf UniProtKB/Swiss-Prot
  Olfac-like_dom UniProtKB/Swiss-Prot
KEGG Report rno:65096 UniProtKB/Swiss-Prot
NCBI Gene 65096 ENTREZGENE
PANTHER ADHESION G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
  PTHR12011:SF62 UniProtKB/Swiss-Prot
Pfam 7tm_2 UniProtKB/Swiss-Prot
  GAIN UniProtKB/Swiss-Prot
  Gal_Lectin UniProtKB/Swiss-Prot
  GPS UniProtKB/Swiss-Prot
  HRM UniProtKB/Swiss-Prot
  Latrophilin UniProtKB/Swiss-Prot
  OLF UniProtKB/Swiss-Prot
PhenoGen Adgrl1 PhenoGen
PRINTS GPCRSECRETIN UniProtKB/Swiss-Prot
  LATROPHILIN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F2_2 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F2_3 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F2_4 UniProtKB/Swiss-Prot
  GPS UniProtKB/Swiss-Prot
  OLF UniProtKB/Swiss-Prot
  SUEL_LECTIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000029134 RatGTEx
SMART GPS UniProtKB/Swiss-Prot
  HormR UniProtKB/Swiss-Prot
  OLF UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A0A8I6A141_RAT UniProtKB/TrEMBL
  A0A8I6A3I4_RAT UniProtKB/TrEMBL
  A0A8I6AB35 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ACM1_RAT UniProtKB/TrEMBL
  A0A8I6AG63 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G3M0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QLY5_RAT UniProtKB/TrEMBL
  A6IYC5 ENTREZGENE, UniProtKB/TrEMBL
  A6IYC6_RAT UniProtKB/TrEMBL
  A6IYC7 ENTREZGENE, UniProtKB/TrEMBL
  AGRL1_RAT UniProtKB/Swiss-Prot
  D4A144_RAT UniProtKB/TrEMBL
  O88917 ENTREZGENE
UniProt Secondary O09026 UniProtKB/Swiss-Prot
  O35818 UniProtKB/Swiss-Prot
  O88916 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-03-16 Adgrl1  adhesion G protein-coupled receptor L1  Lphn1  latrophilin 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Lphn1  latrophilin 1  CL1BA  CL1BA protein  Symbol and Name updated 1299863 APPROVED
2002-08-07 CL1BA  CL1BA protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product a member of the secretin receptor family 632419