RGD Reference Report - Involvement of the calcium-independent receptor for alpha-latrotoxin in brain ischemia. - Rat Genome Database

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Involvement of the calcium-independent receptor for alpha-latrotoxin in brain ischemia.

Authors: Bin Sun, H  Ruan, Y  Xu, ZC  Yokota, H 
Citation: Bin Sun H, etal., Brain Res Mol Brain Res. 2002 Aug 15;104(2):246-9.
RGD ID: 2314400
Pubmed: PMID:12225880   (View Abstract at PubMed)

Cerebral ischemia is caused by a reduced blood supply to neurons, and vulnerability to neurodegeneration varies considerably among neuronal types. In hippocampus, neurons in the CA1 region are more susceptible to ischemia-induced neuronal death than neurons in the CA3 region, and in response to transient forebrain ischemia a family of calcium-dependent receptors for alpha-latrotoxin is differentially expressed in the two regions. Here, we report that an ischemic insult up-regulated a family of calcium-independent receptors for alpha-latrotoxin (CIRL) mRNAs in CA1 neurons and down-regulated their mRNAs in CA3 neurons. Furthermore, antisense oligonucleotides complementary to CIRL-1 mRNA or CIRL-3 mRNA suppressed neuronal death associated with hypoxia in hippocampal and cortical cell cultures. The observed region-specific CIRL mRNA expression in hippocampus and an in vitro rescue experiment by antisense oligonucleotides against CIRL mRNAs suggest a functional importance of CIRL in neurodegeneration.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Objects Annotated

Genes (Rattus norvegicus)
Adgrl1  (adhesion G protein-coupled receptor L1)
Adgrl3  (adhesion G protein-coupled receptor L3)

Genes (Mus musculus)
Adgrl1  (adhesion G protein-coupled receptor L1)
Adgrl3  (adhesion G protein-coupled receptor L3)

Genes (Homo sapiens)
ADGRL1  (adhesion G protein-coupled receptor L1)
ADGRL3  (adhesion G protein-coupled receptor L3)


Additional Information