Rps6ka2 (ribosomal protein S6 kinase A2) - Rat Genome Database

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Gene: Rps6ka2 (ribosomal protein S6 kinase A2) Rattus norvegicus
Analyze
Symbol: Rps6ka2
Name: ribosomal protein S6 kinase A2
RGD ID: 620676
Description: Predicted to enable protein serine/threonine/tyrosine kinase activity and ribosomal protein S6 kinase activity. Predicted to be involved in several processes, including TORC1 signaling; negative regulation of cell population proliferation; and positive regulation of apoptotic process. Predicted to act upstream of or within several processes, including cardiac muscle cell apoptotic process; oocyte maturation; and regulation of gene expression. Predicted to be located in meiotic spindle and nucleus. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human RPS6KA2 (ribosomal protein S6 kinase A2); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; long term potentiation; mitogen activated protein kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ribosomal protein S6 kinase alpha-2; ribosomal protein S6 kinase polypeptide 2; ribosomal protein S6 kinase, 90kD, polypeptide 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8155,178,988 - 55,454,271 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl155,179,319 - 55,454,338 (+)EnsemblGRCr8
mRatBN7.2152,631,582 - 52,906,739 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl152,631,736 - 52,906,739 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx153,478,991 - 53,614,454 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0159,464,385 - 59,599,587 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0153,554,603 - 53,690,056 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0153,219,346 - 53,499,445 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl153,360,157 - 53,499,445 (+)Ensemblrn6Rnor6.0
Rnor_5.0154,469,155 - 54,747,731 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4147,424,106 - 47,560,373 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera148,533,427 - 48,667,077 (+)NCBICelera
RGSC_v3.1147,535,295 - 47,553,857 (+)NCBI
Cytogenetic Map1q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cantharidin  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
Dibutyl phosphate  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ferroheme b  (ISO)
fulvestrant  (ISO)
heme b  (ISO)
hydroquinone  (ISO)
lead(0)  (ISO)
Licochalcone B  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
maneb  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-nitrosodiethylamine  (EXP)
nitrogen mustard  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
obeticholic acid  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenethyl caffeate  (ISO)
phenylmercury acetate  (ISO)
phosgene  (ISO)
pioglitazone  (ISO)
potassium chromate  (ISO)
propanal  (ISO)
raloxifene  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
taurine  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
meiotic spindle  (IEA,ISO)
nucleoplasm  (IBA,IEA,ISO)
nucleus  (IEA,ISO)
spindle  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Fingar DC, etal., Genes Dev 2002 Jun 15;16(12):1472-87.
2. MAPKAP kinases - MKs - two's company, three's a crowd. Gaestel M Nat Rev Mol Cell Biol. 2006 Feb;7(2):120-30.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Effect of long-term exercise on gene expression of insulin signaling pathway intermediates in skeletal muscle. Kim YB, etal., Biochem Biophys Res Commun 1999 Jan 27;254(3):720-7.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7508917   PMID:10635333   PMID:11684016   PMID:15509711   PMID:15526037   PMID:16585392   PMID:16878154   PMID:19418583   PMID:21891976   PMID:22797923   PMID:22997248  


Genomics

Comparative Map Data
Rps6ka2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8155,178,988 - 55,454,271 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl155,179,319 - 55,454,338 (+)EnsemblGRCr8
mRatBN7.2152,631,582 - 52,906,739 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl152,631,736 - 52,906,739 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx153,478,991 - 53,614,454 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0159,464,385 - 59,599,587 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0153,554,603 - 53,690,056 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0153,219,346 - 53,499,445 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl153,360,157 - 53,499,445 (+)Ensemblrn6Rnor6.0
Rnor_5.0154,469,155 - 54,747,731 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4147,424,106 - 47,560,373 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera148,533,427 - 48,667,077 (+)NCBICelera
RGSC_v3.1147,535,295 - 47,553,857 (+)NCBI
Cytogenetic Map1q12NCBI
RPS6KA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386166,409,364 - 166,862,773 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6166,409,364 - 166,906,451 (-)Ensemblhg38GRCh38
GRCh376166,822,852 - 167,276,013 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366166,742,844 - 167,195,761 (-)NCBIBuild 36Build 36hg18NCBI36
Build 346166,793,264 - 167,011,137NCBI
Celera6167,562,220 - 168,016,996 (-)NCBICelera
Cytogenetic Map6q27NCBI
HuRef6164,294,243 - 164,748,630 (-)NCBIHuRef
CHM1_16167,086,555 - 167,538,409 (-)NCBICHM1_1
T2T-CHM13v2.06167,786,324 - 168,245,548 (-)NCBIT2T-CHM13v2.0
Rps6ka2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39177,356,384 - 7,570,714 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl177,292,942 - 7,570,726 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38177,088,971 - 7,303,315 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl177,170,115 - 7,303,315 (+)Ensemblmm10GRCm38
MGSCv37177,374,464 - 7,507,664 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36177,019,773 - 7,152,973 (+)NCBIMGSCv36mm8
Celera177,033,227 - 7,165,891 (-)NCBICelera
Cytogenetic Map17A1NCBI
cM Map174.7NCBI
Rps6ka2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543915,332,165 - 15,487,305 (+)Ensembl
ChiLan1.0NW_00495543915,210,882 - 15,487,305 (+)NCBIChiLan1.0ChiLan1.0
RPS6KA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25186,615,281 - 187,112,903 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16184,511,214 - 185,009,053 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06164,373,829 - 164,829,195 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16169,355,114 - 169,806,718 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6169,355,136 - 169,806,337 (-)EnsemblpanPan2panpan1.1
RPS6KA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1154,413,805 - 54,757,067 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl154,416,758 - 54,757,067 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha155,202,572 - 55,547,248 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0154,592,807 - 54,938,176 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl154,592,818 - 54,938,570 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1154,489,815 - 54,835,148 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0154,338,945 - 54,683,764 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0154,963,546 - 55,308,688 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rps6ka2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946148,959,493 - 149,261,887 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648916,214,871 - 16,355,388 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648916,214,790 - 16,355,372 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RPS6KA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl12,203,606 - 2,522,599 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.112,203,825 - 2,522,604 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213,346,751 - 3,662,181 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RPS6KA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11394,141,648 - 94,605,750 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1394,140,111 - 94,357,688 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604065,964,531 - 66,420,530 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rps6ka2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478512,657,845 - 12,839,569 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478512,450,686 - 12,839,563 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Rps6ka2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12186,684,234 - 186,828,845 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rps6ka2
2085 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:332
Count of miRNA genes:203
Interacting mature miRNAs:237
Transcripts:ENSRNOT00000017809
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12940927974409279Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12050832665508326Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12065642065656420Rat

Markers in Region
D1Rat489  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8155,260,312 - 55,260,571 (+)Marker Load Pipeline
mRatBN7.2152,712,762 - 52,713,019 (+)MAPPERmRatBN7.2
Rnor_6.0153,301,737 - 53,301,995NCBIRnor6.0
Rnor_5.0154,551,265 - 54,551,523UniSTSRnor5.0
RGSC_v3.4147,364,594 - 47,364,852UniSTSRGSC3.4
RGSC_v3.4147,364,593 - 47,364,852RGDRGSC3.4
Celera148,475,189 - 48,475,447UniSTS
RGSC_v3.1147,367,538 - 47,367,797RGD
FHH x ACI Map129.09UniSTS
FHH x ACI Map129.09RGD
Cytogenetic Map1q11UniSTS
RH127829  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2152,906,396 - 52,906,609 (+)MAPPERmRatBN7.2
Rnor_6.0153,499,103 - 53,499,315NCBIRnor6.0
Rnor_5.0154,747,389 - 54,747,601UniSTSRnor5.0
RGSC_v3.4147,560,031 - 47,560,243UniSTSRGSC3.4
Celera148,666,735 - 48,666,947UniSTS
RH 3.4 Map1627.0UniSTS
Cytogenetic Map1q11UniSTS
BF386574  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2152,724,859 - 52,725,038 (+)MAPPERmRatBN7.2
Rnor_6.0153,313,830 - 53,314,008NCBIRnor6.0
Rnor_5.0154,563,358 - 54,563,536UniSTSRnor5.0
RGSC_v3.4147,376,693 - 47,376,871UniSTSRGSC3.4
Celera148,487,288 - 48,487,466UniSTS
RH 3.4 Map1624.3UniSTS
Cytogenetic Map1q11UniSTS
BE096506  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2152,789,815 - 52,790,003 (+)MAPPERmRatBN7.2
Rnor_6.0153,378,554 - 53,378,741NCBIRnor6.0
Rnor_5.0154,628,022 - 54,628,209UniSTSRnor5.0
RGSC_v3.4147,443,145 - 47,443,332UniSTSRGSC3.4
Celera148,552,001 - 48,552,188UniSTS
RH 3.4 Map1624.4UniSTS
Cytogenetic Map1q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 13 70 209 91 90 59 126 59 6 421 234 17 185 104 99 31 33 33

Sequence


Ensembl Acc Id: ENSRNOT00000017809   ⟹   ENSRNOP00000017809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl155,318,811 - 55,454,271 (+)Ensembl
mRatBN7.2 Ensembl152,771,260 - 52,906,739 (+)Ensembl
Rnor_6.0 Ensembl153,360,157 - 53,499,445 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094462   ⟹   ENSRNOP00000086785
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl155,318,811 - 55,454,271 (+)Ensembl
mRatBN7.2 Ensembl152,825,976 - 52,906,739 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095647   ⟹   ENSRNOP00000088182
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl155,288,568 - 55,454,338 (+)Ensembl
mRatBN7.2 Ensembl152,741,017 - 52,906,739 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103591   ⟹   ENSRNOP00000097579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl155,179,319 - 55,454,268 (+)Ensembl
mRatBN7.2 Ensembl152,631,736 - 52,906,739 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107274   ⟹   ENSRNOP00000084178
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl155,231,682 - 55,454,268 (+)Ensembl
mRatBN7.2 Ensembl152,684,153 - 52,906,739 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112387   ⟹   ENSRNOP00000076821
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl155,244,445 - 55,454,338 (+)Ensembl
mRatBN7.2 Ensembl152,704,915 - 52,906,739 (+)Ensembl
RefSeq Acc Id: NM_057128   ⟹   NP_476469
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8155,318,811 - 55,454,271 (+)NCBI
mRatBN7.2152,771,260 - 52,906,739 (+)NCBI
Rnor_6.0153,360,157 - 53,499,445 (+)NCBI
Rnor_5.0154,469,155 - 54,747,731 (+)NCBI
RGSC_v3.4147,424,106 - 47,560,373 (+)RGD
Celera148,533,427 - 48,667,077 (+)RGD
Sequence:
RefSeq Acc Id: XM_039078975   ⟹   XP_038934903
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8155,178,988 - 55,454,271 (+)NCBI
mRatBN7.2152,631,582 - 52,906,739 (+)NCBI
RefSeq Acc Id: XM_039079021   ⟹   XP_038934949
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8155,231,696 - 55,454,271 (+)NCBI
mRatBN7.2152,684,170 - 52,906,739 (+)NCBI
RefSeq Acc Id: XM_039079056   ⟹   XP_038934984
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8155,288,449 - 55,454,271 (+)NCBI
mRatBN7.2152,740,903 - 52,906,739 (+)NCBI
RefSeq Acc Id: XM_039079122   ⟹   XP_038935050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8155,288,833 - 55,454,271 (+)NCBI
mRatBN7.2152,741,284 - 52,906,739 (+)NCBI
RefSeq Acc Id: NP_476469   ⟸   NM_057128
- UniProtKB: F1M7N7 (UniProtKB/TrEMBL),   A6KK46 (UniProtKB/TrEMBL),   A0A8I6GEE6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017809   ⟸   ENSRNOT00000017809
RefSeq Acc Id: XP_038934903   ⟸   XM_039078975
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AWJ2 (UniProtKB/TrEMBL),   A0A8I5Y0U0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934949   ⟸   XM_039079021
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZYL5 (UniProtKB/TrEMBL),   A0A8I5Y0U0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934984   ⟸   XM_039079056
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A7B5 (UniProtKB/TrEMBL),   A0A8I6GEE6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935050   ⟸   XM_039079122
- Peptide Label: isoform X4
- UniProtKB: A0A8I5Y0U0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000088182   ⟸   ENSRNOT00000095647
Ensembl Acc Id: ENSRNOP00000097579   ⟸   ENSRNOT00000103591
Ensembl Acc Id: ENSRNOP00000076821   ⟸   ENSRNOT00000112387
Ensembl Acc Id: ENSRNOP00000084178   ⟸   ENSRNOT00000107274
Ensembl Acc Id: ENSRNOP00000086785   ⟸   ENSRNOT00000094462
Protein Domains
AGC-kinase C-terminal   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M7N7-F1-model_v2 AlphaFold F1M7N7 1-733 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689633
Promoter ID:EPDNEW_R157
Type:initiation region
Name:Rps6ka2_1
Description:ribosomal protein S6 kinase A2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0153,360,166 - 53,360,226EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620676 AgrOrtholog
BioCyc Gene G2FUF-61506 BioCyc
Ensembl Genes ENSRNOG00000013194 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017809 ENTREZGENE
  ENSRNOT00000017809.7 UniProtKB/TrEMBL
  ENSRNOT00000094462.2 UniProtKB/TrEMBL
  ENSRNOT00000095647 ENTREZGENE
  ENSRNOT00000095647.2 UniProtKB/TrEMBL
  ENSRNOT00000103591 ENTREZGENE
  ENSRNOT00000103591.2 UniProtKB/TrEMBL
  ENSRNOT00000107274 ENTREZGENE
  ENSRNOT00000107274.2 UniProtKB/TrEMBL
  ENSRNOT00000112387.2 UniProtKB/TrEMBL
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ribosomal_S6_kinase_II UniProtKB/TrEMBL
  RSK3_STKc UniProtKB/TrEMBL
  RSK_N UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:117269 UniProtKB/TrEMBL
NCBI Gene 117269 ENTREZGENE
PANTHER RIBOSOMAL PROTEIN S6 KINASE UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
PhenoGen Rps6ka2 PhenoGen
PIRSF Ribsml_S6_kin_2 UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013194 RatGTEx
SMART S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A8I5Y0U0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZYL5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A7B5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AWJ2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GEE6 ENTREZGENE, UniProtKB/TrEMBL
  A6KK46 ENTREZGENE, UniProtKB/TrEMBL
  F1M7N7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-11-29 Rps6ka2  ribosomal protein S6 kinase A2  Rps6ka2  ribosomal protein S6 kinase polypeptide 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Rps6ka2  ribosomal protein S6 kinase, polypeptide 2    ribosomal protein S6 kinase, 90kD, polypeptide 2  Name updated 1299863 APPROVED
2002-08-07 Rps6ka2  ribosomal protein S6 kinase, 90kD, polypeptide 2      Symbol and Name status set to provisional 70820 PROVISIONAL