Nphs2 (NPHS2 stomatin family member, podocin) - Rat Genome Database

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Gene: Nphs2 (NPHS2 stomatin family member, podocin) Rattus norvegicus
Analyze
Symbol: Nphs2
Name: NPHS2 stomatin family member, podocin
RGD ID: 620461
Description: Predicted to be involved in actin cytoskeleton organization and metanephric podocyte development. Predicted to act upstream of or within gene expression. Predicted to be located in cytoplasmic side of plasma membrane; membrane raft; and slit diaphragm. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Used to study membranous glomerulonephritis and proteinuria. Biomarker of nephrotic syndrome. Human ortholog(s) of this gene implicated in nephrotic syndrome type 2. Orthologous to human NPHS2 (NPHS2 stomatin family member, podocin); INTERACTS WITH 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine; acrylamide; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC112589; nephrosis 2 homolog (human); nephrosis 2 homolog, podocin; nephrosis 2 homolog, podocin (human); nephrosis 2 idiopathic steroid-resistant (podocin); nephrosis 2, idiopathic, steroid-resistant; nephrosis 2, idiopathic, steroid-resistant (podocin); NPHS2, podocin; podocin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81370,993,622 - 71,011,585 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1370,999,186 - 71,011,572 (+)EnsemblGRCr8
mRatBN7.21368,448,720 - 68,461,312 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1368,448,926 - 68,461,313 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1371,027,985 - 71,040,345 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01372,348,422 - 72,360,808 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01369,609,908 - 69,622,294 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1370,322,497 - 70,334,857 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1370,532,908 - 70,545,268 (+)NCBILyon_Normotensive
Lyon_Hypertensive1370,473,127 - 70,485,487 (+)NCBILyon_Hypertensive
F344_StmMcwi1370,527,901 - 70,540,285 (+)NCBIF344_StmMcwi
Rnor_6.01373,929,136 - 73,941,522 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1373,929,136 - 73,941,522 (+)Ensemblrn6Rnor6.0
Rnor_5.01378,853,114 - 78,865,500 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41371,296,482 - 71,308,868 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1368,309,838 - 68,322,218 (+)NCBICelera
RGSC_v3.11371,310,669 - 71,323,056 (+)NCBI
Cytogenetic Map13q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Cloning of rat homologue of podocin: expression in proteinuric states and in developing glomeruli. Kawachi H, etal., J Am Soc Nephrol 2003 Jan;14(1):46-56.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Nephrin and podocin dissociate at the onset of proteinuria in experimental membranous nephropathy. Nakatsue T, etal., Kidney Int. 2005 Jun;67(6):2239-53.
6. Glomerular abundance of nephrin and podocin in experimental nephrotic syndrome: different effects of antiproteinuric therapies. Nakhoul F, etal., Am J Physiol Renal Physiol. 2005 Oct;289(4):F880-90. Epub 2005 Jun 7.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Involvement of renal corpuscle microRNA expression on epithelial-to-mesenchymal transition in maternal low protein diet in adult programmed rats. Sene Lde B, etal., PLoS One. 2013 Aug 19;8(8):e71310. doi: 10.1371/journal.pone.0071310. eCollection 2013.
Additional References at PubMed
PMID:11733557   PMID:11786407   PMID:12477932   PMID:15579503   PMID:15924139   PMID:16572591   PMID:17429054   PMID:17675666   PMID:19056867   PMID:21565142   PMID:23376485   PMID:23533145  
PMID:24553432   PMID:25025298   PMID:25676004   PMID:26539476   PMID:27995418  


Genomics

Comparative Map Data
Nphs2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81370,993,622 - 71,011,585 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1370,999,186 - 71,011,572 (+)EnsemblGRCr8
mRatBN7.21368,448,720 - 68,461,312 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1368,448,926 - 68,461,313 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1371,027,985 - 71,040,345 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01372,348,422 - 72,360,808 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01369,609,908 - 69,622,294 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1370,322,497 - 70,334,857 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1370,532,908 - 70,545,268 (+)NCBILyon_Normotensive
Lyon_Hypertensive1370,473,127 - 70,485,487 (+)NCBILyon_Hypertensive
F344_StmMcwi1370,527,901 - 70,540,285 (+)NCBIF344_StmMcwi
Rnor_6.01373,929,136 - 73,941,522 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1373,929,136 - 73,941,522 (+)Ensemblrn6Rnor6.0
Rnor_5.01378,853,114 - 78,865,500 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41371,296,482 - 71,308,868 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1368,309,838 - 68,322,218 (+)NCBICelera
RGSC_v3.11371,310,669 - 71,323,056 (+)NCBI
Cytogenetic Map13q22NCBI
NPHS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381179,550,539 - 179,575,948 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1179,550,494 - 179,575,952 (-)Ensemblhg38GRCh38
GRCh371179,519,674 - 179,545,083 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361177,786,299 - 177,811,691 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341176,251,332 - 176,276,725NCBI
Celera1152,627,305 - 152,652,723 (-)NCBICelera
Cytogenetic Map1q25.2NCBI
HuRef1150,746,292 - 150,771,710 (-)NCBIHuRef
CHM1_11180,943,494 - 180,968,904 (-)NCBICHM1_1
T2T-CHM13v2.01178,905,541 - 178,930,958 (-)NCBIT2T-CHM13v2.0
Nphs2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391156,138,105 - 156,155,605 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1156,138,297 - 156,155,605 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381156,310,535 - 156,328,035 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1156,310,727 - 156,328,035 (+)Ensemblmm10GRCm38
MGSCv371158,240,866 - 158,258,166 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361158,147,412 - 158,164,712 (+)NCBIMGSCv36mm8
Celera1158,706,623 - 158,724,043 (+)NCBICelera
Cytogenetic Map1G3NCBI
cM Map167.71NCBI
Nphs2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540618,863,446 - 18,885,279 (-)Ensembl
ChiLan1.0NW_00495540618,862,054 - 18,885,214 (-)NCBIChiLan1.0ChiLan1.0
NPHS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2170,184,353 - 70,209,779 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1169,842,636 - 69,868,081 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01155,038,753 - 155,064,332 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NPHS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1720,347,526 - 20,375,975 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl720,354,134 - 20,374,020 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha719,880,091 - 19,899,246 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0720,091,600 - 20,110,548 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl720,091,036 - 20,110,222 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1720,000,474 - 20,019,613 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0720,106,845 - 20,127,281 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0720,242,370 - 20,261,517 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nphs2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934491,649,128 - 91,669,416 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364819,496,127 - 9,515,534 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364819,496,083 - 9,516,086 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPHS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9121,218,369 - 121,236,430 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.19121,217,734 - 121,236,214 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29133,034,063 - 133,052,590 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPHS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12549,786,126 - 49,804,917 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605551,211,593 - 51,236,827 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nphs2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247712,828,104 - 2,849,254 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247712,828,758 - 2,847,995 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Nphs2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11035,682,238 - 35,694,708 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nphs2
118 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:86
Count of miRNA genes:37
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000005425, ENSRNOT00000041107
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132624480871244808Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132624480871244808Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 11 50 110 65 64 33 32 33 6 226 106 2 89 69 65 31 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000005425   ⟹   ENSRNOP00000005425
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1370,999,186 - 71,011,572 (+)Ensembl
mRatBN7.2 Ensembl1368,448,929 - 68,461,313 (+)Ensembl
Rnor_6.0 Ensembl1373,929,136 - 73,941,522 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094869   ⟹   ENSRNOP00000088544
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1368,448,926 - 68,461,118 (+)Ensembl
RefSeq Acc Id: NM_130828   ⟹   NP_570841
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81370,999,186 - 71,011,572 (+)NCBI
mRatBN7.21368,448,926 - 68,461,312 (+)NCBI
Dahl_SR_JrHsd1370,322,497 - 70,334,857 (+)NCBI
Lyon_Normotensive1370,532,908 - 70,545,268 (+)NCBI
Lyon_Hypertensive1370,473,127 - 70,485,487 (+)NCBI
F344_StmMcwi1370,527,901 - 70,540,285 (+)NCBI
Rnor_6.01373,929,136 - 73,941,522 (+)NCBI
Rnor_5.01378,853,114 - 78,865,500 (+)NCBI
RGSC_v3.41371,296,482 - 71,308,868 (+)RGD
Celera1368,309,838 - 68,322,218 (+)RGD
Sequence:
RefSeq Acc Id: XM_039090291   ⟹   XP_038946219
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81370,993,622 - 71,011,585 (+)NCBI
mRatBN7.21368,448,720 - 68,461,196 (+)NCBI
RefSeq Acc Id: NP_570841   ⟸   NM_130828
- UniProtKB: Q8K4G9 (UniProtKB/Swiss-Prot),   Q8CJE4 (UniProtKB/Swiss-Prot),   Q80WP2 (UniProtKB/Swiss-Prot),   Q4G090 (UniProtKB/Swiss-Prot),   Q920E2 (UniProtKB/Swiss-Prot),   A6ID08 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005425   ⟸   ENSRNOT00000005425
RefSeq Acc Id: XP_038946219   ⟸   XM_039090291
- Peptide Label: isoform X1
- UniProtKB: A6ID09 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000088544   ⟸   ENSRNOT00000094869
Protein Domains
Band

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K4G9-F1-model_v2 AlphaFold Q8K4G9 1-383 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698914
Promoter ID:EPDNEW_R9439
Type:single initiation site
Name:Nphs2_1
Description:NPHS2, podocin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01373,929,136 - 73,929,196EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620461 AgrOrtholog
BioCyc Gene G2FUF-17813 BioCyc
Ensembl Genes ENSRNOG00000004030 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005425 ENTREZGENE
  ENSRNOT00000005425.7 UniProtKB/Swiss-Prot
  ENSRNOT00000094869.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.479.30 UniProtKB/Swiss-Prot
  6.10.250.2090 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7127895 IMAGE-MGC_LOAD
InterPro Band-7_stomatin-like UniProtKB/Swiss-Prot
  Band_7 UniProtKB/Swiss-Prot
  Band_7/SPFH_dom_sf UniProtKB/Swiss-Prot
  Stomatin_fam UniProtKB/Swiss-Prot
KEGG Report rno:170672 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112589 IMAGE-MGC_LOAD
NCBI Gene 170672 ENTREZGENE
PANTHER PODOCIN UniProtKB/Swiss-Prot
  PTHR10264 UniProtKB/Swiss-Prot
Pfam Band_7 UniProtKB/Swiss-Prot
PhenoGen Nphs2 PhenoGen
PRINTS STOMATIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004030 RatGTEx
SMART PHB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF117892 UniProtKB/Swiss-Prot
UniProt A6ID08 ENTREZGENE, UniProtKB/TrEMBL
  A6ID09 ENTREZGENE, UniProtKB/TrEMBL
  PODO_RAT UniProtKB/Swiss-Prot
  Q4G090 ENTREZGENE
  Q80WP2 ENTREZGENE
  Q8CJD4_RAT UniProtKB/TrEMBL
  Q8CJD5_RAT UniProtKB/TrEMBL
  Q8CJD6_RAT UniProtKB/TrEMBL
  Q8CJD7_RAT UniProtKB/TrEMBL
  Q8CJD8_RAT UniProtKB/TrEMBL
  Q8CJE4 ENTREZGENE
  Q8K4G9 ENTREZGENE
  Q920E2 ENTREZGENE
UniProt Secondary Q4G090 UniProtKB/Swiss-Prot
  Q80WP2 UniProtKB/Swiss-Prot
  Q8CJE4 UniProtKB/Swiss-Prot
  Q920E2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-04 Nphs2  NPHS2 stomatin family member, podocin  Nphs2  NPHS2, podocin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-02-01 Nphs2  NPHS2, podocin  Nphs2  nephrosis 2, idiopathic, steroid-resistant  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-07-06 Nphs2  nephrosis 2, idiopathic, steroid-resistant  Nphs2  nephrosis 2 homolog (human)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-11-06 Nphs2  nephrosis 2 homolog (human)  Nphs2  nephrosis 2 homolog, podocin (human)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Nphs2  nephrosis 2 homolog, podocin (human)    nephrosis 2, idiopathic, steroid-resistant (podocin)  Name updated 1299863 APPROVED
2002-08-07 Nphs2  nephrosis 2, idiopathic, steroid-resistant (podocin)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease human homolog is mutated in autosomal recessive steroid resistant nephrotic syndrome 724395
gene_expression expressed in renal glomeruli and nerve tissues 724395